Tag Archives: TOP25

Long-term treatment with metformin in type 2 diabetes and vitamin D levels: A post hoc analysis of a randomised placebo-controlled trial.

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Long-term treatment with metformin in type 2 diabetes and vitamin D levels: A post hoc analysis of a randomised placebo-controlled trial.
Diabetes Obes Metab. 2018 Apr 17;:
Authors: Out M, Top WMC, L… Continue reading

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Long-term outcome of selective neurectomy for refractory periocular synkinesis.

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Long-term outcome of selective neurectomy for refractory periocular synkinesis.

Laryngoscope. 2018 Apr 18;:

Authors: van Veen MM, Dusseldorp JR, Hadlock TA

Abstract
OBJECTIVE: The objective of this study was to investigate the long-term effect and treatment stability of selective neurectomy for refractory periocular synkinesis.
METHODS: We performed a retrospective review of all patients treated with highly selective neurectomy for refractory periocular synkinesis between August 2009 and August 2015. Primary outcome was time to recommencing treatment for periocular synkinesis. Palpebral fissure width was measured preoperatively, postoperatively, and at long-term ( > 2.5 years) follow-up. Mean units of botulinum toxin used pre- and postoperatively were compared.
RESULTS: Of the 12 patients, 10 could be included. Only one was free of treatment for periocular synkinesis at a follow-up of 3.5 years. The other nine patients recommenced treatment with botulinum toxin after a median time of 1.2 (interquartile range 0.6-2.6) years. Palpebral fissure width while smiling was significantly different between the pre- and postoperative (P = 0.008) and preoperative and long-term (P = 0.008) measurements. Postoperatively, previously refractory patients demonstrated good response to botulinum toxin treatments.
CONCLUSION: This study demonstrates that most patients require renewed pharmacological treatment of periocular synkinesis after neurectomy. Although the effect of neurectomy in the treatment of refractory synkinesis does not appear to be sustained, patients usually experience a symptom-free interval and demonstrate larger palpebral fissure width at long-term follow-up compared to preoperative measurements.
LEVEL OF EVIDENCE: IV. Laryngoscope, 2018.

PMID: 29668050 [PubMed – as supplied by publisher]

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Interpretability in atopic dermatitis: all about the anchor.

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Interpretability in atopic dermatitis: all about the anchor.
Br J Dermatol. 2018 Apr;178(4):832-833
Authors: Oosterhaven JAF
PMID: 29668100 [PubMed – in process]

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A System Biology Perspective on Environment-Host-Microbe Interactions.

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A System Biology Perspective on Environment-Host-Microbe Interactions.
Hum Mol Genet. 2018 Apr 16;:
Authors: Chen L, Garmaeva S, Zherankova A, Fu J, Wijmenga C
Abstract
A vast, comple… Continue reading

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Methotrexate and Thioguanine Rescue Therapy for Conventional Thiopurine Failing Ulcerative Colitis Patients: A Multi-center Database Study on Tolerability and Effectiveness.

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Methotrexate and Thioguanine Rescue Therapy for Conventional Thiopurine Failing Ulcerative Colitis Patients: A Multi-center Database Study on Tolerability and Effectiveness.
Inflamm Bowel Dis. 2018 Apr 13;:
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Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study.

Development and external validation of a prediction rule for an unfavorable course of late-life depression: A multicenter cohort study.

J Affect Disord. 2018 Apr 06;235:105-113

Authors: Maarsingh OR, Heymans MW, Verhaak PF, Penninx BWJH, Comijs HC

Abstract
BACKGROUND: Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression.
METHODS: For development and internal validation of the model, we used The Netherlands Study of Depression in Older Persons (NESDO) data. We included participants with a major depressive disorder (MDD) at baseline (n = 270; 60-90 years), assessed with the Composite International Diagnostic Interview (CIDI). For external validation of the model, we used The Netherlands Study of Depression and Anxiety (NESDA) data (n = 197; 50-66 years). The outcome was MDD after 2 years of follow-up, assessed with the CIDI. Candidate predictors concerned sociodemographics, psychopathology, physical symptoms, medication, psychological determinants, and healthcare setting. Model performance was assessed by calculating calibration and discrimination.
RESULTS: 111 subjects (41.1%) had MDD after 2 years of follow-up. Independent predictors of MDD after 2 years were (older) age, (early) onset of depression, severity of depression, anxiety symptoms, comorbid anxiety disorder, fatigue, and loneliness. The final model showed good calibration and reasonable discrimination (AUC of 0.75; 0.70 after external validation). The strongest individual predictor was severity of depression (AUC of 0.69; 0.68 after external validation).
LIMITATIONS: The model was developed and validated in The Netherlands, which could affect the cross-country generalizability.
CONCLUSIONS: Based on rather simple clinical indicators, it is possible to predict the 2-year course of MDD. The prediction rule can be used for monitoring MDD patients and identifying those at risk of an unfavourable outcome.

