Category Archives: PLoS One

Mother’s knowledge on prevention of mother-to-child transmission of HIV, Ethiopia: A cross sectional study.

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Mother’s knowledge on prevention of mother-to-child transmission of HIV, Ethiopia: A cross sectional study.
PLoS One. 2018;13(9):e0203043
Authors: Alemu YM, Habtewold TD, Alemu SM
Abstract
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An above-knee compression garment does not improve passive knee joint position sense in healthy adults.

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An above-knee compression garment does not improve passive knee joint position sense in healthy adults.
PLoS One. 2018;13(9):e0203288
Authors: Négyesi J, Mobark A, Zhang LY, Hortobagyi T, Nagatomi R… Continue reading

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The establishment of hybrids of the Daphnia longispina complex explained by a mathematical model incorporating different overwintering life history strategies.

The establishment of hybrids of the Daphnia longispina complex explained by a mathematical model incorporating different overwintering life history strategies.
PLoS One. 2018;13(7):e0200802
Authors: Griebel J, Utz M,… Continue reading

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Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect.

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Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect.
PLoS One. 2018;13(7):e0198755
Authors: Nijboer TCW, Winters C, Kollen BJ, Kwakkel G
Abstract
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Internists’ dilemmas in their interactions with chronically ill patients; A comparison of their interaction strategies and dilemmas in two different medical contexts.

Internists’ dilemmas in their interactions with chronically ill patients; A comparison of their interaction strategies and dilemmas in two different medical contexts.
PLoS One. 2018;13(5):e0194133
Authors: Kromme NMH… Continue reading

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Mindset switching increases the use of ‘want-based’ over ‘should-based’ behaviors.

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Mindset switching increases the use of ‘want-based’ over ‘should-based’ behaviors.
PLoS One. 2018;13(4):e0196269
Authors: Yan J, Zhang NN, Xu DX
Abstract
This study examines the conseq… Continue reading

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Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.

Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study.
PLoS One. 2018;13(4):… Continue reading

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Do single people want to date a cancer survivor? A vignette study.

Do single people want to date a cancer survivor? A vignette study.

PLoS One. 2018;13(3):e0194277

Authors: Tuinman MA, Lehmann V, Hagedoorn M

Abstract
OBJECTIVE: Qualitative studies indicated that cancer survivors may be worried about finding a partner in the future, but whether this concern is warranted is unknown. We examined single people´s interest in dating a cancer survivor, how they perceive survivors’ traits, and their preferences about the timing of disclosing a cancer history.
METHODS: In three experimental vignette studies, dating website members (n = 324) and college students (n = 138 and n = 131) were randomly assigned to a vignette of a person with or without a history of cancer (experiment 1 & 2), or a cancer survivor beyond or during active follow-up (experiment 3). Respondents rated their interest in dating this fictive person, this person’s traits, and indicated their preferences about the timing of disclosure. ANOVAs with main and interaction effects of condition, gender, and relationship history were conducted, partial eta squared and Cohen’s d were used to estimate the magnitude of effects. Correlations were used to investigate relationships between interest in a date and assessment of traits.
RESULTS: Cancer survivors’ traits were assessed more positively, but interest to date them did not differ from healthy vignettes for both men and women. However, widowed respondents were much less interested in a date with a cancer survivor, and women showed less interest in a cancer survivor during active follow-up relative to survivors beyond follow-up. Most respondents wanted to hear about the cancer diagnosis after a few dates, hardly anyone wanted to hear about this before the first date (2% – 5%).
CONCLUSION AND IMPLICATIONS FOR CANCER SURVIVORS: Cancer survivors do not have to expect any more problems in finding a date than people without a cancer history, and can wait a few dates before disclosing. Survivors dating widowed people and survivors in active follow-up could expect more hesitant reactions and should disclose earlier.

PMID: 29566002 [PubMed – in process]

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Comparison of different approaches for estimating age-specific alcohol-attributable mortality: The cases of France and Finland.

Comparison of different approaches for estimating age-specific alcohol-attributable mortality: The cases of France and Finland.

