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- Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
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Tag Archives: PubMed
Electrically controlled cloud of bulk nanobubbles in water solutions.
Electrically controlled cloud of bulk nanobubbles in water solutions.
PLoS One. 2017;12(7):e0181727
Authors: Postnikov AV, Uvarov IV, Lokhanin MV, Svetovoy VB
Abstract
Using different experimental techniques we visualize a cloud of gas in water that is produced electrochemically by the alternating polarity process. Liquid enriched with gas does not contain bubbles strongly scattering visible light but its refractive index changes significantly near the electrodes. The change of the refractive index is a collective effect of bulk nanobubbles with a diameter smaller than 200 nm. Any alternative explanation fails to explain the magnitude of the effect. Spatial structure of the cloud is investigated with the optical lever method. Its dynamics is visualised observing optical distortion of the electrode images or using differential interference contrast method. The cloud covers concentric electrodes, in a steady state it is roughly hemispherical with a size two times larger than the size of the electrode structure. When the electrical pulses are switched off the cloud disappears in less than one second. The total concentration of gases can reach very high value estimated as 3.5 × 1020 cm-3 that corresponds to an effective supersaturation of 500 and 150 for hydrogen and oxygen, respectively.
PMID: 28727812 [PubMed – in process]
An unexpected role for bile acid synthesis in adaptation to low temperature.
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An unexpected role for bile acid synthesis in adaptation to low temperature.
Nat Med. 2017 Jul 11;23(7):800-802
Authors: Kuipers F, Groen AK
PMID: 28697185 [PubMed – in process]
Construct validity and test-retest reliability of the revised Upper Extremity Work Demands (UEWD-R) Scale.
Construct validity and test-retest reliability of the revised Upper Extremity Work Demands (UEWD-R) Scale.
Occup Environ Med. 2017 Jul 08;:
Authors: Cavalini MA, Berduszek RJ, van der Sluis CK
Abstract
… Continue reading
Interim Fluorodeoxyglucose Positron Emission Tomography-Adapted Therapy Is Not an Efficient Approach to Improving Outcome in Early-Stage Hodgkin Lymphoma.
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Interim Fluorodeoxyglucose Positron Emission Tomography-Adapted Therapy Is Not an Efficient Approach to Improving Outcome in Early-Stage Hodgkin Lymphoma.
J Clin Oncol. 2017 Jul 06;:JCO2017733816
Autho… Continue reading
A personalised or procrustean approach to treating hypertension?
A personalised or procrustean approach to treating hypertension?
Lancet. 2017 Jul 01;390(10089):26-27
Authors: Gabb GM, Mol PGM, Arnolda LF
PMID: 28677555 [PubMed – in process]
Partially hydrolyzed whey proteins prevent clinical symptoms in a cow’s milk allergy mouse model and enhance regulatory T and B cell frequencies.
Partially hydrolyzed whey proteins prevent clinical symptoms in a cow’s milk allergy mouse model and enhance regulatory T and B cell frequencies.
Mol Nutr Food Res. 2017 Jul 05;:
Authors: Kiewiet MBG, van Esch BCAM, … Continue reading
Chromosome segregation drives division site selection in Streptococcus pneumoniae.
Chromosome segregation drives division site selection in Streptococcus pneumoniae.
Proc Natl Acad Sci U S A. 2017 Jul 03;:
Authors: van Raaphorst R, Kjos M, Veening JW
Abstract
Accurate spatial and te… Continue reading
The inverse association of HDL-cholesterol with future risk of hypertension is not modified by its antioxidant constituent, paraoxonase-1: The PREVEND prospective cohort study.
The inverse association of HDL-cholesterol with future risk of hypertension is not modified by its antioxidant constituent, paraoxonase-1: The PREVEND prospective cohort study.
Atherosclerosis. 2017 Jun 21;263:219-226
Authors: Kunutsor SK, Kieneker LM, Bakker SJL, James RW, Dullaart RPF
Abstract
BACKGROUND AND AIMS: High-density lipoprotein cholesterol (HDL-C), an established risk marker for atherosclerotic cardiovascular disease (CVD), has been shown to be inversely and independently associated with incident hypertension. Paraoxonase-1 (PON-1) is an HDL-bound esterase enzyme associated with CVD, but its relationship with incident hypertension has not been previously investigated. We aimed at evaluating the prospective association between PON-1 and hypertension risk.
METHODS: PON-1 arylesterase activity was measured in serum at baseline in 3988 participants without pre-existing hypertension in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective population-based study. During a median follow-up of 10.7 years, 1206 participants developed hypertension.
