Tag Archives: TOP25

Flavor pleasantness processing in the ventral emotion network.






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Flavor pleasantness processing in the ventral emotion network.
PLoS One. 2017;12(2):e0170310
Authors: Dalenberg JR, Weitkamp L, Renken RJ, Nanetti L, Ter Horst GJ
Abstract
The ventral … Continue reading

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Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.






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Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.
Health Place. 2017 Feb 01;44:43-51
Authors: Klijs B, Mende… Continue reading






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Genius begins at home: Shared social identity enhances the recognition of creative performance.






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Genius begins at home: Shared social identity enhances the recognition of creative performance.
Br J Psychol. 2017 Feb 05;:
Authors: Steffens NK, Haslam SA, Ryan MK, Millard K
Abstract
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Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.






Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.

J Biomed Mater Res A. 2017 Feb 02;:

Authors: Bochyńska AI, Hannink G, Verhoeven R, Grijpma DW, Buma P

Abstract
Current treatment methods to repair meniscal tears do not bring fully satisfactory results. Tissue adhesives are considered promising alternatives, since they are easy to apply and cause minimal tissue trauma. The first aim of this study was to analyze the adhesive properties of and tissue response to two recently developed biodegradable block copolymeric three-armed- and hyper-branched tissue adhesives. The second aim was to investigate if tissue surface modification with collagenase improves the attachment of the adhesives and increases the healing potential of the tissue. Cylindrical explants were harvested from bovine menisci. The central core of the explants was removed and glued back into the defect, with or without incubation in collagenase solution prior to gluing, using one of the novel glues, Dermabond® or fibrin glue. The repair constructs were cultured in vitro for 1 and 28 days. Adhesion tests and histology were performed to analyze the effects of the glue in combination with the additional treatment. The adhesive strength of the novel glues was 40-50 kPa, which was significantly higher than that of fibrin glue (15 kPa). Cells were present in direct contact with the glues, and the tissue remained vital during the whole culture period. Increased cellularity around the tear in the collagenase treated explants was observed after 1 day. The two newly developed tissue adhesives are attractive materials to be used for repair of meniscal tears. The beneficial influence of collagenase treatment in treating meniscal tears with glues still needs to be confirmed in more clinical relevant studies. This article is protected by copyright. All rights reserved.

PMID: 28152576 [PubMed – as supplied by publisher]

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A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.






A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.

Ophthalmology. 2017 Jan 28;:

Authors: Vehof J, Hysi PG, Hammond CJ

Abstract
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach.
DESIGN: Cross-sectional association study.
PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years).
METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc., Durham, NC). Dry eye disease was defined from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED by a clinician or “often” or “constant” symptoms of dryness and irritation. Analyses were performed with linear mixed effect models that included age, BMI, and sex as covariates, corrected for multiple testing.
MAIN OUTCOME MEASURES: Primary outcome was DED as defined by the SQDES, and secondary outcomes were symptom score of DED and a clinical diagnosis of DED.
RESULTS: Prevalence of DED as defined by the SQDES was 15.5% (n = 436). A strong and metabolome-wide significant association with DED was found with decreased levels of the metabolites androsterone sulfate (P = 0.00030) and epiandrosterone sulfate (P = 0.00036). Three other metabolites involved in androgen metabolism, 4-androsten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most strongly associated of the 222 metabolites, but did not reach metabolome-wide significance. Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, P = 0.000000029; epiandrosterone sulfate, P = 0.0000040; 4-androsten-3beta,17beta-diol disulfate 1, P = 0.000016; 4-androsten-3beta,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011). Of these 5 androgens, epiandrosterone sulfate (P = 0.0076) was most associated with 2-year incidence of clinician-diagnosed DED. In addition, we found decreased glycerophosphocholines to be associated with DED, although not at metabolome-wide significance.
CONCLUSIONS: This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of research that links androgens to ocular surface disease and DED.

PMID: 28139245 [PubMed – as supplied by publisher]

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Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.






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Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.
Disabil Rehabil. 2017 Jan 27;:1-9
Authors: Kaptein S, Geertzen JH, Dijkstra PU
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Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?






