Improviserende hersenen gaan anders om met muziek

​Robert Harris: The cerebral organization of audiomotor transformations in music Tussen improviserende musici en klassiek geschoolde musici, die …

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Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.

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Do social relations buffer the effect of neighborhood deprivation on health-related quality of life? Results from the LifeLines Cohort Study.

Health Place. 2017 Feb 01;44:43-51

Authors: Klijs B, Mendes de Leon CF, Kibele EU, Smidt N

Abstract
We investigated whether social relations buffer the effect of neighborhood deprivation on mental and physical health-related quality of life. Baseline data from the LifeLines Cohort Study (N=68,111) and a neighborhood deprivation index were used to perform mixed effect linear regression analyses. Results showed that fewer personal contacts (b, 95%CI: -0.88(-1.08;-0.67)) and lower social need fulfillment (-4.52(-4.67;-4.36)) are associated with lower mental health-related quality of life. Higher neighborhood deprivation was also associated with lower mental health related quality of life (-0.18(-0.24;-0.11)), but only for those with few personal contacts or low social need fulfillment. Our results suggest that social relations buffer the effect of neighborhood deprivation on mental health-related quality of life.

PMID: 28160672 [PubMed – as supplied by publisher]

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Genius begins at home: Shared social identity enhances the recognition of creative performance.

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Genius begins at home: Shared social identity enhances the recognition of creative performance.

Br J Psychol. 2017 Feb 05;:

Authors: Steffens NK, Haslam SA, Ryan MK, Millard K

Abstract
The present research examines the extent to which the recognition of creative performance is structured by social group membership. It does this by analysing the award of merit prizes for Best Actor and Actress in a Leading Role for the international award of US-based Oscars and British-based BAFTAs since BAFTA’s inception of this category in 1968. For both awards, the exclusive assessment criterion is the quality of artists’ performance in the international arena. Results show that US artists won a greater proportion of Oscars than BAFTAs (odds ratio: 2.10), whereas British artists won a greater proportion of BAFTAs than Oscars (OR: 2.26). Furthermore, results support the hypothesis that these patterns are more pronounced as the diagnostic value of a quality indicator increases – that is, in the conferring of actual awards rather than nominations. Specifically, US artists won a greater proportion of Oscar awards than nominations (OR: 1.77), while British artists won a greater proportion of BAFTA awards than nominations (OR: 1.62). Additional analyses show that the performances of in-group actors in movies portraying in-group culture (US culture in the case of Oscars, British culture in the case of BAFTAs) are more likely to be recognized than the performances of in-group actors in movies portraying the culture of other (out-)groups. These are the first data to provide clear evidence from the field that the recognition of exceptional creative performance is enhanced by shared social identity between perceivers and performers.

PMID: 28161891 [PubMed – as supplied by publisher]

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Analyse en kwaliteitsverbetering van de huidige prenatale screening

​Merel Bakker: Challenges in prenatal screening and diagnosis in the Netherlands De relatief lage opkomst van zwangere vrouwen voor de combinatietest …

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Metabolic syndrome after liver transplantation : Differences in the occurrence of metabolic syndrome between patients treated with a calcineurin inhibitor and patients treated with an mTOR inhibitor after liver transplantation