PMID: 29655070 [PubMed – as supplied by publisher]

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Response to Alwardat comments on our systematic review entitled: “Predictors of adherence to exercise interventions during and after cancer treatment: A systematic review”.

Response to Alwardat comments on our systematic review entitled: “Predictors of adherence to exercise interventions during and after cancer treatment: A systematic review”.
Psychooncology. 2018 Apr;27(4):1354
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A spatial analysis of dietary patterns in a large representative population in the north of The Netherlands – the Lifelines cohort study.

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A spatial analysis of dietary patterns in a large representative population in the north of The Netherlands – the Lifelines cohort study.

Int J Behav Nutr Phys Act. 2017 Dec 07;14(1):166

Authors: Dekker LH, Rijnks RH, Strijker D, Navis GJ

Abstract
BACKGROUND: Diet is an important modifiable risk factor for chronic diseases. In the search for effective strategies to improve dietary patterns in order to promote healthy ageing, new approaches considering contextual factors in public health medicine are warranted. The aim of this study is to examine the spatial clustering of dietary patterns in a large representative sample of adults.
METHODS: Dietary patterns were defined on the basis of a 111 item Food Frequency Questionnaire among n = 117,570 adults using principal components analysis. We quantified the spatial clustering of dietary pattern scores at the neighborhood level using the Global Moran’s I spatial statistic, taking into consideration individual demographic and (neighborhood) socioeconomic indicators.
RESULTS: Four dietary patterns explaining 27% of the variance in dietary data were extracted in this population and named the “bread and cookies” pattern, the “snack” pattern, the “meat and alcohol” pattern and the “vegetable, fruit and fish” pattern. Significant spatial clustering of high (hot spot) and low (cold spot) dietary pattern scores was found for all four dietary patterns irrespective of age and gender differences. Educational attainment and neighborhood income explained the global clustering to some extent, although clustering at smaller regional scales persisted.
CONCLUSION: The significant region-specific hot and cold spots of the four dietary patterns illustrate the existence of regional “food cultures” and underscore the need for interventions targeted at the sub-national level in order to tackle unhealthy dietary behavior and to stimulate people to make healthy dietary choices.

PMID: 29212502 [PubMed – indexed for MEDLINE]

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Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.
PLoS One. 2018;13(4):… Continue reading

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Intra- and Interindividual Variability in the Behavioral, Affective, and Perceptual Effects of Alcohol Consumption in a Social Context.

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Intra- and Interindividual Variability in the Behavioral, Affective, and Perceptual Effects of Alcohol Consumption in a Social Context.

Alcohol Clin Exp Res. 2018 Apr 03;:

Authors: Franzen M, Sadikaj G, Moskowitz DS, Ostafin BD, Aan Het Rot M

Abstract
BACKGROUND: We examined the influence of interindividual differences in alcohol use on the intraindividual associations of drinking occurrence with interpersonal behaviors, affect, and perceptions of others during naturally occurring social interactions.
METHODS: For 14 consecutive days, 219 psychology freshmen (55% female; Mage  = 20.7 years, SD = 2.18) recorded their behaviors, affect, and perceptions in social interactions soon after an interpersonal event occurred. Interpersonal behaviors and perceptions were assessed in terms of dominance-submissiveness and agreeableness-quarrelsomeness. Participants also reported the number of alcoholic drinks consumed within 3 hours of each interaction. We considered the intraindividual associations of (i) having a drinking episode and (ii) the number of drinks during an episode with behaviors, affect, and perceptions and examined interindividual differences in drinking frequency and intensity during social interactions as potential moderators of these associations.
RESULTS: Social drinking frequency and intensity moderated the associations between drinking episode and behaviors, affect, and perceptions in social interactions. During a drinking episode, more frequent social drinkers perceived others as more dominant than less frequent social drinkers. During a drinking episode in which more alcohol was consumed than usual, more frequent social drinkers also reported behaving more dominantly and experiencing less pleasant affect.
CONCLUSIONS: As more frequent social drinkers had different interpersonal responses to drinking than less frequent social drinkers, including when they had consumed larger amounts of alcohol than usual, our results suggest a differential susceptibility to the effects of alcohol during naturally occurring social interactions among drinkers with varying drinking frequency.