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Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?
J Clin Psychiatry. 2017 Jan;78(1):e71
Authors: Apeldoorn SY, de Boer MK, Schoevers RA
PMID: 28129500 [PubMed – … Continue reading






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Shutting down the power supply for DNA repair in cancer cells.






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Shutting down the power supply for DNA repair in cancer cells.
J Cell Biol. 2017 Jan 25;:
Authors: van Vugt MA
Abstract
Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In th… Continue reading






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Climate predicts which sex acts as helpers among cooperatively breeding bird species.






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Climate predicts which sex acts as helpers among cooperatively breeding bird species.

Biol Lett. 2017 Jan;13(1):

Authors: Zhang G, Zhao Q, Møller AP, Komdeur J, Lu X

Abstract
Among avian cooperative breeders, help in raising offspring is usually provided by males or by both sexes. Sex bias in helping should evolve in response to sex-specific ecological constraints on independent reproduction, with mate shortage for males and breeding vacancy shortage for each sex. Given that male-biased adult sex ratios are prevalent among birds, we predict that male-only helping mainly occurs in temperate species where fast population turnovers deriving from low adult annual survival allow all adult females to hold breeding vacancies, whereas some males overflow as helpers, and both-sex helping in tropical species where saturated habitats prevent not only males, but also females from breeding themselves. As expected, we found that across species, adult survival increased towards tropical zones and warmer climates, and higher adult survival tended to be associated with both-sex helping. Furthermore, sex bias in helping was predicted by latitude and ambient temperature. Our findings of demographic response of species to climate as a potential determinant of bias in helper sex uncover how ecological constraints operate to limit independent reproduction in sex-specific ways.

PMID: 28123111 [PubMed – in process]

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To find glomerulonephritis you have to look for it.






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To find glomerulonephritis you have to look for it.
Neth J Med. 2017 Jan;75(1):2-3
Authors: Stegeman CA
PMID: 28124666 [PubMed – in process]

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Fever and painful skin lesions after a holiday in Gambia.






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Fever and painful skin lesions after a holiday in Gambia.
Neth J Med. 2017 Jan;75(1):41
Authors: Bouma HR, Kloppenburg WD
PMID: 28124672 [PubMed – in process]

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Changes of Perceived Control after Kidney Transplantation: a prospective Study.






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Changes of Perceived Control after Kidney Transplantation: a prospective Study.
J Adv Nurs. 2017 Jan 25;:
Authors: Schulz T, Niesing J, Homan Van Der Heide JJ, Westerhuis R, Ploeg RJ, Ranchor AV
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Retro-Active Emotion: Do Negative Emotional Stimuli Disrupt Consolidation in Working Memory?






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Retro-Active Emotion: Do Negative Emotional Stimuli Disrupt Consolidation in Working Memory?

PLoS One. 2017;12(1):e0169927

Authors: Kandemir G, Akyürek EG, Nieuwenstein MR

Abstract
While many studies have shown that a task-irrelevant emotionally arousing stimulus can interfere with the processing of a shortly following target, it remains unclear whether an emotional stimulus can also retro-actively interrupt the ongoing processing of an earlier target. In two experiments, we examined whether the presentation of a negative emotionally arousing picture can disrupt working memory consolidation of a preceding visual target. In both experiments, the effects of negative emotional pictures were compared with the effects of neutral pictures. In Experiment 1, the pictures were entirely task-irrelevant whereas in Experiment 2 the pictures were associated with a 2-alternative forced choice task that required participants to respond to the color of a frame surrounding the pictures. The results showed that the appearance of the pictures did not interfere with target consolidation when the pictures were task-irrelevant, whereas such interference was observed when the pictures were associated with a 2-AFC task. Most importantly, however, the results showed no effects of whether the picture had neutral or emotional content. Implications for further research are discussed.

PMID: 28103267 [PubMed – in process]

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Size-dependent and tunable crystallization of GeSbTe phase-change nanoparticles.






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Size-dependent and tunable crystallization of GeSbTe phase-change nanoparticles.

