Category Archives: Schizophr Res

The efficacy of computerized cognitive drill and practice training for patients with a schizophrenia-spectrum disorder: A meta-analysis.

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The efficacy of computerized cognitive drill and practice training for patients with a schizophrenia-spectrum disorder: A meta-analysis.

Schizophr Res. 2018 Aug 07;:

Authors: Prikken M, Konings MJ, Lei WU, Begemann MJH, Sommer IEC

Abstract
BACKGROUND: Computerized methods for improving cognitive functioning in schizophrenia have gained popularity during the past decades. Therefore, this study evaluates the available evidence for the efficacy of computerized cognitive drill and practice training for patients with schizophrenia-spectrum disorders.
METHODS: A systematic search was carried out using PubMed, Embase, Cochrane Database of Systematic Reviews, and PsycINFO. A meta-analysis was performed to compare cognitive drill and practice training in patients with a schizophrenia-spectrum disorder with non-cognitively oriented control conditions. The primary outcome was cognitive functioning. Secondary outcome measures included psychotic symptoms, depressive symptoms, and functional outcomes. Effect sizes (ES) for all included studies were calculated as Hedges’ g.
RESULTS: 24 studies were included with 1262 patients in total. Compared to a control condition, patients receiving computerized cognitive drill and practice training showed significantly more improvement on attention (ES = 0.31, p = 0.001), working memory (ES = 0.38, p < 0.001), positive symptoms (ES = 0.31, p = 0.003), and depressive symptoms (ES = 0.37, p = 0.002). Small, marginally significant effect sizes were found for processing speed, verbal and visual learning and memory, and verbal fluency. However, significant effects on functional outcomes and social cognition were absent.
DISCUSSION: The current study showed evidence for the efficacy of computerized cognitive drill and practice training in patients with schizophrenia-spectrum disorders. However, the absence of effects on social cognition and functional outcomes questions the generalization of treatment effects. Together, these results stimulate further development of computerized training programs for schizophrenia that not only improve cognitive functioning, but also generalize cognitive improvement to functional outcomes.

PMID: 30097278 [PubMed – as supplied by publisher]

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Is it still correct to differentiate between early and very early onset psychosis?

Is it still correct to differentiate between early and very early onset psychosis?

Schizophr Res. 2015 Nov 27;

Authors: Lin A, Wardenaar KJ, Pontillo M, De Crescenzo F, Mazzone L, Vicari S, Wood SJ, Beavan A, Armando M

Abstract
OBJECTIVE: It remains unclear whether very early onset psychosis (VEOP; ≤12years of age) and early onset psychosis (EOP; onset 13-17years of age) are homogeneous in their clinical presentation. We investigated the predictive value of age of psychosis onset for severity, functioning and demographic variation by: 1) comparing groups based on traditional cut-offs for age of psychosis onset, and 2) using receiver operating characteristic (ROC)-curve calculations, without a priori age of onset cut-offs.
METHOD: Participants were 88 (45 female, 43 male) children and adolescents with a recent onset of psychosis (age range=6.7-17.5years; M=13.74, SD=2.37).
RESULTS: The VEOP group had significantly shorter duration of untreated illness and untreated psychosis, and lower functioning than the EOP group. The VEOP and EOP groups did not differ significantly on gender proportion, urbanicity, psychotic diagnosis, family history of psychotic disorder, psychotic, depressive and anxiety symptoms or IQ. When applying ROC-curves to the lowest three quartiles of positive psychotic symptoms scores, the optimal age-cut-off was 14.0years (sensitivity=0.62; specificity=0.75). For the highest quartile of functioning scores, the optimal differentiating cut-off for age of psychosis onset was 14.7years (sensitivity=0.71; specificity=0.70).
CONCLUSIONS: Larger samples of patients, assessed at presentation and followed-up, are necessary to clearly examine clinical presentation and outcome as a function of social and neural development to better understand if the differentiation between VEOP and EOP is justified. This will aid the development of predictive diagnostic tools, more accurate prognosis prediction, and age-tailored therapeutic interventions.

PMID: 26639553 [PubMed – as supplied by publisher]

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Effect of rTMS on brain activation in schizophrenia with negative symptoms: A proof-of-principle study.

