Category Archives: Psychosom Med

GUT MICROBIOTA AND THE GUT-BRAIN AXIS: NEW INSIGHTS IN THE PATHOPHYSIOLOGY OF METABOLIC SYNDROME.






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GUT MICROBIOTA AND THE GUT-BRAIN AXIS: NEW INSIGHTS IN THE PATHOPHYSIOLOGY OF METABOLIC SYNDROME.
Psychosom Med. 2017 May 27;:
Authors: de Clercq N, Frissen MN, Groen AK, Nieuwdorp M
Abstract
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Risk of Coronary Heart Disease in Men with Poor Emotional Control: A Prospective Study.






Risk of Coronary Heart Disease in Men with Poor Emotional Control: A Prospective Study.
Psychosom Med. 2015 Nov 13;
Authors: Potijk MR, Janszky I, Reijneveld SA, Falkstedt D
Abstract
OBJECTIVE: Many p… Continue reading






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Association of Depressive and Anxiety Disorders With Diagnosed Versus Undiagnosed Diabetes: An Epidemiological Study of 90,686 Participants.






Association of Depressive and Anxiety Disorders With Diagnosed Versus Undiagnosed Diabetes: An Epidemiological Study of 90,686 Participants.

Psychosom Med. 2015 Oct 8;

Authors: Meurs M, Roest AM, Wolffenbuttel BH, Stolk RP, de Jonge P, Rosmalen JG

Abstract
OBJECTIVE: To compare the odds of depressive and anxiety disorders for participants with diagnosed diabetes, participants with diabetes but unaware of this, and participants without diabetes. Such knowledge might improve etiological insight into psychopathology in diabetes.
METHODS: Data of 90,686 participants (mean age = 45 years; 59% female) was used from LifeLines. Depressive and anxiety disorders were assessed by the Mini-International Neuropsychiatric Interview. The odds of depression and anxiety were assessed for three groups: a) diagnosed diabetes, diabetes medication use and/or self-reported “diabetes”; b) undiagnosed diabetes, fasting blood glucose ≥7.0 mmol/l, but no diabetes medication use and self-reported “no diabetes”; and c) no diabetes, fasting blood glucose <7.0 mmol/l and self-reported “no diabetes.” Logistic regression was performed to compare the odds of depression and anxiety in these groups, adjusting for age, sex, diabetes-related diseases, comorbid depressive or anxiety disorders, and glycosylated hemoglobin.
RESULTS: A total of 3002 (3.3%) participants were diagnosed as having depression and 9018 (9.9%) as having anxiety; 1781 (2.0%) had diagnosed and 786 (0.9%) had undiagnosed diabetes. Both diagnosed (odds ratio [OR] = 1.4:1.1-1.8, p = .006) and undiagnosed (OR = 1.8:1.3-2.6, p = .001) diabetes were independently associated with depression. The odds of depression did not differ between diagnosed and undiagnosed diabetes (OR = 0.7, p = .17). Diagnosed diabetes was independently associated with anxiety (OR = 1.4:1.2-1.7, p < .001), but undiagnosed diabetes was not (OR = 0.8:0.6-1.1, p = .20). The odds of anxiety were significantly higher in diagnosed compared with undiagnosed diabetes (1.68:1.23-2.31, p = .001).
CONCLUSIONS: Depression was more prevalent in participants with diagnosed and undiagnosed diabetes, whereas anxiety was more prevalent only in participants who were aware of their diabetes. Longitudinal research is needed to assess the causal pathways of these associations.

PMID: 26452174 [PubMed – as supplied by publisher]

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Systematic Review and Individual Patient Data Meta-Analysis of Sex Differences in Depression and Prognosis in Persons With Myocardial Infarction: A MINDMAPS Study.






Systematic Review and Individual Patient Data Meta-Analysis of Sex Differences in Depression and Prognosis in Persons With Myocardial Infarction: A MINDMAPS Study.
Psychosom Med. 2015 Apr 17;
Authors: Doyle F, McGee … Continue reading






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Adverse Life Events and Allele-Specific Methylation of the Serotonin Transporter Gene (SLC6A4) in Adolescents: The TRAILS Study.






