Ondervoeding bij patiënten met hoofd-halskanker

​Martine Sealy: Assessment of malnutrition in patients with head and neck cancer: a multidimensional approach Patiënten met hoofd-halskanker hebben …

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Ertapenem veelbelovend als nieuw middel tegen tuberculose

​Sander van Rijn: Clinical pharmacology of ertapenem in the treatment of multidrug-resistant tuberculosis Het middel ertapenem in combinatie met …

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Effects of sodium glucose cotransporter 2 inhibitors on mineral metabolism in type 2 diabetes mellitus.

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Effects of sodium glucose cotransporter 2 inhibitors on mineral metabolism in type 2 diabetes mellitus.

Curr Opin Nephrol Hypertens. 2019 Apr 04;:

Authors: Vinke JSJ, Heerspink HJL, de Borst MH

Abstract
PURPOSE OF REVIEW: Sodium glucose cotransporter 2 (SGLT2) inhibitors are relatively novel antidiabetic drugs that improve glycemic control and reduce cardiovascular outcomes as well as renal function decline. SGLT2 inhibitors act by inhibiting glucose reabsorption in the proximal tubule of the kidney. Emerging data suggest that these drugs may also influence bone and mineral metabolism. This review summarizes clinical trial data on bone and mineral outcomes, and discusses potential underlying mechanisms.
RECENT FINDINGS: Three large randomized controlled trials documented cardiovascular and renal protective effects of SGLT2 inhibitors. Recent studies indicate that SGLT2 inhibitors influence renal phosphate reabsorption and calciuria. Although the CANVAS trial suggested an increased fracture risk associated with canagliflozin compared with placebo, the vast majority of trials and meta-analyses did not demonstrate an increased fracture risk associated with SGLT2 inhibitor use.
SUMMARY: SGLT2 inhibitors have shown clinically relevant cardiovascular and renal protective effects. The long-term implications for bone health, in particular in the context of chronic kidney disease, are still incompletely understood and warrant further investigation.

PMID: 30958403 [PubMed – as supplied by publisher]

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Obese patients have higher rates of polymicrobial and Gram-negative early periprosthetic joint infections of the hip than non-obese patients.

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Obese patients have higher rates of polymicrobial and Gram-negative early periprosthetic joint infections of the hip than non-obese patients.

PLoS One. 2019;14(4):e0215035

Authors: Löwik CAM, Zijlstra WP, Knobben BAS, Ploegmakers JJW, Dijkstra B, de Vries AJ, Kampinga GA, Mithoe G, Al Moujahid A, Jutte PC, Wouthuyzen-Bakker M, Northern Infection Network Joint Arthroplasty (NINJA)

Abstract
BACKGROUND: Obese patients are more likely to develop periprosthetic joint infection (PJI) after primary total joint arthroplasty. This study compared the clinical and microbiological characteristics of non-obese, obese and severely obese patients with early PJI, in order to ultimately optimize antibiotic prophylaxis and other prevention measures for this specific patient category.
METHODS: We retrospectively evaluated patients with early PJI of the hip and knee treated with debridement, antibiotics and implant retention (DAIR) between 2006 and 2016 in three Dutch hospitals. Only patients with primary arthroplasties indicated for osteoarthritis were included. Early PJI was defined as an infection that developed within 90 days after index surgery. Obesity was defined as a BMI ≥30kg/m2 and severe obesity as a BMI ≥35kg/m2.
RESULTS: A total of 237 patients were analyzed, including 64 obese patients (27.0%) and 62 severely obese patients (26.2%). Compared with non-obese patients, obese patients had higher rates of polymicrobial infections (60.3% vs 33.3%, p<0.001) with more often involvement of Enterococcus species (27.0% vs 11.7%, p = 0.003). Moreover, severely obese patients had more Gram-negative infections, especially with Proteus species (12.9% vs 2.3%, p = 0.001). These results were only found in periprosthetic hip infections, comprising Gram-negative PJIs in 34.2% of severely obese patients compared with 24.7% in obese patients and 12.7% in non-obese patients (p = 0.018).
CONCLUSIONS: Our results demonstrate that obese patients with early periprosthetic hip infections have higher rates of polymicrobial infections with enterococci and Gram-negative rods, which stresses the importance of improving preventive strategies in this specific patient category, by adjusting antibiotic prophylaxis regimens, improving disinfection strategies and optimizing postoperative wound care.

