Tag Archives: PubMed

Sleep-Related Painful Erections Following Sexual Intercourse.

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Sleep-Related Painful Erections Following Sexual Intercourse.
Arch Sex Behav. 2017 Dec 08;:
Authors: Barnhoorn PC, Gianotten WL, van Driel MF
Abstract
Sleep-related painful erections … Continue reading

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Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention.

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Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention.

Brain Cogn. 2017 Dec 06;120:8-16

Authors: Leonte A, Colzato LS, Steenbergen L, Hommel B, Akyürek EG

Abstract
In a randomized, double-blind, and placebo-controlled experiment, the acute effects of gamma-aminobutyric acid (GABA) supplementation on temporal and spatial attention in young healthy adults were investigated. A hybrid two-target rapid serial visual presentation task was used to measure temporal attention and integration. Additionally, a visual search task was used to measure the speed and accuracy of spatial attention. While temporal attention depends primarily on the distribution of limited attentional resources across time, spatial attention represents the engagement and disengagement by relevant and irrelevant stimuli across the visual field. Although spatial attention was unaffected by GABA supplementation altogether, we found evidence supporting improved performance in the temporal attention task. The attentional blink was numerically, albeit not significantly, attenuated at Lag 3, and significantly fewer order errors were committed at Lag 1, compared to the placebo condition. No effect was found on temporal integration rates. Although there is controversy about whether oral GABA can cross the blood-brain barrier, our results offer preliminary evidence that GABA intake might help to distribute limited attentional resources more efficiently, and can specifically improve the identification and ordering of visual events that occur in close temporal succession.

PMID: 29222993 [PubMed – as supplied by publisher]

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Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

PLoS One. 2017;12(12):e0189251

Authors: Brinkhof S, Groen HJM, Siesling SS, IJzerman MJ

Abstract
OBJECTIVES: The main objective of this study is to determine the current use of lung cancer diagnostic procedures in two large hospitals in the Netherlands, to explore deviations in guideline adherence between the hospitals, and to estimate the budget impact of the diagnostic work-up as well as the over- and underutilization.
MATERIALS & METHODS: A state transition model for the diagnostic pathway for lung cancer patients was developed using existing clinical practice guidelines (CPG) combined with a systematic literature. In addition to the CPGs depicting current practice, diagnostic utilization was gathered in two large hospitals representing an academic tertiary care hospital and a large regional teaching hospital for patients, who were selected from the Netherlands cancer registry.
RESULTS: The total population consisted of 376 patients with lung cancer. Not in all cases the guideline was followed, for instance in the usage of MR brain with stage III lung cancer patients (n = 70). The state-transition model predicts an average budget impact for the diagnostic pathway per patient estimated of € 2496 in the academic tertiary care hospital and € 2191 in the large regional teaching hospital.
CONCLUSION: The adherence to the CPG’s differed between hospitals, which questions the adherence to CPG’s in general. Adherence to CPG’s could lead to less costs in the diagnostic pathway for lung cancer patients.

PMID: 29216302 [PubMed – in process]

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Shoulder complaints in wheelchair athletes: A systematic review.

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Shoulder complaints in wheelchair athletes: A systematic review.
PLoS One. 2017;12(11):e0188410
Authors: Heyward OW, Vegter RJK, de Groot S, van der Woude LHV
Abstract
BACKGROUND: In … Continue reading

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Response to cautious use of platelet as relevant inducer of liver regeneration following partial hepatectomy in patients with metastatic hepatic carcinoma.

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Response to cautious use of platelet as relevant inducer of liver regeneration following partial hepatectomy in patients with metastatic hepatic carcinoma.
Liver Int. 2017 Dec;37(12):1918-1919
Authors:… Continue reading

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Response to the role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation.

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Response to the role of platelets on regenerating liver: Thoughts beyond parenchymal proliferation.
Liver Int. 2017 Dec;37(12):1917
Authors: Lisman T
PMID: 29149491 [PubMed – in process]

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Public Health Practice and Policy to Improve Child and Adolescent Health in Europe.