RESULTS: In age- and sex-adjusted analysis, the hazard ratio (95% CI) for incident hypertension per 1 standard deviation increase in PON-1 was 1.01 (0.96-1.07; p = 0.656), which remained non-significant after adjustment for several established hypertension risk factors and other potential confounders (0.99, 0.93 to 1.05; p = 0.764). The association was also non-existent on further adjustment for HDL-C (1.00 (0.94-1.06; p = 0.936)) and did not importantly vary across several clinical subgroups. In analyses in the same set of participants, HDL-C was continuously inversely and independently associated with hypertension risk; the association persisted after further adjustment for PON-1 activity and was not modified by PON-1 activity.
CONCLUSIONS: In this Caucasian cohort of men and women, HDL-C, but not its anti-oxidant constituent – PON-1, is inversely, continuously and independently associated with future risk of hypertension. The association is independent of and not modified by PON-1.
PMID: 28667918 [PubMed – as supplied by publisher]
Depressed gut? The microbiota-diet-inflammation trialogue in depression.
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Depressed gut? The microbiota-diet-inflammation trialogue in depression.
Curr Opin Psychiatry. 2017 Jun 24;:
Authors: Daniels JK, Koopman M, Aidy SE
Abstract
PURPOSE OF REVIEW: Accordi… Continue reading
Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.
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Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.
PLoS One. 2017;12(6):e0179244
Authors: Akkermans DHM
Abstract
AIM OF THE PAPER: The p… Continue reading
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.
Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.
Placenta. 2017 Jun 07;:
Authors: Göhner C, Plösch T, Faas MM
Abstract
Unique immunologic adaptations exist to successfully establish and maintain pregnancy and to avoid an immune attack against the semi allogenic fetus. These adaptations occur both locally at the maternofetal interface and in the peripheral circulation and affect the innate as well as the adaptive immune system. Pregnancy is characterized by a general inflammatory state with activation of monocytes and granulocytes, but also with suppressive lymphocytes (regulatory T cells), and skewing towards T helper 2 immunity. The pregnancy complication preeclampsia is associated with an exaggerated inflammatory state and predominance of T helper 1 and 17 immunity. The syncytiotrophoblast has been found to secrete extracellular vesicles as communication factors into the maternal circulation. Syncytiotrophoblast extracellular vesicles from normal pregnancy have been shown to interact with monocytes, granulocytes, T cells and natural killer cells and influence the function of these cells. In doing so, they may support the inflammatory state of normal pregnancy as well as the suppressive lymphocyte phenotype. During preeclampsia, syncytiotrophoblast extracellular vesicles are not only increased in numbers but also showed an altered molecular load. Based on data from in vitro studies, it can be suggested that syncytiotrophoblast extracellular vesicles from preeclamptic pregnancies may support the exaggerated inflammatory state during preeclampsia. In this review, we discuss the immunological functions of syncytiotrophoblast extracellular vesicles and their involvement in adapting the maternal peripheral immunological adaptations to pregnancy.
PMID: 28647398 [PubMed – as supplied by publisher]
Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.
Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.
Ann Rheum Dis. 2017 Jun 24;:
Authors: Graver JC, Sandovici M, Diepstra A, Boots AMH, Brouwer E
… Continue reading
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.
The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.
Surg Obes Relat Dis. 2017 Apr 28;:
Authors: Emous M, Wolffenbuttel BHR, Totté E, van Beek AP
Abstract
BACKGROUND: Early and late dumping are complications of gastric bypass surgery. Early dumping occurs within an hour after eating, when the emptying of food into the small intestine triggers rapid fluid shifts into the intestinal lumen and the release of gastrointestinal hormones, resulting in gastrointestinal and vasomotor symptoms. Late dumping occurs between 1 and 3 hours after carbohydrate ingestion and is caused by an exaggerated insulin release, resulting in hypoglycemia. Almost no data are currently available on the prevalence of early and late dumping or their impact on health-related quality of life (QoL).
OBJECTIVES: To study the prevalence of early and late dumping in a large population of patients having undergone a primary Roux-en-Y gastric bypass (RYGB) and its effect on QoL.
SETTING: Cross-sectional study at a single bariatric department in the Medical Center Leeuwarden, The Netherlands between 2008 and 2011.
METHODS: In 2013, this descriptive cohort study approached by email or post all patients who underwent a primary RYGB in the setting between 2008 and 2011 in one hospital. These patients were asked to fill in standardized questionnaires measuring their QoL (RAND-36), anxiety and depression (HADS), fatigue (MFI-20) and any disease specific indicators of early and late dumping syndrome.
RESULTS: The questionnaire was completed and returned by 351 of 613 patients (57.1%) and 121 nonobese volunteers. Participants were mostly female (80%), aged 42 (40-54 years), with an excess weight loss of 76.8% [IQR 61-95] after RYGB surgery 2.3 [ IQR 1.6-3.4] years earlier. Self-reported complaints of moderate to severe intensity suggestive of early and late dumping were present in 18.8% and 11.7% of patients, respectively. Patients with early and late dumping demonstrated significantly lower scores on the RAND-36 and HADS compared with patients without dumping. No differences were seen in the MFI-20 scores between patients with or without early and late dumping.