PMID: 29611874 [PubMed – as supplied by publisher]

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Presenteeism in a Dutch hand eczema population-a cross-sectional survey.

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Presenteeism in a Dutch hand eczema population-a cross-sectional survey.

Contact Dermatitis. 2018 Apr 01;:

Authors: Oosterhaven JAF, Flach PA, Bültmann U, Schuttelaar MLA

Abstract
BACKGROUND: Presenteeism (attending work despite complaints and ill health, which should prompt rest and absence) has been overlooked in the field of hand eczema.
OBJECTIVES: To examine the 1-year prevalence of presenteeism related to hand eczema in a population of hand eczema patients who visited a tertiary referral centre. Secondary objectives: to identify intrinsic/extrinsic reasons for presenteeism and to evaluate associated factors.
METHODS: This was a cross-sectional questionnaire study. Presenteeism was defined as “going to work despite feeling you should have taken sick leave because of hand eczema”. Respondents answered questions about socio-demographic factors, clinical features, occupational characteristics, and hand eczema related to occupational exposure.
RESULTS: Forty-one per cent (141/346) of patients who had both worked and had hand eczema during the past 12 months reported presenteeism. The most often reported reasons were: “Because I do not want to give in to my impairment/weakness” (46%) and “Because I enjoy my work” (40%). Presenteeism was associated with: mean hand eczema severity; absenteeism because of hand eczema; improvement of hand eczema when away from work; and high-risk occupations.
CONCLUSIONS: In this study, presenteeism was common and predominantly observed in patients with more severe hand eczema and occupational exposure. The most frequently reported reasons for presenteeism were of an intrinsic nature.

PMID: 29607512 [PubMed – as supplied by publisher]

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The sentence wrap-up dogma.

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The sentence wrap-up dogma.
Cognition. 2018 Mar 30;176:232-247
Authors: Stowe LA, Kaan E, Sabourin L, Taylor RC
Abstract
Current sentence processing research has focused on early effec… Continue reading

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The optimal TSH level necessary for successful radioiodine ablation of differentiated thyroid carcinoma, as well as the time to reach this level, is a work in progress.

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The optimal TSH level necessary for successful radioiodine ablation of differentiated thyroid carcinoma, as well as the time to reach this level, is a work in progress.
Eur J Nucl Med Mol Imaging. 2018 Mar 29;… Continue reading

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Is plasticity caused by single genes?

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Is plasticity caused by single genes?
Nature. 2018 Mar 28;555(7698):E19-E20
Authors: van Gestel J, Weissing FJ
PMID: 29595768 [PubMed – in process]

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When is quitting an escape? How different job demands affect physical and mental health outcomes of retirement.

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When is quitting an escape? How different job demands affect physical and mental health outcomes of retirement.
Eur J Public Health. 2018 Mar 26;:
Authors: van den Bogaard L, Henkens K
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Atrial remodelling and function: implications for atrial fibrillation surgery.

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Atrial remodelling and function: implications for atrial fibrillation surgery.
Eur J Cardiothorac Surg. 2018 Apr 01;53(suppl_1):i2-i8
Authors: Benussi S, de Maat GE
Abstract
The exact… Continue reading

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Topical Gentamicin for the Treatment of Genetic Skin Diseases.

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Topical Gentamicin for the Treatment of Genetic Skin Diseases.
J Invest Dermatol. 2018 Apr;138(4):731-734
Authors: Pasmooij AMG
Abstract
Clinical application of topical gentamicin is a… Continue reading

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Do single people want to date a cancer survivor? A vignette study.