PLoS One. 2018;13(3):e0194478

Authors: Trias-Llimós S, Martikainen P, Mäkelä P, Janssen F

Abstract
BACKGROUND: Accurate estimates of the impact of alcohol on overall and age-specific mortality are crucial for formulating health policies. However, different approaches to estimating alcohol-attributable mortality provide different results, and a detailed comparison of age-specific estimates is missing.
METHODS: Using data on cause of death, alcohol consumption, and relative risks of mortality at different consumption levels, we compare eight estimates of sex- and age-specific alcohol-attributable mortality in France (2010) and Finland (2013): five estimates using cause-of-death approaches (with one accounting for contributory causes), and three estimates using attributable fraction (AF) approaches.
RESULTS: AF-related approaches and the approach based on alcohol-related underlying and contributory causes of death provided estimates of alcohol-attributable mortality that were twice as high as the estimates found using underlying cause-of-death approaches in both countries and sexes. The differences across the methods were greatest among older age groups An inverse U-shape in age-specific alcohol-attributable mortality (peaking at around age 65) was observed for cause-of-death approaches, with this shape being more pronounced in Finland. AF-related approaches resulted in different estimates at older ages: i.e., mortality was found to increase with age in France; whereas in Finland mortality estimates depended on the underlying assumptions regarding the effects of alcohol consumption on cardiovascular mortality.
CONCLUSIONS: While the most detailed approaches (i.e., the AF-related approach and the approach that includes underlying and contributory causes) are theoretically able to provide more accurate estimates of alcohol-attributable mortality, they-especially the AF approaches- depend heavily on data availability and quality. To enhance the reliability of alcohol-attributable mortality estimates, data quality for older age groups needs to be improved.

PMID: 29566081 [PubMed – in process]

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Individual differences in satisfaction with activity-based work environments.

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Individual differences in satisfaction with activity-based work environments.
PLoS One. 2018;13(3):e0193878
Authors: Hoendervanger JG, Ernst AF, Albers CJ, Mobach MP, Van Yperen NW
Abstract
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Increased fecal calprotectin levels in Crohn’s disease correlate with elevated serum Th1- and Th17-associated cytokines.

Increased fecal calprotectin levels in Crohn’s disease correlate with elevated serum Th1- and Th17-associated cytokines.

PLoS One. 2018;13(2):e0193202

Authors: Bourgonje AR, von Martels JZH, de Vos P, Faber KN, Dijkstra G

Abstract
BACKGROUND: Patient-reported symptoms and endoscopic disease activity do not correlate well in Crohn’s disease (CD). This warrants the need for reliable biomarkers to early detect active intestinal inflammation. Currently, the fecal calprotectin level is the most commonly used biomarker for inflammatory activity in CD. However, the diagnostic accuracy of the fecal calprotectin level is not fully efficacious and diagnosis may be further improved by the identification of other biomarkers for active CD. Here, we studied the association of a variety of serum disease markers with fecal calprotectin levels in CD patients.
METHODS: 39 CD patients were included and subdivided into ‘normal’ (defined as < 200 mg/kg feces) and ‘increased’ (defined as > 200 mg/kg feces) fecal calprotectin level groups. Serum levels of 37 different cytokines, chemokines and markers for angiogenesis and vascular injury were quantified by an electrochemiluminescence multiplex assay (V-PLEX Human Biomarker 40-Plex Kit of Meso Scale Discovery ®). Correlations between individual biomarkers and the fecal calprotectin level were assessed using Spearman’s correlation coefficient (ρ).
RESULTS: A highly significant positive correlation was observed between the pro-inflammatory serum cytokines IFN-γ and CRP and fecal calprotectin levels (P < 0.01). Moreover, fecal calprotectin levels showed a significant positive correlation with IL-6, TNF-β, SAA and IL-17A (P < 0.05).
CONCLUSION: We show that a positive correlation exists between multiple serum Th1- and Th17-associated cytokines and the fecal calprotectin level. These cytokines and CRP may serve as additional biomarkers for determining disease activity and evaluating treatment response in CD. Ultimately, this may result in more efficient treatment of active disease in CD patients and prevention of complications.

PMID: 29466406 [PubMed – in process]

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Early intervention for subthreshold panic disorder in the Netherlands: A model-based economic evaluation from a societal perspective.

Early intervention for subthreshold panic disorder in the Netherlands: A model-based economic evaluation from a societal perspective.

PLoS One. 2018;13(2):e0193338

Authors: Ophuis RH, Lokkerbol J, Hiligsmann M, Evers SMAA

Abstract
BACKGROUND: Panic disorder (PD) is associated with impaired functioning and reduced quality of life. In the Netherlands, almost 2% of the population experiences clinically relevant panic symptoms without meeting the diagnostic criteria for PD, which is referred to as subthreshold PD (STHPD). Evidence suggests that subthreshold mental disorders may have a similar impact on quality of life and functioning in comparison with full-blown mental disorders, which draws attention to the need for interventions for STHPD. These interventions are currently not systematically provided in clinical practice. This study aims to investigate the population cost-effectiveness of adding a CBT-based early intervention for adults with STHPD to the existing health care for people with PD in the Netherlands.
METHODS: A health-economic Markov model was constructed in order to compare quality adjusted life-years (QALYs) and societal costs of adding an early intervention to usual care for PD. The model compares usual care with an alternative program in which usual care is supplemented with a CBT-based early intervention. Input parameters for the model were derived from national sources and published literature where possible, and based on expert opinion otherwise. Probabilistic and deterministic sensitivity analyses were conducted to evaluate the uncertainty of the model input parameters.
RESULTS: On average, the added CBT-based early intervention was dominant in comparison with usual care, meaning that the early intervention yielded more QALYs at lower costs. At a willingness-to-pay threshold of €20,000 per QALY, the cost-effectiveness probability of the added early intervention was 98%. Sensitivity analyses showed that the results were robust.
CONCLUSIONS: This study showed that offering an early intervention in addition to usual care for PD is potentially cost-effective, but it should be further investigated to what extent trial results can be extrapolated to the level of the population before such interventions are implemented on a large scale.

