MJP van Wanrooy, MMG Rodgers, DRA Uges, JP Arends, JG Zijlstra, TS van der Werf, JGW Kosterink, JWC Alffenaar*
*Corresponding author: JWC Alffenaar
Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, Groningen, Netherlands
F1000 Posters 2012, 3: 318 (poster) [English] Poster [206.96 KB]
22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2012, 31 Mar – 3 Apr 2012,
Early antifungal treatment with adequate drug exposure reduces mortality in patients with candidemia. Efficacy of anidulafungin is driven by the AUC (area under the curve)/MIC ratio. As anidulafungin clearance is approximately 30% higher in patients with invasive candidiasis than in patients with oesophageal candidiasis, patients at the ICU may be at risk of underexposure. Therefore, insight in anidulafungin pharmacokinetics in a ‘real-life’ population of critically ill patients is important.
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