Category Archives: Am J Clin Nutr

Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial.

Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial.

Am J Clin Nutr. 2016 Apr 6;

Authors: Joris PJ, Plat J, Bakker SJ, Mensink RP

Abstract
BACKGROUND: Epidemiologic studies have suggested a protective effect of magnesium intake on cardiovascular disease risk. However, intervention trials of magnesium supplementation on blood pressure and conventional cardiometabolic risk markers are inconsistent. Effects on vascular function markers related to cardiovascular disease risk have rarely been studied.
OBJECTIVE: The objective was to evaluate the effects of long-term magnesium supplementation on arterial stiffness.
DESIGN: We performed a 24-wk, randomized, double-blind, placebo-controlled intervention study. Fifty-two overweight and slightly obese individuals (30 men and 22 postmenopausal women, mean ± SD age: 62 ± 6 y) were randomly allocated to receive either 3 times daily magnesium (3 × 117 mg or 350 mg/d) or placebo capsules. Twenty-four-hour urine collections and 24-h ambulatory blood pressure assessments were performed at the start and end of the study. Carotid-to-femoral pulse wave velocity (PWVc-f) was assessed at baseline, after 12 wk, and at week 24.
RESULTS: Serum magnesium concentrations did not differ after 12 wk but tended to increase after 24-wk magnesium supplementation compared with placebo by 0.02 mmol/L (95% CI: 0.00, 0.04 mmol/L;P= 0.09). Twenty-four-hour urinary magnesium excretion increased by 2.01 mmol (95% CI: 1.22, 2.93 mmol;P< 0.001) at week 24. PWVc-fwas not changed after 12 wk (0.0 m/s; 95% CI: -0.6, 0.5 m/s;P= 0.90) but was improved in the magnesium compared with the placebo group by 1.0 m/s (95% CI: 0.4, 1.6 m/s;P= 0.001) after 24 wk. Office and 24-h ambulatory blood pressure levels were not changed. No adverse events were observed.
CONCLUSION: Our data indicate that a daily magnesium supplement of 350 mg for 24 wk in overweight and obese adults reduces arterial stiffness, as estimated by a decrease in PWVc-f, suggesting a potential mechanism by which an increased dietary magnesium intake beneficially affects cardiovascular health. This trial was registered atclinicaltrials.govasNCT02235805.

PMID: 27053384 [PubMed – as supplied by publisher]

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Assessing magnesium by 24-h urinary excretion.

Assessing magnesium by 24-h urinary excretion.
Am J Clin Nutr. 2015 Jan;101(1):240-1
Authors: Joosten MM, Gansevoort RT, Bakker SJ
PMID: 25527768 [PubMed – in process]

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Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study.

Cost-effectiveness of intestinal transplantation for adult patients with intestinal failure: a simulation study.

Am J Clin Nutr. 2015 Jan;101(1):79-86

Authors: Roskott AM, Groen H, Rings EH, Haveman JW, Ploeg RJ, Serlie MJ, Wanten G, Krabbe PF, Dijkstra G

Abstract
BACKGROUND: Home parenteral nutrition (HPN) and intestinal transplantation (ITx) are the 2 treatment options for irreversible intestinal failure (IF).
OBJECTIVE: This study simulated the disease course of irreversible IF and both of these treatments-HPN and ITx-to estimate the cost-effectiveness of ITx.
DESIGN: We simulated IF treatment in adults as a discrete event model with variables derived from the Dutch Registry of Intestinal Failure and Intestinal Transplantation, the Intestinal Transplant Registry, hospital records, the literature, and expert opinions. Simulated patients were enrolled at a rate of 40/mo for 10 y. The maximum follow-up was 40 y. Survival was simulated as a probabilistic function. ITx was offered to 10% of patients with <12 mo of remaining life expectancy with HPN if they did not undergo ITx. Costs were calculated according to Dutch guidelines, with discounting. We evaluated the cost-effectiveness of ITx by comparing models conducted with and without ITx and by calculating the cost difference per life-year gained [incremental cost-effectiveness ratio (ICER)].
RESULTS: The average survival was 14.6 y without ITx and 14.9 y with ITx. HPN costs were €13,276 for treatment introduction, followed by €77,652 annually. The costs of ITx were ∼€73,000 during the first year and then €13,000 annually. The ICER was €19,529 per life-year gained.
CONCLUSION: Our simulations show that ITx slightly improves survival of patients with IF in comparison with HPN at an additional cost of €19,529 per life-year gained.

PMID: 25527753 [PubMed – in process]

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Can we define an infant’s need from the composition of human milk?

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Can we define an infant’s need from the composition of human milk?

Am J Clin Nutr. 2013 Aug;98(2):521S-8S

Authors: Stam J, Sauer PJ, Boehm G

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Urinary and plasma magnesium and risk of ischemic heart disease.

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Urinary and plasma magnesium and risk of ischemic heart disease.

Am J Clin Nutr. 2013 Jun;97(6):1299-306

Authors: Joosten MM, Gansevoort RT, Mukamal KJ,…

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Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men.

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Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men.

Am J Clin Nutr….

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Should dietary SFA be exchanged for linoleic acid?

Should dietary SFA be exchanged for linoleic acid?
Am J Clin Nutr. 2012 Oct;96(4):944-5
Authors: Muskiet FA, Muskiet MH
PMID: 22996625 [PubMed – in process]

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Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations.

Prenatal and early postnatal supplementation with long-chain polyunsaturated fatty acids: neurodevelopmental considerations.

Am J Clin Nutr. 2011 Dec;94(6 Suppl):1874S-1879S

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An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
Am J Clin Nutr. 2010 Apr;91(4):1044-59
Authors: Bakker GC, van Erk MJ, Pellis L, Wopereis S… Continue reading

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Combined effect of alcohol consumption and lifestyle behaviors on risk of type 2 diabetes.

Combined effect of alcohol consumption and lifestyle behaviors on risk of type 2 diabetes.
Am J Clin Nutr. 2010 Jun;91(6):1777-83
Authors: Joosten MM, Grobbee DE, van der A DL, Verschuren WM, Hendriks HF, Beulens JW
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