PMID: 29466470 [PubMed – in process]

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The added value of a family-centered approach to optimize infants’ social-emotional development: A quasi-experimental study.

The added value of a family-centered approach to optimize infants’ social-emotional development: A quasi-experimental study.
PLoS One. 2017;12(12):e0187750
Authors: Reijneveld SA, Hielkema M, Stewart RE, de Winter AF… Continue reading

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Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

Resource utilization in lung cancer diagnostic procedures: Current use and budget consequences.

PLoS One. 2017;12(12):e0189251

Authors: Brinkhof S, Groen HJM, Siesling SS, IJzerman MJ

Abstract
OBJECTIVES: The main objective of this study is to determine the current use of lung cancer diagnostic procedures in two large hospitals in the Netherlands, to explore deviations in guideline adherence between the hospitals, and to estimate the budget impact of the diagnostic work-up as well as the over- and underutilization.
MATERIALS & METHODS: A state transition model for the diagnostic pathway for lung cancer patients was developed using existing clinical practice guidelines (CPG) combined with a systematic literature. In addition to the CPGs depicting current practice, diagnostic utilization was gathered in two large hospitals representing an academic tertiary care hospital and a large regional teaching hospital for patients, who were selected from the Netherlands cancer registry.
RESULTS: The total population consisted of 376 patients with lung cancer. Not in all cases the guideline was followed, for instance in the usage of MR brain with stage III lung cancer patients (n = 70). The state-transition model predicts an average budget impact for the diagnostic pathway per patient estimated of € 2496 in the academic tertiary care hospital and € 2191 in the large regional teaching hospital.
CONCLUSION: The adherence to the CPG’s differed between hospitals, which questions the adherence to CPG’s in general. Adherence to CPG’s could lead to less costs in the diagnostic pathway for lung cancer patients.

PMID: 29216302 [PubMed – in process]

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Shoulder complaints in wheelchair athletes: A systematic review.

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Shoulder complaints in wheelchair athletes: A systematic review.
PLoS One. 2017;12(11):e0188410
Authors: Heyward OW, Vegter RJK, de Groot S, van der Woude LHV
Abstract
BACKGROUND: In … Continue reading

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Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.

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Feeling younger and identifying with older adults: Testing two routes to maintaining well-being in the face of age discrimination.
PLoS One. 2017;12(11):e0187805
Authors: Armenta BM, Stroebe K, Scheib… Continue reading

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The effects of normal aging on multiple aspects of financial decision-making.

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The effects of normal aging on multiple aspects of financial decision-making.
PLoS One. 2017;12(8):e0182620
Authors: Bangma DF, Fuermaier ABM, Tucha L, Tucha O, Koerts J
Abstract
OBJEC… Continue reading

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Electrically controlled cloud of bulk nanobubbles in water solutions.

Electrically controlled cloud of bulk nanobubbles in water solutions.

PLoS One. 2017;12(7):e0181727

Authors: Postnikov AV, Uvarov IV, Lokhanin MV, Svetovoy VB

Abstract
Using different experimental techniques we visualize a cloud of gas in water that is produced electrochemically by the alternating polarity process. Liquid enriched with gas does not contain bubbles strongly scattering visible light but its refractive index changes significantly near the electrodes. The change of the refractive index is a collective effect of bulk nanobubbles with a diameter smaller than 200 nm. Any alternative explanation fails to explain the magnitude of the effect. Spatial structure of the cloud is investigated with the optical lever method. Its dynamics is visualised observing optical distortion of the electrode images or using differential interference contrast method. The cloud covers concentric electrodes, in a steady state it is roughly hemispherical with a size two times larger than the size of the electrode structure. When the electrical pulses are switched off the cloud disappears in less than one second. The total concentration of gases can reach very high value estimated as 3.5 × 1020 cm-3 that corresponds to an effective supersaturation of 500 and 150 for hydrogen and oxygen, respectively.

PMID: 28727812 [PubMed – in process]

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Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.

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Net profit flow per country from 1980 to 2009: The long-term effects of foreign direct investment.
PLoS One. 2017;12(6):e0179244
Authors: Akkermans DHM
Abstract
AIM OF THE PAPER: The p… Continue reading

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An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.

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An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks.
PLoS One. 2017;12(6):e0178586
Authors: de Vos S, Wardenaar KJ, Bos E… Continue reading

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