Tag Archives: TOP25

The contribution of alcohol to the East-West life expectancy gap in Europe from 1990 onward.

The contribution of alcohol to the East-West life expectancy gap in Europe from 1990 onward.

Int J Epidemiol. 2017 Dec 08;:

Authors: Trias-Llimós S, Kunst AE, Jasilionis D, Janssen F

Abstract
Background: Central and Eastern European (CEE) countries have lower life expectancies and higher alcohol-attributable mortality than Western European countries. We examine the contribution of alcohol consumption to mortality across Europe, and specifically to the East-West life expectancy gap from 1990 onward.
Methods: We retrieved alcohol-attributable mortality rates (GBD Study 2013) and all-cause mortality rates (Human Mortality Database) by age and sex for nine CEE countries and for the EU-15 countries. We assessed country-specific potential gains in life expectancy (PGLE) by eliminating alcohol-attributable mortality using associated single decrement life tables. We decomposed the life expectancy differences between each CEE country and the EU-15 population-weighted average for 1990-2012/13 into alcohol-attributable and non-alcohol-attributable mortality.
Results: In 2012/13, the PGLE for men and women were, respectively, 2.15 and 1.00 years in the CEE region and 0.90 and 0.44 years in the EU-15 region. The contribution of alcohol to the East-West gap in life expectancy was largest among men in Russia {2.88 years [uncertainty interval (UI): 1.57-4.06]}, Belarus [3.70 years (UI: 1.75-5.45)] and Ukraine [2.47 years (UI: 0.90-3.88)]. The relative contributions increased in most of the countries between 1990 and 2005 (on average, from 17.0% to 25.4% for men, and from 14.7% to 22.5% for women), and declined thereafter (20.2% for men and 20.5% for women in 2012/13).
Conclusions: Alcohol contributed substantially to the East-West life expectancy gap in Europe, and to its increase (1990-2005) and decline (2005 onward). Diminishing alcohol consumption in CEE countries to Western European levels can contribute to mortality convergence across Europe.

PMID: 29228198 [PubMed – as supplied by publisher]

Continue reading

Posted in Int J Epidemiol | Tagged , | Leave a comment

Seeing the signs: Using the course of residual depressive symptomatology to predict patterns of relapse and recurrence of major depressive disorder.

Seeing the signs: Using the course of residual depressive symptomatology to predict patterns of relapse and recurrence of major depressive disorder.

Depress Anxiety. 2017 Dec 11;:

Authors: Verhoeven FEA, Wardenaar KJ, Ruhé HGE, Conradi HJ, de Jonge P

Abstract
BACKGROUND: Major depressive disorder (MDD) is characterized by high relapse/recurrence rates. Predicting individual patients’ relapse/recurrence risk has proven hard, possibly due to course heterogeneity among patients. This study aimed to (1) identify homogeneous data-driven subgroups with different patterns of relapse/recurrence and (2) identify associated predictors.
METHODS: For a year, we collected weekly depressive symptom ratings in 213 primary care MDD patients. Latent class growth analyses (LCGA), based on symptom-severity during the 24 weeks after no longer fulfilling criteria for the initial major depressive episode (MDE), were used to identify groups with different patterns of relapse/recurrence. Associations of baseline predictors with these groups were investigated, as were the groups’ associations with 3- and 11-year follow-up depression outcomes.
RESULTS: LCGA showed that heterogeneity in relapse/recurrence after no longer fulfilling criteria for the initial MDE was best described by four classes: “quick symptom decline” (14.0%), “slow symptom decline” (23.3%), “steady residual symptoms” (38.7%), and “high residual symptoms” (24.1%). The latter two classes showed lower self-esteem at baseline, and more recurrences and higher severity at 3-year follow-up than the first two classes. Moreover, the high residual symptom class scored higher on neuroticism and lower on extraversion and self-esteem at baseline. Interestingly, the steady residual symptoms and high residual symptoms classes still showed higher severity of depressive symptoms after 11 years.
CONCLUSION: Some measures were associated with specific patterns of relapse/recurrence. Moreover, the data-driven relapse/recurrence groups were predictive of long-term outcomes, suggesting that patterns of residual symptoms could be of prognostic value in clinical practice.

