Category Archives: Curr Opin Rheumatol

Usefulness of antineutrophil cytoplasmic autoantibodies in diagnosing and managing systemic vasculitis.

Usefulness of antineutrophil cytoplasmic autoantibodies in diagnosing and managing systemic vasculitis.
Curr Opin Rheumatol. 2016 Jan;28(1):8-14
Authors: Kallenberg CG
Abstract
PURPOSE OF REVIEW: Anti… Continue reading

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Infectious triggers for vasculitis.

Infectious triggers for vasculitis.
Curr Opin Rheumatol. 2014 May 13;
Authors: van Timmeren MM, Heeringa P, Kallenberg CG
Abstract
PURPOSE OF REVIEW: Infections have been suggested to contribute to di… Continue reading

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Is B-cell depletion first choice in antineutrophil cytoplasmic antibody-associated vasculitis?

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Is B-cell depletion first choice in antineutrophil cytoplasmic antibody-associated vasculitis?

Curr Opin Rheumatol. 2014 Mar 19;

Authors: Kallenberg CG

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Clinical studies on bone-related outcome and the effect of TNF-α blocking therapy in ankylosing spondylitis.

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Clinical studies on bone-related outcome and the effect of TNF-α blocking therapy in ankylosing spondylitis.

Curr Opin Rheumatol. 2014 Mar 12;

Authors: Arends S, Spoorenberg A, Brouwer E, van der Veer E

Abstract
PURPOSE OF REVIEW: To provide an overview of clinical trials and observational studies investigating the effect of tumor necrosis factor-alpha (TNF-α) blocking therapy on bone formation and bone loss in patients with ankylosing spondylitis (AS).
RECENT FINDINGS: The effect of TNF-α blocking therapy on excessive bone formation or osteoproliferation remains inconclusive. Radiographic assessment of spinal osteoproliferation is complicated by the overall slow rate of progression and the high variability between individual AS patients. Multiple studies demonstrated that TNF-α blocking therapy results in a significant increase in bone mineral density (BMD) at the lumbar spine and hip. Based on bone turnover marker (BTM) analysis, this can mainly be explained by an increase in mineralization and decrease in bone resorption.
SUMMARY: Both osteoproliferation (e.g. syndesmophytes and ankylosis of vertebrae) and excessive bone loss resulting in osteoporosis and vertebral fractures are frequently present in AS. Previous studies showed that BMD increases during TNF-α blocking therapy. Long-term follow-up in a large cohort of patients is needed to investigate whether TNF-α blockers can consolidate or stop spinal osteoproliferation and prevent vertebral fractures. Future studies should focus on the effect of these agents on bone-related outcome in AS patients with early vs. advanced disease.

PMID: 24625371 [PubMed – as supplied by publisher]

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Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models.

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Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models.

Curr Opin Rheumatol. 2013 Mar;25(2):254-9

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Lessons to be learned from periodontitis.

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Lessons to be learned from periodontitis.

Curr Opin Rheumatol. 2013 Mar;25(2):241-7

Authors: Janssen KM, Vissink A, de Smit MJ, Westra J, Brouwer E

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Etiopathogenesis of systemic autoimmune diseases.

Etiopathogenesis of systemic autoimmune diseases.

Curr Opin Rheumatol. 2012 Dec 15;

Authors: Kallenberg CG

PMID: 23249832 [PubMed – as supplied by publisher]

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Refractory disease in antineutrophil cytoplasmic antibodies associated vasculitis.

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Refractory disease in antineutrophil cytoplasmic antibodies associated vasculitis.

Curr Opin Rheumatol. 2012 May;24(3):245-51

Authors: Rutgers A,…

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Baseline predictors of response to TNF-α blocking therapy in ankylosing spondylitis.

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Baseline predictors of response to TNF-α blocking therapy in ankylosing spondylitis.

Curr Opin Rheumatol. 2012 May;24(3):290-8

Authors: Arends S, van der…

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How to assess treatment efficacy in Sjögren’s syndrome?

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How to assess treatment efficacy in Sjögren’s syndrome?

Curr Opin Rheumatol. 2012 May;24(3):281-9

Authors: Vissink A, Bootsma H, Kroese FG, Kallenberg CG

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Bacterial infections in Wegener’s granulomatosis: mechanisms potentially involved in autoimmune pathogenesis.

Bacterial infections in Wegener’s granulomatosis: mechanisms potentially involved in autoimmune pathogenesis.

Curr Opin Rheumatol. 2011 Jul;23(4):366-71

Authors: Tadema H, Heeringa…

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Pathogenesis of ANCA-associated vasculitis: recent insights from animal models.

Pathogenesis of ANCA-associated vasculitis: recent insights from animal models.

Curr Opin Rheumatol. 2011 Nov 13;

Authors: van Timmeren MM, Heeringa P

Abstract

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