Category Archives: Phys Med Biol

Time-resolved dosimetry for validation of 4D dose calculation in PBS proton therapy.

Time-resolved dosimetry for validation of 4D dose calculation in PBS proton therapy.
Phys Med Biol. 2020 Apr 27;:
Authors: Kostiukhina N, Palmans H, Stock M, Knopf AC, Georg D, Knaeusl B
Abstract
4D… Continue reading

Posted in Phys Med Biol | Tagged | Leave a comment

Short-lived positron emitters in beam-on PET imaging during proton therapy.

Short-lived positron emitters in beam-on PET imaging during proton therapy.

Phys Med Biol. 2015 Nov 5;60(23):8923-8947

Authors: Dendooven P, Buitenhuis HJ, Diblen F,…

Continue reading

Posted in Phys Med Biol | Tagged | Leave a comment

Simulation and experimental verification of prompt gamma-ray emissions during proton irradiation.

Related Articles

Simulation and experimental verification of prompt gamma-ray emissions during proton irradiation.

Phys Med Biol. 2015 May 8;60(10):4197-4207

Continue reading

Posted in Phys Med Biol | Tagged | Leave a comment

Relative electron density determination using a physics based parameterization of photon interactions in medical DECT.

Relative electron density determination using a physics based parameterization of photon interactions in medical DECT.

Phys Med Biol. 2015 May 7;60(9):3825-3846

Authors: van Abbema JK, van Goethem MJ, Greuter MJ, van der Schaaf A, Brandenburg S, van der Graaf ER

Abstract
Radiotherapy and particle therapy treatment planning require accurate knowledge of the electron density and elemental composition of the tissues in the beam path to predict the local dose deposition. We describe a method for the analysis of dual energy computed tomography (DECT) images that provides the electron densities and effective atomic numbers of tissues. The CT measurement process is modelled by system weighting functions, which apply an energy dependent weighting to the parameterization of the total cross section for photon interactions with matter. This detailed parameterization is based on the theoretical analysis of Jackson and Hawkes and deviates, at most, 0.3% from the tabulated NIST values for the elements H to Zn. To account for beam hardening in the object as present in the CT image we implemented an iterative process employing a local weighting function, derived from the method proposed by Heismann and Balda. With this method effective atomic numbers between 1 and 30 can be determined. The method has been experimentally validated on a commercially available tissue characterization phantom with 16 inserts made of tissue substitutes and aluminium that has been scanned on a dual source CT system with tube potentials of 100 kV and 140 kV using a clinical scan protocol. Relative electron densities of all tissue substitutes have been determined with accuracy better than 1%. The presented DECT analysis method thus provides high accuracy electron densities and effective atomic numbers for radiotherapy and especially particle therapy treatment planning.

PMID: 25905890 [PubMed – as supplied by publisher]

Continue reading

Posted in Phys Med Biol | Leave a comment

Range assessment in particle therapy based on prompt γ-ray timing measurements.

Related Articles

Range assessment in particle therapy based on prompt γ-ray timing measurements.

Phys Med Biol. 2014 Aug 26;59(18):5399-5422

Authors: Golnik C,…

Continue reading

Posted in Phys Med Biol | Tagged | Leave a comment

Time-of-flight neutron rejection to improve prompt gamma imaging for proton range verification: a simulation study.

Time-of-flight neutron rejection to improve prompt gamma imaging for proton range verification: a simulation study.
Phys Med Biol. 2012 Sep 21;57(20):6429-6444
Authors: Biegun AK, Seravalli E, Lopes PC, Rinaldi I, Pinto M, Oxl… Continue reading

Posted in Phys Med Biol | Tagged , | Leave a comment

Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction.

Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction.

Phys Med Biol. 2011 Sep 21;56(18):N183-93

Authors: Wu C, de Jong JR, Gratama…

Continue reading

Posted in Phys Med Biol | Tagged | Leave a comment