Onderzoek naar mitochondriale functie en groei van gekweekte hartspieren

​Wardit Tigchelaar: Mitochondrial function in cardiomyocytes Wardit Tigchelaar verrichte, samen met collega’s van het UMCG, onderzoek naar de relatie …

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Fruitvliegje geschikt om zeldzame hersenziekte te bestuderen

​Jan Vonk: Characterization of a Drosophila model for Chorea‐Acanthocytosis Drosophila melanogaster, beter bekend als de fruitvlieg, is een geschikt …

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Videofeedback lijkt effectief voor preventie voorste kruisband blessures

​Joan Dallinga: Injury prevention in team sport athletes Visuele feedback met behulp van videobeelden helpt met name bij mannen een veilige …

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Voorvoetproblemen worden vaak onderschat en niet goed behandeld

​Joost Schrier: Forefoot disorders Bijna een kwart (22%) van alle Nederlandse volwassenen heeft gedurende korte of langere tijd last van pijnklachten …

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The inverse association of HDL-cholesterol with future risk of hypertension is not modified by its antioxidant constituent, paraoxonase-1: The PREVEND prospective cohort study.

The inverse association of HDL-cholesterol with future risk of hypertension is not modified by its antioxidant constituent, paraoxonase-1: The PREVEND prospective cohort study.

Atherosclerosis. 2017 Jun 21;263:219-226

Authors: Kunutsor SK, Kieneker LM, Bakker SJL, James RW, Dullaart RPF

Abstract
BACKGROUND AND AIMS: High-density lipoprotein cholesterol (HDL-C), an established risk marker for atherosclerotic cardiovascular disease (CVD), has been shown to be inversely and independently associated with incident hypertension. Paraoxonase-1 (PON-1) is an HDL-bound esterase enzyme associated with CVD, but its relationship with incident hypertension has not been previously investigated. We aimed at evaluating the prospective association between PON-1 and hypertension risk.
METHODS: PON-1 arylesterase activity was measured in serum at baseline in 3988 participants without pre-existing hypertension in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective population-based study. During a median follow-up of 10.7 years, 1206 participants developed hypertension.
RESULTS: In age- and sex-adjusted analysis, the hazard ratio (95% CI) for incident hypertension per 1 standard deviation increase in PON-1 was 1.01 (0.96-1.07; p = 0.656), which remained non-significant after adjustment for several established hypertension risk factors and other potential confounders (0.99, 0.93 to 1.05; p = 0.764). The association was also non-existent on further adjustment for HDL-C (1.00 (0.94-1.06; p = 0.936)) and did not importantly vary across several clinical subgroups. In analyses in the same set of participants, HDL-C was continuously inversely and independently associated with hypertension risk; the association persisted after further adjustment for PON-1 activity and was not modified by PON-1 activity.
CONCLUSIONS: In this Caucasian cohort of men and women, HDL-C, but not its anti-oxidant constituent – PON-1, is inversely, continuously and independently associated with future risk of hypertension. The association is independent of and not modified by PON-1.

PMID: 28667918 [PubMed – as supplied by publisher]

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Time to improve statin prescription guidelines in low-risk patients?

Original language English
Pages (from-to) 1064-1070
Number of pages 7
Journal European Journal of Preventive Cardiology
Volume 24
Issue number 10
State Published – Jul-2017
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Het oor. Fysische werking, gehoorverlies en gehoorrevalidatie

Original language Dutch
Journal Nederlands Tijdschrift voor Natuurkunde
Volume Juli
State Published – Jul-2017
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Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands

Presence of anticitrullinated protein antibodies in a large population-based cohort from the Netherlands

van Zanten, A., Arends, S., Roozendaal, C., Limburg, P. C., Maas, F., Trouw, L. A., Toes, R. E. M., Huizinga, T. W. J., Bootsma, H. & Brouwer, E. Jul-2017 In : Annals of the Rheumatic Diseases. 76, 7, p. 1184-1190 7 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 1184-1190
Number of pages 7
Journal Annals of the Rheumatic Diseases
Volume 76
Issue number 7
State Published – Jul-2017
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Depressed gut? The microbiota-diet-inflammation trialogue in depression.

