Longitudinal growth and emotional and behavioral problems at age 7 in moderate and late preterms

Longitudinal growth and emotional and behavioral problems at age 7 in moderate and late preterms

Dotinga, B. M., de Winter, A. F., Bocca-Tjeertes, I. F. A., Kerstjens, J. M., Reijneveld, S. A. & Bos, A. F., 31-Jan-2019, In : PLoS ONE. 14, 1, 11 p., e0211427.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number e0211427
Number of pages 11
Journal PLoS ONE
Volume 14
Issue number 1
Publication status Published – 31-Jan-2019
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Evaluatie van HER-eiwitten in tumoren voor het verbeteren van kankertherapie

Arjan Kol: Preclinical evaluation and molecular imaging of HER family dynamics to guide cancer therapy Combinatietherapieën die gebruik maken van …

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Similar but different

​Titel promotie:Similar but different: Implications for the one versus many functional somatic syndromes discussion

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The Effect of FG-Nup Phosphorylation on NPC Selectivity: A One-Bead-Per-Amino-Acid Molecular Dynamics Study

The Effect of FG-Nup Phosphorylation on NPC Selectivity: A One-Bead-Per-Amino-Acid Molecular Dynamics Study

Mishra, A., Sipma, W., Veenhoff, L. M., Van der Giessen, E. & Onck, P. R., 30-Jan-2019, In : International Journal of Molecular Sciences. 20, 3, 18 p., 596.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 596
Number of pages 18
Journal International Journal of Molecular Sciences
Volume 20
Issue number 3
Publication status Published – 30-Jan-2019
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Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis

Massive B-Cell Infiltration and Organization Into Artery Tertiary Lymphoid Organs in the Aorta of Large Vessel Giant Cell Arteritis

Graver, J. C., Boots, A. M. H., Haacke, E. A., Diepstra, A., Brouwer, E. & Sandovici, M., 29-Jan-2019, In : Frontiers in Immunology. 10, 8 p., 83.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 83
Number of pages 8
Journal Frontiers in Immunology
Volume 10
Publication status Published – 29-Jan-2019
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Verbloedingsshock en bloedvergiftiging

​Rui Yan: Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock Bij kritisch zieke patiënten met …

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verbloedingsshock en bloedvergiftiging

​Rui Yan: Exploring mechanisms of and therapeutic interventions for microvascular endothelial activation in shock Bij kritisch zieke patiënten met …

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Determinants of adherence to wrap-around care in child and family services

Determinants of adherence to wrap-around care in child and family services

Pannebakker, N. M., Fleuren, M. A. H., Vlasblom, E., Numans, M. E., Reijneveld, S. A. & Kocken, P. L., 28-Jan-2019, In : BMC Health Services Research. 19, 1, 8 p., 76.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 76
Number of pages 8
Journal BMC Health Services Research
Volume 19
Issue number 1
Publication status Published – 28-Jan-2019
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Assessing the Needs and Perspectives of Patients With Asthma and Chronic Obstructive Pulmonary Disease on Patient Web Portals: Focus Group Study.

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Assessing the Needs and Perspectives of Patients With Asthma and Chronic Obstructive Pulmonary Disease on Patient Web Portals: Focus Group Study.