PMID: 29228458 [PubMed – as supplied by publisher]

Continue reading

Posted in Depress Anxiety | Tagged , | Leave a comment

Factors predicting quality of life and societal participation after survival of a cardiac arrest: a prognostic longitudinal cohort study.

Factors predicting quality of life and societal participation after survival of a cardiac arrest: a prognostic longitudinal cohort study.
Resuscitation. 2017 Dec 06;:
Authors: Verberne D, Moulaert V, Verbunt J, van H… Continue reading

Posted in Resuscitation | Tagged , | Leave a comment

Factors predicting quality of life and societal participation after survival of a cardiac arrest: a prognostic longitudinal cohort study.

Factors predicting quality of life and societal participation after survival of a cardiac arrest: a prognostic longitudinal cohort study.
Resuscitation. 2017 Dec 06;:
Authors: Verberne D, Moulaert V, Verbunt J, van H… Continue reading

Posted in Resuscitation | Tagged , | Leave a comment

Elevated inflammatory Lp-PLA2 and IL-6 link e-waste Pb toxicity to cardiovascular risk factors in preschool children.

Elevated inflammatory Lp-PLA2 and IL-6 link e-waste Pb toxicity to cardiovascular risk factors in preschool children.

Environ Pollut. 2017 Dec 07;234:601-609

Authors: Lu X, Xu X, Zhang Y, Zhang Y, Wang C, Huo X

Abstract
Cardiovascular toxicity of lead (Pb) manifests primarily as an effect on blood pressure and eventual increased risk of atherosclerosis and cardiovascular events. Therefore, we investigated vascular inflammatory biomarkers and cardiovascular effects of Pb-exposed children. A total of 590 children (3-7 years old) were recruited from Guiyu (n = 337), an electronic waste (e-waste)-exposed group, and Haojiang (n = 253), a reference group, from November to December 2016. We measured child blood Pb levels (BPbs), and systolic and diastolic blood pressure. Pulse pressure was calculated for the latter two. Serum biomarkers including lipid profiles and inflammatory cytokines, and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) were detected. Unadjusted regression analysis illustrated that higher ln-transformed BPb associated with lower systolic blood pressure and pulse pressure. After adjustment for various confounders, the relational degree of lnBPb and blood pressure measures became slightly attenuated or not significant. Elevated BPb was associated with higher Lp-PLA2, interleukin (IL)-6, triglycerides (TG) and lower high-density lipoprotein (HDL). Lp-PLA2 remained inversely associated with pulse pressure and HDL, but positively with ratios of total cholesterol to HDL (Tc/HDL) and low-density lipoprotein to HDL (LDL/HDL). IL-6 was associated negatively with systolic blood pressure, pulse pressure and HDL, and positively associated with TG, Tc/HDL and LDL/HDL. The mediation effect of biomarkers on the association of BPb with pulse pressure was insignificant except for Lp-PLA2. Available data supports the conclusion that e-waste-exposed children with higher BPbs and concomitant abnormal measures of cardiovascular physiology have an augmented prevalence of vascular inflammation, as well as lipid disorder.

PMID: 29223817 [PubMed – as supplied by publisher]

Continue reading

Posted in Environ Pollut | Tagged , | Leave a comment

Elevated inflammatory Lp-PLA2 and IL-6 link e-waste Pb toxicity to cardiovascular risk factors in preschool children.

Elevated inflammatory Lp-PLA2 and IL-6 link e-waste Pb toxicity to cardiovascular risk factors in preschool children.