Adverse Life Events and Allele-Specific Methylation of the Serotonin Transporter Gene (SLC6A4) in Adolescents: The TRAILS Study.
Psychosom Med. 2015 Mar 18;
Authors: van der Knaap LJ, Riese H, Hudziak JJ, Verbiest MM… Continue reading






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Nitric Oxide Dysregulation in Patients With Heart Failure: The Association of Depressive Symptoms With L-Arginine, Asymmetric Dimethylarginine, Symmetric Dimethylarginine, and Isoprostane.






Nitric Oxide Dysregulation in Patients With Heart Failure: The Association of Depressive Symptoms With L-Arginine, Asymmetric Dimethylarginine, Symmetric Dimethylarginine, and Isoprostane.

Psychosom Med. 2015 Apr 19;

Authors: Mommersteeg PM, Schoemaker RG, Eisel UL, Garrelds IM, Schalkwijk CG, Kop WJ

Abstract
OBJECTIVE: Nitric oxide (NO) regulation plays a critical role in cardiovascular diseases including heart failure (HF). Markers of NO dysregulation have been found in individuals with depression without cardiovascular disease. Because depression is associated with poor HF outcomes, the present study tested the hypothesis that depression is associated with a dysregulated NO pathway in patients with HF.
METHODS: Serum levels of NO regulation (L-arginine, asymmetric dimethylarginine [ADMA], and symmetric dimethylarginine [SDMA]) and oxidative stress (isoprostane 8-epi prostaglandin F2α) were measured in 104 patients with HF (mean [standard deviation] age = 65.7 [8.4] years, 28% women) at baseline and 12 months. Depressive symptoms were measured using the Beck Depression Inventory. The associations between depressive symptoms with markers of NO regulation were examined with mixed-model analysis, adjusted for age, sex, time of assessment, left ventricular ejection fraction, creatinine, and hypertension.
RESULTS: Depressive symptoms were correlated with a lower L-arginine/ADMA ratio (r = -0.22, p = .003) and higher SDMA levels (r = 0.28, p < .001). Associations were similar for somatic depressive symptoms and cognitive-affective symptoms (L-arginine/ADMA ratio: r = -0.20 [p = .009] versus r = -0.19 [p = .013]; ADMA: r = 0.16 [p = .043] versus r = 0.10 [p = .20]; SDMA: r = 0.27 [p < .001] versus r = 0.22 [p = .005], respectively). No associations were found between depressive symptoms and isoprostane. The association between depression and the L-arginine/ADMA ratio remained significant in multivariate adjusted models.
CONCLUSIONS: Depressive symptoms were associated with markers of NO dysregulation, particularly the L-arginine/ADMA ratio and SDMA, in patients with HF. The lower L-arginine/ADMA ratio indicates less available NO, suggesting that NO-related endothelial dysfunction may play a role in the adverse risk of HF progression associated with depression.

PMID: 25790241 [PubMed – as supplied by publisher]

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Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study.






Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study.
Psychosom Med. 2015 Mar 12;
Authors: Janssens KA, Zijlema WL, Joustra ML, R… Continue reading






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Ethnic Differences in Resting Heart Rate Variability: A Systematic Review and Meta-Analysis.






Ethnic Differences in Resting Heart Rate Variability: A Systematic Review and Meta-Analysis.
Psychosom Med. 2014 Dec 30;
Authors: Hill LK, Hu DD, Koenig J, Sollers JJ, Kapuku G, Wang X, Snieder H, Thayer JF
A… Continue reading






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Significance and Costs of Complex Biopsychosocial Health Care Needs in Elderly People: Results of a Population-Based Study.






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Significance and Costs of Complex Biopsychosocial Health Care Needs in Elderly People: Results of a Population-Based Study.