CONCLUSION: In this descriptive cohort, self-reported complaints suggestive of early and late dumping of moderate-to-severe intensity were, respectively, 18.8% and 11.7% in a cohort after primary gastric bypass surgery. These complaints were associated with markedly reduced health-related QoL.
PMID: 28624531 [PubMed – as supplied by publisher]
Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.
Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.
Knee Surg Sports Traumatol Arthrosc. 2017 Jun 17;:
Authors: Keizer MNJ, Hoogeslag RAG, van Raay JJAM, Otten E, Brouwer RW
Abstract
PURPOSE: After revision anterior cruciate ligament reconstruction (ACLR), the rate of return to the pre-injury type of sport (RTS type) is low and graft choice might be an important factor. The aim of this study was to determine whether there is a difference in outcome after revision ACLR using a patellar tendon allograft compared to an ipsilateral patellar tendon autograft. It was hypothesized that the rate of RTS type using an ipsilateral patellar tendon autograft will be superior to using patellar tendon allograft.
METHODS: The design is a retrospective cohort study. Inclusion criteria were patients who underwent revision ACLR with a minimum follow-up of 1 year after revision using a patellar allograft or ipsilateral autograft. Primary study parameter was rate of RTS type. Secondary study parameters were RTS level, subscores of the KOOS, the IKDCsubjective, the Tegner score and reasons for no RTS.
RESULTS: Eighty-two patients participated in this study (36 allografts and 46 autografts). In patients with a minimum follow-up of 1 year, rate of RTS type was 51.4% for the patellar tendon allograft and 62.8% for the patellar tendon autograft group (n.s.). In patients with a minimum follow-up rate of 2 years, rate of RTS type was 43.3 versus 75.0%, respectively (p = 0.027). No differences in secondary study parameters were found. In patients with a minimum follow-up of 1 year, rate of RTS type was significantly higher (p = 0.025) for patients without anxiety compared to patients who were anxious to perform certain movements.
CONCLUSION: After a minimum follow-up of 2 years, rate of RTS type is in favour of using an ipsilateral patellar tendon autograft when compared to using a patellar tendon allograft in patients undergoing revision ACLR; after a minimum follow-up of 1 year, no significant difference was found. In revision ACLR, the results of this study might influence graft choice in favour of autologous graft when the use of an allograft or autograft patellar tendon is considered.
LEVEL OF EVIDENCE: III.
PMID: 28624854 [PubMed – as supplied by publisher]
EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.
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EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.
Eur J Nucl Med Mol Imaging. 2017 Jun 16;:
Authors: Aide N, Lasnon C, Veit-Haibach P, S… Continue reading
Assessment of variant pathogenicity in a highly admixed population.
Assessment of variant pathogenicity in a highly admixed population.
Hum Mutat. 2017 Jul;38(7):749
Authors: Guryev V
PMID: 28609575 [PubMed – in process]
Hemostatic Complications in Hepatobiliary Surgery.
Hemostatic Complications in Hepatobiliary Surgery.
Semin Thromb Hemost. 2017 Jun 13;:
Authors: Bos S, Bernal W, Porte R, Lisman T
PMID: 28609799 [PubMed – as supplied by publisher]
The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.
The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.
Adv Health Sci Educ Theory Pract. 2017 Jun 10;:
Authors: de Visser M, Fluit C, Cohen-Schotanus J, Laan R
Abstract
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor’s curriculum simultaneously. 574 students (2013 and 2014 cohorts), admitted through non-cognitive selection (based on portfolio, CASPer and MMI, n = 135) or cognitive selection (curriculum sample selection, n = 439) were included in the study. We compared dropout rates, course credits and grades, using logistic and linear regression. The dropout rate was the highest in the non-cognitive selection group (p < 0.001). Students admitted through non-cognitive selection more often obtained the highest grade for the nursing attachment (p = 0.02) and had a higher mean grade for the practical clinical course in year 3 (p = .04). No differences in course grades were found. The results indicate that students perform best on the elements of the curriculum that are represented most strongly in the selection procedure they had participated in. We recommend the use of curriculum sample procedures, resembling the early medical school curriculum,-whether it has a more cognitive or a more non-cognitive focus-, to select the students who are likely to be successful in the subsequent curriculum.
PMID: 28601913 [PubMed – as supplied by publisher]
Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.
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Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.
Chest. 2017 Jun;151(6):1406-1407
Authors: van der Schans J, Aikman B, de Vries TW, Hoekstra … Continue reading
An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.
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An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.
PLoS One. 2017;12(6):e0178586
Authors: de Vos S, Wardenaar KJ, Bos E… Continue reading