Category Archives: Am J Respir Crit Care Med

Setting PEEP in Pediatric Acute Respiratory Distress Syndrome: Cookbook or Individualized Titration?

Setting PEEP in Pediatric Acute Respiratory Distress Syndrome: Cookbook or Individualized Titration?
Am J Respir Crit Care Med. 2018 Jun 29;:
Authors: Koopman AA, Kneyber MCJ
PMID: 29958026 [PubMed – as suppl… Continue reading

Posted in Am J Respir Crit Care Med | Tagged , | Leave a comment

Air Trapping in Emphysema.

Related Articles
Air Trapping in Emphysema.
Am J Respir Crit Care Med. 2015 Sep 1;192(5):e45
Authors: Slebos DJ, van Rikxoort EM, van der Bij W
PMID: 26325161 [PubMed – as supplied by publisher]

Continue reading

Posted in Am J Respir Crit Care Med | Leave a comment

Development of a Hypercoagulable Status in Patients Undergoing Off-Pump Lung Transplantation despite Prolonged Conventional Coagulation Tests.

Development of a Hypercoagulable Status in Patients Undergoing Off-Pump Lung Transplantation despite Prolonged Conventional Coagulation Tests.
Am J Respir Crit Care Med. 2015 Jan 15;191(2):230-233
Authors: Ruitenbeek… Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Novel Genes for Airway Wall Thickness Identified with Combined Genome Wide Association and Expression Analyses.

Novel Genes for Airway Wall Thickness Identified with Combined Genome Wide Association and Expression Analyses.

Am J Respir Crit Care Med. 2014 Dec 17;

Authors: Dijkstra AE, Postma DS, van Ginneken B, Wielpütz MO, Schmidt M, Becker N, Owsijewitsch M, Kauczor HU, de Koning HJ, Lammers JW, Oudkerk M, Brandsma CA, Bossé Y, Nickle DC, Sin DD, Hiemstra PS, Wijmenga C, Smolonska J, Zanen P, Vonk JM, van den Berge M, Boezen HM, Groen HJ

Abstract
Rationale Airway wall thickness (AWT) is affected by both environmental and genetic factors and is strongly associated with airflow limitation in smaller airways. Objectives The aim of our study was to investigate its genetic component. Methods AWT was measured on low-dose CT-scans in male heavy smokers participating in a lung cancer screening study (n = 2,640). Genome wide association studies on AWT were performed under an additive model using linear regression (adjusted for pack-years, lung volume), followed by meta-analysis. An independent cohort was used for validation of the most strongly associated single nucleotide polymorphisms (SNPs). The functional relevance of significant SNPs was evaluated. Measurements and main results Three significant loci on chromosomes 2q (rs734556, p = 6.2×10-7) and 10q (rs10794108, p = 8.6×10-8; rs7078439, p = 2.3×10-7) were associated with AWT and confirmed in the meta-analysis in cohorts with comparable lung function: p-values 4.6×10-8, 7.4×10-8 and 7.5×10-8, respectively. SNP rs734556 was associated with decreased lung tissue expression of SERPINE2, a susceptibility gene for emphysema. Two nominally significant SNPs showed effects with similar direction: rs10251504 in MAGI2 (p = 5.8×10-7) and rs4796712 in NT5C3B (p = 3.1×10-6). Higher MAGI2 expression in bronchial biopsies of COPD patients was significantly associated with lower inflammatory cell numbers, lower NT5C3B expression with worse lung function. The NT5C3B risk allele was associated with higher lung tissue expression (p = 1.09×10-41). Conclusions Genetic variants contribute to AWT. Amongst others, the identified genes are involved in emphysema, airway obstruction and bronchial inflammation.

PMID: 25517131 [PubMed – as supplied by publisher]

Continue reading

Posted in Am J Respir Crit Care Med | Leave a comment

NOS1: A Susceptibility Gene for Reduced Level of FEV1 in the Setting of Pesticide Exposure.

NOS1: A Susceptibility Gene for Reduced Level of FEV1 in the Setting of Pesticide Exposure.
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1188-1190
Authors: de Jong K, Vonk JM, Kromhout H, Vermeulen R, Postma DS, Bo… Continue reading

Posted in Am J Respir Crit Care Med | Leave a comment

The Child Is Father of the Man?