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Effect of rTMS on brain activation in schizophrenia with negative symptoms: A proof-of-principle study.

Schizophr Res. 2015 Jul 14;

Authors: Dlabac-de Lange JJ, Liemburg EJ, Bais L, Renken RJ, Knegtering H, Aleman A

Abstract
BACKGROUND: Prefrontal cortical dysfunction is frequently reported in schizophrenia and is thought to underlie negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in patients with schizophrenia, but the underlying neural mechanism is unknown.
OBJECTIVE: To examine whether 3weeks of 10Hz rTMS treatment of the bilateral dorsolateral prefrontal cortex (DLPFC) would improve frontal brain activation in patients with negative symptoms of schizophrenia, as measured by functional magnetic resonance imaging (fMRI) during the Tower of London (ToL) task.
METHODS: 24 patients with the diagnosis of schizophrenia with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale≥15) participated. Patients were randomized to a 3-week (15day) course of active or sham rTMS. All patients performed the ToL task during fMRI scanning both pre-treatment and post-treatment. Differences in brain activation between the two groups were compared non-parametrically.
RESULTS: After rTMS treatment, brain activity in the active group increased in the right DLPFC and the right medial frontal gyrus as compared to the sham group. In addition, the groups significantly differed with regard to activation change in the left posterior cingulate, with decreased activation in the active and increased activation in the sham group.
CONCLUSIONS: Treatment with rTMS over the DLPFC may have the potential for increasing task-related activation in frontal areas in patients with schizophrenia. Effects of different rTMS parameters and fMRI tasks targeting relevant brain circuitry deserve further investigation.
TRIAL REGISTRATION: Nederlands Trial Register, registration number: NTR1261.

PMID: 26187147 [PubMed – as supplied by publisher]

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The Arcuate Fasciculus in auditory-verbal hallucinations: a meta-analysis of diffusion-tensor-imaging studies.

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The Arcuate Fasciculus in auditory-verbal hallucinations: a meta-analysis of diffusion-tensor-imaging studies.

Schizophr Res. 2014 Oct;159(1):234-7

Authors: Geoffroy PA, Houenou J, Duhamel A, Amad A, De Weijer AD, Curčić-Blake B, Linden DE, Thomas P, Jardri R

Abstract
Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy controls (HCs). Five studies were retained gathering 256 DTI data points, divided into AVHs (n=106) and HCs (n=150). The meta-analysis demonstrated a reduced fractional anisotropy in the left Arcuate Fasciculus (AF) of hallucinators (hg= -0.42; CI[-0.69,-0.16]; p<10(-3)). The current meta-analysis confirmed disruptions of white matter integrity in the left AF bundle of schizophrenia patients with AVHs.

PMID: 25112160 [PubMed – indexed for MEDLINE]

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Psychotic experiences in the population: Association with functioning and mental distress.

Psychotic experiences in the population: Association with functioning and mental distress.
Schizophr Res. 2015 Apr 10;
Authors: Kelleher I, Wigman JT, Harley M, O’Hanlon E, Coughlan H, Rawdon C, Murphy J, Power E, Hi… Continue reading

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Emotion processing in schizophrenia is state and trait dependent.

Emotion processing in schizophrenia is state and trait dependent.

Schizophr Res. 2014 Dec 24;

Authors: Maat A, van Montfort SJ, de Nijs J, Derks EM, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, GROUP Investigators

Abstract
BACKGROUND: Substantial evidence exists about emotion processing (EP) impairments in schizophrenia patients. However, whether these deficits are present primarily during psychosis (i.e., state dependent) or an integral part of the disorder (i.e., trait dependent) remains unclear.
METHODS: EP was assessed with the degraded facial affect recognition task in schizophrenia patients (N=521) and healthy controls (N=312) at baseline (T1) and after a three year follow-up (T2). In schizophrenia patients symptomatic remission was assessed with the Positive and Negative Syndrome Scale (PANSS) remission tool. Patients were divided into four groups: remission T1 and remission T2 (RR); remission T1 and non-remission T2 (RN); non-remission T1 and non-remission T2 (NN) and non-remission T1 and remission T2 (NR). Factorial repeated measures ANCOVA was used to compare EP performance over time between groups. Age, gender and general cognition were included as covariates.
RESULTS: Schizophrenia patients performed worse than healthy controls on EP at T1 (p=0.001). The patients that were in symptomatic remission at both time points (the RR group) performed worse than the healthy controls at T2 (p<0.001). Significant group×time interactions were found between RR and RN (p=0.001), and between NR and RN (p=0.04), indicating a differential EP performance over time. No group×time interaction was found between NN and NR.
CONCLUSION: The results show relatively poor EP performance in schizophrenia patients compared to healthy controls. EP performance in schizophrenia patients was associated with symptomatic remission. The results provide support for the hypothesis that EP deficits in schizophrenia are both state and trait dependent.

