Category Archives: Br J Dermatol

Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals.






Continuous usage of a hair dye product containing 2-methoxymethyl-p-phenylenediamine by hair dye allergic individuals.

Br J Dermatol. 2016 Jan 8;

Authors: Kock M, Coenraads PJ, Blömeke B, Goebel C

Abstract
BACKGROUND: Despite a positive patch test reaction to p-phenylenediamine (PPD) and/or toluene-2,5-diamine (PTD) many people attempt to continue dyeing their hair with products containing PPD or its derivatives.
OBJECTIVES: Investigation of elicitation reactions among PPD/PTD allergic individuals to hair dye products containing the less-sensitizing PPD-derivative 2-methoxymethyl-p-phenylenediamine (ME-PPD).
METHODS: Elicitation reactions were studied in 43 PPD/PTD allergic individuals by a 45-min pre-test with a ME-PPD containing hair dye on their forearm and upon negative result followed by exposure to subsequent hair colour treatment(s).
RESULTS: 38/43 PPD/PTD allergic individuals did not develop an elicitation reaction during the pre-test with ME-PPD containing hair dye products and were eligible for subsequent hair colour treatments. Of these 38 PPD/PTD allergic individuals 29 tolerated subsequent hair dyeing with ME-PPD containing hair dye products while 9 showed mild to moderate allergic reactions upon the first hair colour treatment.
CONCLUSIONS: Hair dye products with the less sensitizing ME-PPD were tolerated by 29/43 (67%) PPD/PTD allergic individuals throughout continued hair dyeing with an average of 9 treatments per year. Five individuals reacted upon pre-testing while only mild to moderate skin reactions occurred upon hair dyeing in 9 individuals who were not identified by the pre-test. To our knowledge this is the first study among PPD/PTD allergic individuals indicating that a negative 45 min pre-testing with a hair dye product helps to avoid severe allergic reactions. This article is protected by copyright. All rights reserved.

PMID: 26749506 [PubMed – as supplied by publisher]

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Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum.






Ustekinumab in hidradenitis suppurativa: clinical results and a search for potential biomarkers in serum.

Br J Dermatol. 2015 Dec 7;

Authors: Blok JL, Li K, Brodmerkel C, Horvátovich P, Jonkman MF, Horváth B

Abstract
BACKGROUND: Treatment of hidradenitis suppurativa (HS) is difficult and the search for effective therapies continues.
OBJECTIVES: 1.To evaluate the efficacy of ustekinumab. 2.To discover a potential biomarker.
METHODS: Seventeen patients were included in this open label study and treated with 45 to 90 mg ustekinumab at weeks 0, 4, 16 and 28. Proteomic technology and enzyme-linked assay analysis (ELISA) was applied on serum.
RESULTS: Twelve patients completed the protocol. Moderate to marked improvement of the modified Sartorius Score was achieved in 82% of patients at week 40 and the hidradenitis suppurativa clinical response (HiSCR-50) in 47%. At baseline, a significant difference was observed in the expression of 54 serum proteins between patients and healthy controls. Involved pathways were related to inflammation, immune cell signaling, and tissue morphology/development. Good responders had milder disease and lower expression of leukotriene A4-hydrolase (LTA4H). IL-2R, TNF-α, IL17A and IL-17F were not elevated and did not change during treatment.
CONCLUSIONS: The majority of patients improved with ustekinumab. Although no biomarker was discovered, low LTA4H concentrations with mild disease severity may be predictive for the effectiveness of ustekinumab. This article is protected by copyright. All rights reserved.

PMID: 26641739 [PubMed – as supplied by publisher]

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Colophony as marker for fragrance allergy in the general European population.






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Colophony as marker for fragrance allergy in the general European population.

Br J Dermatol. 2015 Nov 19;

Authors: Ofenloch R, Diepgen TL, Bruze…

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Direct and indirect immunofluorescence staining patterns in the diagnosis of paraneoplastic pemphigus.






Direct and indirect immunofluorescence staining patterns in the diagnosis of paraneoplastic pemphigus.
Br J Dermatol. 2015 Nov 11;
Authors: Poot AM, Siland J, Jonkman MF, Pas HH, Diercks GF
Abstract
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Contact dermatitis in the construction industry: the role of filaggrin loss-of-function mutations.






Contact dermatitis in the construction industry: the role of filaggrin loss-of-function mutations.
Br J Dermatol. 2015 Oct 9;
Authors: Timmerman JG, Heederik D, Spee T, van Rooy FG, Krop EJ, Koppelman GH, Rustemeyer … Continue reading






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Prevalence of contact allergy in the general population in different European regions.