Introduction: The proportion of patients with metabolic syndrome (MetS) after orthotopic
liver transplantation (OLT) is substantial higher compared to the general population. MetS
consists of a cluster of obesity, raised glucose, raised triglycerides, reduced High-Density
Lipoproteins and raised blood pressure, which is associated with an increased risk of
cardiovascular disease, diabetes mellitus and liver steatosis. The difference in prevalence might
among other things be attributed to the use of immunosuppressants.
Objectives: The main goal was to investigate whether there is a difference in occurrence of
MetS after OLT between patients treated with a calcineurin inhibitor (CNi) and patients treated
with an mTOR inhibitor (mTORi), two common used immunosuppressive drugs. In addition,
the responsible components for the development and disappearance of MetS were studied.
Methods: In this retrospective study, patients who underwent an OLT between 2006 and 2012
at the Universitätsklinikum Münster were observed. The MetS status (no MetS, new developed
MetS, persistent MetS and disappeared MetS) was determined at baseline (T0), one (T1), three
(T3), five (T5) and eight (T8) years after OLT. In addition, the responsible components for the
development and disappearance of MetS were determined. Patients who were continuously
treated with a CNi were compared with patients who were switched from a CNi to an mTORi.
At baseline, all patients were evaluated in the continuous CNi group.
Results: In total, 134 patients were included in this study. The incidence of MetS in the
continuous CNi group was 18.8%, 12.8%, 14.3% and 50.0%, while the incidence in the mTORi
switchers group was 47.8%, 23.8%, 23.1% and 60.0% at T1, T3, T5 and T8, respectively. In
the continuous CNi group, MetS disappeared in 41.7%, 46.7%, 28.6% and 0%, while it
disappeared in the mTORi switchers group in 42.9%, 12.5%, 12.5% and 25.0% of the patients
at T1, T3, T5 and T8, respectively. Within both groups, the component raised triglycerides
arose most often in patients who developed MetS. However, this proportion was substantially
higher in the mTORi switchers group. Within both groups the component reduced HDL
disappeared most often.
Conclusion: Liver transplant recipients who are switched to an mTORi seem to develop more
often MetS than patients who are continuously treated with a CNi. Furthermore, patients who
are continuously treated with a CNi seem to have a greater chance to recover from MetS. In
most cases, development of MetS seem to be caused by increased triglyceride levels, especially
in the mTORi switchers group. Independent of the immunosuppressant group, disappearance
of MetS seems to be most often the consequence of normalization of the HDL concentration.

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Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.

Evaluation of novel biodegradable three-armed- and hyper-branched tissue adhesives in a meniscus explant model.

J Biomed Mater Res A. 2017 Feb 02;:

Authors: Bochyńska AI, Hannink G, Verhoeven R, Grijpma DW, Buma P

Abstract
Current treatment methods to repair meniscal tears do not bring fully satisfactory results. Tissue adhesives are considered promising alternatives, since they are easy to apply and cause minimal tissue trauma. The first aim of this study was to analyze the adhesive properties of and tissue response to two recently developed biodegradable block copolymeric three-armed- and hyper-branched tissue adhesives. The second aim was to investigate if tissue surface modification with collagenase improves the attachment of the adhesives and increases the healing potential of the tissue. Cylindrical explants were harvested from bovine menisci. The central core of the explants was removed and glued back into the defect, with or without incubation in collagenase solution prior to gluing, using one of the novel glues, Dermabond® or fibrin glue. The repair constructs were cultured in vitro for 1 and 28 days. Adhesion tests and histology were performed to analyze the effects of the glue in combination with the additional treatment. The adhesive strength of the novel glues was 40-50 kPa, which was significantly higher than that of fibrin glue (15 kPa). Cells were present in direct contact with the glues, and the tissue remained vital during the whole culture period. Increased cellularity around the tear in the collagenase treated explants was observed after 1 day. The two newly developed tissue adhesives are attractive materials to be used for repair of meniscal tears. The beneficial influence of collagenase treatment in treating meniscal tears with glues still needs to be confirmed in more clinical relevant studies. This article is protected by copyright. All rights reserved.

PMID: 28152576 [PubMed – as supplied by publisher]

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Evaluatie poortwachtersrol van de huisarts in de huidkankerzorg : een retrospectieve dwarsdoorsnede studie

