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Tag Archives: PubMed
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.
Placenta. 2017 Jun 07;:
Authors: Göhner C, Plösch T, Faas MM
Abstract
Unique immunologic adaptations exist to successfully establish and maintain pregnancy and to avoid an immune attack against the semi allogenic fetus. These adaptations occur both locally at the maternofetal interface and in the peripheral circulation and affect the innate as well as the adaptive immune system. Pregnancy is characterized by a general inflammatory state with activation of monocytes and granulocytes, but also with suppressive lymphocytes (regulatory T cells), and skewing towards T helper 2 immunity. The pregnancy complication preeclampsia is associated with an exaggerated inflammatory state and predominance of T helper 1 and 17 immunity. The syncytiotrophoblast has been found to secrete extracellular vesicles as communication factors into the maternal circulation. Syncytiotrophoblast extracellular vesicles from normal pregnancy have been shown to interact with monocytes, granulocytes, T cells and natural killer cells and influence the function of these cells. In doing so, they may support the inflammatory state of normal pregnancy as well as the suppressive lymphocyte phenotype. During preeclampsia, syncytiotrophoblast extracellular vesicles are not only increased in numbers but also showed an altered molecular load. Based on data from in vitro studies, it can be suggested that syncytiotrophoblast extracellular vesicles from preeclamptic pregnancies may support the exaggerated inflammatory state during preeclampsia. In this review, we discuss the immunological functions of syncytiotrophoblast extracellular vesicles and their involvement in adapting the maternal peripheral immunological adaptations to pregnancy.
PMID: 28647398 [PubMed – as supplied by publisher]
Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.
Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.
Ann Rheum Dis. 2017 Jun 24;:
Authors: Graver JC, Sandovici M, Diepstra A, Boots AMH, Brouwer E
… Continue reading
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.
Surg Obes Relat Dis. 2017 Apr 28;:
Authors: Emous M, Wolffenbuttel BHR, Totté E, van Beek AP
Abstract
BACKGROUND: Early and late dumping are complications of gastric bypass surgery. Early dumping occurs within an hour after eating, when the emptying of food into the small intestine triggers rapid fluid shifts into the intestinal lumen and the release of gastrointestinal hormones, resulting in gastrointestinal and vasomotor symptoms. Late dumping occurs between 1 and 3 hours after carbohydrate ingestion and is caused by an exaggerated insulin release, resulting in hypoglycemia. Almost no data are currently available on the prevalence of early and late dumping or their impact on health-related quality of life (QoL).
OBJECTIVES: To study the prevalence of early and late dumping in a large population of patients having undergone a primary Roux-en-Y gastric bypass (RYGB) and its effect on QoL.
SETTING: Cross-sectional study at a single bariatric department in the Medical Center Leeuwarden, The Netherlands between 2008 and 2011.
METHODS: In 2013, this descriptive cohort study approached by email or post all patients who underwent a primary RYGB in the setting between 2008 and 2011 in one hospital. These patients were asked to fill in standardized questionnaires measuring their QoL (RAND-36), anxiety and depression (HADS), fatigue (MFI-20) and any disease specific indicators of early and late dumping syndrome.
RESULTS: The questionnaire was completed and returned by 351 of 613 patients (57.1%) and 121 nonobese volunteers. Participants were mostly female (80%), aged 42 (40-54 years), with an excess weight loss of 76.8% [IQR 61-95] after RYGB surgery 2.3 [ IQR 1.6-3.4] years earlier. Self-reported complaints of moderate to severe intensity suggestive of early and late dumping were present in 18.8% and 11.7% of patients, respectively. Patients with early and late dumping demonstrated significantly lower scores on the RAND-36 and HADS compared with patients without dumping. No differences were seen in the MFI-20 scores between patients with or without early and late dumping.
CONCLUSION: In this descriptive cohort, self-reported complaints suggestive of early and late dumping of moderate-to-severe intensity were, respectively, 18.8% and 11.7% in a cohort after primary gastric bypass surgery. These complaints were associated with markedly reduced health-related QoL.
PMID: 28624531 [PubMed – as supplied by publisher]
Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.
Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.
Knee Surg Sports Traumatol Arthrosc. 2017 Jun 17;:
Authors: Keizer MNJ, Hoogeslag RAG, van Raay JJAM, Otten E, Brouwer RW
Abstract
PURPOSE: After revision anterior cruciate ligament reconstruction (ACLR), the rate of return to the pre-injury type of sport (RTS type) is low and graft choice might be an important factor. The aim of this study was to determine whether there is a difference in outcome after revision ACLR using a patellar tendon allograft compared to an ipsilateral patellar tendon autograft. It was hypothesized that the rate of RTS type using an ipsilateral patellar tendon autograft will be superior to using patellar tendon allograft.
