Category Archives: Ann Surg Oncol

Stage IV melanoma: completely resectable patients are scarce.

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Stage IV melanoma: completely resectable patients are scarce.
Ann Surg Oncol. 2013 Jul;20(7):2352-6
Authors: Wevers KP, Hoekstra HJ
Abstract
BACKGROUND: In melanoma, about 1 in 5 patients devel… Continue reading

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Relation Between Age, Comorbidity, and Complications in Patients Undergoing Major Surgery for Head and Neck Cancer.

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Relation Between Age, Comorbidity, and Complications in Patients Undergoing Major Surgery for Head and Neck Cancer.
Ann Surg Oncol. 2013 Nov 19;
Authors: Peters TT, van Dijk BA, Roodenburg JL, van der Laan BF,… Continue reading

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Breast-Conserving Surgery With or Without Radiotherapy in Older Breast Patients With Early Stage Breast Cancer: A Systematic Review and Meta-analysis.

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Breast-Conserving Surgery With or Without Radiotherapy in Older Breast Patients With Early Stage Breast Cancer: A Systematic Review and Meta-analysis.

Ann Surg Oncol. 2013 Nov 23;

Authors: van de Water W, Bastiaannet E, Scholten AN, Kiderlen M, de Craen AJ, Westendorp RG, van de Velde CJ, Liefers GJ

Abstract
BACKGROUND: In early stage breast cancer, radiotherapy is an integral part of locoregional treatment with breast-conserving surgery. However, few older patients are included in the clinical trials upon which these recommendations are based. Therefore, we performed a systematic review and meta-analysis to evaluate outcomes of radiotherapy after breast-conserving surgery in older patients.
METHODS: A systematic search of PubMed and Embase was undertaken. Inclusion was restricted to randomized controlled trials in postmenopausal breast cancer patients. Pooled odds ratios were calculated for locoregional recurrence, distant recurrence, and overall survival.
RESULTS: We included 5 randomized clinical trials comprising 3,190 patients. Overall, 39 % of the patients were ≥70 years old, and most had hormone receptor-positive T1 tumors without nodal involvement. All patients received adjuvant systemic therapy. Patients who received radiotherapy had a lower relative risk of locoregional recurrence (pooled odds ratio [OR] 0.36; 95 % confidence interval [CI] 0.25-0.50). The 5-year absolute risk was 2.2 % (95 % CI 1.6-3.1) among patients who received radiotherapy, versus 6.5 % (95 % CI 5.3-7.9) among patients who did not. The absolute risk difference was 4.3 % (95 % CI 2.9-5.7), corresponding with a number needed to treat of 24. No differences were observed for distant recurrence or overall survival.
CONCLUSIONS: Although patients who received radiotherapy had a lower relative risk of locoregional recurrence, the absolute risk was low, and overall survival was not affected. We propose that the debate should not only focus on the relative risk but also on the absolute benefit of radiotherapy and the number needed to treat. Both treatment options may be reasonable in clinical practice.

PMID: 24271158 [PubMed – as supplied by publisher]

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Impact of Neoadjuvant Chemoradiotherapy on Postoperative Course after Curative-intent Transthoracic Esophagectomy in Esophageal Cancer Patients.

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Impact of Neoadjuvant Chemoradiotherapy on Postoperative Course after Curative-intent Transthoracic Esophagectomy in Esophageal Cancer Patients.

Ann Surg Oncol. 2013 Oct 8;

Authors: Bosch DJ, Muijs CT, Mul VE, Beukema JC, Hospers GA, Burgerhof JG, Plukker JT

Abstract
BACKGROUND: Neoadjuvant chemoradiotherapy (CRT) improves locoregional control and overall survival in esophageal cancer patients. Although adverse events are relatively low during neoadjuvant CRT, severe postoperative adverse effects may occur, leading to morbidity and even mortality. We investigated the impact of a more frequently used neoadjuvant CRT regimen of 41.4 Gy/5 weeks radiotherapy with concurrent carboplatin and paclitaxel (CROSS schedule) on the postoperative course.
METHODS: Between 2006 and 2012, a total of 96 esophageal cancer patients (staged cT1N+/T2-4a/N0-3 and M0) were treated according to the above neoadjuvant scheme. To reduce bias in this single-center study, we performed a propensity score-matched analysis with patients who underwent surgery alone (n = 230) from a prospectively maintained database (n = 326).
RESULTS: Baseline characteristics between both groups were equally distributed in the matched cohort. In the neoadjuvant treated group, significantly more patients were diagnosed with pneumonia (27.1 vs. 51.0 %; p = 0.001), pleural effusion (12.5 vs. 24.0 %; p = 0.040), and arrhythmia (20.4 vs. 34.4 %; p = 0.008). In addition, in the multivariate analysis, neoadjuvant CRT was significantly associated with an increased risk of pneumonia (p = 0.001, odds ratio 2.896), pleural effusion (p = 0.041, odds ratio 2.268), and arrhythmia (p = 0.023, odds ratio 2.215). Despite these outcomes, no differences were detected in duration of intensive care unit or hospital stay. Short-term mortality did not differ between both groups.
CONCLUSIONS: We observed an increase of cardiopulmonary complications in the neoadjuvant CRT group, without any effect on hospital or intensive care unit stay and mortality. Further research is warranted on the limitation of chemoradiation-induced cardiopulmonary toxicity.