Prevalence of contact allergy in the general population in different European regions.

Br J Dermatol. 2015 Sep 15;

Authors: Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads PJ, Elsner P, Goncalo M, Svensson Å, Naldi L

Abstract
BACKGROUND: Population-based studies about contact allergy are scarce.
OBJECTIVES: To obtain reliable estimates of prevalence of contact allergy in the general population in Europe.
METHODS: Cross-sectional study of a random sample from the general population, aged 18 to 74 years, in 5 different European countries (Sweden, The Netherlands, Germany, Italy, Portugal). In total 12,377 subjects were interviewed and a random sample (n=3,119) patch tested to TRUE-test panel 1, 2 and 3 plus fragrance mix II, HICC, and sesquiterpene lactone mix. A positive patch test reaction is considered as contact allergy.
RESULTS: In total, 27.0% (95% CI 25.5-28.5) had at least one positive reaction to an allergen of the European baseline series with a significant higher prevalence in females compared to males. The highest age-standardized prevalences (≥ 1%) were found for nickel (14.5%; 95% CI 13.2-15.8), thimerosal (5.0%; 95% CI 4.2-5.8), cobalt (2.2%; 95% CI 1.7-2.7), fragrance mix II (1.9%, 95% CI 1.5-2.5), fragrance mix I (1.8% 95% CI 1.4-2.3), hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC)(1.4%, 95% CI 1.0-1.9), p-tert-butylphenol- formaldehyde-resin (1.3%; 95% CI 0.9-1.7), and p-phenylenediamine (1.0%; 95% CI 0.6-1.3). Only Nickel and Thimerosal showed a statistically significant different prevalence for contact allergy amongst the different European populations. Subjects that reported contact dermatitis in lifetime (age-standardized prevalence 15.1%, 95%CI 13.8-16.3) had an increased risk for contact allergy (OR 1.9, 95% CI 1.5-2.5) the risk of having a contact allergy was not increase in those with atopic dermatitis (prevalence 7.6%, 95% CI 6.7-8.6; OR 1.0, 95% CI 0.7-1.4).
CONCLUSIONS: Contact allergy to at least one allergen of the European baseline series was diagnosed in more than one quarter of the general European population. Therefore measures to improve the primary prevention of contact allergy have to be enforced. This article is protected by copyright. All rights reserved.

PMID: 26370659 [PubMed – as supplied by publisher]

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Prevalence of fragrance contact allergy in the general population of five European countries – a cross-sectional study.






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Prevalence of fragrance contact allergy in the general population of five European countries – a cross-sectional study.

Br J Dermatol. 2015 Sep 2;

Authors: Diepgen TL, Ofenloch R, Bruze M, Cazzaniga S, Coenraads PJ, Elsner P, Goncalo M, Svensson Å, Naldi L

Abstract
BACKGROUND: Contact allergy to fragrances is mostly assessed in clinical populations of patients. Studies in the general population are scarce and vary in their methodology across countries.
OBJECTIVES: To determine the prevalence of fragrance contact allergy in the European general population and to assess the clinical relevance of positive patch test reactions to different fragrances.
METHODS: In five European countries (Germany, Italy, The Netherlands, Portugal and Sweden) a random sample from the general population aged 18 to 74 years was drawn. In total 12,377 subjects were interviewed in this cross-sectional study and a random sample (n=3,119) was patch tested using True test and Finn chamber technique. Patch test procedures were harmonized by a mandatory training in advance of and a monitoring during the study.
RESULTS: The highest prevalence for contact allergy of 2.6% (95% CI 2.1-3.2) was found for FM I in petrolatum with a high content of atranol and chloratranol, and 1.9% (95% CI 1.5-2.4) for FM II in petrolatum. The conservatively estimated prevalence of fragrance contact allergy (defined by the existence of a positive patch test to Fragrance Mix I (FM I) or Fragrance Mix II (FM II) or any of the individual materials in either FM I or FM II or Myroxylon pereirae or sesquiterpene lactones or 3 and 4-hydroxyisohexyl 3-cyclohexene carboxaldehyde) that show clinical relevance, defined conservatively as lifetime avoidance of scented products and an itchy skin rash lasting more than 3 days in a lifetime, was 1.9% (95% CI 1.5-2.5). If we use the reported lifetime prevalence of any contact dermatitis instead of the lifetime prevalence of any itchy skin rash, the prevalence is 0.8% (95% CI 0.5-1.2).The prevalence rates of contact allergy to fragrances in females are about two times higher than in males.
CONCLUSIONS: The study helps identifying targets for prevention of fragrance allergy. This article is protected by copyright. All rights reserved.

