Category Archives: Q J Nucl Med Mol Imaging

Sympathetic denervation in patients with ischemic cardiomyopathy and risk on ventricular tachy-arrhythmias. A pilot study.

Sympathetic denervation in patients with ischemic cardiomyopathy and risk on ventricular tachy-arrhythmias. A pilot study.

Q J Nucl Med Mol Imaging. 2016 Apr 5;

Authors: Noordzij W, Elvan A, Demirel F, Jager P, Tio R, Slart R

Abstract
BACKGROUND: Patients with ischemic cardiomyopathy (ICM) are at risk for ventricular arrhythmias and are protected by an implantable cardioverter defibrillator (ICD). Visualization of cardiac sympathetic innervation may play an additional role to left ventricular ejection fraction (LVEF) in identifying those patients who will benefit from ICD therapy. The purpose of this study was to detect the role of sympathetic denervation in the genesis of ventricular arrhythmias in ICM patients.
METHOD: 20 patients with ICM and LVEF < 30% were included in this pilot study. Included patients were equally stratified into two groups: no history of arrhythmias (group A) and recurrent arrhythmias (group B). All patients underwent cardiac sympathetic denervation (using carbon-11 labelled meta-hydroxy-ephedrine ([11C]-mHED)), myocardial ischemia and viability detection. Patients were followed up to one year after the imaging studies.
RESULTS: Mean age was 63 ± 7.5 years. Mean global retention of [11C]-mHED was 0.055 ± 0,012 min-1, and was not different between the two patient groups: 0.056 ± 0.011 min-1 vs 0.054 ± 0.013 min-1 for group A vs group B, respectively. During follow-up, seven patients developed ventricular arrhythmias, and four patients died. No difference in [11C]-mHED retention was found between patients with and without ventricular arrhythmia during follow up. However, size of denervated area was larger in patients who died during follow up: 10 ± 1 segments vs 6 ± 2 segments, p = 0.002.
CONCLUSION: Cardiac sympathetic innervation is impaired in patients with ischemic cardiomyopathy. All-cause mortality occurred in those patients with large areas of [11C]- mHED defect.

PMID: 27045577 [PubMed – as supplied by publisher]

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PET beyond 18F-FDG: second generation PET tracers in clinical oncology.

PET beyond 18F-FDG: second generation PET tracers in clinical oncology.
Q J Nucl Med Mol Imaging. 2015 Mar;59(1):1-3
Authors: Brouwers AH, Glaudemans AW, De Vries EF
PMID: 25854554 [PubMed – in process]

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Diagnostic flowcharts in osteomyelitis, spondylodiscitis and prosthetic joint infection.

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Q J Nucl Med Mol Imaging. 2014 Mar;58(1):2-19

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Detection of extranodal spread in head and neck cancer with [18F]FDG PET and MRI: improved accuracy?

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Q J Nucl Med Mol Imaging. 2014 Jan 2;
Authors: Lodder WL, Vogel WV, Lange CA, Hamming-Vrieze O, Van Velthuyse… Continue reading

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Correlation of [11C]choline PET-CT with time to treatment and disease-specific survival in men with recurrent prostate cancer after radical prostatectomy.

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Correlation of [11C]choline PET-CT with time to treatment and disease-specific survival in men with recurrent prostate cancer after radical prostatectomy.

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[11C]choline PET for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT.

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