PMID: 24100962 [PubMed – as supplied by publisher]

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Detection of recurrences during follow-up after liver surgery for colorectal metastases: both carcinoembryonic antigen (CEA) and imaging are important.

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Detection of recurrences during follow-up after liver surgery for colorectal metastases: both carcinoembryonic antigen (CEA) and imaging are important.

Ann Surg…

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Therapeutic lymph node dissection in melanoma: different prognosis for different macrometastasis sites?

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Therapeutic lymph node dissection in melanoma: different prognosis for different macrometastasis sites?

Ann Surg Oncol. 2012 Nov;19(12):3913-8

Authors: …

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Radiation-associated angiosarcoma after breast cancer: high recurrence rate and poor survival despite surgical treatment with R0 resection.

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Radiation-associated angiosarcoma after breast cancer: high recurrence rate and poor survival despite surgical treatment with R0 resection.

Ann Surg Oncol. 2012…

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Use of S-100B to evaluate therapy effects during bevacizumab induction treatment in AJCC stage III melanoma.

Use of S-100B to evaluate therapy effects during bevacizumab induction treatment in AJCC stage III melanoma.

Ann Surg Oncol. 2012 Feb;19(2):620-6

Authors: Kruijff S, Bastiaannet E,…

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Risk Factors for Excess Mortality in the First Year After Curative Surgery for Colorectal Cancer.

Risk Factors for Excess Mortality in the First Year After Curative Surgery for Colorectal Cancer.
Ann Surg Oncol. 2012 Mar 7;
Authors: Gooiker GA, Dekker JW, Bastiaannet E, van der Geest LG, Merkus JW, van de Velde CJ, Tollena… Continue reading

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Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients.

Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients.
Ann Surg Oncol. 2011 Jun;18(6):1533-9
Authors: Dekker JW, van den Broek CB, Bastiaannet E, van de Geest LG, Tollenaar RA, Lief… Continue reading

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Enhancing Surgical Vision by Using Real-Time Imaging of α(v)β (3)-Integrin Targeted Near-Infrared Fluorescent Agent.

Enhancing Surgical Vision by Using Real-Time Imaging of α(v)β (3)-Integrin Targeted Near-Infrared Fluorescent Agent.
Ann Surg Oncol. 2011 Apr 21;
Authors: Themelis G, Harlaar NJ, Kelder W, Bart J, Sarantopoulos A, van Dam GM… Continue reading

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Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer?

Value of EUS in Determining Curative Resectability in Reference to CT and FDG-PET: The Optimal Sequence in Preoperative Staging of Esophageal Cancer?
Ann Surg Oncol. 2011 May 6;
Authors: Schreurs LM, Janssens AC, Groen H, Fock… Continue reading

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Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis.

Surgical management of hepatic neuroendocrine tumor metastasis: results from an international multi-institutional analysis.
Ann Surg Oncol. 2010 Dec;17(12):3129-36
Authors: Mayo SC, de Jong MC, Pulitano C, Clary BM, Reddy SK… Continue reading

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Factors determining the sensitivity of intraoperative ultrasonography in detecting colorectal liver metastases in the modern era.

Factors determining the sensitivity of intraoperative ultrasonography in detecting colorectal liver metastases in the modern era.
Ann Surg Oncol. 2010 Oct;17(10):2756-63
Authors: van Vledder MG, Pawlik TM, Munireddy S, Hampe… Continue reading

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Surgical Management and Emerging Therapies to Prolong Survival in Metastatic Neuroendocrine Cancer.

Surgical Management and Emerging Therapies to Prolong Survival in Metastatic Neuroendocrine Cancer.
Ann Surg Oncol. 2010 Sep 17;
Authors: Mayo SC, de Jong MC, Pawlik TM
PMID: 20848222 [PubMed – as supplied by publish… Continue reading

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Liver resection for colorectal metastases in presence of extrahepatic disease: results from an international multi-institutional analysis.

Liver resection for colorectal metastases in presence of extrahepatic disease: results from an international multi-institutional analysis.
Ann Surg Oncol. 2011 May;18(5):1380-8
Authors: Pulitanò C, Bodingbauer M, Aldrighett… Continue reading

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Surgery Versus Intra-arterial Therapy for Neuroendocrine Liver Metastasis: A Multicenter International Analysis.

Surgery Versus Intra-arterial Therapy for Neuroendocrine Liver Metastasis: A Multicenter International Analysis.
Ann Surg Oncol. 2011 Jun 17;
Authors: Mayo SC, de Jong MC, Bloomston M, Pulitano C, Clary BM, Reddy SK, Clark G… Continue reading

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