Sci Rep. 2016 Dec 20;6:39546

Authors: Chen B, Ten Brink GH, Palasantzas G, Kooi BJ

Abstract
Chalcogenide-based nanostructured phase-change materials (PCMs) are considered promising building blocks for non-volatile memory due to their high write and read speeds, high data-storage density, and low power consumption. Top-down fabrication of PCM nanoparticles (NPs), however, often results in damage and deterioration of their useful properties. Gas-phase condensation based on magnetron sputtering offers an attractive and straightforward solution to continuously down-scale the PCMs into sub-lithographic sizes. Here we unprecedentedly present the size dependence of crystallization for Ge2Sb2Te5 (GST) NPs, whose production is currently highly challenging for chemical synthesis or top-down fabrication. Both amorphous and crystalline NPs have been produced with excellent size and composition control with average diameters varying between 8 and 17 nm. The size-dependent crystallization of these NPs was carefully analyzed through in-situ heating in a transmission electron microscope, where the crystallization temperatures (Tc) decrease when the NPs become smaller. Moreover, methane incorporation has been observed as an effective method to enhance the amorphous phase stability of the NPs. This work therefore elucidates that GST NPs synthesized by gas-phase condensation with tailored properties are promising alternatives in designing phase-change memories constrained by optical lithography limitations.

PMID: 27996054 [PubMed – in process]

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Challenges on the road to a multicellular bioartificial liver.






Challenges on the road to a multicellular bioartificial liver.
J Tissue Eng Regen Med. 2016 Dec 12;:
Authors: Starokozhko V, Groothuis GM
Abstract
Over the past years the progress in the development o… Continue reading






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Structure and elevator mechanism of the Na(+)-citrate transporter CitS.






Structure and elevator mechanism of the Na(+)-citrate transporter CitS.
Curr Opin Struct Biol. 2016 Oct 21;45:1-9
Authors: Lolkema JS, Slotboom DJ
Abstract
The recently determined crystal structure of… Continue reading






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A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.






A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.

J Am Acad Child Adolesc Psychiatry. 2016 Oct;55(10):896-905.e6

Authors: Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B, Greven CU, Pappa I, Tiesler CM, Ang W, Nolte IM, Vilor-Tejedor N, Bacelis J, Ebejer JL, Zhao H, Davies GE, Ehli EA, Evans DM, Fedko IO, Guxens M, Hottenga JJ, Hudziak JJ, Jugessur A, Kemp JP, Krapohl E, Martin NG, Murcia M, Myhre R, Ormel J, Ring SM, Standl M, Stergiakouli E, Stoltenberg C, Thiering E, Timpson NJ, Trzaskowski M, van der Most PJ, Wang C, EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Psychiatric Genomics Consortium ADHD Working Group, Nyholt DR, Medland SE, Neale B, Jacobsson B, Sunyer J, Hartman CA, Whitehouse AJ, Pennell CE, Heinrich J, Plomin R, Davey Smith G, Tiemeier H, Posthuma D, Boomsma DI

Abstract
OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis.
METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests, and the overlap in results with a meta-analysis in the Psychiatric Genomics Consortium (PGC) case-control ADHD study was investigated.
RESULTS: SNP-based heritability ranged from 5% to 34%, indicating that variation in common genetic variants influences ADHD symptom scores. The meta-analysis did not detect genome-wide significant SNPs, but three genes, lying close to each other with SNPs in high linkage disequilibrium (LD), showed a gene-wide significant association (p values between 1.46 × 10(-6) and 2.66 × 10(-6)). One gene, WASL, is involved in neuronal development. Both SNP- and gene-based analyses indicated overlap with the PGC meta-analysis results with the genetic correlation estimated at 0.96.
CONCLUSION: The SNP-based heritability for ADHD symptom scores indicates a polygenic architecture, and genes involved in neurite outgrowth are possibly involved. Continuous and dichotomous measures of ADHD appear to assess a genetically common phenotype. A next step is to combine data from population-based and case-control cohorts in genetic association studies to increase sample size and to improve statistical power for identifying genetic variants.

PMID: 27663945 [PubMed – in process]

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Understanding the Mismatch Between Coaches’ and Players’ Perceptions of Exertion.






Understanding the Mismatch Between Coaches’ and Players’ Perceptions of Exertion.

