Category Archives: Pediatr Res

Near-infrared spectroscopy as a diagnostic tool for necrotizing enterocolitis in preterm infants.

Near-infrared spectroscopy as a diagnostic tool for necrotizing enterocolitis in preterm infants.
Pediatr Res. 2020 Oct 08;:
Authors: van der Heide M, Hulscher JBF, Bos AF, Kooi EMW
Abstract
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Repetitive bilirubin measurements in preterm infants prior to phototherapy: is it wise to use the rate of rise?

Repetitive bilirubin measurements in preterm infants prior to phototherapy: is it wise to use the rate of rise?
Pediatr Res. 2019 Jun 18;:
Authors: Hulzebos CV, Tiribelli C
PMID: 31212306 [PubMed – as suppl… Continue reading

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Assessing cerebrovascular autoregulation in infants with necrotizing enterocolitis using near-infrared spectroscopy.

Assessing cerebrovascular autoregulation in infants with necrotizing enterocolitis using near-infrared spectroscopy.
Pediatr Res. 2015 Sep 18;
Authors: Schat TE, van der Laan ME, Schurink M, Hulscher JB, Hulzebos CV,… Continue reading

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In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction.

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In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction.

Pediatr Res. 2015 Feb 9;

Authors: Roescher AM, Timmer A, van der Laan ME, Erwich JJ, Bos AF, Kooi EM, Verhagen EA

Abstract
BackgroundPlacental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (rcSO2) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first five days after birth. We hypothesized that as a result of cerebral hypoperfusion, regional cerebral tissue oxygen saturation would be lower and fractional tissue oxygen extraction would be higher.MethodA prospective, observational study of 42 preterm infants (GA <32wk). The infants’ placentas were examined for histopathology. We measured rcSO2 and transcutaneous arterial oxygen saturation on days one to five. FTOE was calculated as FTOE = (transcutaneous arterial oxygen saturation – rcSO2)/transcutaneous arterial oxygen saturation.ResultsOnly three placentas showed no pathology. Ascending intrauterine infection (n=16) was associated with lower rcSO2 and higher FTOE values on days two, three, and four (P≤05). Other placental lesions were not associated with rcSO2 and FTOE.ConclusionAscending intrauterine infection is associated with lower rcSO2, and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.Pediatric Research (2015); doi:10.1038/pr.2015.20.

PMID: 25665059 [PubMed – as supplied by publisher]

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Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model.

Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model.

Pediatr Res. 2014 Oct 3;

Authors: Khemani RG, Flink R, Hotz J, Ross PA, Ghuman A, Newth CJ

Abstract
BackgroundTo determine optimal methods of Respiratory Inductance Plethysmography (RIP) flow calibration for application to pediatric post-extubation upper airway obstruction.MethodsWe measured RIP, spirometry, and esophageal manometry in spontaneously breathing, intubated Rhesus monkeys with increasing inspiratory resistance. RIP calibration was based on: ?µVao ˜ M[?µVRC + K(?µVAB)] where K establishes the relationship between the uncalibrated rib cage (?µVRC) and abdominal (?µVAB) RIP signals. We calculated K during: (1) isovolume maneuvers during a negative inspiratory force (NIF) (2) Quantitative Diagnostic Calibration (QDC) during (a) tidal breathing, (b) continuous positive airway pressure (CPAP), and (c) increasing degrees of UAO. We compared the calibrated RIP flow waveform to spirometry quantitatively and qualitatively.ResultsIsovolume calibrated RIP flow tracings were more accurate (against spirometry) both quantitatively and qualitatively than those from QDC (p<0.0001), with bigger differences as UAO worsened. Isovolume calibration yielded nearly identical clinical interpretation of inspiratory flow limitation as spirometry.ConclusionsIn an animal model of pediatric UAO, Isovolume calibrated RIP flow tracings are accurate against spirometry. QDC during tidal breathing yields poor RIP flow calibration, particularly as UAO worsens. Routine use of a NIF maneuver before extubation affords the opportunity to use RIP to study post extubation UAO in children.Pediatric Research (2014); doi:10.1038/pr.2014.144.

PMID: 25279987 [PubMed – as supplied by publisher]

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Maternal or neonatal infection: association with neonatal encephalopathy outcomes.

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Maternal or neonatal infection: association with neonatal encephalopathy outcomes.

Pediatr Res. 2014 Jul;76(1):93-9

Authors: Jenster M,…

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Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial.

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Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial.