PMID: 30958847 [PubMed – in process]

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Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment.

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Perinatal fluoxetine exposure changes social and stress-coping behavior in adult rats housed in a seminatural environment.

Neuropharmacology. 2019 Apr 05;:

Authors: Houwing DJ, Heijkoop R, Olivier JDA, Snoeren EMS

Abstract
The use of selective serotonin reuptake inhibitors (SSRI) during pregnancy has increased tremendously, but the consequences for the offspring remain largely unclear. Several studies have described potential effects of perinatal SSRI-exposure on neurobehavioral outcomes using simplified rodent test set-ups, however these set-ups only assess a small fraction of the behavior. For translational purposes it is important to take the environmental influences into account which children are exposed to in real life. By using a seminatural environmental set-up, this study is the first to assess behavioral outcomes in offspring exposed to perinatal SSRI exposure under seminatural circumstances. Mothers received daily the SSRI fluoxetine (FLX, 10 mg/kg p.o.) or vehicle (CTR) from gestational day 1 until postnatal day 21. To assess the effect of FLX exposure during early development, female and male offspring were behaviorally tested in the seminatural environment at adulthood. Baseline behavior was measured in addition to responses during and after stressful white-noise events. Behavior was observed on two days, day 4 on which females were sexually non-receptive, and day 7, on which females were sexual receptive. Perinatal FLX exposure reduced general activity in females and increased behavior related to a social context in both males and females. After a stressful white-noise event some behaviors switched. Whereas FLX-females switch from resting socially to resting more solitarily, FLX-males show an increase in self-grooming behavior after the stressor and showed more freezing behavior in the open area. We conclude that perinatal FLX exposure leads to alterations in social and stress-coping behaviors in adulthood, when observed in a seminatural environment. Whether these adaptations in behavior are advantageous or disadvantageous remains to be established.

PMID: 30959021 [PubMed – as supplied by publisher]

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A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia

A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia

Osmanova, D. Z., Freidin, M. B., Fedorenko, O. Y., Pozhidaev, I. V., Boiko, A. S., Vyalova, N. M., Tiguntsev, V. V., Kornetova, E. G., Loonen, A. J. M., Semke, A. V., Wilffert, B., Bokhan, N. A. & Ivanova, S. A., 9-Apr-2019, In : BMC MEDICAL GENETICS. 20, Suppl 1, p. 47

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Pages (from-to) 47
Journal BMC MEDICAL GENETICS
Volume 20
Issue number Suppl 1
Publication status Published – 9-Apr-2019
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Evaluation of Fecal Hormones for Noninvasive Research on Reproduction and Stress in Humpback Whales (Megaptera novaeangliae).

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Evaluation of Fecal Hormones for Noninvasive Research on Reproduction and Stress in Humpback Whales (Megaptera novaeangliae).

Gen Comp Endocrinol. 2019 Apr 02;:

Authors: Hunt KE, Robbins J, Loren Buck C, Bérubé M, Rolland RM

Abstract
Fecal hormone analysis shows high potential for noninvasive assessment of population-level patterns in stress and reproduction of marine mammals. However, the marine environment presents unique challenges for fecal sample collection. Data are still lacking on collection methodology and assay validations for most species, particularly for those mysticete whales that have variable diets. In this study we tested collection techniques for fecal samples of free-swimming humpback whales (Megaptera novaeangliae), and validated immunoassays for five steroid and thyroid hormones. Resulting data were used for preliminary physiological validations, i.e., comparisons to independently confirmed sex and reproductive state. Pregnant females had significantly higher fecal progestins and glucocorticoids than did other demographic categories of whales. Two possible cases of previously undetected pregnancies were noted. Males had significantly higher fecal testosterone metabolites than nonpregnant females. Fecal glucocorticoids were significantly elevated in pregnant females and mature males compared to nonpregnant females. Calf fecal samples had elevated concentrations of all fecal hormones. Fecal thyroid hormones showed a significant seasonal decline from spring to summer. Though sample sizes were small, and sampling was necessarily opportunistic, these patterns indicate that noninvasive fecal hormone analysis may facilitate studies of reproduction, stress and potentially energetics in humpback whales.

