Joost Caumanns: Kinome directed target discovery and validation in unique ovarian clear cell carcinoma models Caumanns behandelt in zijn …
Marco van Londen: Living kidney donor evaluation and safety assessment Niertransplantatie met een nier van een levende donor is momenteel de best …
Irene Zwarts: Intestinal nuclear receptors in control of energy metabolism Tegenwoordig worden welvaartsziekten, zoals type 2 diabetes, beschouwd …
Jakub Wudarski: Development of genetic manipulation tools in Macrostomum lignano for dissection of molecular mechanisms of regeneration In dit …
Four or 6 implants in the maxillary posterior region to support an overdenture: 5-year results from a randomized controlled trial.
Clin Oral Implants Res. 2019 Jan 12;:
Authors: Slot W, Raghoebar GM, Cune MS, Vissink A, Meijer HJA
OBJECTIVE: To compare clinical and patient-reported outcomes when providing maxillary overdentures on 4-bar and 6-bar connected implants placed in the posterior region during a 5-year follow-up period.
MATERIALS AND METHODS: Sixty-six fully edentulous patients with functional maxillary denture complaints and insufficient bone volume to allow implant placement were scheduled for a maxillary sinus floor elevation procedure with bone from the anterior iliac crest and randomized to receive either 4 or 6 implants in the posterior maxilla and 4 implants in the mandible. After 3 months of osseointegration, a bar-supported overdenture was constructed. Maxillary implant survival, overdenture survival, clinical scores, peri-implant bone height changes and patient satisfaction were assessed.
RESULTS: Sixty patients completed the 5-year follow-up. Implant survival was 100% in the 4-implants group and 99.5% in the 6-implants group. No new overdentures had to be made in the 4-implants group, three new overdentures were made in the 6-implants group due to excessive wear of the denture base and teeth (90.9% overdenture survival). Clinical parameters did not differ significantly between groups. Mean marginal bone loss compared to baseline was 0.58±0.51 mm in the 4-implants group and 0.60±0.58 mm in the 6-implants group, respectively. Overall, patient satisfaction improved significantly, but did not differ between groups.
CONCLUSION: Following a bilateral maxillary sinus floor elevation procedure, a bar-supported overdenture on 4 implants in the posterior maxillary region is not inferior to an overdenture supported by 6 implants after a 5-year evaluation period in patients with functional maxillary denture complaints and marked posterior resorption. This article is protected by copyright. All rights reserved.
PMID: 30636064 [PubMed – as supplied by publisher]
Volume of motor area predicts motor impulsivity.
Eur J Neurosci. 2019 Jan 12;:
Authors: Ai H, Xin Y, Luo Y, Gu R, Xu P
Impulsivity is a personality trait associated with many maladaptive behaviors. Trait impulsivity is typically divided into three different dimensions, including attentional impulsiveness, motor impulsiveness, and non-planning impulsiveness. The present work aimed to investigate the neuroanatomical basis of the multidimensional impulsivity trait. Eighty-four healthy subjects were studied with structural magnetic resonance imaging. Multiple regression analyses revealed that the score of motor impulsiveness was negatively correlated with gray matter volumes of the right supplementary motor area and paracentral lobule. A machine-learning based prediction analysis indicated that decreased gray matter volumes of the supplementary motor area and paracentral lobule strongly predicted deficits in motor impulsiveness control. Our findings provide insights into the predictive role of motor brain structures in motor impulsivity and inhibition control. This article is protected by copyright. All rights reserved.
PMID: 30636081 [PubMed – as supplied by publisher]
Hilde Nienhuis: Targeting breast cancer cells and their microenvironment; preclinical models and translational studies Borstkanker is wereldwijd de …
Federica Fontanella: Antenatal diagnosis and management of fetal megacystis and lower urinary tract obstruction Bij een Lower Urinary Tract …
Harmke Polinder-Bos: A geriatric perspective on chronic kidney disease – the three M’s Wereldwijd worden we steeds ouder en is de levensverwachting …
Niels Grote Beverborg: Anemia, erythropoietin and iron in heart failure Op dit moment is het niet mogelijk hartfalen te genezen. De behandeling …
The cellular stress response in hepatitis C virus infection: a balancing act to promote viral persistence and host cell survival.
Virus Res. 2018 Dec 29;:
Authors: Ríos-Ocampo WA, Navas MC, Faber KN, Daemen T, Moshage H
Oxidative- and endoplasmic reticulum (ER)-stress are common events during hepatitis C virus (HCV) infection and both regulate cell survival and determine clinical outcome. In response to intrinsic and extrinsic cellular stress, different adaptive mechanisms have evolved in hepatocytes to restore cellular homeostasis like the anti-oxidant response, the unfolded protein response (UPR) and the integrated stress response (ISR). In this review, we focus on the cellular stress response in the context of acute and chronic HCV infection. The mechanisms of induction and modulation of oxidative- and ER-stress are reviewed and analyzed from both perspectives: viral persistence and cell survival. Besides, we delve into the activation of the eIF2α/ATF4 pathway and selective autophagy induction; pathways involved in the elimination of harmful viral proteins after oxidative stress induction. For this, the negative role of autophagy upon HCV infection or negative regulation of viral replication is analyzed. Finally, we hypothesize that the cellular stress response in hepatocytes plays a major role for HCV control thus acting as an important host-factor for virus clearance during the early stages of HCV infection.
PMID: 30599163 [PubMed – as supplied by publisher]
Posted in Virus Res
“There is a chance for me” – Risk communication in advanced maternal age genetic counseling sessions in South Africa.
Eur J Med Genet. 2018 Dec 29;:
Authors: Wessels TM, Koole T
Providing risk information is central to genetic counselling. Many studies have examined risk communication, but the focus has been on professional and patient perspectives. Less information is available on risk communication in interactions. This study aimed to examine genetic counselors’ (GCs) risks communication in multicultural genetic counseling sessions with women of advanced maternal age (AMA). Six GCs (2-20 years’ experience) conducted AMA sessions in English (women’s second language). The sessions were video and voice recorded and transcribed verbatim. Data was analysed using conversation analysis (CA). CA examines discourse as a topic, i.e. describing the turns, its functions and how these functions are accomplished. Analysis revealed that the GCs presented the risks of having a baby with a chromosome abnormality in several ways and that they invite the women to reflect on the risk information. This discussion was found to be a five step process and showed that the women responded to the invitation to reflect rather than the risk information itself. It therefore seems that the way in which risks are presented are less important than the meaning of the risks for the women. Examination drawing on CA principles revealed that bothcounselors and women orientated to an interpretation of the risk. The data suggests that the risk is dichotomized by both the women and the counsellors. This is evident in the women and the counsellor’s responses. The research showed the power of interactional research such as CA methodology to gain new insights into old problems. Importantly, the study revealed some on the nuances of risk communication in genetic counseling.
PMID: 30599214 [PubMed – as supplied by publisher]