Psychosom Med. 2014 Aug 13;

Authors: Wild B, Heider D, Maatouk I, Slaets J, König HH, Niehoff D, Saum KU, Brenner H, Söllner W, Herzog W

Abstract
OBJECTIVE: To improve health care for the elderly, a consideration of biopsychosocial health care needs may be of particular importance-especially because of the prevalence of multiple conditions, mental disorders, and social challenges facing elderly people. The aim of the study was to investigate significance and costs of biopsychosocial health care needs in elderly people.
METHODS: Data were derived from the 8-year follow-up of the ESTHER study-a German epidemiological study in the elderly population. A total of 3124 participants aged 57 to 84 years were visited at home by trained medical doctors. Biopsychosocial health care needs were assessed using the INTERMED for the Elderly (IM-E) interview. Health-related quality of life (HRQOL) was measured by the 12-Item Short-Form Health Survey, and psychosomatic burden was measured by the Patient Health Questionnaire.
RESULTS: The IM-E correlated with decreased mental (mental component score: r = -0.38, p < .0001) and physical HRQOL (physical component score: r = -0.45, p < .0001), increased depression severity (r = 0.53, p < .0001), and costs (R = 0.41, p < .0001). The proportion of the participants who had an IM-E score of at least 21 was 8.2%; according to previous studies, they were classified as complex patients (having complex biopsychosocial health care needs). Complex patients showed a highly reduced HRQOL compared with participants without complex health care needs (mental component score: 37.0 [10.8] versus 48.7 [8.8]; physical component score: 33.0 [9.1] versus 41.6 [9.5]). Mean health care costs per 3 months of complex patients were strongly increased (1651.1 &euro; [3192.2] versus 764.5 &euro; [1868.4]).
CONCLUSIONS: Complex biopsychosocial health care needs are strongly associated with adverse health outcomes in elderly people. It should be evaluated if interdisciplinary treatment plans would improve the health outcomes for complex patients.

PMID: 25121639 [PubMed – as supplied by publisher]

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Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue.






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Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue.

Psychosom Med. 2014 Mar 14;

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Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue.






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Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue.

Psychosom Med. 2014 Mar 14;

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Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress.






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Genetic influence on blood pressure and underlying hemodynamics measured at rest and during stress.
Psychosom Med. 2013 May;75(4):404-12
Authors: Wu T, Treiber FA, Snieder H
Abstract
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Cognitive-Affective Symptoms of Depression After Myocardial Infarction: Different Prognostic Importance Across Age Groups.






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Cognitive-Affective Symptoms of Depression After Myocardial Infarction: Different Prognostic Importance Across Age Groups.

Psychosom Med. 2013 Jul 19;

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Structural and Electrical Myocardial Remodeling in a Rodent Model of Depression.






Structural and Electrical Myocardial Remodeling in a Rodent Model of Depression.

Psychosom Med. 2012 Dec 20;

Authors: Carnevali L, Trombini M, Rossi S, Graiani G, Manghi M,…

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Longitudinal Relationship of Depressive and Anxiety Symptoms With Dyslipidemia and Abdominal Obesity.






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Longitudinal Relationship of Depressive and Anxiety Symptoms With Dyslipidemia and Abdominal Obesity.
Psychosom Med. 2012 Nov 28;
Authors: van Reedt Dortland AK, Giltay EJ, van Veen T, Zitman FG, Penninx BW
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The Temporal Relation Between Pain and Depression: Results From the Longitudinal Aging Study Amsterdam.






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The Temporal Relation Between Pain and Depression: Results From the Longitudinal Aging Study Amsterdam.
Psychosom Med. 2012 Oct 31;
Authors: Hilderink PH, Burger H, Deeg DJ, Beekman AT, Oude Voshaar RC
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Revealing causal heterogeneity using time series analysis of ambulatory assessments: application to the association between depression and physical activity after myocardial infarction.






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Revealing causal heterogeneity using time series analysis of ambulatory assessments: application to the association between depression and physical activity after myocardial infarction.
Psychosom Med. 2012 May;74(4):37… Continue reading






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Vital exhaustion and somatic depression: the same underlying construct in patients with myocardial infarction?






Vital exhaustion and somatic depression: the same underlying construct in patients with myocardial infarction?
Psychosom Med. 2012 Jun;74(5):446-51
Authors: Vroege EM, Zuidersma M, de Jonge P
Abstract
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Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study.






Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study.

Psychosom Med. 2011 Sep;73(7):541-7

Authors: Hoen PW, de Jonge…

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Lack of prognostic value of type d personality for mortality in a large sample of heart failure patients.






Lack of prognostic value of type d personality for mortality in a large sample of heart failure patients.
Psychosom Med. 2011 Sep;73(7):557-62
Authors: Coyne JC, Jaarsma T, Luttik ML, van Sonderen E, van Veldhuisen DJ, Sanderm… Continue reading






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