PMID: 30951726 [PubMed – as supplied by publisher]

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The relationship between occupation and dry eye.

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The relationship between occupation and dry eye.

Ocul Surf. 2019 Apr 02;:

Authors: Bazeer S, Jansonius N, Snieder H, Hammond C, Vehof J

Abstract
INTRODUCTION: Environmental factors play an important aetiological role in dry eye. This cross-sectional study investigated the relationship between types of occupation and symptomatic dry eye.
METHODS: 40,501 employed people working ≥8 h a week were included from the population-based Lifelines cohort in the Netherlands. Logistic regression was used to determine the association between symptomatic dry eye (assessed by the WHS questionnaire) and occupation (using the ISCO-08 classification system).
RESULTS: After correction for age and sex, the professionals (e.g. legal, health, and business and administration professionals) (OR = 1.14, 95%CI = 1.08-1.19, P < 0.001) and clerical support workers (OR = 1.14, 95%CI = 1.07-1.22, P < 0.001) had the highest risk of dry eye of all 10 major occupation groups. Skilled agricultural workers (OR = 0.57, 95%CI = 0.49-0.67, P < 0.001) and elementary occupations (OR = 0.77, 95%CI = 0.69-0.85, P < 0.001), such as cleaners and carers, carried the lowest risk of dry eye. After additional correction for 45 dry eye associated comorbidities, professionals and clerical support workers showed no increased risk anymore, while craft and related trades workers, e.g. building workers and metal and machinery workers, showed the highest risk of dry eye (OR = 1.12, 95%CI = 1.02-1.24, P = 0.01).
CONCLUSIONS: This study underlines the importance of asking about type of occupation in dry eye patients. Screening for symptomatic dry eye in high risk occupations such as in building workers and in indoor occupations with high screen use is relevant from an occupational health and work productivity perspective. The lower risk of dry eye in outdoor and active occupation is intriguing and justifies future studies to investigate potential protective and treatment effects.

PMID: 30951831 [PubMed – as supplied by publisher]

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Comparative genomics reveals a lack of evidence for pigeons as a main source of stx2f-carrying Escherichia coli causing disease in humans and the common existence of hybrid Shiga toxin-producing and enteropathogenic E. coli pathotypes

Comparative genomics reveals a lack of evidence for pigeons as a main source of stx2f-carrying Escherichia coli causing disease in humans and the common existence of hybrid Shiga toxin-producing and enteropathogenic E. coli pathotypes

van Hoek, A. H. A. M., van Veldhuizen, J. N. J., Friesema, I., Coipan, C., Rossen, J. W. A., Bergval, I. L. & Franz, E., 5-Apr-2019, In : BMC Genomics. 20, 1, 14 p., 271.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 271
Number of pages 14
Journal BMC Genomics
Volume 20
Issue number 1
Publication status Published – 5-Apr-2019
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Bepaling van de biomarkers HER2 en Ki67 bij kanker

​Timco Koopman: Assessment of HER2 and Ki67 in adenocarcinomas Biomarkers in tumoren op weefselniveau kunnen het gedrag van kanker voorspellen of …

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Slaap- en vermoeidheidsklachten bij offshore werknemers

​Vanessa Riethmeister:Sleep and fatigue offshore Slaap- en vermoeidheidsklachten hebben een negatieve invloed op de gezondheid, veiligheid, …

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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging.

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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging.