Int J Sports Physiol Perform. 2016 Sep 6;

Authors: Brink MS, Kersten AW, Frencken WG

Abstract
A mismatch between the intended training exertion by the coach and the perceived exertion by players is well established in sports. However, it is unknown if coaches are able to accurately observe exertion of individual players during training. Furthermore, the discrepancy in coaches’ and players’ perceptions has not been explained.
PURPOSE: We aim to 1) determine the relation between intended and observed training exertion by the coach and perceived training exertion by the player and 2) establish if on-field training characteristics, intermittent endurance capacity and maturity status explain the mismatch.
METHODS: During two mesocycles of 4 weeks (November and March) intended (RIE), observed (ROE) and perceived (RPE) exertion were monitored of 31 young elite soccer players. External and internal training load were objectively quantified with accelerometers (PlayerLoad) and heart rate monitors (TRIMPmod). Interval Shuttle Run Test (ISRT) and age at peak height velocity (APHV) were determined for all players.
RESULTS: 977 training sessions were monitored with RIE, ROE and RPE. The correlations between RIE and RPE (r=.58; p<0.01) and ROE and RPE (r=.64; p<0.01) were moderate. The mean difference between RIE and RPE was -0.31±1.99 and between ROE and RPE was -0.37±1.87. Multilevel analyses showed that PlayerLoad and ISRT predicted RIE and ROE.
CONCLUSION: Coaches base their intended and observed exertion on what they expect players will do and what they actually did on the field. When doing this, they consider the intermittent endurance capacity of individual players.

PMID: 27618715 [PubMed – as supplied by publisher]

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Fullerene C60 with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in Dermatology?






Fullerene C60 with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in Dermatology?

Exp Dermatol. 2016 Aug 19;

Authors: Rondags A, Yuen WY, Jonkman MF, Horváth B

Abstract
Fullerenes, discovered in 1985, form the third major carbon allotrope besides diamond and graphite.(1,2) They exclusively exist out of n-three-coordinate carbon atoms that are arranged in exactly12 pentagons and (n/2-10) hexagons, where n ≥ 20, forming hollow spheres, tubes, and other shapes.(2) In 1990, the synthesis of macroscopic (milligrams) amounts of fullerenes through resistive heating of graphite began to develop.(3) Because it appeared that fullerenes possessed many unique and attractive physiochemical properties, such as light weight, high tensile strength, thermal/chemical stability and conductivity, the possibilities of these carbon molecules have been extensively explored in many fields of science. The discovery of fullerenes was considered of great importance and has strongly influenced the field of chemistry, which therefore resulted in an award of the Nobel Prize in Chemistry to the discoverers of fullerenes in 1996. This article is protected by copyright. All rights reserved.

PMID: 27541937 [PubMed – as supplied by publisher]

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Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM).






Performance of cardiac cadmium-zinc-telluride gamma camera imaging in coronary artery disease: a review from the cardiovascular committee of the European Association of Nuclear Medicine (EANM).

Eur J Nucl Med Mol Imaging. 2016 Aug 19;

Authors: Agostini D, Marie PY, Ben-Haim S, Rouzet F, Songy B, Giordano A, Gimelli A, Hyafil F, Sciagrà R, Bucerius J, Verberne HJ, Slart RH, Lindner O, Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)

Abstract
The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques. CZT image quality is further improved by the development of a dedicated three-dimensional iterative reconstruction algorithm, based on maximum likelihood expectation maximization (MLEM), which corrects for the loss in spatial resolution due to line response function of the collimator. All these innovations significantly reduce imaging time and result in a lower patient’s radiation exposure compared with standard SPECT. To guide current and possible future users of the CZT technique for myocardial perfusion imaging, the Cardiovascular Committee of the European Association of Nuclear Medicine, starting from the experience of its members, has decided to examine the current literature regarding procedures and clinical data on CZT cameras. The committee hereby aims 1) to identify the main acquisitions protocols; 2) to evaluate the diagnostic and prognostic value of CZT derived myocardial perfusion, and finally 3) to determine the impact of CZT on radiation exposure.

PMID: 27542010 [PubMed – as supplied by publisher]

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