Do single people want to date a cancer survivor? A vignette study.

PLoS One. 2018;13(3):e0194277

Authors: Tuinman MA, Lehmann V, Hagedoorn M

Abstract
OBJECTIVE: Qualitative studies indicated that cancer survivors may be worried about finding a partner in the future, but whether this concern is warranted is unknown. We examined single people´s interest in dating a cancer survivor, how they perceive survivors’ traits, and their preferences about the timing of disclosing a cancer history.
METHODS: In three experimental vignette studies, dating website members (n = 324) and college students (n = 138 and n = 131) were randomly assigned to a vignette of a person with or without a history of cancer (experiment 1 & 2), or a cancer survivor beyond or during active follow-up (experiment 3). Respondents rated their interest in dating this fictive person, this person’s traits, and indicated their preferences about the timing of disclosure. ANOVAs with main and interaction effects of condition, gender, and relationship history were conducted, partial eta squared and Cohen’s d were used to estimate the magnitude of effects. Correlations were used to investigate relationships between interest in a date and assessment of traits.
RESULTS: Cancer survivors’ traits were assessed more positively, but interest to date them did not differ from healthy vignettes for both men and women. However, widowed respondents were much less interested in a date with a cancer survivor, and women showed less interest in a cancer survivor during active follow-up relative to survivors beyond follow-up. Most respondents wanted to hear about the cancer diagnosis after a few dates, hardly anyone wanted to hear about this before the first date (2% – 5%).
CONCLUSION AND IMPLICATIONS FOR CANCER SURVIVORS: Cancer survivors do not have to expect any more problems in finding a date than people without a cancer history, and can wait a few dates before disclosing. Survivors dating widowed people and survivors in active follow-up could expect more hesitant reactions and should disclose earlier.

PMID: 29566002 [PubMed – in process]

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Comparison of different approaches for estimating age-specific alcohol-attributable mortality: The cases of France and Finland.

Comparison of different approaches for estimating age-specific alcohol-attributable mortality: The cases of France and Finland.

PLoS One. 2018;13(3):e0194478

Authors: Trias-Llimós S, Martikainen P, Mäkelä P, Janssen F

Abstract
BACKGROUND: Accurate estimates of the impact of alcohol on overall and age-specific mortality are crucial for formulating health policies. However, different approaches to estimating alcohol-attributable mortality provide different results, and a detailed comparison of age-specific estimates is missing.
METHODS: Using data on cause of death, alcohol consumption, and relative risks of mortality at different consumption levels, we compare eight estimates of sex- and age-specific alcohol-attributable mortality in France (2010) and Finland (2013): five estimates using cause-of-death approaches (with one accounting for contributory causes), and three estimates using attributable fraction (AF) approaches.
RESULTS: AF-related approaches and the approach based on alcohol-related underlying and contributory causes of death provided estimates of alcohol-attributable mortality that were twice as high as the estimates found using underlying cause-of-death approaches in both countries and sexes. The differences across the methods were greatest among older age groups An inverse U-shape in age-specific alcohol-attributable mortality (peaking at around age 65) was observed for cause-of-death approaches, with this shape being more pronounced in Finland. AF-related approaches resulted in different estimates at older ages: i.e., mortality was found to increase with age in France; whereas in Finland mortality estimates depended on the underlying assumptions regarding the effects of alcohol consumption on cardiovascular mortality.
CONCLUSIONS: While the most detailed approaches (i.e., the AF-related approach and the approach that includes underlying and contributory causes) are theoretically able to provide more accurate estimates of alcohol-attributable mortality, they-especially the AF approaches- depend heavily on data availability and quality. To enhance the reliability of alcohol-attributable mortality estimates, data quality for older age groups needs to be improved.

PMID: 29566081 [PubMed – in process]

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Childhood Socioeconomic Status and Late-Adulthood Mental Health: Results from the Survey on Health, Ageing and Retirement in Europe.

Childhood Socioeconomic Status and Late-Adulthood Mental Health: Results from the Survey on Health, Ageing and Retirement in Europe.
J Gerontol B Psychol Sci Soc Sci. 2018 Mar 16;:
Authors: Angelini V, Howdon DDD, Mi… Continue reading

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