Category Archives: J Am Acad Dermatol

Response to letter to the editor: “Pruritus with pemphigoid autoantibodies is the tip of an iceberg”.

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Response to letter to the editor: “Pruritus with pemphigoid autoantibodies is the tip of an iceberg”.
J Am Acad Dermatol. 2019 Jul 29;:
Authors: Lamberts A, Meijer J, Diercks G, Pas H, Horváth B
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Nonbullous cutaneous pemphigoid: a systematic review.

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Nonbullous cutaneous pemphigoid: a systematic review.
J Am Acad Dermatol. 2017 Nov 01;:
Authors: Lamberts A, Meijer JM, Jonkman MF
Abstract
BACKGROUND: Cutaneous pemphigoid (bullous pe… Continue reading

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Pain management in patients with hidradenitis suppurativa.

Pain management in patients with hidradenitis suppurativa.

J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S47-51

Authors: Horváth B, Janse IC, Sibbald GR

Abstract

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Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts.

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Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts.

J Am Acad Dermatol. 2015 Jan;72(1):168-74

Authors: Murrell DF, Marinovic B, Caux F, Prost C, Ahmed R, Wozniak K, Amagai M, Bauer J, Beissert S, Borradori L, Culton D, Fairley JA, Fivenson D, Jonkman MF, Marinkovich MP, Woodley D, Zone J, Aoki V, Bernard P, Bruckner-Tuderman L, Cianchini G, Venning V, Diaz L, Eming R, Grando SA, Hall RP, Hashimoto T, Herrero-González JE, Hertl M, Joly P, Karpati S, Kim J, Chan Kim S, Korman NJ, Kowalewski C, Lee SE, Rubenstein DR, Sprecher E, Yancey K, Zambruno G, Zillikens D, Doan S, Daniel BS, Werth VP

Abstract
Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

PMID: 25443626 [PubMed – indexed for MEDLINE]

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Comments on: DRESS syndrome.

Comments on: DRESS syndrome.
J Am Acad Dermatol. 2014 Nov;71(5):1000-1000.e2
Authors: Kardaun SH, Mockenhaupt M, Roujeau JC
PMID: 25437959 [PubMed – as supplied by publisher]

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Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification.

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Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification.
J Am Acad Dermatol. 2014 Jun;70(6):1103-26
Authors: Fine JD, Bruckner-Tuderman L, Eady RA, Bauer EA, Bauer JW… Continue reading

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Successful therapeutic transplantation of revertant skin in epidermolysis bullosa.

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Successful therapeutic transplantation of revertant skin in epidermolysis bullosa.

J Am Acad Dermatol. 2014 Jan;70(1):98-101

Authors: Gostyński A, Pasmooij AM, Jonkman MF

Abstract
BACKGROUND: Epidermolysis bullosa (EB) is a group of genetic blistering diseases. Despite many efforts, treatment for EB remains symptomatic. Revertant mosaicism, coexistence of cells carrying disease-causing mutations with cells in which the inherited mutation is genetically corrected by a spontaneous genetic event (revertant cells) in 1 individual, can be found in EB. The naturally corrected revertant keratinocytes provide an opportunity for autologous cell therapy.
OBJECTIVE: We sought to locally treat EB by transplantation of revertant skin.
METHODS: Persistent ulcers in a patient with non-Herlitz junctional EB caused by mutations in the LAMB3 gene were treated by transplantation of split-thickness biopsy specimens from one of his revertant patches.
RESULTS: All transplanted biopsy specimens were accepted and complete re-epithelialization occurred within 14 days. During 18 months of follow-up, the patient never experienced blisters or wounds in the grafted area, nor in the healed donor site. Immunofluorescence and DNA sequencing showed that acceptor sites healed with transplanted revertant keratinocytes.
LIMITATIONS: Punch grafting allows only limited expansion of revertant skin.
CONCLUSIONS: We demonstrate that phenotypical and genotypical correction of skin in patients with revertant mosaicism by expansion of revertant skin might be a promising therapeutic option for cutaneous manifestations of EB.

PMID: 24176523 [PubMed – indexed for MEDLINE]

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Punch grafting of chronic ulcers in patients with laminin-332-deficient, non-Herlitz junctional epidermolysis bullosa.

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Punch grafting of chronic ulcers in patients with laminin-332-deficient, non-Herlitz junctional epidermolysis bullosa.

J Am Acad Dermatol. 2013 Jan;68(1):93-7, 97.e1-2

Authors: Yuen WY, Huizinga J, Jonkman MF

Abstract
BACKGROUND: Epidermolysis bullosa (EB) is a genetic, heterogeneous, trauma-induced blistering disease. Patients with laminin-332-deficient non-Herlitz junctional EB (JEB-nH) can have impaired wound healing witnessed by persistent, small, deep ulcers on the hands and feet that adversely affect the quality of life.
OBJECTIVE: We sought to present the results of punch grafting in patients with laminin-332-deficient JEB-nH, and to discuss its therapeutic value.
METHODS: Retrospective analysis of the Dutch EB Registry revealed 4 patients with laminin-332-deficient JEB-nH who were treated with punch grafting. Punch grafting was performed according to protocol, and the patients were followed up.
RESULTS: In the past 10 years we have treated 23 ulcers in 4 patients with JEB-nH using punch grafting without any complications or adverse effects. The ulcers had on average persisted 6 years before treatment. Healing rate after punch grafting was 70% (n = 16), with a mean healing time of 2 months. Thirty percent (n = 7) of the treated ulcers did not completely heal, but did show improvement. The recurrence rate after 3 months was 13% (n = 2), and was a result of renewed blistering.
LIMITATIONS: Limitations of the study are the retrospective design, small number of patients, absence of a control group, and follow-up and ulcer measurement that were not standardized.
CONCLUSIONS: Punch grafting can be used as a first-line treatment in small persistent ulcers in patients with JEB-nH. The method is easy, is inexpensive, has little risk of complications, and results in significant healing rates and improvement in quality of life.

PMID: 22633040 [PubMed – indexed for MEDLINE]

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Topical sirolimus for oral pemphigus vulgaris: 3 unresponsive cases.

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Topical sirolimus for oral pemphigus vulgaris: 3 unresponsive cases.
J Am Acad Dermatol. 2012 Nov;67(5):e228-9
Authors: Poot AM, Jonkman MF
PMID: 23062929 [PubMed – in process]

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Reply.

Reply.

J Am Acad Dermatol. 2012 May;66(5):857-8

Authors: Yuen WY, Jonkman MF

PMID: 22507579 [PubMed – in process]

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Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: Report of 7 cases and a review of the literature.

Risk of squamous cell carcinoma in junctional epidermolysis bullosa, non-Herlitz type: Report of 7 cases and a review of the literature.
J Am Acad Dermatol. 2011 May 28;
Authors: Yuen WY, Jonkman MF
Abstract
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