Category Archives: Invest Ophthalmol Vis Sci

Visual Performance as a Function of Luminance in Glaucoma: The De Vries-Rose, Weber’s, and Ferry-Porter’s Law.

Visual Performance as a Function of Luminance in Glaucoma: The De Vries-Rose, Weber’s, and Ferry-Porter’s Law.

Invest Ophthalmol Vis Sci. 2018 Jul 02;59(8):3416-3423

Authors: Bierings RAJM, de Boer MH, Jansonius NM

Abstract
Purpose: To determine whether the De Vries-Rose, Weber’s, and Ferry-Porter’s law, which describe visual performance as a function of luminance, also hold in patients with glaucoma.
Methods: A case-control study with 19 glaucoma patients and 45 controls, all with normal visual acuity. We measured foveal and peripheral contrast sensitivity (CS) using static perimetry and foveal and peripheral critical fusion frequency (CFF; stimulus diameter 1°) as a function of luminance (0.02 to 200 cd/m2). ANOVA was used to analyze the effect of glaucoma and luminance on CS and CFF; analyses were adjusted for age and sex.
Results: Foveally, logCS was proportional to log luminance at lower luminances (de Vries-Rose) and saturated at higher luminances (Weber); glaucoma patients had a 0.4 log unit lower logCS than controls (P < 0.001), independent of luminance. Peripherally, the difference was more pronounced at lower luminances (P = 0.007). CFF was linearly related to log luminance (Ferry-Porter). Glaucoma patients had a lower CFF compared with controls (P < 0.001), with a smaller slope of the CFF versus log luminance curve, for both the fovea (6.8 vs. 8.7 Hz/log unit; P < 0.001) and the periphery (2.5 vs. 3.4 Hz/log unit; P = 0.012).
Conclusions: Even in apparently intact areas of the visual field, visual performance is worse in glaucoma patients than in healthy subjects for a wide range of luminances, without a clear luminance dependency that is consistent across the various experiments. This indicates impaired signal processing downstream in the retina and beyond, rather than an impaired light adaptation in the strictest sense.

PMID: 30025071 [PubMed – in process]

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A Nonsense Mutation in FAM161A Is a Recurrent Founder Allele in Dutch and Belgian Individuals With Autosomal Recessive Retinitis Pigmentosa.

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A Nonsense Mutation in FAM161A Is a Recurrent Founder Allele in Dutch and Belgian Individuals With Autosomal Recessive Retinitis Pigmentosa.
Invest Ophthalmol Vis Sci. 2015 Nov 1;56(12):7418-7426
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Immunohistochemical Evaluation of Idiopathic Epiretinal Membranes and In Vitro Studies on the Effect of TGF-β on Müller Cells.

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Immunohistochemical Evaluation of Idiopathic Epiretinal Membranes and In Vitro Studies on the Effect of TGF-β on Müller Cells.

Invest Ophthalmol Vis Sci….

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Influence of the Retinal Blood Vessel Topography on the Variability of the Retinal Nerve Fiber Bundle Trajectories in the Human Retina.

Influence of the Retinal Blood Vessel Topography on the Variability of the Retinal Nerve Fiber Bundle Trajectories in the Human Retina.
Invest Ophthalmol Vis Sci. 2015 Oct 1;56(11):6320-6325
Authors: Qiu K, Schiefer … Continue reading

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Substrate Elastic Modulus Regulates the Morphology, Focal Adhesions, and α-Smooth Muscle Actin Expression of Retinal Müller Cells.

Substrate Elastic Modulus Regulates the Morphology, Focal Adhesions, and α-Smooth Muscle Actin Expression of Retinal Müller Cells.

Invest Ophthalmol Vis Sci. 2015 Sep 1;56(10):5974-82

Authors: Bu SC, Kuijer R, van der Worp RJ, van Putten SM, Wouters O, Li XR, Hooymans JM, Los LI

Abstract
PURPOSE: The stiffness of the extracellular matrix has been shown to regulate cell adhesion, migration, and transdifferentiation in fibrotic processes. Retinal Müller cells have been shown to be mechanosensitive; they are involved in fibrotic vitreoretinal diseases. Since fibrosis increases the rigidity of the extracellular matrix, our aim was to develop an in vitro model for studying Müller cell morphology and differentiation state in relation to matrix stiffness.
METHODS: A spontaneously immortalized human Müller cell line (MIO-M1) was cultured on type I collagen-coated polyacrylamide gels with Young’s moduli ranging from 2 to 92 kPa. Cell surface area, focal adhesion, and the expression and morphology of α-smooth muscle actin induced by transforming growth factor β (TGF-β [10 ng/mL for 48 hours]) were analyzed by immunocytology. The images were documented by using fluorescence microscopy and confocal scanning laser microscopy.
RESULTS: MIO-M1 cells cultured on stiff substrates exhibited a significant increase in cell surface area, stress fiber, and mature focal adhesion formation. Furthermore, Müller cells treated with TGF-β1 and TGF-β2 and cultured on stiff substrates showed an increased incorporation of α-smooth muscle actin into stress fibers when compared to those grown on soft surfaces.
CONCLUSIONS: Compliance of the surrounding matrix seems to influence the morphology and contraction of retinal Müller cells in fibrotic conditions. Development of an in vitro model simulating both the normally compliant retinal tissue and the rigid retinal fibrotic tissue helps fill the gap between the results of petri-dish cell culture with rigid surfaces and in vivo findings.

