Category Archives: Clin Nucl Med

FDG-PET/CT as a New Method for Diagnosis and Whole-Body Evaluation of Lemierre Syndrome.






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FDG-PET/CT as a New Method for Diagnosis and Whole-Body Evaluation of Lemierre Syndrome.
Clin Nucl Med. 2017 May 19;:
Authors: Pijl JP, Glaudemans AWJM, Slart RHJA, Kwee TC
Abstract
Le… Continue reading

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18F-FDOPA Accumulation in Traumatic Rib Fractures: A Potential Pitfall.






18F-FDOPA Accumulation in Traumatic Rib Fractures: A Potential Pitfall.
Clin Nucl Med. 2015 Feb 4;
Authors: Stormezand GN, Glaudemans AW, Slart RH
Abstract
F-FDOPA (6-[F]fluoro-L-DOPA) is used for the… Continue reading






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18F-FDG-PET Increases Visibility of Bone Lesions in Relapsed Multiple Myeloma: Is this Hypoxia Driven?






18F-FDG-PET Increases Visibility of Bone Lesions in Relapsed Multiple Myeloma: Is this Hypoxia Driven?

Clin Nucl Med. 2014 Dec 26;

Authors: de Waal EG, Slart RH, Leene MJ, Kluin PM, Vellenga E

Abstract
INTRODUCTION: Whole-body x-ray (WBX) is used for detecting skeleton abnormalities in patients with multiple myeloma (MM). An alternative might be F-FDG-PET, which makes use of metabolic changes of malignant cells. The aims of this study were to evaluate whether F-FDG-PET detects more lesions compared with WBX in patients with relapsing MM and to define its prognostic value. In addition 1-α-D: -(5-deoxy-5-[F]-fluoroarabinofuranosyl)-2-nitroimidazole (F-FAZA) scan and immunohistochemical staining on bone marrow were performed to define whether FDG uptake coincides with angiogenesis-related tumor hypoxia.
PATIENTS AND METHODS: F-FDG-PET (n = 44) and F-FAZA-PET (n = 5) were performed in patients with relapsed MM. Bone marrow biopsies (n = 20) were evaluated for hypoxia inducible factors (HIF) 1α and 2α, vascular endothelial growth factor, glucose transport proteins 1 and 3, and the microvessel density.
RESULTS: New lesions were more frequently demonstrated on F-FDG-PET than on WBX (P = 0.000001). F-FDG-PET was not predictive for progression-free survival and overall survival. Immunohistochemical staining on bone marrow biopsies demonstrated a significant increase in microvessel density and elevated expression of vascular endothelial growth factor, HIF-2α, and glucose transport protein 3 by the malignant plasma cells. However, HIF-1α expression and F-FAZA scan results were negative.
CONCLUSIONS: Our results demonstrate that F-FDG-PET is relevant for diagnostic purposes compared with WBX in relapsing MM. The enhanced uptake of F-FDG-PET is likely related to the activation of the HIF-2α signaling pathway but probably independent of hypoxia-induced signaling in view of the negative findings on both F-FAZA-PET and HIF-1α expression.

PMID: 25546223 [PubMed – as supplied by publisher]

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Head and neck tumor hypoxia imaging by 18F-fluoroazomycin-arabinoside (18F-FAZA)-PET: a review.






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Head and neck tumor hypoxia imaging by 18F-fluoroazomycin-arabinoside (18F-FAZA)-PET: a review.
Clin Nucl Med. 2014 Jan;39(1):44-8
Authors: Halmos GB, Bruine de Bruin L, Langendijk JA, van der Laan B… Continue reading






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Diagnostic Utility of 18F-FDG PET/CT in Inflammation of Unknown Origin.






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Diagnostic Utility of 18F-FDG PET/CT in Inflammation of Unknown Origin.

Clin Nucl Med. 2014 Mar 21;

Authors: Balink H, Bennink RJ, Veeger NJ, van Eck-Smit…

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Is FDG PET a better imaging tool than somatostatin receptor scintigraphy in patients with relapsing multiple myeloma?






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Is FDG PET a better imaging tool than somatostatin receptor scintigraphy in patients with relapsing multiple myeloma?

Clin Nucl Med. 2012 Oct;37(10):939-42

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Early CT Compared With Bone Scintigraphy in Suspected Schapoid Fractures.






Early CT Compared With Bone Scintigraphy in Suspected Schapoid Fractures.

Clin Nucl Med. 2012 Oct;37(10):981

Authors: de Zwart A, Rhemrev SJ, Kingma LM, Meylaerts SA, Arndt JW,…

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Unilateral hyperlucent lung in a child caused by a foreign body identified with v/q scintigraphy.






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Unilateral hyperlucent lung in a child caused by a foreign body identified with v/q scintigraphy.
Clin Nucl Med. 2012 Sep;37(9):916-7
Authors: Balink H, Collins J, Korsten-Meijer AG, Rottier BL
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F-18 FLT PET: a noninvasive diagnostic tool for visualization of the bone marrow compartment in patients with aplastic anemia: a pilot study.






F-18 FLT PET: a noninvasive diagnostic tool for visualization of the bone marrow compartment in patients with aplastic anemia: a pilot study.
Clin Nucl Med. 2011 Apr;36(4):286-9
Authors: Agool A, Slart RH, Kluin PM, de Wolf JT… Continue reading






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