Category Archives: Nephron Clin Pract

Pathogenesis of Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis and Potential Targets for Biologic Treatment.

Pathogenesis of Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis and Potential Targets for Biologic Treatment.

Nephron Clin Pract. 2014 Nov 11;

Authors: Sanders JS, Abdulahad WH, Stegeman CA, Kallenberg CG

Abstract
Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases in which the small vessels are inflamed. Clinical observations suggest a pathogenic role for ANCA. Such a role is supported by in vitro experimental data and animal models, particularly for myeloperoxidase-ANCA. An in vivo pathogenic role of ANCA directed to proteinase 3 has, however, not been fully substantiated. Additionally, the pathogenic role of B cells, T cells, and the alternative pathway of complement in AAV have been elucidated. Insight into these pathogenic pathways involved in AAV has opened and will further open new ways for targeted biologic treatment. In this review the pathogenesis of AAV and potential targets for biologic treatment are discussed. © 2014 S. Karger AG, Basel.

PMID: 25401277 [PubMed – as supplied by publisher]

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Effect of Nocturnal Haemodialysis on Body Composition.

Effect of Nocturnal Haemodialysis on Body Composition.

Nephron Clin Pract. 2014 Nov 6;

Authors: Ipema KJ, Westerhuis R, van der Schans CP, de Jong PE, Gaillard CA, Krijnen WP, Slart RH, Franssen CF

Abstract
Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Therefore, we studied whether 1 year of NHD is associated with a change in body composition. Methods: Whole-body composition using dual-energy X-ray absorptiometry (DEXA) and normalised protein catabolic rate (nPCR) were measured in 11 adult patients before and 1 year after the transition from CHD (12 h dialysis/week) to NHD (28-48 h dialysis/week). Similar measurements were performed in a matched control group of 13 patients who stayed on CHD. Differences between groups were analysed with linear mixed models. Results: At baseline, nPCR, total mass, fat-free mass, and fat mass did not differ significantly between the CHD and NHD groups. nPCR increased in the NHD group (from 0.96 ± 0.23 to 1.12 ± 0.20 g/kg/day; p = 0.027) whereas it was stable in the CHD group (0.93 ± 0.21 at baseline and 0.87 ± 0.09 g/kg/day at 1 year, n.s.). The change in nPCR differed significantly between the two groups (p = 0.027). We observed no significant differences in the course of total mass, fat-free mass, and fat mass during the 1-year observation period between the NHD and CHD groups. Conclusions: One year of NHD had no significant effect on body composition in comparison with CHD, despite a significantly higher protein intake in patients on NHD. © 2014 S. Karger AG, Basel.

PMID: 25376526 [PubMed – as supplied by publisher]

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Is doubling of serum creatinine a valid clinical ‘hard’ endpoint in clinical nephrology trials?

Is doubling of serum creatinine a valid clinical ‘hard’ endpoint in clinical nephrology trials?

Nephron Clin Pract. 2011;119(3):c195-9; discussion c199

Authors: Lambers Heerspink…

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