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Depressed gut? The microbiota-diet-inflammation trialogue in depression.

Curr Opin Psychiatry. 2017 Jun 24;:

Authors: Daniels JK, Koopman M, Aidy SE

Abstract
PURPOSE OF REVIEW: According to the WHO reports, around 350 billion people worldwide suffer from depression. Despite its high prevalence, the complex interaction of multiple mechanisms underlying depression still needs to be elucidated.
RECENT FINDINGS: Over the course of the last few years, several neurobiological alterations have been linked to the development and maintenance of depression. One basic process that seems to link many of these findings is inflammation. Chronic inflammation has been associated with both biological factors such as excessive neurotransmitter concentrations as well as psychological processes such as adult stress reactivity and a history of childhood trauma. As a balanced microbial community, modulated by diet, is a key regulator of the host physiology, it seems likely that gut microbiota plays a role in depression.
SUMMARY: The review summarizes the existent literature on this emerging research field and provides a comprehensive overview of the multifaceted links between the microbiota, diet, and depression. Several pathways linking early life trauma, pharmacological treatment effects, and nutrition to the microbiome in depression are described aiming to foster the psychotherapeutic treatment of depressed patients by interventions targeting the microbiota.

PMID: 28654462 [PubMed – as supplied by publisher]

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Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.

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Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.

PLoS One. 2017;12(6):e0179244

Authors: Akkermans DHM

Abstract
AIM OF THE PAPER: The paper aims at describing and explaining net profit flows per country for the period 1980-2009. Net profit flows result from Foreign Direct Investment (FDI) stock and profit repatriation: inward stock creating a profit outflow and outward FDI stock a profit inflow. Profit flows, especially ‘normal’ ones are not commonly researched.
THEORETICAL BACKGROUND: According to world-system theory, countries are part of a system characterised by a core, semi-periphery and periphery, as shown by network analyses of trade relations. Network analyses based on ownership relations of TransNational Corporations (TNCs) show that the top 50 firms that control about 40% of the world economy are almost exclusively located in core countries. So, we may expect a hierarchy in net profit flows with core countries on top and the periphery at the bottom. FDI outflows from the core countries especially rose in the 1990s, so we may expect that the difference has grown in time.
DATA AND RESULTS: A dataset on ‘net profit flow’ per country is developed. There are diverging developments in net profit flows since the 1980s, as expected: ever more positive for core countries, negative and ever lower for semi-peripheral and peripheral countries, in particular from the 1990s onwards. A fixed effects quantile regression using publicly available data confirms the prediction that peripheral countries share a unique characteristic: their outward investments do not have a positive influence on net profit flow as is the case with semi-peripheral and core countries. The most probable explanation is that peripheral outward investments are indirectly owned by firms located in core and semi-peripheral countries, so all peripheral profit inflows end up in those countries.

PMID: 28654644 [PubMed – in process]

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Nieuwe beeldvormingstechniek laat tumorcellen in buikholte tijdens operatie oplichten

​Niels Harlaar: Molecular fluorescence guided surgery of peritoneal metastasisL Niels Harlaar beschrijft in zijn promotieonderzoek de ontwikkeling …

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Voorstel voor alternatieve behandelrichtlijn jonge PKU-patiënten

​Rianne Jahja: A lifetime with Phenylketonuria. Towards a better understanding of therapeutic targets Artsen kunnen in de behandeling van kinderen …

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Niet minder ziekenhuisopnames bij gebruik van bètablokkers na bypassoperatie

​Harmen Booij : Metabolic interventions in heart failure Patiënten die na een bypass-operatie bètablokkers krijgen voorgeschreven, krijgen niet …

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Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.

Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia.