Introduction: The incidence of skin malignancies is increasing annually, amplifying the importance of primary care physicians role in diagnosing and treating dermatologic malignancies. It is estimated that 40% of skin lesions excised in primary care offices are not submitted for histopathological examination. Prior studies suggest that clinical diagnosis of primary care physicians is inaccurate, causing potential skin (pre-)malignancies to remain unrecognized. Furthermore, skin malignancies are more often radically excised by dermatologists than by primary care physicians. The role of the primary care physician is to recognize pre-malignancies as early as possible and then initiate an appropriate follow-up; either with a specialized care referral or treatment in the primary care office. In our opinion prior research lacks full information to draw conclusions on the clinical diagnosis of the primary care physician in skin malignancy care.
Study objective: To gain insight in the recognition of skin malignancies by primary care physicians and the effect of the clinical suspicion on the radicality of the cutting surfaces of the excised skin lesion. Methods: A retrospective cross-sectional study was performed; all skin excisions completed and sent in by primary care physicians in the catchment area of Isala during a 4 year timeframe were analysed. First, the histopathological diagnoses were grouped into either the benign or malignant category. The paired differential diagnosis and the general practitioner malignancy scale (1=definitely benign, 5=definitely malignant) were compared to the histopathological diagnoses. Second, the effect of a clinical suspicion of a (pre)malignancy or lack thereof on the percentage of radically excised skin malignancies was studied. Results: This study shows general practitioners predict a correct histopathological diagnosis based on the clinical suspicion in only 38.1%. However, when combining the differential diagnosis with the general practitioner malignancy scale, the general practitioners predict the correct histopathological nature of 78.9% of the (pre-)malignant lesions. Furthermore, this study showed that 1 in 22.7 skin excisions with no clinical suspicion for malignancy was diagnosed as a (pre)malignancy. One in every 200 skin lesions without any suspicion turned out to be a melanoma. The cutting surfaces of excised lesions were non-radical in 29.9%.The highest percentage, 43.2%, of non-radicality was found in the head-neck area.
Conclusion: Primary care physicians are quite capable of recognizing skin malignancies; however, 1 in 200 skin lesions with no clinical suspicion of malignancy turned out to be a melanoma. Therefore, to improve the accuracy of recognition, a guideline on “suspicious skin lesions” by the Dutch primary care physician society (Nederlands huisartsen genootschap, NHG) is necessary. Considering the high percentage of non-radical excisions of skin malignancies in the head-neck area, we advise primary care physicians to first take a biopsy of lesions in the head-neck area when there is a clinical suspicion of malignancy. When there is a histopathological diagnosed malignancy, we advise them to refer their patients to specialized care.

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Het effect van neurolyse bij ramus infrapatellaris neuropathie

Objective: Entrapment neuropathy of the infrapatellar branch of the saphenous nerve is generally an unknown and unfrequently diagnosed cause of knee pain. The aim of this study was to evaluate the efficacy of surgery used by plastic surgeons to treat this neuropathy: neurolysis of the infrapatellar branch.
Methods: A cohort of patiënts diagnosed with infrapatellar neuropathy was evaluated. Patiënts that received treatment were asked their pain scores (Numeral Rating Scale 0-10) before and after surgery, their global perceived effect, and the influence of this disease on their life in terms of working and sporting. Patients treated with neurolysis between September 2014 and Februari 2015 were also evaluated prospectively. Their pain score was evaluated using the visual analog scale (10-100mm). In addition, neural conduction was measured before and after surgery using somatosensory evoked potentials (SSEP).
Results: A total of 55 patiënts with infrapatellar neuropathy were evaluated, of which 50 patiënts were treated by neurolysis. 74 percent of the treated patiënts (n = 32) demonstrated a numeral rating scale reduction of at least 50% in the first 6 months. On the long term, 96 percent (n = 48) showed a numeral rating scale reduction of on average 4 in 12 months after surgery. The reduction in pain score in treated patiënts differs significantly from that of untreated patients. Prospectively, 2 patiënt were evaluated. Both showed a visual analog scale reduction of at least 50% in 3 months after surgery. With the used SSEP technique described in literature no results could be reproduced that indicate neural conduction impairment.
Conclusion: Surgical neurolysis as a treatment for infrapatellar neuropathy is effective in about two-thirds of the patiënts. In addition, almost all patiënts (96%) will retrieve a significant reduction in pain in a 12 months recovery period.

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A prospective cohort study on acute radiation-induced toxicity in the head andneck region : Development of normal tissue complication probability models.

Background: The purpose of this study was to identify which dose-volume parameters and
other pre-treatment factors can be used to predict most prevalent acute radiation-induced
toxicities, including xerostomia, dysphagia, mucositis, sticky saliva and loss of taste during
and immediately after radiation in the head and neck region.
Materials and methods: At the department of Radiation Oncology of the UMCG, a
retrospective analysis in a prospective cohort study was performed including 210 patients
with head and neck squamous cell carcinoma (HNSCC) treated with curative
(chemo)radiation. In all patients, acute radiation-induced toxicity was scored prospectively.
Univariable and multivariable logistic regression analysis were performed to develop
predictive models for grade ≥2 xerostomia, grade ≥4 dysphagia, grade ≥3 mucositis and grade
≥2 sticky saliva, scored at a weekly basis according to the CTCAEv4.0 international toxicity
scoring system to determine which dose-volume parameters were the most important
prognostic factors for the development of acute side effects.
Results: The multivariable logistic regression analyses revealed different prognostic factors:
the mean dose to the oral cavity for xerostomia, the mean dose to the pharyngeal constrictor
muscle for dysphagia, the mean dose to the oral cavity for mucositis and the mean dose to the
contralateral submandibular gland for sticky saliva.
Conclusion: A number of significant associations were found between the dose distribution in
certain organs-at-risk (OARs) and acute toxicity in HNSCC. However, for introduction into
routine clinical practice, further research with more advanced statistical methods to improve
the reliability of the models followed by external validation in an independent patient cohort
is needed.