PMID: 26332456 [PubMed – as supplied by publisher]

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Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa – best clinical practice guidelines.






Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa – best clinical practice guidelines.
Br J Dermatol. 2015 Aug 24;
Authors: Mellerio JE, Robertson SJ, Bernardis C, Diem A, Fine JD… Continue reading






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Body mass index, chronological age and hormonal status are better predictors of biological skin age than arm skin autofluorescence in healthy women who have never smoked.






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Body mass index, chronological age and hormonal status are better predictors of biological skin age than arm skin autofluorescence in healthy women who have never smoked.

Br J Dermatol. 2015 Jul 25;

Authors: Randag AC, Graaff R, Dreise MM, Vierkötter A, Werker PM, Stenekes MW

Abstract
BACKGROUND: as life expectancy is increasing and healthy ageing becomes more and more important, skin ageing is a growing topic of interest both from a medical and a commercial point of view. The urgency to unravel the causes of skin ageing is rising. However, there is a lack of objective, simple, non-invasive methods to assess biological skin age – a term introduced to describe how old someone looks, covering both appearance and function of the skin. A rapid, non-invasive assessment of biological skin age would greatly facilitate the execution of the studies required to find the causes of skin ageing.
OBJECTIVES: to find an objective, easy-to-apply method to assess biological skin age.
METHODS: Skin Age Score (SAS) was compared to skin autofluorescence, a measure of advanced glycation endproducts in the skin, and several subject characteristics in 32 healthy, Caucasian women with little sun-exposed skin and no history of smoking.
RESULTS: a moderate, positive correlation (R(2) = 0.32, p = 0.001) between SAS and skin autofluorescence-based biological skin age was found. However, the variation in biological skin age according to SAS could better be explained by chronological age, BMI and hormonal status (R(2) = 0.86, p < 0.001).
CONCLUSIONS: in the current setting skin autofluorescence did not better contribute to the prediction of biological skin age than chronological age. Biological skin age was best predicted by chronological, BMI and hormonal status and this approach provides a considerable simplification of the application of biological skin age. This article is protected by copyright. All rights reserved.

PMID: 26211555 [PubMed – as supplied by publisher]

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Drug survival for methotrexate in a daily practice cohort of adult patients with severe atopic dermatitis.






Drug survival for methotrexate in a daily practice cohort of adult patients with severe atopic dermatitis.
Br J Dermatol. 2015 Jun 25;
Authors: Politiek K, Schaft JV, Coenraads PJ, de Bruin-Weller MS, Schuttelaar ML
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Recommendations for treatment of Lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group.






Recommendations for treatment of Lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group.

Br J Dermatol. 2015 May 22;

Authors: Bruijn MS, Horváth B, van Voorst Vader PC, Willemze R, Vermeer MH

Abstract
Primary cutaneous CD30+ lymphoproliferative disorders includes primary cutaneous anaplastic large cell lymphoma (C-ALCL), lymphomatoid papulosis (LyP) and borderline cases. LyP is characterized by a chronic course with recurrent papulonodular lesions, which undergo spontaneous regression after weeks or months(1) . LyP has an excellent prognosis with a 10-year disease-specific survival of almost 100%(2) . For patients with limited lesions an expectant policy is a legitimate approach. This article is protected by copyright. All rights reserved.

PMID: 25998985 [PubMed – as supplied by publisher]

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Significantly higher prevalence of circulating bullous pemphigoid (BP)-specific IgG autoantibodies in elderly patients with a non-bullous skin disorder.






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Significantly higher prevalence of circulating bullous pemphigoid (BP)-specific IgG autoantibodies in elderly patients with a non-bullous skin disorder.

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Omalizumab in patients with chronic spontaneous urticaria: a systematic review and GRADE assessment.






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Omalizumab in patients with chronic spontaneous urticaria: a systematic review and GRADE assessment.
Br J Dermatol. 2015 Apr 18;
Authors: Urgert MC, van den Elzen MT, Knulst AC, Fedorowicz Z, van Zuur… Continue reading






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Late onset perforating folliculitis induced by lenalidomide: a case report.






