Category Archives: Clin Microbiol Infect

Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.

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Practical Issues in Implementing Whole-Genome-Sequencing in Routine Diagnostic Microbiology.
Clin Microbiol Infect. 2017 Nov 05;:
Authors: Rossen JWA, Friedrich AW, Moran-Gilad J, ESCMID Study Group f… Continue reading

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Acute Hepatitis C in the Netherlands; characteristics of the epidemic in 2014.

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Acute Hepatitis C in the Netherlands; characteristics of the epidemic in 2014.
Clin Microbiol Infect. 2015 Oct 16;
Authors: Hullegie SJ, van den Berk GE, Leyten EM, Arends JE, Lauw FN, van der Meer JT… Continue reading

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Education in Infection Control: a need for European certification.

Education in Infection Control: a need for European certification.
Clin Microbiol Infect. 2015 Sep 9;
Authors: Zingg W, Mutters NT, Harbarth S, Friedrich AW
Abstract
Healthcare-associated infections a… Continue reading

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The population structure of Staphylococcus aureus in China and Europe assessed by Multiple-Locus Variable Number Tandem Repeat Analysis; clues to geographical origins of emergence and dissemination.

The population structure of Staphylococcus aureus in China and Europe assessed by Multiple-Locus Variable Number Tandem Repeat Analysis; clues to geographical origins of emergence and dissemination.
Clin Microbiol Infect. 201… Continue reading

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The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation.

The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation.
Clin Microbiol Infect. 2014 Dec 27;
Authors: Zhou K, Ferdous M, de Boer RF, Kooistra-Smi… Continue reading

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Staphylococcus aureus spa type t437: identification of the most dominant community-associated clone from Asia across Europe.

Staphylococcus aureus spa type t437: identification of the most dominant community-associated clone from Asia across Europe.

Clin Microbiol Infect. 2014 Oct 29;

Authors: Glasner C, Pluister G, Westh H, Arends JP, Empel J, Giles E, Laurent F, Layer F, Marstein L, Matussek A, Mellmann A, Pérez-Vásquez M, Ungvári E, Yan X, Žemličková H, Grundmann H, van Dijl JM

Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) belonging to the multilocus sequence type clonal complex 59 (MLST CC59) is the predominant community-associated MRSA clone in Asia. This clone, which is primarily linked with the spa type t437, has so far only been reported in low numbers among large epidemiological studies in Europe. Nevertheless, the overall numbers identified in some Northern European reference laboratories have increased during the past decade. To determine whether the S. aureus t437 clone is present in other European countries, and to assess its genetic diversity across Europe, we analysed 147 S. aureus t437 isolates from 11 European countries collected over a period of 11 years using multiple locus variable number tandem repeat fingerprinting/analysis (MLVF/MLVA) and MLST. Additionally 16 S. aureus t437 isolates from healthy carriers and patients from China were included. Most isolates were shown to be monophyletic with 98% of the isolates belonging to the single MLVA complex 621, to which nearly all included isolates from China also belonged. More importantly, all MLST-typed isolates belonged to CC59. Our study implies that the European S. aureus t437 population represents a genetically tight cluster, irrespective of the year, country and site of isolation. This underpins the view that S. aureus CC59 has been introduced into several European countries, not being restricted to particular geographical regions or specific host environments. The European S. aureus t437 isolates thus bear the general hallmarks of a high-risk clone.

PMID: 25658555 [PubMed – as supplied by publisher]

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Factors associated with Staphylococcus aureus nasal carriage among healthy people in Northern China.

Factors associated with Staphylococcus aureus nasal carriage among healthy people in Northern China.

Clin Microbiol Infect. 2014 Oct 29;

Authors: Yan X, Song Y, Yu X, Tao X, Yan J, Luo F, Zhang H, Zhang J, Li Q, He L, Li S, Meng F, Zhang J, Grundmann H

Abstract
There is still limited knowledge about the prevalence and risk factors of nasal carriage for Staphylococcus aureus among healthy carriers in China. We investigated 2448 healthy adults (≥18 years of age) from Beijing (n = 1530) and Harbin (n = 918) by nasal screening. Participants were checked for carriage of S. aureus, and health-related and demographic information between 2009 and 2011 was gathered. A total of 403 S. aureus (403/2448, 16.5%) were recovered, 8 of which were methicillin resistant (8/2448, 0.33%). Three factors were independently associated with S. aureus nasal carriage: Harbin as city of residence (odds ratio (OR) = 2.0, 95% confidence interval (CI) = 1.41 to 2.85), age ≤24 years (OR = 1.77, 95% CI = 1.30-2.44) and non-Han ethnicity (OR = 1.58, 95% CI = 1.05 to 2.38). On the basis of population genetic analysis using multiple locus variable number of tandem repeats analysis (MLVA) and spa typing, MLVA complex (MC) 398 and MC5a were the most prevalent clonal lineages in this collection. In multivariate models, residing in Harbin (OR = 1.77, 95% CI = 1.07-2.92) and having household members in the healthcare profession (OR = 3.69, 95% CI = 1.14-11.92) were factors associated with carriage of clonal lineage MC398. On the other hand, female sex (OR = 3.15, 95% CI = 1.35-7.33) and a history of chronic liver disease (OR = 16.93, 95% CI = 2.91-98.59) were associated with the clonal lineage MC5a. The three most common spa types were t571 (10.9%), t189 (9.9%) and t701 (7.2%). These findings provide insight into the determinants of nasal carriage and ecology for some of the most successful strains of S. aureus among healthy people in Northern China.

PMID: 25658548 [PubMed – as supplied by publisher]

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The influence of incubation time, sample preparation and exposure to oxygen on the quality of the MALDI-TOF MS spectrum of anaerobic bacteria.

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The influence of incubation time, sample preparation and exposure to oxygen on the quality of the MALDI-TOF MS spectrum of anaerobic bacteria.

Clin…

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The significance of rhinovirus detection in hospitalized children: clinical, epidemiological and virological features.

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The significance of rhinovirus detection in hospitalized children: clinical, epidemiological and virological features.

Clin Microbiol Infect. 2013…

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The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System.

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The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System.
Clin Microbiol Infect. 2012 Oct 3;
Authors: de Kraker ME, Jarlier V, Monen JC, Heuer … Continue reading

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Comparison of two matrix-assisted laser desorption ionisation-time of flight mass spectrometry methods for the identification of clinically relevant anaerobic bacteria.

Comparison of two matrix-assisted laser desorption ionisation-time of flight mass spectrometry methods for the identification of clinically relevant anaerobic bacteria.

Clin Microbiol…

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Relationship between cytomegalovirus infection and procoagulant changes in human immunodeficiency virus-infected patients.

Relationship between cytomegalovirus infection and procoagulant changes in human immunodeficiency virus-infected patients.

Clin Microbiol Infect. 2011 May;17(5):747-9

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