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A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.

A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers.

Ophthalmology. 2017 Jan 28;:

Authors: Vehof J, Hysi PG, Hammond CJ

Abstract
PURPOSE: To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach.
DESIGN: Cross-sectional association study.
PARTICIPANTS: A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17-82 years).
METHODS: We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc., Durham, NC). Dry eye disease was defined from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED by a clinician or “often” or “constant” symptoms of dryness and irritation. Analyses were performed with linear mixed effect models that included age, BMI, and sex as covariates, corrected for multiple testing.
MAIN OUTCOME MEASURES: Primary outcome was DED as defined by the SQDES, and secondary outcomes were symptom score of DED and a clinical diagnosis of DED.
RESULTS: Prevalence of DED as defined by the SQDES was 15.5% (n = 436). A strong and metabolome-wide significant association with DED was found with decreased levels of the metabolites androsterone sulfate (P = 0.00030) and epiandrosterone sulfate (P = 0.00036). Three other metabolites involved in androgen metabolism, 4-androsten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most strongly associated of the 222 metabolites, but did not reach metabolome-wide significance. Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, P = 0.000000029; epiandrosterone sulfate, P = 0.0000040; 4-androsten-3beta,17beta-diol disulfate 1, P = 0.000016; 4-androsten-3beta,17beta-diol disulfate 2, P = 0.000064; and dehydroepiandrosterone sulfate, P = 0.00011). Of these 5 androgens, epiandrosterone sulfate (P = 0.0076) was most associated with 2-year incidence of clinician-diagnosed DED. In addition, we found decreased glycerophosphocholines to be associated with DED, although not at metabolome-wide significance.
CONCLUSIONS: This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of research that links androgens to ocular surface disease and DED.

PMID: 28139245 [PubMed – as supplied by publisher]

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Neonates at risk of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: a perinatal protocol for before population neonatal screening test results become available

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Inborn errors of metabolism causing Sudden Infant Death: a systematic review with implications for population neonatal screening programs

Inborn errors of metabolism causing Sudden Infant Death: a systematic review with implications for population neonatal screening programs

van Rijt, W., Koolhaas, G. D., Bekhof, J., Heiner Fokkema, M. R., de Koning, T. J., Visser, G., Schielen, P. C. J. I. & Derks, T. G. J. Feb-2017 In : Neonatology. 14 p.

Research output: Scientific – peer-reviewArticle

Original language English
Number of pages 14
Journal Neonatology
State Accepted/In press – Feb-2017
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The advantages of high-frame-rate videos in fiber endoscopic evaluation of swallowing.

Objectives: The purpose of this study was to verify whether or not high-frame-rate (HFR) videos were superior to standard-frame-rate (SFR) videos in the visual recognition of motion of the laryngopharyngeal structures during the pharyngeal phase of swallowing.
Method: Five healthy subjects were asked to swallow 0.5 ml water under fiberoptic transnasal laryngoscopy. The endoscope was connected to a high-speed digital imaging (HSDI) camera, which recorded the laryngopharyngeal view throughout the swallowing process at 4000 frames per second (fps). A total of five HFR videos were recorded, and were then copied and downsampled into a standard-frame-rate video version with 30 fps. Fifteen otorhinolaryngologists observed all ten HFR and SFR videos in random order, and rated the videos on a four-point rating scale reflecting the degree of the visual recognition of the rapid motions of the laryngopharyngeal structures just before the ‘white-out’ phenomenon.
Results: The number of observers judging the HFR videos with higher scores compared to the SFR videos was significantly higher for most laryngopharyngeal structures. These structures include: the posterior pharyngeal wall (p=0.001), the left lateral pharyngeal wall (p=0.015), the right lateral pharyngeal (p=0.035), the tongue base (p=0.005), and the epiglottis tilting (p=0.005). Only the recognition of laryngeal elevation (p=0.059) did not seem to benefit from a higher frame rate.
Conclusion: These results demonstrated the superiority of HFR videos compared to SFR videos in the evaluation of the contractive motions of the pharyngeal structures during the pharyngeal phase of swallowing.