PMID: 25543332 [PubMed – as supplied by publisher]

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Neural correlates of planning performance in patients with schizophrenia – Relationship with apathy.

Neural correlates of planning performance in patients with schizophrenia – Relationship with apathy.
Schizophr Res. 2014 Dec 9;
Authors: Liemburg EJ, Dlabac-De Lange JJ, Bais L, Knegtering H, van Osch MJ, Renken RJ, … Continue reading

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Relationship between cognition, clinical and cognitive insight in psychotic disorders: a review and meta-analysis.

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Relationship between cognition, clinical and cognitive insight in psychotic disorders: a review and meta-analysis.
Schizophr Res. 2014 Jan;152(1):191-200
Authors: Nair A, Palmer EC, Aleman A, David A… Continue reading

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Factors contributing to the duration of untreated psychosis.

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Factors contributing to the duration of untreated psychosis.

Schizophr Res. 2014 Jul 18;

Authors: Apeldoorn SY, Sterk B, van den Heuvel ER,…

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Psychotic symptoms, cognition and affect as predictors of psychosocial problems and functional change in first-episode psychosis.

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Psychotic symptoms, cognition and affect as predictors of psychosocial problems and functional change in first-episode psychosis.
Schizophr Res. 2014 Jul 5;
Authors: Stouten LH, Veling W, Laan W, van … Continue reading

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Improving functional outcomes for schizophrenia patients in the Netherlands using Cognitive Adaptation Training as a nursing intervention – A pilot study.

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Improving functional outcomes for schizophrenia patients in the Netherlands using Cognitive Adaptation Training as a nursing intervention – A pilot study.

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The Antipsychotics and Sexual Functioning Questionnaire (ASFQ): preliminary evidence for reliability and validity.

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The Antipsychotics and Sexual Functioning Questionnaire (ASFQ): preliminary evidence for reliability and validity.

Schizophr Res. 2013 Nov;150(2-3):410-5

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The influence of adjunctive treatment and metacognitive deficits in schizophrenia on the experience of work.

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The influence of adjunctive treatment and metacognitive deficits in schizophrenia on the experience of work.
Schizophr Res. 2014 Jun 4;
Authors: de Jong S, Renard SB, van Donkersgoed RJ, van der Gaag … Continue reading

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The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates.

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The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates.

Schizophr Res. 2013 Dec 19;

Authors: …

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A brief version of the Subjects’ Response to Antipsychotics questionnaire to evaluate treatment effects.

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A brief version of the Subjects’ Response to Antipsychotics questionnaire to evaluate treatment effects.
Schizophr Res. 2013 Jun;147(1):175-80
Authors: Lako IM, Bruggeman R, Liemburg EJ, van den Heuvel ER, Kne… Continue reading

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Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score.

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Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: part II: the use of subscales of the PANSS score.

Schizophr Res….

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Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

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Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: the use of PANSS total score and clinical utility.

Schizophr…

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Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia.

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Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in…

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The auditory dorsal stream plays a crucial role in projecting hallucinated voices into external space.

The auditory dorsal stream plays a crucial role in projecting hallucinated voices into external space.

Schizophr Res. 2013 Mar 1;

Authors: Looijestijn J, Diederen KM, Goekoop R,…

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Changes in insight during treatment for psychotic disorders: A meta-analysis.

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Changes in insight during treatment for psychotic disorders: A meta-analysis.
Schizophr Res. 2013 Jan 7;
Authors: Pijnenborg GH, van Donkersgoed RJ, David AS, Aleman A
Abstract
OBJECTIVE: Poor i… Continue reading

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