Category Archives: Hepatology

Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?
Hepatology. 2020 Jul 04;:
Authors: Lisman T
Abstract
Historically, patients with liver disease were consider… Continue reading

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Reply to: “Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria”.

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Reply to: “Impaired expression of multidrug resistance-associated protein 2 and liver damage in erythropoietic protoporphyria”.

Hepatology. 2015 Jul 14;

Authors: Bloks VW, Plösch T, Jonker JW, Kuipers F

PMID: 26173575 [PubMed – as supplied by publisher]

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Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

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Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

Hepatology. 2015 Jul 14;

Authors: Wang Y, van der Tuin S, Tjeerdema N, van Dam AD, Rensen SS, Hendrikx T, Berbée JF, Atanasovska B, Fu J, Hoekstra M, Bekkering S, Riksen NP, Buurman WA, Greve JW, Hofker MH, Shiri-Sverdlov R, Meijer OC, Smit JW, Havekes LM, van Dijk KW, Rensen PC

Abstract
The role of Kupffer cells (KCs) in the pathophysiology of the liver has been firmly established. Nevertheless, KCs have been underexplored as target for the diagnosis and treatment of liver diseases due to the lack of non-invasive diagnostic tests. We addressed the hypothesis that cholesteryl ester transfer protein (CETP) is mainly derived from KCs and may predict KC content. Microarray analysis of liver and adipose tissue biopsies, obtained from 93 obese subjects who underwent elective bariatric surgery, showed that expression of CETP is markedly higher in liver than adipose tissue. The hepatic expression of CETP correlated strongly with that of KC markers, and CETP mRNA and protein co-localized specifically with KCs in human liver sections. Hepatic KC content as well as hepatic CETP expression correlated strongly with the plasma CETP concentration. Mechanistic and intervention studies on the role of KCs in determining the plasma CETP concentration were performed in a transgenic mouse model expressing human CETP. Selective elimination of KCs from the liver in CETP transgenic mice virtually abolished hepatic CETP expression and largely reduced the plasma CETP concentration, consequently improving the lipoprotein profile. Conversely, augmentation of KCs after BCG vaccination largely increased hepatic CETP expression and plasma CETP. Also, lipid-lowering drugs fenofibrate and niacin reduced the liver KC content accompanied by reduced plasma CETP concentration.
CONCLUSIONS: Plasma CETP is predominantly derived from KCs, and plasma CETP level predicts the hepatic KC content in humans. This article is protected by copyright. All rights reserved.

PMID: 26174697 [PubMed – as supplied by publisher]

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Evidence against a role of serotonin in liver regeneration in humans.

Evidence against a role of serotonin in liver regeneration in humans.
Hepatology. 2014 Dec 24;
Authors: Alkozai EM, vanFaassen M, Kema IP, Porte RJ, Lisman T
PMID: 25546821 [PubMed – as supplied by publisher]

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Decreased in vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis.

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Decreased in vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis.
Hepatology. 2014 Aug 1;
Authors: Potze W, Adelmeijer J, Lisman T
PMID: 25088782 [P… Continue reading

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New highlights for relaxin.

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New highlights for relaxin.
Hepatology. 2014 Apr;59(4):1223-4
Authors: Poelstra K
PMID: 24038109 [PubMed – indexed for MEDLINE]

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An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome.

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An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: implications for hemostasis and clinical outcome.
Hepatology. 2013 Aug;58(2):752-61
Authors: Hugenholtz GC, Adelmeijer J, Meijers… Continue reading

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Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice.

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Scavenger receptor BI and ABCG5/G8 differentially impact biliary sterol secretion and reverse cholesterol transport in mice.

Hepatology. 2013 Jul;58(1):293-303

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Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model.

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Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model.

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Ductular reactions in human liver: Diversity at the interface.

Ductular reactions in human liver: Diversity at the interface.

Hepatology. 2011 Aug 16;

Authors: Gouw AS, Clouston AD, Theise ND

Abstract

Interest in hepatic…

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Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.

Hepatology. 2011 Aug;54(2):586-96

Authors: Bansal R, Prakash J, Post E, Beljaars L, Schuppan D,…

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Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
Hepatology. 2011 Jun;53(6):1977-85
Authors: Janse M, Lamberts LE, Franke L, Raychaudh… Continue reading

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Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation.

Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation.
Hepatology. 2010 Dec;52(6):2167-76
Authors: Rembacz KP, Woudenberg J, Hoekstra M, Jonkers EZ, van den Heuvel FA, Buist-Homan M, Woudenberg… Continue reading

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