Public Health Practice and Policy to Improve Child and Adolescent Health in Europe.
J Pediatr. 2017 Nov;190:293-294.e2
Authors: Jansen D, Saxena S, Azzopardi-Muscat N
PMID: 29144263 [PubMed – in process]

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Probing the mechanical stability of bridged DNA-H-NS protein complexes by single-molecule AFM pulling.

Probing the mechanical stability of bridged DNA-H-NS protein complexes by single-molecule AFM pulling.
Sci Rep. 2017 Nov 10;7(1):15275
Authors: Liang Y, van der Valk RA, Dame RT, Roos WH, Wuite GJL
Abstract
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Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.

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Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.
PLoS One. 2017;12(11):e0187805
Authors: Armenta BM, Stroebe K, Scheib… Continue reading

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Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.

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Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.
Clin Microbiol Infect. 2017 Nov 05;:
Authors: Rossen JWA, Friedrich AW, Moran-Gilad J, ESCMID Study Group f… Continue reading

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Sleep and Alzheimer’s disease: A pivotal role for the suprachiasmatic nucleus.

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Sleep and Alzheimer’s disease: A pivotal role for the suprachiasmatic nucleus.
Sleep Med Rev. 2017 Jul 28;:
Authors: Van Erum J, Van Dam D, De Deyn PP
Abstract
Alzheimer’s disease (AD)… Continue reading

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Nonbullous cutaneous pemphigoid: a systematic review.

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Nonbullous cutaneous pemphigoid: a systematic review.
J Am Acad Dermatol. 2017 Nov 01;:
Authors: Lamberts A, Meijer JM, Jonkman MF
Abstract
BACKGROUND: Cutaneous pemphigoid (bullous pe… Continue reading

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Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases.

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Acquiring new N-glycosylation sites in variable regions of immunoglobulin genes by somatic hypermutation is a common feature of autoimmune diseases.
Ann Rheum Dis. 2017 Nov 04;:
Authors: Visser A, Ham… Continue reading

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The structural basis of proton driven zinc transport by ZntB.

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The structural basis of proton driven zinc transport by ZntB.
Nat Commun. 2017 Nov 03;8(1):1313
Authors: Gati C, Stetsenko A, Slotboom DJ, Scheres SHW, Guskov A
Abstract
Zinc is an ess… Continue reading

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Estimating the population-level effectiveness of vaccination program in the Netherlands.

Estimating the population-level effectiveness of vaccination program in the Netherlands.
Epidemiology. 2017 Oct 30;:
Authors: van Wijhe M, McDonald SA, de Melker HE, Postma MJ, Wallinga J
Abstract
BAC… Continue reading

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Characterization of the population structure, drug resistance mechanisms and plasmids of the community-associated Enterobacter cloacae complex in China.

Characterization of the population structure, drug resistance mechanisms and plasmids of the community-associated Enterobacter cloacae complex in China.

J Antimicrob Chemother. 2017 Oct 27;:

Authors: Zhou K, Yu W, Cao X, Shen P, Lu H, Luo Q, Rossen JWA, Xiao Y

Abstract
Objectives: To investigate the population structure, drug resistance mechanisms and plasmids of community-associated Enterobacter cloacae complex (CA-ECC) isolates in China.
Methods: Sixty-two CA-ECC isolates collected from 31 hospitals across China were typed by hsp60 typing and MLST. ESBL and AmpC-overexpression phenotype was determined by double-disc synergy test. Replicon typing and conjugation were performed for plasmid analysis. All ESBL-positive isolates and representative conjugants were subjected to detailed characterization by WGS.
Results: Enterobacter hormaechei and Enterobacter kobei were predominant in our collections. MLST distinguished 46 STs with a polyclonal structure. ST591 was the most prevalent clone detected in northern China. Twenty-two isolates (35.5%) were ESBL positive and half of them were E. kobei. ESBL positivity was related to ESBL production (15/22) and to AmpC overexpression (18/22). Core-genome phylogenetic analysis identified intra- and inter-regional dissemination of ESBL-producing E. kobei clones. ESBL producers were exclusively classified as E. hormaechei and E. kobei, and blaCTX-M-3 was the most prevalent ESBL genotype (10/15) detected in four different environments. In the ESBL-positive population, the ESBL producers encoded more drug resistance genes (8-24 genes) by carrying more plasmids (1-3 plasmids) than the non-ESBL-producing isolates, resulting in an inter-group difference in drug susceptibilities. IncHI-type plasmids were prevalent in the ESBL producers (12/15). All IncHI2-type plasmids (n = 11) carried ESBL genes and shared a similar backbone to p09-036813-1A_261 recovered from Salmonella enterica in Canada.
Conclusions: The species-specific distribution, species-dependent ESBL mechanism and endemic plasmids identified in our study highlight the necessity for tailored surveillance of CA-ECC in the future.

