Category Archives: Med Hypotheses

Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer’s disease.

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Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer’s disease.
Med Hypotheses. 2019 Jan;122:57
Authors: Wostyn P, Van Dam D, De Deyn PP
PMID: 30593424 … Continue reading

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Circuits regulating pleasure and happiness in major depression.

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Circuits regulating pleasure and happiness in major depression.

Med Hypotheses. 2016 Feb;87:14-21

Authors: Loonen AJ, Ivanova SA

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Circumference as an alternative for diameter measurement in endovascular aneurysm repair.

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Circumference as an alternative for diameter measurement in endovascular aneurysm repair.

Med Hypotheses. 2015 May 12;

Authors: Tielliu IF, Buijs RV, Greuter MJ, Vainas T, Wallis de Vries BM, Prins TR, Zeebregts CJ

Abstract
Appropriate sizing of endografts for endovascular aneurysm repair has traditionally been performed by one standardized method. By measuring the average of the minor and major axes in the sealing zone, the endograft size is traditionally calculated. However, no adequate scientific evaluation has been performed to validate this method. The guidelines that were published are based on theories and experience, more than scientific evidence. In case the central lumen line artery cross-section is a circular disk, the vessel diameter is a reliable estimation. Yet the aortic neck cross-section may not always be geometrically a perfect circular disk. Application of the standardized method might therefore lead to inaccurate endograft sizing, potentially leading to endoleaks. We hypothesize that in these cases the circumference of the vessel is a mathematically correct reference to deduct the appropriate endograft diameter. The following formula was applied in this study: diameter of the corresponding circle (d) equals circumference (C) divided by πd=Cπ. This study provides a theoretical analysis of the mathematical implications of this method. Only in case of highly irregularly shaped cylinders, the circumference-based method was more accurate than the standardized method. Nonetheless, the circumferential method was a practical reference in case the aortic neck was irregularly shaped. Also, the circumference method was accurate in all cases in deducting the diameter of a matching circle. Therefore, the hypothesis that was raised in this study has a strong theoretical base. We predict that in case this hypothesis holds true in the clinical practice, application of the circumference method might lead to less endoleaks than the standardized method.

PMID: 26001992 [PubMed – as supplied by publisher]

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Delayed mood transitions in major depressive disorder.

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Delayed mood transitions in major depressive disorder.

Med Hypotheses. 2014 Feb 22;

Authors: Korf J

Abstract

The hypothesis defended…

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Harvey with a modern twist: How and why conducting arteries amplify the pressure wave originating from the heart.

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Harvey with a modern twist: How and why conducting arteries amplify the pressure wave originating from the heart.
Med Hypotheses. 2014 Feb 24;
Authors: Schaafsma A
Abstract
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Lactase persistence and augmented salivary alpha-amylase gene copy numbers might have been selected by the combined toxic effects of gluten and (food born) pathogens.

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Lactase persistence and augmented salivary alpha-amylase gene copy numbers might have been selected by the combined toxic effects of gluten and (food born) pathogens.

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Gompertz’ survivorship law as an intrinsic principle of aging.

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Gompertz’ survivorship law as an intrinsic principle of aging.

Med Hypotheses. 2012 May;78(5):659-63

Authors: Sas AA, Snieder H, Korf J

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Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status.

Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status.

Med Hypotheses. 2011 Jun;76(6):794-801

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