JMIR Form Res. 2018 Nov 22;2(2):e22

Authors: Metting E, Schrage AJ, Kocks JW, Sanderman R, van der Molen T

Abstract
BACKGROUND: As accessibility to the internet has increased in society, many health care organizations have developed patient Web portals (PWPs), which can provide a range of self-management options to improve patient access. However, the available evidence suggests that they are used inefficiently and do not benefit patients with low health literacy. Asthma and chronic obstructive pulmonary disease (COPD) are common chronic diseases that require ongoing self-management. Moreover, patients with COPD are typically older and have lower health literacy.
OBJECTIVE: This study aimed to obtain and present an overview of patients’ perspectives of PWPs to facilitate the development of a portal that better meets the needs of patients with asthma and COPD.
METHODS: We performed a focus group study using semistructured interviews in 3 patient groups from the north of the Netherlands who were recruited through the Dutch Lung Foundation. Each group met 3 times for 2 hours each at a 1-week interval. Data were analyzed with coding software, and patient descriptors were analyzed with nonparametric tests. The consolidated criteria for reporting qualitative research were followed when conducting the study.
RESULTS: We included 29 patients (16/29, 55% male; mean age 65 [SD 10] years) with COPD (n=14), asthma-COPD overlap (n=4), asthma (n=10), or other respiratory disease (n=1). There was a large variation in the internet experience; some patients hardly used the internet (4/29, 14%), whereas others used internet >3 times a week (23/29, 79%). In general, patients were positive about having access to a PWP, considering access to personal medical records as the most important option, though only after discussion with their physician. A medication overview was considered a useful option. We found that communication between health care professionals could be improved if patients could use the PWP to share information with their health care professionals. However, as participants were worried about the language and usability of portals, it was recommended that language should be adapted to the patient level. Another concern was that disease monitoring through Web-based questionnaire use would only be useful if the results were discussed with health care professionals.
CONCLUSIONS: Participants were positive about PWPs and considered them a logical step. Today, most patients tend to be better educated and have internet access, while also being more assertive and better informed about their disease. A PWP could support these patients. Our participants also provided practical suggestions for implementation in current and future PWP developments. The next step will be to develop a portal based on these recommendations and assess whether it meets the needs of patients and health care providers.

PMID: 30684436 [PubMed]

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A double hit preeclampsia model results in sex-specific growth restriction patterns

A double hit preeclampsia model results in sex-specific growth restriction patterns

Stojanovska, V., Dijkstra, D. J., Vogtmann, R., Gellhaus, A., Scherjon, S. A. & Plösch, T., 25-Jan-2019, In : Disease models & mechanisms. 36 p.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Number of pages 36
Journal Disease models & mechanisms
Publication status E-pub ahead of print – 25-Jan-2019
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Editorial: Immunomodulatory Functions of Nutritional Ingredients in Health and Disease

Editorial: Immunomodulatory Functions of Nutritional Ingredients in Health and Disease

Sun, J. & de Vos, P., 24-Jan-2019, In : Frontiers in Immunology. 10, 3 p., 50.

Research output: Contribution to journalEditorialAcademicpeer-review

Original language English
Article number 50
Number of pages 3
Journal Frontiers in Immunology
Volume 10
Publication status Published – 24-Jan-2019
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De impact van het onzichtbare: cognitieve stoornissen, gedragsveranderingen en vermoeidheid na een subarachnoïdale bloeding

​Anne Marie Buunk: The impact of the invisible: cognitive deficits, behavioral changes, and fatigue after subarachnoid hemorrhage Een subarachnoïdale …

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Klinische ontwikkelingen in musculoskeletale beeldvorming

​Ömer Kasalak: Clinical advances in musculoskeletal imaging: spondylodiscitis and pediatric oncology Kasalak richt zich in zijn proefschrift op het …

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Neurale processen tijdens de staande balans

​Tulika Nandi: Neural control of balance in increasingly difficult standing tasks Al bijna 150 jaar houden onderzoekers zich bezig met de complexe …

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Lifelines Cohort Study, 22-Jan-2019, In : Nature Communications. 10, 11 p., 376.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 376
Number of pages 11
Journal Nature Communications
Volume 10
Publication status Published – 22-Jan-2019
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Revised Approach to the Role of Fatigue in Anterior Cruciate Ligament Injury Prevention: A Systematic Review with Meta-Analyses.

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Revised Approach to the Role of Fatigue in Anterior Cruciate Ligament Injury Prevention: A Systematic Review with Meta-Analyses.

