LATEST OPEN ACCESS UMCG- p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies
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- The intention of Dutch general practitioners to offer vaccination against pneumococcal disease, herpes zoster and pertussis to people aged 60 years and older
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- Predicting attention-deficit/hyperactivity disorder severity from psychosocial stress and stress-response genes: a random forest regression approach
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Tag Archives: PubMed
Mining prokaryotes for antimicrobial compounds: from diversity to function.
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Mining prokaryotes for antimicrobial compounds: from diversity to function.
FEMS Microbiol Rev. 2017 Apr 11;:
Authors: Tracanna V, de Jong A, Medema MH, Kuipers OP
Abstract
The bacter… Continue reading
Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review.
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Effect of parathyroidectomy and cinacalcet on quality of life in patients with end-stage renal disease-related hyperparathyroidism: a systematic review.
Nephrol Dial Transplant. 2017 Apr 10;:
Authors: van der Plas WY, Dulfer RR, Engelsman AF, Vogt L, de Borst MH, van Ginhoven TM, Kruijff S, Dutch Hyperparathryoid Study Group (DHSG)
Abstract
Background.: Patients with end-stage renal disease (ESRD) have a decreased quality of life (QoL), which is attributable in part to ESRD-related hyperparathyroidism (HPT). Both cinacalcet and parathyroidectomy (PTx) are treatments for advanced HPT, but their effects on QoL are unclear. We performed a systematic review to evaluate the impact of cinacalcet and PTx on QoL.
Methods.: A systematic literature search was performed using PubMed and EMBASE databases to identify relevant articles. The search was based on the following keywords: ‘parathyroidectomy’ or ‘cinacalcet’, ‘secondary hyperparathyroidism’ or ‘renal hyperparathyroidism’ combined with ‘quality of life’ or ‘SF-36’ or ‘symptomatology’. Only studies reporting on QoL at baseline and during follow-up were included. QoL scores were extracted from the selected manuscripts and weighted means were calculated. Due to a lack of available data on QoL improvement in patients using cinacalcet, a meta-analysis could not be performed.
Results.: In all, eight articles reached our inclusion criteria. Of this, five articles reported the effect of PTx on QoL. All PTx studies were observational and non-controlled. The physical component scores of the 36-item Medical Outcomes Study Short-Form Health Survey increased significantly with a weighted mean of 35.5% (P < 0.05). Mental component scores increased with 13.7% (P < 0.05). Parathyroidectomy assessment of symptom scores improved from 561 preoperatively to 302 postoperatively (-259 points; -46.2%). Visual analogue scale scores decreased significantly for skin itching (46.6%), joint pain (30.4%) and muscle weakness (28.7%) (P < 0.05). Three studies on the effect of cinacalcet on QoL were included, including one randomized controlled trial. None of these studies showed significant improvement of physical component and mental component scores.
Conclusions.: PTx improved QoL in patients treated for ESRD-related HPT, whereas cinacalcet did not. The difference in impact between PTx and cinacalcet on QoL has not been compared directly.
PMID: 28402557 [PubMed – as supplied by publisher]
Characterization of the Paenibacillus beijingensis DSM 24997 GtfD and its glucan polymer products representing a new glycoside hydrolase 70 subfamily of 4,6-α-glucanotransferase enzymes.
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Characterization of the Paenibacillus beijingensis DSM 24997 GtfD and its glucan polymer products representing a new glycoside hydrolase 70 subfamily of 4,6-α-glucanotransferase enzymes.