PMID: 26377083 [PubMed – in process]

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Phakic Iris-Fixated Intraocular Lens Placement in the Anterior Chamber: Effects on Aqueous Flow.

Phakic Iris-Fixated Intraocular Lens Placement in the Anterior Chamber: Effects on Aqueous Flow.
Invest Ophthalmol Vis Sci. 2015 May 1;56(5):3061-3068
Authors: Repetto R, Pralits JO, Siggers JH, Soleri P
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Infantile Nystagmus Syndrome is Associated with Inefficiency of Goal-directed Hand Movements.

Infantile Nystagmus Syndrome is Associated with Inefficiency of Goal-directed Hand Movements.
Invest Ophthalmol Vis Sci. 2014 Dec 23;
Authors: Liebrand-Schurink J, Cox R, van Rens GH, Cillessen T, Meulenbroek RG, Boo… Continue reading

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Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma.

Population-based evaluation of retinal nerve fiber layer, retinal ganglion cell layer, and inner plexiform layer as a diagnostic tool for glaucoma.

Invest Ophthalmol Vis Sci. 2014 Nov 20;

Authors: Springelkamp H, Lee K, Wolfs RC, Buitendijk GH, Ramdas WD, Hofman A, Vingerling JR, Klaver CC, Abràmoff MD, Jansonius NM

Abstract
Purpose: To determine the glaucoma screening performance of regional OCT layer thickness measurements in the peripapillary and macular region, in a population-based setting. Methods: Subjects (n=1,224) in the Rotterdam Study underwent visual field testing (Humphrey Field Analyzer) and OCT of macula and optic nerve head (Topcon 3-D OCT-1000). We determined the mean thicknesses of the RNFL, retinal ganglion cell layer (RGCL), and inner plexiform layer for regions-of-interest, thus defining a series of OCT parameters, using the Iowa Reference Algorithms. Reference standard was the presence of glaucomatous visual field loss (GVFL); controls were subjects without GVFL, an IOP of 21 mmHg or less, and no positive family history for glaucoma. We calculated the area under the receiver operating characteristics curve (AUCs) and the sensitivity at 97.5% specificity for each parameter. Results: After excluding 23 subjects with an IOP >21 mmHg and 73 subjects with a positive family history for glaucoma, there were 1,087 controls and 41 glaucoma cases. Mean RGCL thickness in the inferior half of the macular region showed the highest AUC (0.85; 95% confidence interval 0.77-0.92) and sensitivity (53.7%; 38.7-68.0%). The mean thickness of the peripapillary RNFL had an AUC of 0.77 (0.69-0.85) and a sensitivity of 24.4% (13.7-39.5%). Conclusions: Macular RGCL loss is at least as common as peripapillary RNFL abnormalities in population-based glaucoma cases. OCT based screening for glaucoma identifies about half of those cases of glaucoma diagnosed by perimetry.

PMID: 25414193 [PubMed – as supplied by publisher]

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The heritability of dry eye disease in a female twin cohort.

The heritability of dry eye disease in a female twin cohort.
Invest Ophthalmol Vis Sci. 2014 Sep 23;
Authors: Vehof J, Wang B, Kozareva D, Hysi PG, Snieder H, Hammond CJ
Abstract
Purpose: To estimate … Continue reading

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Car Driving Performance in Hemianopia: an On-Road Driving Study.

Car Driving Performance in Hemianopia: an On-Road Driving Study.
Invest Ophthalmol Vis Sci. 2014 Sep 11;
Authors: de Haan GA, Melis-Dankers B, Brouwer WH, Bredewoud RA, Tucha O, Heutink J
Abstract
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Glaucoma considered as an imbalance between production and clearance of neurotoxins.

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Glaucoma considered as an imbalance between production and clearance of neurotoxins.

Invest Ophthalmol Vis Sci. 2014;55(8):5351-2

Authors: …

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Predicting and Preventing Visual Impairment and Blindness by Incorporating Individual Progression Velocity in Glaucoma Care.

Predicting and Preventing Visual Impairment and Blindness by Incorporating Individual Progression Velocity in Glaucoma Care.

Invest Ophthalmol Vis Sci. 2014;55(7):4470-4474

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Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season.

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Factors that influence standard automated perimetry test results in glaucoma: test reliability, technician experience, time of day, and season.

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Antithrombotic medication and incident open-angle glaucoma.

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Antithrombotic medication and incident open-angle glaucoma.

Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3801-5

Authors: Marcus MW, Müskens RP, Ramdas WD,…

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Force analysis of bacterial transmission from contact lens cases to corneas, with the contact lens as the intermediary.

Force analysis of bacterial transmission from contact lens cases to corneas, with the contact lens as the intermediary.
Invest Ophthalmol Vis Sci. 2011 Apr;52(5):2565-70
Authors: Qu W, Hooymans JM, de Vries J, van der Mei HC, … Continue reading

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