Sports Med. 2019 Jan 18;:

Authors: Benjaminse A, Webster KE, Kimp A, Meijer M, Gokeler A

Abstract
BACKGROUND: Causes of anterior cruciate ligament (ACL) injuries are multifactorial. Anterior cruciate ligament injury prevention should thus be approached from a multifactorial perspective as well. Training to resist fatigue is an underestimated aspect of prevention programs given that the presence of fatigue may play a crucial role in sustaining an ACL injury.
OBJECTIVES: The primary objective of this literature review was to summarize research findings relating to the kinematic and kinetic effects of fatigue on single-leg landing tasks through a systematic review and meta-analysis. Other objectives were to critically appraise current approaches to examine the effects of fatigue together with elucidating and proposing an optimized approach for measuring the role of fatigue in ACL injury prevention.
METHODS: A systematic literature search was conducted in the databases PubMed (1978-November 2017), CINAHL (1992-November 2017), and EMBASE (1973-November 2017). The inclusion criteria were: (1) full text, (2) published in English, German, or Dutch, (3) healthy subjects, (4) average age ≥ 18 years, (5) single-leg jump landing task, (6) evaluation of the kinematics and/or kinetics of the lower extremities before and after a fatigue protocol, and (7) presentation of numerical kinematic and/or kinetic data. Participants included healthy subjects who underwent a fatigue protocol and in whom the effects of pre- and post-fatigue on three-dimensional lower extremity kinematic and kinetics were compared. Methods of data collection, patient selection, blinding, prevention of verification bias, and study design were independently assessed.
RESULTS: Twenty studies were included, in which four types of single-leg tasks were examined: the single-leg drop vertical jump, the single-leg drop landing, the single-leg hop for distance, and sidestep cutting. Fatigue seemed to mostly affect initial contact (decreased angles post-fatigue) and peak (increased angles post-fatigue) hip and knee flexion. Sagittal plane variables at initial contact were mostly affected under the single-leg hop for distance and sidestep cutting conditions whilst peak angles were affected during the single-leg drop jump.
CONCLUSIONS: Training to resist fatigue is an underestimated aspect of prevention programs given that the presence of fatigue may play a crucial role in sustaining an ACL injury. Considering the small number of variables affected after fatigue, the question arises whether the same fatigue pathways are affected by the fatigue protocols used in the included laboratory studies as are experienced on the sports field.

PMID: 30659497 [PubMed – as supplied by publisher]

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Seasonal differences in baseline innate immune function are better explained by environment than annual cycle stage in a year-round breeding tropical songbird.

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Seasonal differences in baseline innate immune function are better explained by environment than annual cycle stage in a year-round breeding tropical songbird.

J Anim Ecol. 2019 Jan 19;:

Authors: Nwaogu CJ, Cresswell W, Versteegh MA, Tieleman BI

Abstract
1.Seasonal variation in innate immunity is often attributed to either temporal environmental variation or to life history trade-offs that arise from specific annual cycle stages but decoupling them is difficult in natural populations. 2.Here, we effectively decouple seasonal environmental variation from annual cycle stage effects by exploiting cross-seasonal breeding and moult in the tropical Common Bulbul Pycnonotus barbatus. We test how annual cycle stage interacts with a key seasonal environmental variable, rainfall, to determine immunity at population and individual level. If immune challenge varies with precipitation, we might expect immune function to be higher in the wet season due to increased environmental productivity. If breeding or moult imposes resource constraints on birds, depending on or independent of precipitation, we might expect lower immune indices during breeding or moult. 3.We sampled blood from 818 birds in four annual cycle stage categories: breeding, moult, simultaneous breeding and moulting, or neither. We quantified indices of innate immunity (haptoglobin, nitric oxide (NOx ) and ovotransferrin concentrations, and haemagglutination and haemolysis titres) over two annual cycles of wet and dry seasons. 4.Environment (but not annual cycle stage or interactions between both) explained variation in all immune indices, except NOx . NOx concentration differed between annual cycle stages but not between seasons. However, within the wet season, haptoglobin, NOx , ovotransferrin and haemolysis differed significantly between breeding and non-breeding females. Aside from some recorded inconsistences, population level results were largely similar to results within individuals that were measured repeatedly. Unexpectedly, most immune indices were higher in the dry season and during breeding. 5.Higher immune indices may be explained if fewer or poorer quality resources force birds to increase social contact, thereby exposing individuals to novel antigens and increased infection risk, independently of environmental productivity. Breeding birds may also show higher immunity if less immune-competent and/or infected females omit breeding. We conclude that seasonal environmental variation impacts immunity more directly in natural animal populations than via resource trade-offs. In addition, immune indices were more often variable within than among individuals, but some indices are characteristic of individuals, and so may offer selective advantages if heritable. This article is protected by copyright. All rights reserved.