J Vis Exp. 2019 Mar 13;(145):

Authors: Chen J, Vachon J, Feringa BL

Abstract
The design and synthesis of a synthetic system that aims for the direct visualization of a synthetic rotary motor at the single molecule level on surfaces are demonstrated. This work requires careful design, considerable synthetic effort, and proper analysis. The rotary motion of the molecular motor in solution is shown by 1H NMR and UV-vis absorption spectroscopy techniques. In addition, the method to graft the motor onto an amine-coated quartz is described. This method helps to gain more insight into molecular machines.

PMID: 30933057 [PubMed – in process]

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The effect of influenza vaccination on the mortality and risk of hospitalization in patients with heart failure: A systematic review and meta-analysis

The effect of influenza vaccination on the mortality and risk of hospitalization in patients with heart failure: A systematic review and meta-analysis

Poudel, S., Shehadeh, F., Zacharioudakis, I. M., Tansarli, G. S., Zervou, F. N., Kalligeros, M., Van Aalst, R., Chit, A. & Mylonakis, E., 2-Apr-2019, (Accepted/In press) In : Open Forum Infectious Diseases. 30 p., 159.

Research output: Contribution to journalReview articleAcademicpeer-review

Original language English
Article number 159
Number of pages 30
Journal Open Forum Infectious Diseases
Publication status Accepted/In press – 2-Apr-2019
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Effects of oxygen during long-term hypothermic machine perfusion in a porcine model of kidney donation after circulatory death

Effects of oxygen during long-term hypothermic machine perfusion in a porcine model of kidney donation after circulatory death

COPE consortium, 2-Apr-2019, In : Transplantation. 36 p.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Number of pages 36
Journal Transplantation
Publication status E-pub ahead of print – 2-Apr-2019
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Een beter vaccin tegen tuberculose

​Matthias Gröschel:Tackling challenges to tuberculosis elimination: Vaccines, drug-resistance, comorbidities Een nieuw, beter vaccin tegen …

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Verbetering van de antimicrobiële therapie voor de infectieziekte Buruli ulcus

​Till Omansen: Improving antimicrobial therapy for Buruli ulcer. Pre clinical studies towards highly efficient, short-course therapy Buruli ulcus is …

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Delivery or expectant management for prevention of adverse maternal and neonatal outcomes in hypertensive disorders of pregnancy: an individual participant data meta-analysis

Delivery or expectant management for prevention of adverse maternal and neonatal outcomes in hypertensive disorders of pregnancy: an individual participant data meta-analysis

Pereira Bernardes, T., Zwertbroek, E. F., Broekhuijsen, K., Koopmans, C., Boers, K., Owens, M., Thornton, J., van Pampus, M. G., Scherjon, S. A., Wallace, K., Langenveld, J., van den Berg, P. P., Franssen, M. T. M., Mol, B. W. J. & Groen, H., Apr-2019, In : Ultrasound in Obstetrics & Gynecology. 53, 4, p. 443-453 11 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Original language English
Pages (from-to) 443-453
Number of pages 11
Journal Ultrasound in Obstetrics & Gynecology
Volume 53
Issue number 4
Publication status Published – Apr-2019
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A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications

Original language English
Pages (from-to) 44-53
Number of pages 10
Journal Journal of Clinical Epidemiology
Volume 108
Publication status Published – Apr-2019
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How representative of a general type 2 diabetes population are patients included in cardiovascular outcome trials with SGLT2 inhibitors? A large European observational study

How representative of a general type 2 diabetes population are patients included in cardiovascular outcome trials with SGLT2 inhibitors? A large European observational study

Birkeland, K. I., Bodegard, J., Norhammar, A., Kuiper, J. G., Georgiado, E., Beekman-Hendriks, W. L., Thuresson, M., Pignot, M., Herings, R. M. C. & Kooy, A., Apr-2019, In : Diabetes obesity & metabolism. 21, 4, p. 968-974 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Pages (from-to) 968-974
Number of pages 7
Journal Diabetes obesity & metabolism
Volume 21
Issue number 4
Publication status Published – Apr-2019
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CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor

Original language English
Article number 455
Number of pages 18
Journal Cancers
Volume 11
Issue number 4
Publication status Published – 30-Mar-2019
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