Category Archives: Liver Transpl

Viability criteria for functional assessment of donor livers during normothermic machine perfusion.

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Viability criteria for functional assessment of donor livers during normothermic machine perfusion.
Liver Transpl. 2018 Sep 07;:
Authors: van Leeuwen OB, de Meijer VE, Porte RJ
Abstract
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Reply to Letter to the Editor by Patrono et al. (LT-18-211), concerning manuscript: Normothermic Machine Perfusion of Donor Livers Without the Need for Human Blood Products (LT-17-589.R2).

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Reply to Letter to the Editor by Patrono et al. (LT-18-211), concerning manuscript: Normothermic Machine Perfusion of Donor Livers Without the Need for Human Blood Products (LT-17-589.R2).
Liver Transpl. 2018 … Continue reading

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End-Ischemic Machine Perfusion Reduces Bile Duct Injury In Donation After Circulatory Death Rat Donor Livers.

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End-Ischemic Machine Perfusion Reduces Bile Duct Injury In Donation After Circulatory Death Rat Donor Livers.
Liver Transpl. 2015 Jun 19;
Authors: Westerkamp AC, Mahboub P, Meyer SL, Hottenrot M, Otte… Continue reading

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Is there a scientific rationale for thrombolytic therapy to prevent biliary complications in donation after circulatory death liver transplantation?

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Is there a scientific rationale for thrombolytic therapy to prevent biliary complications in donation after circulatory death liver transplantation?
Liver Transpl. 2015 Jun 4;
Authors: Burlage LC, Kar… Continue reading

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Prevalence of psychological problems and associated transplant-related variables at different time periods after liver transplantation.

Prevalence of psychological problems and associated transplant-related variables at different time periods after liver transplantation.

Liver Transpl. 2014 Dec 30;

Authors: Annema C, Roodbol PF, Stewart RE, Porte RJ, Ranchor AV

Abstract
After liver transplantation, recipients often experience psychological problems that are influenced by demographic, personal and transplant-related variables. However, because previous studies have mostly reported on psychological problems and their influencing factors in the first years after transplantation, less is known about their prevalence and influence in the long run. The aim of this study was to examine point-prevalence rates of symptoms of anxiety, depression and posttraumatic stress at different time periods after transplantation, as well as transplant-related variables associated with these problems. A cross-sectional survey was performed among 373 liver transplant recipients transplanted between 1979 and 2009 at our center. Five clinically relevant time periods were identified: 0.5-<2 years, 2-<5 years, 5-<10 years, 10-<15 years, and ≥15 years after transplantation. The response rate was 75% (n=281). Overall, 33.4% of the respondents experienced clinically relevant symptom levels of anxiety (28.7%), depression (16.5%), or posttraumatic stress (10.0%). Symptoms of anxiety and depression were more prevalent in the first two years and at long-term after transplantation. Posttraumatic stress symptoms were more prevalent in the first five years after transplantation. However, the prevalence rates did not differ significantly between time periods. Viral hepatitis and the number of side-effects of the immunosuppressive medication were found to be associated with all psychological problems. Alcoholic liver disease was associated with anxiety and depression at short-term after transplantation. In conclusion, a significant subset of transplant recipients experience psychological problems, both shortly after transplantation and in the long run. These problems are often associated with side-effects of the immunosuppressive medication. Therefore monitoring of psychological problems, offering psychological counseling and managing medication side-effects should be part of the routine care of transplant recipients. This article is protected by copyright. All rights reserved.

PMID: 25556775 [PubMed – as supplied by publisher]

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Experience with Molecular Adsorbents Recirculation System Treatment in Twenty Children Listed for High Urgency Liver Transplantation.

Experience with Molecular Adsorbents Recirculation System Treatment in Twenty Children Listed for High Urgency Liver Transplantation.

Liver Transpl. 2014 Nov 4;

Authors: Lexmond WS, Van Dael CM, Scheenstra R, Goorhuis JF, Sieders E, Verkade HJ, Van Rheenen PF, Kömhoff M

Abstract
For over 10 years, children in our national center for pediatric liver transplantation have been treated with Molecular Adsorbent Recirculation System (MARS) liver dialysis as a bridging therapy to high urgency liver transplantation. Treatment was reserved for 20 patients with the highest degrees of hepatic encephalopathy (median grade 3.5), in whom death from neurological sequelae was considered imminent, which was further reflected in significantly higher INR, ammonia levels and worse prognostic liver indexes (MELD/PELD and Liver Injury Units) than in 32 waitlisted patients who did not receive MARS dialysis. MARS therapy was generally well tolerated, with a reduction in thrombocytes and hemorrhage as most common side effects. Improvement of hepatic encephalopathy was documented in 30% of treated patients, but progression to grade IV encephalopathy occurred in 45% of patients despite treatment. Serum ammonia, bilirubin, bile acids and creatinine significantly decreased during treatment. 80% of MARS treated patients survived to undergo liver transplantation, and survival was equivalent to that of non-MARS-treated patients with severe liver failure (69%, p=0.52). The heterogeneity between MARS-treated and -untreated patients in our cohort precludes the statistical evaluation of a benefit of MARS on patient survival. Our data demonstrate safety of MARS even in the most severely ill patients awaiting liver transplantation, but strategies that promote a more rapid and widespread availability of high-quality donor organs remain of critical importance for improving patient survival in cases of severe acute liver failure. Liver Transpl , 2014. © 2014 AASLD.

PMID: 25366362 [PubMed – as supplied by publisher]

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Response letter to: “Patient Preferences about Organ Offers in Liver Transplantation”

Response letter to: “Patient Preferences about Organ Offers in Liver Transplantation”
Liver Transpl. 2014 Oct 28;
Authors: Op den Dries S, Porte RJ
PMID: 25348089 [PubMed – as supplied by publisher]

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Opportunities for scientific expansion of the deceased donor pool.

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Opportunities for scientific expansion of the deceased donor pool.

Liver Transpl. 2014 Sep 13;

Authors: Porte RJ

PMID: 25219379 [PubMed…

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Shared Decision Making in Transplantation: How Patients See Their Role in The Decision Process of Accepting a Donor Liver.

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Shared Decision Making in Transplantation: How Patients See Their Role in The Decision Process of Accepting a Donor Liver.

Liver Transpl. 2014 May 24;

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Duct-to-duct reconstruction in liver transplantation for PSC is associated with less biliary complications, compared with hepatico-jejunostomy.

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Duct-to-duct reconstruction in liver transplantation for PSC is associated with less biliary complications, compared with hepatico-jejunostomy.

Liver Transpl. 2014…

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Markers for microvascular invasion in hepatocellular carcinoma: Where do we stand?

Markers for microvascular invasion in hepatocellular carcinoma: Where do we stand?

Liver Transpl. 2011 Oct;17 Suppl 2:S72-80

Authors: Gouw AS, Balabaud C, Kusano H, Todo S, Ichida…

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No evidence for systemic platelet activation during or after orthotopic liver transplantation.

No evidence for systemic platelet activation during or after orthotopic liver transplantation.
Liver Transpl. 2009 Aug;15(8):956-62
Authors: Pereboom IT, Adelmeijer J, van Leeuwen Y, Hendriks HG, Porte RJ, Lisman T
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