METHODS: The design is a retrospective cohort study. Inclusion criteria were patients who underwent revision ACLR with a minimum follow-up of 1 year after revision using a patellar allograft or ipsilateral autograft. Primary study parameter was rate of RTS type. Secondary study parameters were RTS level, subscores of the KOOS, the IKDCsubjective, the Tegner score and reasons for no RTS.
RESULTS: Eighty-two patients participated in this study (36 allografts and 46 autografts). In patients with a minimum follow-up of 1 year, rate of RTS type was 51.4% for the patellar tendon allograft and 62.8% for the patellar tendon autograft group (n.s.). In patients with a minimum follow-up rate of 2 years, rate of RTS type was 43.3 versus 75.0%, respectively (p = 0.027). No differences in secondary study parameters were found. In patients with a minimum follow-up of 1 year, rate of RTS type was significantly higher (p = 0.025) for patients without anxiety compared to patients who were anxious to perform certain movements.
CONCLUSION: After a minimum follow-up of 2 years, rate of RTS type is in favour of using an ipsilateral patellar tendon autograft when compared to using a patellar tendon allograft in patients undergoing revision ACLR; after a minimum follow-up of 1 year, no significant difference was found. In revision ACLR, the results of this study might influence graft choice in favour of autologous graft when the use of an allograft or autograft patellar tendon is considered.
LEVEL OF EVIDENCE: III.
PMID: 28624854 [PubMed – as supplied by publisher]
EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.
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EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.
Eur J Nucl Med Mol Imaging. 2017 Jun 16;:
Authors: Aide N, Lasnon C, Veit-Haibach P, S… Continue reading
Assessment of variant pathogenicity in a highly admixed population.
Assessment of variant pathogenicity in a highly admixed population.
Hum Mutat. 2017 Jul;38(7):749
Authors: Guryev V
PMID: 28609575 [PubMed – in process]
Hemostatic Complications in Hepatobiliary Surgery.
Hemostatic Complications in Hepatobiliary Surgery.
Semin Thromb Hemost. 2017 Jun 13;:
Authors: Bos S, Bernal W, Porte R, Lisman T
PMID: 28609799 [PubMed – as supplied by publisher]
The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.
The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.
Adv Health Sci Educ Theory Pract. 2017 Jun 10;:
Authors: de Visser M, Fluit C, Cohen-Schotanus J, Laan R
Abstract
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor’s curriculum simultaneously. 574 students (2013 and 2014 cohorts), admitted through non-cognitive selection (based on portfolio, CASPer and MMI, n = 135) or cognitive selection (curriculum sample selection, n = 439) were included in the study. We compared dropout rates, course credits and grades, using logistic and linear regression. The dropout rate was the highest in the non-cognitive selection group (p < 0.001). Students admitted through non-cognitive selection more often obtained the highest grade for the nursing attachment (p = 0.02) and had a higher mean grade for the practical clinical course in year 3 (p = .04). No differences in course grades were found. The results indicate that students perform best on the elements of the curriculum that are represented most strongly in the selection procedure they had participated in. We recommend the use of curriculum sample procedures, resembling the early medical school curriculum,-whether it has a more cognitive or a more non-cognitive focus-, to select the students who are likely to be successful in the subsequent curriculum.
PMID: 28601913 [PubMed – as supplied by publisher]
Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.
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Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.
Chest. 2017 Jun;151(6):1406-1407
Authors: van der Schans J, Aikman B, de Vries TW, Hoekstra … Continue reading
An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.
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An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.
PLoS One. 2017;12(6):e0178586
Authors: de Vos S, Wardenaar KJ, Bos E… Continue reading
A life course perspective on mental health problems, employment, and work outcomes.
| Related Articles |
A life course perspective on mental health problems, employment, and work outcomes.
Scand J Work Environ Health. 2017 Jun 01;:
Authors: Veldman K, Reijneveld SA, Verhulst FC, Ortiz JA, Bültmann U
Abstract
Objectives Little is known about how employment and work outcomes among young adults are influenced by their life-course history of mental health problems. Therefore, the aims of this study were to (i) identify trajectories of mental health problems from childhood to young adulthood and (ii) investigate the association between these trajectories and employment and work outcomes among young adults. Methods Data were used from 360 participants of the Tracking Adolescents’ Individual Lives Survey (TRAILS), a Dutch prospective cohort study, with 12-year follow-up. Trajectories of externalizing and internalizing problems were identified with latent class growth models. Employment conditions and work outcomes (ie, psychosocial work characteristics) were measured at age 22. We assessed the association between mental health trajectories and employment conditions and work outcomes. Results Four trajectories of mental health problems were identified: high-stable, decreasing, moderate-stable and low-stable. Young adults with high-stable trajectories of externalizing problems worked over six hours more [B=6.71, 95% confidence interval (95% CI) 2.82-10.6] and had a higher income [odds ratio (OR) 0.33, 95% CI 0.15-0.71], than young adults with low-stable trajectories. Young adults with high-stable trajectories of internalizing problems worked six hours less per week (B=-6.07, 95% CI -10.1- -2.05) and reported lower income (OR 3.44, 95% CI 1.53-7.74) and poorer psychosocial work characteristics, compared to young adults with low-stable trajectories. Conclusions Among young adults who had a paid job at the age of 22 (and were not a student or unemployed), those with a history of internalizing problems are less likely to transition successfully into the labor market, compared to other young adults.