PMID: 29088362 [PubMed – as supplied by publisher]

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Clinical and molecular effects of CHD7 in the heart.

Clinical and molecular effects of CHD7 in the heart.
Am J Med Genet C Semin Med Genet. 2017 Oct 31;:
Authors: Corsten-Janssen N, Scambler PJ
Abstract
Heart defects caused by loss-of-function mutations… Continue reading

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Uneasy to talk about costs of stillbirth?

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Uneasy to talk about costs of stillbirth?

BJOG. 2017 Oct 21;:

Authors: Erwich JJHM

Abstract
In this BJOG stillbirth themed issue, Campbell et al BJOG 2018 XX.XXX report on a population-based cost of illness study. Although reports on costs in healthcare are not unusual, and even quality of life studies are incorporating translations of quality of life into money-estimates, one can feel uneasy when talking about money regarding stillbirth. It seems insensitive towards the people suffering from their loss. How can one put a monetary value on a life not yet lived? However, these authors should be congratulated for building upon earlier work in their effort to tackle this difficult and long neglected topic (Heazell et al Lancet 2016;387:604-616). This article is protected by copyright. All rights reserved.

PMID: 29055084 [PubMed – as supplied by publisher]

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Does obesity along with major depression or anxiety lead to higher use of health care and costs? A 6-year follow-up study.

Does obesity along with major depression or anxiety lead to higher use of health care and costs? A 6-year follow-up study.

Eur J Public Health. 2017 Sep 11;:

Authors: Nigatu YT, Bültmann U, Schoevers RA, Penninx BWJH, Reijneveld SA

Abstract
Background: Evidence lacks on whether obesity along with major depression (MD)/anxiety leads to higher health care use (HCU) and health care-related costs (HCC) compared with either condition alone. The objective of the study was to examine the longitudinal associations of obesity, MD/anxiety, and their combination with HCU and HCC.
Methods: Longitudinal data (2004-2013) among N = 2706 persons at baseline and 2-,4-, and 6-year follow-up were collected on obesity, MD/anxiety and HCU.
Results: The combination of obesity and MD/anxiety was associated with an increased risk of primary and specialty care visits, and of hospitalizations, odds ratios (95%-confidence intervals): 1.83 (1.44; 2.34), 1.31 (1.06; 1.61) and 1.79 (1.40; 2.29) compared to non-obese and non-depressed individuals. The primary and specialty care costs were higher in persons with obesity and MD/anxiety than in persons without these conditions, but the relative excess risk due to interactions between obesity and MD/anxiety regarding HCU and HCC were not statistically significant (i.e. no synergistic effect).
Conclusions: Obesity along with MD/anxiety leads to higher HCU and HCC over time. However, the HCC associated with the joint presence of both conditions are not higher than the sum of the HCC due to each condition independently.

PMID: 29020407 [PubMed – as supplied by publisher]

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Saccharide-Containing Dynamic Proteoids.

Saccharide-Containing Dynamic Proteoids.
Chemistry. 2017 Oct 05;:
Authors: Liu Y, Stuart M, Witte M, Buhler E, Hirsch AKH
Abstract
Dynamic proteoids are dynamic covalent analogues of proteins which ca… Continue reading

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