Environ Pollut. 2017 Dec 07;234:601-609

Authors: Lu X, Xu X, Zhang Y, Zhang Y, Wang C, Huo X

Abstract
Cardiovascular toxicity of lead (Pb) manifests primarily as an effect on blood pressure and eventual increased risk of atherosclerosis and cardiovascular events. Therefore, we investigated vascular inflammatory biomarkers and cardiovascular effects of Pb-exposed children. A total of 590 children (3-7 years old) were recruited from Guiyu (n = 337), an electronic waste (e-waste)-exposed group, and Haojiang (n = 253), a reference group, from November to December 2016. We measured child blood Pb levels (BPbs), and systolic and diastolic blood pressure. Pulse pressure was calculated for the latter two. Serum biomarkers including lipid profiles and inflammatory cytokines, and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) were detected. Unadjusted regression analysis illustrated that higher ln-transformed BPb associated with lower systolic blood pressure and pulse pressure. After adjustment for various confounders, the relational degree of lnBPb and blood pressure measures became slightly attenuated or not significant. Elevated BPb was associated with higher Lp-PLA2, interleukin (IL)-6, triglycerides (TG) and lower high-density lipoprotein (HDL). Lp-PLA2 remained inversely associated with pulse pressure and HDL, but positively with ratios of total cholesterol to HDL (Tc/HDL) and low-density lipoprotein to HDL (LDL/HDL). IL-6 was associated negatively with systolic blood pressure, pulse pressure and HDL, and positively associated with TG, Tc/HDL and LDL/HDL. The mediation effect of biomarkers on the association of BPb with pulse pressure was insignificant except for Lp-PLA2. Available data supports the conclusion that e-waste-exposed children with higher BPbs and concomitant abnormal measures of cardiovascular physiology have an augmented prevalence of vascular inflammation, as well as lipid disorder.

PMID: 29223817 [PubMed – as supplied by publisher]

Continue reading

Posted in Environ Pollut | Tagged , | Leave a comment

Sleep-Related Painful Erections Following Sexual Intercourse.

Related Articles
Sleep-Related Painful Erections Following Sexual Intercourse.
Arch Sex Behav. 2017 Dec 08;:
Authors: Barnhoorn PC, Gianotten WL, van Driel MF
Abstract
Sleep-related painful erections … Continue reading

Posted in Arch Sex Behav | Tagged , | Leave a comment

Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention.

Related Articles

Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention.

Brain Cogn. 2017 Dec 06;120:8-16

Authors: Leonte A, Colzato LS, Steenbergen L, Hommel B, Akyürek EG

Abstract
In a randomized, double-blind, and placebo-controlled experiment, the acute effects of gamma-aminobutyric acid (GABA) supplementation on temporal and spatial attention in young healthy adults were investigated. A hybrid two-target rapid serial visual presentation task was used to measure temporal attention and integration. Additionally, a visual search task was used to measure the speed and accuracy of spatial attention. While temporal attention depends primarily on the distribution of limited attentional resources across time, spatial attention represents the engagement and disengagement by relevant and irrelevant stimuli across the visual field. Although spatial attention was unaffected by GABA supplementation altogether, we found evidence supporting improved performance in the temporal attention task. The attentional blink was numerically, albeit not significantly, attenuated at Lag 3, and significantly fewer order errors were committed at Lag 1, compared to the placebo condition. No effect was found on temporal integration rates. Although there is controversy about whether oral GABA can cross the blood-brain barrier, our results offer preliminary evidence that GABA intake might help to distribute limited attentional resources more efficiently, and can specifically improve the identification and ordering of visual events that occur in close temporal succession.

PMID: 29222993 [PubMed – as supplied by publisher]

Continue reading

Posted in Brain Cogn | Tagged , | Leave a comment

Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

PLoS One. 2017;12(12):e0189251

Authors: Brinkhof S, Groen HJM, Siesling SS, IJzerman MJ

Abstract
OBJECTIVES: The main objective of this study is to determine the current use of lung cancer diagnostic procedures in two large hospitals in the Netherlands, to explore deviations in guideline adherence between the hospitals, and to estimate the budget impact of the diagnostic work-up as well as the over- and underutilization.
MATERIALS & METHODS: A state transition model for the diagnostic pathway for lung cancer patients was developed using existing clinical practice guidelines (CPG) combined with a systematic literature. In addition to the CPGs depicting current practice, diagnostic utilization was gathered in two large hospitals representing an academic tertiary care hospital and a large regional teaching hospital for patients, who were selected from the Netherlands cancer registry.
RESULTS: The total population consisted of 376 patients with lung cancer. Not in all cases the guideline was followed, for instance in the usage of MR brain with stage III lung cancer patients (n = 70). The state-transition model predicts an average budget impact for the diagnostic pathway per patient estimated of € 2496 in the academic tertiary care hospital and € 2191 in the large regional teaching hospital.
CONCLUSION: The adherence to the CPG’s differed between hospitals, which questions the adherence to CPG’s in general. Adherence to CPG’s could lead to less costs in the diagnostic pathway for lung cancer patients.