The Child Is Father of the Man?
Am J Respir Crit Care Med. 2014 Aug 15;190(4):358-359
Authors: Postma DS, Koppelman GH
PMID: 25127301 [PubMed – as supplied by publisher]

Continue reading

Posted in Am J Respir Crit Care Med | Tagged , | Leave a comment

Eosinophilic inflammation in subjects with mild-to-moderate asthma with and without obesity: disparity between sputum and biopsies.

Related Articles

Eosinophilic inflammation in subjects with mild-to-moderate asthma with and without obesity: disparity between sputum and biopsies.

Am J Respir Crit Care…

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.

Related Articles
Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 2014 Jun 1;189(11):1439-42
Authors: Heijink IH, Noordhoek JA, Timens W, van O… Continue reading

Posted in Am J Respir Crit Care Med | Leave a comment

Ventilator-induced Lung Injury: Similarity and Differences Between Children and Adults.

Related Articles

Ventilator-induced Lung Injury: Similarity and Differences Between Children and Adults.

Am J Respir Crit Care Med. 2014 Jul 8;

Authors: Kneyber…

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Untargeted Lipidomic Analysis in COPD: Uncovering Sphingolipids.

Related Articles
Untargeted Lipidomic Analysis in COPD: Uncovering Sphingolipids.
Am J Respir Crit Care Med. 2014 May 28;
Authors: Telenga ED, Hoffmann RF, t’Kindt R, Hoonhorst SJ, Willemse BW, van Oosterhout AJ, Heij… Continue reading

Posted in Am J Respir Crit Care Med | Tagged , | Leave a comment

Hemoptysis and hydrocephalus. Follow the lead.

Related Articles
Hemoptysis and hydrocephalus. Follow the lead.
Am J Respir Crit Care Med. 2014 Feb 1;189(3):e6
Authors: van den Biggelaar RJ, Kerstjens HA, de Jong WK
PMID: 24484353 [PubMed – indexed for MEDL… Continue reading

Posted in Am J Respir Crit Care Med | Tagged , | Leave a comment

Occupational exposure to vapors, gases, dusts, and fumes is associated with small airways obstruction.

Related Articles

Occupational exposure to vapors, gases, dusts, and fumes is associated with small airways obstruction.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):487-90

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

The future of nature versus nurture in understanding chronic obstructive pulmonary disease.

Related Articles
The future of nature versus nurture in understanding chronic obstructive pulmonary disease.
Am J Respir Crit Care Med. 2013 Oct 15;188(8):891-2
Authors: Boezen HM, Mannino DM
PMID: 24127794 [PubMed – in… Continue reading

Posted in Am J Respir Crit Care Med | Leave a comment

Severe sepsis: stay and play or scoop and run?

Severe sepsis: stay and play or scoop and run?

Am J Respir Crit Care Med. 2013 Aug 15;188(4):513

Authors: Ligtenberg JJ, Azizi N, Glatman K, Ter Maaten JC, Zijlstra JG

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Moderately preterm children have more respiratory problems during their first 5 years of life than children born full term.

Related Articles

Moderately preterm children have more respiratory problems during their first 5 years of life than children born full term.

Am J Respir Crit Care Med. 2013 Jun…

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Burnout or built in?

Burnout or built in?
Am J Respir Crit Care Med. 2012 Apr 1;185(7):787-8
Authors: Zijlstra JG, Aardema H, Van Meurs M
PMID: 22467808 [PubMed – in process]

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Leave a comment

Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma.

Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma.

Am J Respir Crit Care Med. 2011 Feb 1;183(3):310-6

Authors: Broekema M, Timens W,…

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Comments Off on Persisting remodeling and less airway wall eosinophil activation in complete remission of asthma.

Does lactate-guided therapy really improve outcome?

Does lactate-guided therapy really improve outcome?
Am J Respir Crit Care Med. 2011 Mar 1;183(5):680; author reply 680-1
Authors: de Ruiter J, Zijlstra JG, Ligtenberg JJ
PMID: 21471058 [PubMed – indexed for MEDLINE]

Continue reading

Posted in Am J Respir Crit Care Med | Tagged | Comments Off on Does lactate-guided therapy really improve outcome?