PLoS One. 2017;12(4):e0172622
Authors: Gangoiti J, Lamothe L, van Leeuwen SS, Vafiadi C, Dijkhuizen L
Abstract
Previously we have reported that the Gram-negative bacterium Azotobacter chroococcum NCIMB 8003 uses the 4,6-α-glucanotransferase GtfD to convert maltodextrins and starch into a reuteran-like polymer consisting of (α1→4) glucan chains connected by alternating (α1→4)/(α1→6) linkages and (α1→4,6) branching points. This enzyme constituted the single evidence for this reaction and product specificity in the GH70 family, mostly containing glucansucrases encoded by lactic acid bacteria (http://www.CAZy.org). In this work, 4 additional GtfD-like proteins were identified in taxonomically diverse plant-associated bacteria forming a new GH70 subfamily with intermediate characteristics between the evolutionary related GH13 and GH70 families. The GtfD enzyme encoded by Paenibacillus beijingensis DSM 24997 was characterized providing the first example of a reuteran-like polymer synthesizing 4,6-α-glucanotransferase in a Gram-positive bacterium. Whereas the A. chroococcum GtfD activity on amylose resulted in the synthesis of a high molecular polymer, in addition to maltose and other small oligosaccharides, two reuteran-like polymer distributions are produced by P. beijingensis GtfD: a high-molecular mass polymer and a low-molecular mass polymer with an average Mw of 27 MDa and 19 kDa, respectively. Compared to the A. chroooccum GtfD product, both P. beijingensis GtfD polymers contain longer linear (α1→4) sequences in their structure reflecting a preference for transfer of even longer glucan chains by this enzyme. Overall, this study provides new insights into the evolutionary history of GH70 enzymes, and enlarges the diversity of natural enzymes that can be applied for modification of the starch present in food into less and/or more slowly digestible carbohydrate structures.
PMID: 28399167 [PubMed – in process]
Functional Capacity Evaluation Research: Report from the Third International Functional Capacity Evaluation Research Meeting.
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Functional Capacity Evaluation Research: Report from the Third International Functional Capacity Evaluation Research Meeting.
J Occup Rehabil. 2017 Apr 08;:
Authors: Edelaar MJ, Gross DP, James CL, R… Continue reading
Flavor pleasantness processing in the ventral emotion network.
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Flavor pleasantness processing in the ventral emotion network.
PLoS One. 2017;12(2):e0170310
Authors: Dalenberg JR, Weitkamp L, Renken RJ, Nanetti L, Ter Horst GJ
Abstract
The ventral … Continue reading
Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.
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Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.
Health Place. 2017 Feb 01;44:43-51
Authors: Klijs B, Mende… Continue reading
Genius begins at home: Shared social identity enhances the recognition of creative performance.
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Genius begins at home: Shared social identity enhances the recognition of creative performance.
Br J Psychol. 2017 Feb 05;:
Authors: Steffens NK, Haslam SA, Ryan MK, Millard K
Abstract
… Continue reading
Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.
Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.
J Biomed Mater Res A. 2017 Feb 02;:
Authors: Bochyńska AI, Hannink G, Verhoeven R, Grijpma DW, Buma P
Abstract
Current treatment methods to repair meniscal tears do not bring fully satisfactory results. Tissue adhesives are considered promising alternatives, since they are easy to apply and cause minimal tissue trauma. The first aim of this study was to analyze the adhesive properties of and tissue response to two recently developed biodegradable block copolymeric three-armed- and hyper-branched tissue adhesives. The second aim was to investigate if tissue surface modification with collagenase improves the attachment of the adhesives and increases the healing potential of the tissue. Cylindrical explants were harvested from bovine menisci. The central core of the explants was removed and glued back into the defect, with or without incubation in collagenase solution prior to gluing, using one of the novel glues, Dermabond® or fibrin glue. The repair constructs were cultured in vitro for 1 and 28 days. Adhesion tests and histology were performed to analyze the effects of the glue in combination with the additional treatment. The adhesive strength of the novel glues was 40-50 kPa, which was significantly higher than that of fibrin glue (15 kPa). Cells were present in direct contact with the glues, and the tissue remained vital during the whole culture period. Increased cellularity around the tear in the collagenase treated explants was observed after 1 day. The two newly developed tissue adhesives are attractive materials to be used for repair of meniscal tears. The beneficial influence of collagenase treatment in treating meniscal tears with glues still needs to be confirmed in more clinical relevant studies. This article is protected by copyright. All rights reserved.