PMID: 29216302 [PubMed – in process]

Continue reading

Posted in PLoS One | Tagged , | Leave a comment

Shoulder complaints in wheelchair athletes: A systematic review.

Related Articles
Shoulder complaints in wheelchair athletes: A systematic review.
PLoS One. 2017;12(11):e0188410
Authors: Heyward OW, Vegter RJK, de Groot S, van der Woude LHV
Abstract
BACKGROUND: In … Continue reading

Posted in PLoS One | Tagged , | Leave a comment

Response to cautious use of platelet as relevant inducer of liver regeneration following partial hepatectomy in patients with metastatic hepatic carcinoma.

Related Articles
Response to cautious use of platelet as relevant inducer of liver regeneration following partial hepatectomy in patients with metastatic hepatic carcinoma.
Liver Int. 2017 Dec;37(12):1918-1919
Authors:… Continue reading

Posted in Liver Int | Tagged , | Leave a comment

Response to the role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation.

Related Articles
Response to the role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation.
Liver Int. 2017 Dec;37(12):1917
Authors: Lisman T
PMID: 29149491 [PubMed – in process]

Continue reading

Posted in Liver Int | Tagged , | Leave a comment

Public Health Practice and Policy to Improve Child and Adolescent Health in Europe.

Public Health Practice and Policy to Improve Child and Adolescent Health in Europe.
J Pediatr. 2017 Nov;190:293-294.e2
Authors: Jansen D, Saxena S, Azzopardi-Muscat N
PMID: 29144263 [PubMed – in process]

Continue reading

Posted in J Pediatr | Tagged , | Leave a comment

Probing the mechanical stability of bridged DNA-H-NS protein complexes by single-molecule AFM pulling.

Probing the mechanical stability of bridged DNA-H-NS protein complexes by single-molecule AFM pulling.
Sci Rep. 2017 Nov 10;7(1):15275
Authors: Liang Y, van der Valk RA, Dame RT, Roos WH, Wuite GJL
Abstract
Continue reading

Posted in Sci Rep | Tagged , | Leave a comment

Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.

Related Articles
Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.
PLoS One. 2017;12(11):e0187805
Authors: Armenta BM, Stroebe K, Scheib… Continue reading

Posted in PLoS One | Tagged , | Leave a comment

Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.

Related Articles
Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.
Clin Microbiol Infect. 2017 Nov 05;:
Authors: Rossen JWA, Friedrich AW, Moran-Gilad J, ESCMID Study Group f… Continue reading

Posted in Clin Microbiol Infect | Tagged , | Leave a comment

Sleep and Alzheimer’s disease: A pivotal role for the suprachiasmatic nucleus.

Related Articles
Sleep and Alzheimer’s disease: A pivotal role for the suprachiasmatic nucleus.
Sleep Med Rev. 2017 Jul 28;:
Authors: Van Erum J, Van Dam D, De Deyn PP
Abstract
Alzheimer’s disease (AD)… Continue reading

Posted in Sleep Med Rev | Tagged , | Leave a comment

Nonbullous cutaneous pemphigoid: a systematic review.

Related Articles
Nonbullous cutaneous pemphigoid: a systematic review.
J Am Acad Dermatol. 2017 Nov 01;:
Authors: Lamberts A, Meijer JM, Jonkman MF
Abstract
BACKGROUND: Cutaneous pemphigoid (bullous pe… Continue reading

Posted in J Am Acad Dermatol | Tagged , | Leave a comment

Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases.

Related Articles
Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases.
Ann Rheum Dis. 2017 Nov 04;:
Authors: Visser A, Ham… Continue reading

Posted in Ann Rheum Dis | Tagged , | Leave a comment

The structural basis of proton driven zinc transport by ZntB.

Related Articles
The structural basis of proton driven zinc transport by ZntB.
Nat Commun. 2017 Nov 03;8(1):1313
Authors: Gati C, Stetsenko A, Slotboom DJ, Scheres SHW, Guskov A
Abstract
Zinc is an ess… Continue reading

Posted in Nat Commun | Tagged , | Leave a comment