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Leefstijl jager-verzamelaars brengt afweersysteem tot rust

​Leo Pruimboom: The multiple faces of the human immune system Een tiendaagse nabootsing van een jager-verzamelaarsleefstijl heeft een gunstig effect …

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Preladenant maakt nieuw hersenonderzoek met PET-scan mogelijk

​Xiaoyun Zhou: PET imaging of adenosine A2A receptors Promovendus Xiaoyun Zhou toont aan dat de stof preladenant geschikt is om via een PET-scan …

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Ontwikkeling van lever- en alvleeskliercellen uit multipotente stamcellen

​Rangarajan Sambathkumar:Development of MAPC derived induced endodermal progenitors. Generation of pancreatic beta cells and hepatocytes Het is …

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Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?

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Reduction in Suicidal Ideation Following Repeated Doses of Intravenous Ketamine?

J Clin Psychiatry. 2017 Jan;78(1):e71

Authors: Apeldoorn SY, de Boer MK, Schoevers RA

PMID: 28129500 [PubMed – in process]

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Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.

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Association between cardiovascular diseases and mobility in persons with lower limb amputation: a systematic review.

Disabil Rehabil. 2017 Jan 27;:1-9

Authors: Kaptein S, Geertzen JH, Dijkstra PU

Abstract
PURPOSE: Persons requiring a lower limb amputation often have cardiovascular diseases that reduce cardiac function, which may complicate recovery and rehabilitation after an amputation. This systematic review analysis the association between cardiovascular diseases and mobility in persons with a lower limb amputation.
METHOD: Four databases were searched for studies published before August 2016 using database-specific keywords and synonyms for amputation, cardiovascular diseases and mobility. Assessment of the publications was performed based on predefined criteria; first title and abstract and thereafter the full text.
RESULTS: Of the 1704 titles and abstracts, 51 full texts were assessed. Ten studies were included. Cardiovascular diseases were associated with cardiac complications during rehabilitation. Prosthetic training improved cardiac function. Seven studies showed that cardiovascular diseases were associated with a smaller chance of becoming a prosthetic walker, and with poorer mobility outcomes.
CONCLUSION: Evidence for effects of cardiovascular diseases on mobility in persons with a lower limb amputation is heterogeneous. Cardiovascular diseases reduce the chance of becoming a prosthetic walker and reduce mobility outcomes after a lower limb amputation. More research with adequate quality about cardiovascular diseases in persons requiring a lower limb amputation is needed, to enable informed choices in the pre- and post-amputation rehabilitation. Implications for rehabilitation Data about the effect of cardiovascular diseases on mobility in persons with a lower limb amputation is limited. More research about cardiovascular diseases in persons requiring a lower limb amputation is needed, to enable informed choices in the pre- and post-amputation rehabilitation.

PMID: 28129515 [PubMed – as supplied by publisher]

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Shutting down the power supply for DNA repair in cancer cells.

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Shutting down the power supply for DNA repair in cancer cells.

J Cell Biol. 2017 Jan 25;:

Authors: van Vugt MA

Abstract
Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination-mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.

PMID: 28122958 [PubMed – as supplied by publisher]

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Climate predicts which sex acts as helpers among cooperatively breeding bird species.

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Climate predicts which sex acts as helpers among cooperatively breeding bird species.

Biol Lett. 2017 Jan;13(1):

Authors: Zhang G, Zhao Q, Møller AP, Komdeur J, Lu X

Abstract
Among avian cooperative breeders, help in raising offspring is usually provided by males or by both sexes. Sex bias in helping should evolve in response to sex-specific ecological constraints on independent reproduction, with mate shortage for males and breeding vacancy shortage for each sex. Given that male-biased adult sex ratios are prevalent among birds, we predict that male-only helping mainly occurs in temperate species where fast population turnovers deriving from low adult annual survival allow all adult females to hold breeding vacancies, whereas some males overflow as helpers, and both-sex helping in tropical species where saturated habitats prevent not only males, but also females from breeding themselves. As expected, we found that across species, adult survival increased towards tropical zones and warmer climates, and higher adult survival tended to be associated with both-sex helping. Furthermore, sex bias in helping was predicted by latitude and ambient temperature. Our findings of demographic response of species to climate as a potential determinant of bias in helper sex uncover how ecological constraints operate to limit independent reproduction in sex-specific ways.

PMID: 28123111 [PubMed – in process]

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