PMID: 28152576 [PubMed – as supplied by publisher]
A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.
A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.
Ophthalmology. 2017 Jan 28;:
Authors: Vehof J, Hysi PG, Hammond CJ
Abstract
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach.
DESIGN: Cross-sectional association study.
PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years).
METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc., Durham, NC). Dry eye disease was defined from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED by a clinician or “often” or “constant” symptoms of dryness and irritation. Analyses were performed with linear mixed effect models that included age, BMI, and sex as covariates, corrected for multiple testing.
MAIN OUTCOME MEASURES: Primary outcome was DED as defined by the SQDES, and secondary outcomes were symptom score of DED and a clinical diagnosis of DED.
RESULTS: Prevalence of DED as defined by the SQDES was 15.5% (n = 436). A strong and metabolome-wide significant association with DED was found with decreased levels of the metabolites androsterone sulfate (P = 0.00030) and epiandrosterone sulfate (P = 0.00036). Three other metabolites involved in androgen metabolism, 4-androsten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most strongly associated of the 222 metabolites, but did not reach metabolome-wide significance. Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, P = 0.000000029; epiandrosterone sulfate, P = 0.0000040; 4-androsten-3beta,17beta-diol disulfate 1, P = 0.000016; 4-androsten-3beta,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011). Of these 5 androgens, epiandrosterone sulfate (P = 0.0076) was most associated with 2-year incidence of clinician-diagnosed DED. In addition, we found decreased glycerophosphocholines to be associated with DED, although not at metabolome-wide significance.
CONCLUSIONS: This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of research that links androgens to ocular surface disease and DED.
PMID: 28139245 [PubMed – as supplied by publisher]
Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.
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Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.
Disabil Rehabil. 2017 Jan 27;:1-9
Authors: Kaptein S, Geertzen JH, Dijkstra PU
… Continue reading
Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?
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Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?
J Clin Psychiatry. 2017 Jan;78(1):e71
Authors: Apeldoorn SY, de Boer MK, Schoevers RA
PMID: 28129500 [PubMed – … Continue reading
Shutting down the power supply for DNA repair in cancer cells.
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Shutting down the power supply for DNA repair in cancer cells.
J Cell Biol. 2017 Jan 25;:
Authors: van Vugt MA
Abstract
Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In th… Continue reading
Climate predicts which sex acts as helpers among cooperatively breeding bird species.
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Climate predicts which sex acts as helpers among cooperatively breeding bird species.
Biol Lett. 2017 Jan;13(1):
Authors: Zhang G, Zhao Q, Møller AP, Komdeur J, Lu X
Abstract
Among avian cooperative breeders, help in raising offspring is usually provided by males or by both sexes. Sex bias in helping should evolve in response to sex-specific ecological constraints on independent reproduction, with mate shortage for males and breeding vacancy shortage for each sex. Given that male-biased adult sex ratios are prevalent among birds, we predict that male-only helping mainly occurs in temperate species where fast population turnovers deriving from low adult annual survival allow all adult females to hold breeding vacancies, whereas some males overflow as helpers, and both-sex helping in tropical species where saturated habitats prevent not only males, but also females from breeding themselves. As expected, we found that across species, adult survival increased towards tropical zones and warmer climates, and higher adult survival tended to be associated with both-sex helping. Furthermore, sex bias in helping was predicted by latitude and ambient temperature. Our findings of demographic response of species to climate as a potential determinant of bias in helper sex uncover how ecological constraints operate to limit independent reproduction in sex-specific ways.
PMID: 28123111 [PubMed – in process]
To find glomerulonephritis you have to look for it.
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To find glomerulonephritis you have to look for it.
Neth J Med. 2017 Jan;75(1):2-3
Authors: Stegeman CA
PMID: 28124666 [PubMed – in process]
Fever and painful skin lesions after a holiday in Gambia.
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Fever and painful skin lesions after a holiday in Gambia.