PMID: 28570743 [PubMed – as supplied by publisher]
GUT MICROBIOTA AND THE GUT-BRAIN AXIS: NEW INSIGHTS IN THE PATHOPHYSIOLOGY OF METABOLIC SYNDROME.
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GUT MICROBIOTA AND THE GUT-BRAIN AXIS: NEW INSIGHTS IN THE PATHOPHYSIOLOGY OF METABOLIC SYNDROME.
Psychosom Med. 2017 May 27;:
Authors: de Clercq N, Frissen MN, Groen AK, Nieuwdorp M
Abstract
… Continue reading
Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3.
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Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3.
Eur J Med Chem. 2017 Apr 24;136:573-584
Authors: Hartman AM, Hirsch AKH
… Continue reading
Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.
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Mms1 binds to G-rich regions in Saccharomyces cerevisiae and influences replication and genome stability.
Nucleic Acids Res. 2017 May 23;:
Authors: Wanzek K, Schwindt E, Capra JA, Paeschke K
A… Continue reading
Positive affective functioning in anhedonic individuals’ daily life: Anything but flat and blunted.
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Positive affective functioning in anhedonic individuals’ daily life: Anything but flat and blunted.
J Affect Disord. 2017 Apr 21;218:437-445
Authors: Heininga VE, Van Roekel E, Ahles JJ, Oldehinkel AJ… Continue reading
FDG-PET/CT as a New Method for Diagnosis and Whole-Body Evaluation of Lemierre Syndrome.
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FDG-PET/CT as a New Method for Diagnosis and Whole-Body Evaluation of Lemierre Syndrome.
Clin Nucl Med. 2017 May 19;:
Authors: Pijl JP, Glaudemans AWJM, Slart RHJA, Kwee TC
Abstract
Le… Continue reading
Measuring BDNF in saliva using commercial ELISA: Results from a small pilot study.
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Measuring BDNF in saliva using commercial ELISA: Results from a small pilot study.
Psychiatry Res. 2017 Apr 22;254:340-346
Authors: Vrijen C, Schenk HM, Hartman CA, Oldehinkel AJ
Abstract
… Continue reading
Optimum Management of Pulmonary Nodules.
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Optimum Management of Pulmonary Nodules.
Radiology. 2017 Jun;283(3):917-919
Authors: de Koning HJ, Oudkerk M, Lammers JJ
PMID: 28514222 [PubMed – in process]
Clinical Utility of Fecal Calprotectin Monitoring in Asymptomatic Patients with Inflammatory Bowel Disease: A Systematic Review and Practical Guide.
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Clinical Utility of Fecal Calprotectin Monitoring in Asymptomatic Patients with Inflammatory Bowel Disease: A Systematic Review and Practical Guide.
Inflamm Bowel Dis. 2017 Jun;23(6):894-902
Authors: … Continue reading
Educational gains in cause-specific mortality: Accounting for cognitive ability and family-level confounders using propensity score weighting.
| Related Articles |
Educational gains in cause-specific mortality: Accounting for cognitive ability and family-level confounders using propensity score weighting.
Soc Sci Med. 2017 May 08;184:49-56
Authors: Bijwaard GE, Myrskylä M, Tynelius P, Rasmussen F
Abstract
A negative educational gradient has been found for many causes of death. This association may be partly explained by confounding factors that affect both educational attainment and mortality. We correct the cause-specific educational gradient for observed individual background and unobserved family factors using an innovative method based on months lost due to a specific cause of death re-weighted by the probability of attaining a higher educational level. We use data on men with brothers from the Swedish Military Conscription Registry (1951-1983), linked to administrative registers. This dataset of some 700,000 men allows us to distinguish between five education levels and many causes of death. The empirical results reveal that raising the educational level from primary to tertiary would result in an additional 20 months of survival between ages 18 and 63. This improvement in mortality is mainly attributable to fewer deaths from external causes. The highly educated gain more than nine months due to the reduction in deaths from external causes, but gain only two months due to the reduction in cancer mortality and four months due to the reduction in cardiovascular mortality. Ignoring confounding would lead to an underestimation of the gains by educational attainment, especially for the less educated. Our results imply that if the education distribution of 50,000 Swedish men from the 1951 cohort were replaced with that of the corresponding 1983 cohort, 22% of the person-years that were lost to death between ages 18 and 63 would have been saved for this cohort.
PMID: 28501020 [PubMed – as supplied by publisher]