Late onset perforating folliculitis induced by lenalidomide: a case report.
Br J Dermatol. 2015 Feb 1;
Authors: Kuiper EM, Kardaun SH
Abstract
Lenalidomide, as monotherapy or in combination with dexam… Continue reading






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Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature.






Rituximab therapy in pemphigus foliaceus: report of 12 cases and review of recent literature.
Br J Dermatol. 2014 Dec 13;
Authors: de Sena Nogueira Maehara L, Huizinga J, Jonkman MF
Abstract
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Laboratory diagnosis of paraneoplastic pemphigus.






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Laboratory diagnosis of paraneoplastic pemphigus.

Br J Dermatol. 2013 Nov;169(5):1016-24

Authors: Poot AM, Diercks GF, Kramer D, Schepens I, Klunder G, Hashimoto T, Borradori L, Jonkman MF, Pas HH

Abstract
BACKGROUND: Paraneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against plakins, desmogleins and the α2-macroglobulin-like-1 (A2ML1) protein, in association with an underlying neoplasm. Accurate diagnosis relies on the demonstration of these autoantibodies in serum.
OBJECTIVES: To evaluate the value of different laboratory techniques in the serological diagnosis of PNP.
METHODS: We performed immunoblotting, envoplakin (EP) enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescence (IIF) on rat bladder, radioactive immunoprecipitation and a nonradioactive combined immunoprecipitation-immunoblot assay. Additional assays included BP180 ELISA and BP230 ELISA. We included the sera of 19 patients with PNP and 40 control subjects.
RESULTS: The sensitivities were 63% for anti-EP ELISA, 74% for rat bladder IIF, 89% for immunoblotting, 95% for radioactive immunoprecipitation and 100% for nonradioactive immunoprecipitation. Specificities ranged from 86% to 100%. The BP180 and BP230 ELISAs had low sensitivity and specificity for PNP. The combination of rat bladder IIF and immunoblot showed 100% sensitivity and specificity. The analysis of sequential PNP sera showed that antibody titres may decrease over time, possibly resulting in negative outcomes for EP ELISA and rat bladder IIF studies.
CONCLUSIONS: The detection of autoantibodies against EP and periplakin, or A2ML1 by immunoprecipitation is most sensitive for PNP. The combination of rat bladder IIF and immunoblotting is equally sensitive and highly specific, and represents an alternative valuable and relatively easy approach for the serological diagnosis of PNP.

PMID: 23796242 [PubMed – indexed for MEDLINE]

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Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.






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Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.
Br J Dermatol. 2013 Nov;169(5):1071-80
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Severe flucloxacillin induced acute generalised exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features; does overlap between AGEP and TEN exist? Clinical report and review of the literature.






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Severe flucloxacillin induced acute generalised exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features; does overlap between AGEP and TEN…

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Assessment of the elicitation response in subjects weakly sensitized to p-phenylenediamine.






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Assessment of the elicitation response in subjects weakly sensitized to p-phenylenediamine.

Br J Dermatol. 2014 May 28;

Authors: Pot LM,…

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The possible association of hidradenitis suppurativa and Down syndrome: is increased APP expression resulting in impaired Notch signaling the missing link?






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The possible association of hidradenitis suppurativa and Down syndrome: is increased APP expression resulting in impaired Notch signaling the missing link?

Br J Dermatol. 2014 Feb 7;

Authors: Blok JL, Jonkman MF, Horváth B

Abstract
Recently, mutations in genes encoding for ү-secretase (GS) have been demonstrated in familial hidradenitis suppurativa (HS), including presenilin-1 (PSEN1), that probably contribute to the pathogenesis of HS by impairing the Notch signaling pathway. Mutations in PSEN1 are also associated with Alzheimer’s disease (AD), a condition that is strongly related to Down syndrome (DS). Here we describe five cases where HS occurred in DS patients. An association between HS and DS is reasonable since trisomy of chromosome 21 probably leads to overexpression of the amyloid precursor protein (APP) resulting in a change of the substrate pool for GS processing at the expense of the Notch receptors. Consequently, Notch signaling is impaired which predisposes DS individuals to HS. Additionally, the relatively high prevalence of obesity in DS patients as well as alterations in their immune system could underlie the possible association between both conditions. To confirm our hypothesis, further studies are needed investigating the expression of Notch receptors and APP in the epidermis of DS patients. This article is protected by copyright. All rights reserved.

PMID: 24506173 [PubMed – as supplied by publisher]

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