Category Archives: Brain Res

Differential parietal and temporal contributions to music perception in improvising and score-dependent musicians, an fMRI study.

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Differential parietal and temporal contributions to music perception in improvising and score-dependent musicians, an fMRI study.
Brain Res. 2015 Jul 20;
Authors: Harris R, de Jong BM
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Disrupting morphosyntactic and lexical semantic processing has opposite effects on the sample entropy of neural signals.

Disrupting morphosyntactic and lexical semantic processing has opposite effects on the sample entropy of neural signals.
Brain Res. 2015 Jan 26;
Authors: Fonseca A, Boboeva V, Brederoo S, Baggio G
Abstract
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The electrophysiological locus of the redundant target effect on visual discrimination in a dual singleton search task.

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The electrophysiological locus of the redundant target effect on visual discrimination in a dual singleton search task.

Brain Res. 2013 Nov 6;1537:180-90

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Transcriptional activity of human brain estrogen receptor-α splice variants: Evidence for cell type-specific regulation.

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Transcriptional activity of human brain estrogen receptor-α splice variants: Evidence for cell type-specific regulation.

Brain Res. 2013 Mar 15;1500:1-9

Authors: Ishunina TA, Sluiter AA, Swaab DF, Verwer RW

Abstract
Estrogen receptor α (ERα) isoforms with complex types of alternative splicing are naturally present in the human brain and may affect canonical receptor signaling. In the present study we investigated transcriptional activity of common ERα splice variants from this group with different molecular defects: MB1 (intron retention), TADDI (small deletion between exons 3 and 4 with an insert), the Δ (deletion) 3(⁎)-7(*)/819 (complete skipping of exons 4, 5 and 6 and partial deletion of exons 3 and 7) and the Δ3-6 (lacking exons 3, 4, 5 and 6) in HeLa and M17 cells upon stimulation with (17β)estradiol or insulin-like growth factor 1 (IGF-1). In HeLa cells, all these splice variants showed the dominant negative function that was more pronounced for the TADDI. In M17 cells the dominant negative variants appeared to be the MB1 and the Δ3-6, whereas TADDI turned out to be a clearly dominant positive variant. In M17 cells mRNA levels of Δ3-6 and Δ3(*)-7(*)/819 variants increased following (17β)estradiol administration. In Hela cells (17β)estradiol up-regulated the IGF-1 receptor mRNA levels in cultures transfected with MB1, TADDI and Δ3(*)-7(*)/819. Our data demonstrate that ERα splice variants show differential levels of the transcriptional activity in a cell type-specific way and that IGF-1 signaling pathways are differentially employed in a cell-type specific manner depending on the level of the discrete ERα splice variants expressed. Functional properties of various ERα splice variants and their cell type-specificity should, thus, be considered as potential confounders of estrogen therapy effects on the brain.

PMID: 23333800 [PubMed – in process]

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Getting real about semantic illusions: rethinking the functional role of the P600 in language comprehension.

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Getting real about semantic illusions: rethinking the functional role of the P600 in language comprehension.

Brain Res. 2012 Mar 29;1446:127-43

Authors: …

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Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.

Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.

Brain Res. 2011 Jun 29;1398:13-20

Authors: Wallinga…

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