Placenta. 2017 Jun 07;:

Authors: Göhner C, Plösch T, Faas MM

Abstract
Unique immunologic adaptations exist to successfully establish and maintain pregnancy and to avoid an immune attack against the semi allogenic fetus. These adaptations occur both locally at the maternofetal interface and in the peripheral circulation and affect the innate as well as the adaptive immune system. Pregnancy is characterized by a general inflammatory state with activation of monocytes and granulocytes, but also with suppressive lymphocytes (regulatory T cells), and skewing towards T helper 2 immunity. The pregnancy complication preeclampsia is associated with an exaggerated inflammatory state and predominance of T helper 1 and 17 immunity. The syncytiotrophoblast has been found to secrete extracellular vesicles as communication factors into the maternal circulation. Syncytiotrophoblast extracellular vesicles from normal pregnancy have been shown to interact with monocytes, granulocytes, T cells and natural killer cells and influence the function of these cells. In doing so, they may support the inflammatory state of normal pregnancy as well as the suppressive lymphocyte phenotype. During preeclampsia, syncytiotrophoblast extracellular vesicles are not only increased in numbers but also showed an altered molecular load. Based on data from in vitro studies, it can be suggested that syncytiotrophoblast extracellular vesicles from preeclamptic pregnancies may support the exaggerated inflammatory state during preeclampsia. In this review, we discuss the immunological functions of syncytiotrophoblast extracellular vesicles and their involvement in adapting the maternal peripheral immunological adaptations to pregnancy.

PMID: 28647398 [PubMed – as supplied by publisher]

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Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.

Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.

Ann Rheum Dis. 2017 Jun 24;:

Authors: Graver JC, Sandovici M, Diepstra A, Boots AMH, Brouwer E

PMID: 28647683 [PubMed – as supplied by publisher]

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Synthesis and evaluation of new fluorine-18 labeled verapamil analogs to investigate the function of P-glycoprotein in the blood-brain barrier

Synthesis and evaluation of new fluorine-18 labeled verapamil analogs to investigate the function of P-glycoprotein in the blood-brain barrier

Raaphorst, R. M., Luurtsema, G., Schuit, R. C., Kooijman, E. J. M., Elsinga, P. H., Lammertsma, A. A. & Windhorst, A. D. 26-Jun-2017 In : ACS chemical neuroscience.

Research output: Scientific – peer-reviewArticle

Original language English
Journal ACS chemical neuroscience
State E-pub ahead of print – 26-Jun-2017
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Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

Methylome analysis of extreme chemoresponsive patients identifies novel markers of platinum sensitivity in high-grade serous ovarian cancer

Tomar, T., Alkema, N. G., Schreuder, L., Meersma, G. J., Meyer, T., Van Criekinge, W., Klip, H. G., Fiegl, H., Van Nieuwenhuysen, E., Vergote, I., Widschwendter, M., Schuuring, E., van der Zee, A. G. J., de Jong, S. & Wisman, G. B. A. 23-Jun-2017 In : BMC Medicine. 15, 16 p., 116

Research output: Scientific – peer-reviewArticle

Original language English
Article number 116
Number of pages 16
Journal BMC Medicine
Volume 15
State Published – 23-Jun-2017
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Within-class differences in cancer risk for sulfonylurea treatments in patients with type 2 diabetes (ZODIAC-55) – a study protocol

Within-class differences in cancer risk for sulfonylurea treatments in patients with type 2 diabetes (ZODIAC-55) – a study protocol

Schrijnders, D., de Bock, G. H., Houweling, S. T., Van Hateren, K. J. J., Groenier, K. H., Johnson, J. A., Bilo, H. J. G., Kleefstra, N. & Landman, G. W. D. 23-Jun-2017 In : BMC CANCER. 17, 5 p., 444

Research output: Scientific – peer-reviewArticle

Original language English
Article number 444
Number of pages 5
Journal BMC CANCER
Volume 17
State Published – 23-Jun-2017
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Beweging witte bloedcellen in beeld gebracht met microfluïdische chips

​​​Beweging witte bloedcellen in beeld gebracht met microfluïdische chips Leo Boneschansker ontwikkelde samen met zijn collega’s de eerste …

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Apathie hangt samen met veranderde hersenactiviteit

​ Apathie hangt samen met een ander volume en ander activiteitsniveau van bepaalde hersengebieden. Dat laat Claire Kos zien in haar proefschrift over …

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