Category Archives: Transpl Infect Dis

Characterization of urinary CD4(+) and CD8(+) T cells in kidney transplantation patients with polyomavirus BK infection and allograft rejection.

Characterization of urinary CD4(+) and CD8(+) T cells in kidney transplantation patients with polyomavirus BK infection and allograft rejection.

Transpl Infect Dis. 2014 Aug 5;

Authors: van Doesum WB, Abdulahad WH, van Dijk MC, Dolff S, van Son WJ, Stegeman CA, Sanders JS

Abstract
BACKGROUND AND OBJECTIVES: The objective of this study was to characterize CD4(+) and CD8(+) T-cell populations in blood and urine of renal transplant patients with BK virus (BKV) infection or allograft rejection.
MATERIALS AND METHODS: Percentages and absolute numbers of CD4(+) and CD8(+) effector memory T-cell subtype (TEM ) and terminal differentiated T cells (TTD ) in renal transplant patients with BKV infection (n = 14), with an episode of allograft rejection (n = 9), and in uncomplicated renal transplant patients with a stable kidney function (n = 12) were measured and compared using 4-color fluorescence-activated cell sorting. Results were correlated with the number of CD4(+) and CD8(+) T cells in renal biopsies.
RESULTS: In patients with allograft rejection, the number of urinary CD4(+) TEM and CD8(+) TEM cells was significantly increased compared to patients with BKV infection or patients without complications. Positive correlation was found between the number of CD4(+) and CD8(+) cells in the renal biopsies and the number of CD4(+) and CD8(+) cells in urine. In patients with rejection, after 2 months of immunosuppressive therapy, a reduction in urinary CD8(+) TEM cells was found.
CONCLUSIONS: CD4(+) TEM and CD8(+) TEM cells in urine could be a marker to distinguish allograft rejection from BKV-associated nephropathy and to monitor therapy effectiveness in renal transplant patients with allograft rejection.

PMID: 25092256 [PubMed – as supplied by publisher]

Continue reading

Posted in Transpl Infect Dis | Leave a comment

Helicobacter canis bacteremia in a renal transplant patient.

Related Articles

Helicobacter canis bacteremia in a renal transplant patient.

Transpl Infect Dis. 2013 Dec 30;

Authors: van der Vusse ML, van Son WJ, Ott A, Manson W

Continue reading

Posted in Transpl Infect Dis | Tagged | Leave a comment

Plasma concentrations of caspofungin at two different dosage regimens in a patient with hepatic dysfunction.

Related Articles

Plasma concentrations of caspofungin at two different dosage regimens in a patient with hepatic dysfunction.

Transpl Infect Dis. 2012 Aug;14(4):440-3

Continue reading

Posted in Transpl Infect Dis | Tagged | Leave a comment

Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection.

Impaired glucose tolerance in rat islet isograft recipients after cytomegalovirus infection.

Transpl Infect Dis. 2012 Dec 20;

Authors: Smelt MJ, de Haan BJ, Faas MM, de Haan A, de…

Continue reading

Posted in Transpl Infect Dis | Tagged | Leave a comment