PMID: 30659607 [PubMed – as supplied by publisher]

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Rowing together: Interpersonal coordination dynamics with and without mechanical coupling.

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Rowing together: Interpersonal coordination dynamics with and without mechanical coupling.

Hum Mov Sci. 2019 Jan 14;64:38-46

Authors: Cuijpers LS, Den Hartigh RJR, Zaal FTJM, de Poel HJ

Abstract
Although most research on interpersonal coordination focuses on perceptual forms of interaction, many interpersonal actions also involve interactions of mechanical nature. We examined the effect of mechanical coupling in a rowing task from a coupled oscillator perspective: 16 pairs of rowers rowed on ergometers that were physically connected through slides (mechanical coupling condition) or on separate ergometers (no mechanical coupling condition). They rowed in two patterns (in- and antiphase) and at two movement frequencies (20 and 30 strokes per minute). Seven out of sixteen pairs showed one or more coordinative breakdowns, which only occurred in the antiphase condition. The occurrence of these breakdowns was not affected by mechanical coupling, nor by movement frequency. For the other nine pairs, variability of steady state coordination was substantially lower in the mechanical coupling condition. Together, these results show that the increase in coupling strength through mechanical coupling stabilizes coordination, even more so for antiphase coordination.

PMID: 30654167 [PubMed – as supplied by publisher]

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Further evaluation of the factor structure, prevalence, and concurrent validity of DSM-5 criteria for Persistent Complex Bereavement Disorder and ICD-11 criteria for Prolonged Grief Disorder.

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Further evaluation of the factor structure, prevalence, and concurrent validity of DSM-5 criteria for Persistent Complex Bereavement Disorder and ICD-11 criteria for Prolonged Grief Disorder.

Psychiatry Res. 2019 Jan 03;273:206-210

Authors: Boelen PA, Lenferink LIM, Smid GE

Abstract
Persistent complex bereavement disorder (PCBD) is a disorder of grief included in DSM-5. Prolonged grief disorder (PGD) is included in ICD-11. Few studies have evaluated and compared criteria sets for DSM-5 PCBD and ICD-11 PGD. The current study explored and compared the dimensionality, prevalence rates, diagnostic agreement, concurrent validity, and socio-demographic and loss-related correlates of both criteria sets. Self-reported data were available from 551 bereaved individuals. Confirmatory factor analysis showed that for DSM-5 PCBD-symptoms, a three-factor model with distinct but correlated factors fit the data well; for ICD-11 PGD-symptoms a one-factor model yielded adequate fit. The prevalence of probable DSM-5 PCBD (8.2%) was significantly lower than ICD-11 PGD (19.2%). Both DSM-5 PCBD and ICD-11 PGD were significantly associated with concurrent overall grief and depression, and varied as a function of education and time since loss. ICD-11 PGD prevalence rates went down and agreement with PCBD-caseness went up, when heightening the number of symptoms required for an ICD-11 PGD diagnosis. This study was limited by its reliance on self-reported data and grief symptoms were derived from two scales. That notwithstanding, findings provide further evidence that differences exist between disturbed grief criteria in DSM-5 and ICD-11 that may negatively impact research and care.

PMID: 30654306 [PubMed – as supplied by publisher]

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Quality of care in early detection and management of pre-eclampsia/eclampsia in health facilities in Afghanistan

Quality of care in early detection and management of pre-eclampsia/eclampsia in health facilities in Afghanistan

Ansari, N., Manalai, P., Maruf, F., Currie, S., Stekelenburg, J., van Roosmalen, J., Kim, Y-M. & Tappis, H., 18-Jan-2019, In : BMC Pregnancy and Childbirth. 19, 12 p., 36.

Research output: Contribution to journalArticleAcademicpeer-review

Original language English
Article number 36
Number of pages 12
Journal BMC Pregnancy and Childbirth
Volume 19
Publication status Published – 18-Jan-2019
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