Neth J Med. 2017 Jan;75(1):41
Authors: Bouma HR, Kloppenburg WD
PMID: 28124672 [PubMed – in process]
Changes of Perceived Control after Kidney Transplantation: a prospective Study.
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Changes of Perceived Control after Kidney Transplantation: a prospective Study.
J Adv Nurs. 2017 Jan 25;:
Authors: Schulz T, Niesing J, Homan Van Der Heide JJ, Westerhuis R, Ploeg RJ, Ranchor AV
… Continue reading
Retro-Active Emotion: Do Negative Emotional Stimuli Disrupt Consolidation in Working Memory?
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Retro-Active Emotion: Do Negative Emotional Stimuli Disrupt Consolidation in Working Memory?
PLoS One. 2017;12(1):e0169927
Authors: Kandemir G, Akyürek EG, Nieuwenstein MR
Abstract
While many studies have shown that a task-irrelevant emotionally arousing stimulus can interfere with the processing of a shortly following target, it remains unclear whether an emotional stimulus can also retro-actively interrupt the ongoing processing of an earlier target. In two experiments, we examined whether the presentation of a negative emotionally arousing picture can disrupt working memory consolidation of a preceding visual target. In both experiments, the effects of negative emotional pictures were compared with the effects of neutral pictures. In Experiment 1, the pictures were entirely task-irrelevant whereas in Experiment 2 the pictures were associated with a 2-alternative forced choice task that required participants to respond to the color of a frame surrounding the pictures. The results showed that the appearance of the pictures did not interfere with target consolidation when the pictures were task-irrelevant, whereas such interference was observed when the pictures were associated with a 2-AFC task. Most importantly, however, the results showed no effects of whether the picture had neutral or emotional content. Implications for further research are discussed.
PMID: 28103267 [PubMed – in process]
A Perceval Valve in Active Infective Bioprosthetic Valve Endocarditis: Case Report.
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A Perceval Valve in Active Infective Bioprosthetic Valve Endocarditis: Case Report.
J Heart Valve Dis. 2016 Jul;25(4):512-514
Authors: Konertz J, Kastrup M, Treskatsch S, Dohmen PM
Abstract
… Continue reading
Size-dependent and tunable crystallization of GeSbTe phase-change nanoparticles.
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Size-dependent and tunable crystallization of GeSbTe phase-change nanoparticles.
Sci Rep. 2016 Dec 20;6:39546
Authors: Chen B, Ten Brink GH, Palasantzas G, Kooi BJ
Abstract
Chalcogenide-based nanostructured phase-change materials (PCMs) are considered promising building blocks for non-volatile memory due to their high write and read speeds, high data-storage density, and low power consumption. Top-down fabrication of PCM nanoparticles (NPs), however, often results in damage and deterioration of their useful properties. Gas-phase condensation based on magnetron sputtering offers an attractive and straightforward solution to continuously down-scale the PCMs into sub-lithographic sizes. Here we unprecedentedly present the size dependence of crystallization for Ge2Sb2Te5 (GST) NPs, whose production is currently highly challenging for chemical synthesis or top-down fabrication. Both amorphous and crystalline NPs have been produced with excellent size and composition control with average diameters varying between 8 and 17 nm. The size-dependent crystallization of these NPs was carefully analyzed through in-situ heating in a transmission electron microscope, where the crystallization temperatures (Tc) decrease when the NPs become smaller. Moreover, methane incorporation has been observed as an effective method to enhance the amorphous phase stability of the NPs. This work therefore elucidates that GST NPs synthesized by gas-phase condensation with tailored properties are promising alternatives in designing phase-change memories constrained by optical lithography limitations.
PMID: 27996054 [PubMed – in process]
Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon in Streptococcus pneumoniae.
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Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon in Streptococcus pneumoniae.
Front Microbiol. 2016;7:1929
Authors: Afzal M, Manzoor I, Kuipers OP, Shafeeq S
Abstract… Continue reading