Pediatr Res. 2013 Nov;74(5):606-14

Authors: Seggers J, Haadsma ML, Bastide-van Gemert Sl, Heineman MJ, Kok JH, Middelburg KJ, Roseboom TJ, Schendelaar P, Van den Heuvel ER, Hadders-Algra M

Abstract
BACKGROUND: Recent studies suggest that in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with suboptimal cardiometabolic outcome in offspring. It is unknown whether preimplantation genetic screening (PGS), which involves embryo biopsy, affects blood pressure (BP), anthropometrics, and the frequency of received medical care.
METHODS: In this prospective multicenter follow-up study, we assessed BP, anthropometrics, and received medical care of 4-y-old children born to women who were randomly assigned to IVF/ICSI with PGS (n = 49) or without PGS (controls; n = 64). We applied linear and generalized linear mixed-effects models to investigate possible effects of PGS.
RESULTS: BP in the PGS and control groups was similar: 102/64 and 100/64 mm Hg, respectively. Main anthropometric outcomes in the PGS vs. control group were: BMI: 16.1 vs. 15.8; triceps skinfold: 108 vs. 98 mm; and subscapular skinfold: 54 vs. 53 mm (all P values > 0.05). More PGS children than controls had received paramedical care (speech, physical, or occupational therapy: 14 (29%) vs. 9 (14%); P = 0.03 in multivariable analysis). The frequency of medicial treatment was comparable.
CONCLUSION: PGS does not seem to affect BP or anthropometrics in 4-y-old children. The higher frequency of received paramedical care after PGS may suggest an effect of PGS on subtle developmental parameters.

PMID: 23949731 [PubMed – indexed for MEDLINE]

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Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile and low-grade inflammation in 3-year-old to 5-year-old children.

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Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile and low-grade inflammation in 3-year-old to 5-year-old children.

Pediatr Res. 2013 Nov 14;

Authors: Bocca G, Corpeleijn E, Stolk RP, Wolffenbuttel BH, Sauer PJ

Abstract
Background:Childhood obesity can cause the development of cardiovascular risk factors. We assessed the effect of a multidisciplinary intervention program on cardiovascular risk factors and compared this effect with a usual-care program in 3- to 5-year-old overweight or obese children.Methods:Seventy-five children were randomly assigned to a multidisciplinary intervention or a usual-care program. Anthropometry, body composition and abdominal adipose tissue were assessed at the start and end of a 16-week program. Concurrently, fasting concentrations of serum lipids, glucose, insulin, HbA1c, leptin, adiponectin, hsCRP, TNFα and IL-6 were determined.Results:In both groups insulin sensitivity improved, demonstrated by decreased insulin concentrations and a decreased HOMA2-IR. In the multidisciplinary intervention group, there was also a decrease of HbA1c and TNFα. In the usual-care group, an increase in glucose concentrations was found. Comparing both groups, changes over time were not different, besides trends in the decrease in total cholesterol and TNFα, in favor of the multidisciplinary intervention group. Combining the results of both groups, a correlation was found between the decrease in body fat percentage (BF%), and both HOMA2-IR and triglyceride concentrations.Conclusion:In 3- to 5-year-old children, both obesity intervention programs improved insulin sensitivity, in parallel with a reduced BF%.Pediatric Research (2013); doi:10.1038/pr.2013.216.

PMID: 24232638 [PubMed – as supplied by publisher]

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Effect of balloon atrial septostomy on cerebral oxygenation in neonates with transposition of the great arteries.

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Effect of balloon atrial septostomy on cerebral oxygenation in neonates with transposition of the great arteries.

Pediatr Res. 2013 Jan;73(1):62-7

Authors:…

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Functional outcome of very preterm-born and small-for-gestational-age children at school age.

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Functional outcome of very preterm-born and small-for-gestational-age children at school age.

Pediatr Res. 2012 Dec;72(6):641-8

Authors: Tanis JC, van der…

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Neurodevelopment after moderate hyperbilirubinemia at term: a prospective, case-control study.

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Neurodevelopment after moderate hyperbilirubinemia at term: a prospective, case-control study.

Pediatr Res. 2013 Feb 13;

Authors: Lunsing RJ, Pardoen WF,…

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Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis.

Effect of antibiotic treatment on fat absorption in mice with cystic fibrosis.
Pediatr Res. 2012 Jan;71(1):4-12
Authors: Wouthuyzen-Bakker M, Bijvelds MJ, de Jonge HR, De Lisle RC, Burgerhof JG, Verkade HJ
Abstract
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Hydrocortisone vs. dexamethasone treatment for bronchopulmonary dysplasia and their effects on general movements in preterm infants.

Hydrocortisone vs. dexamethasone treatment for bronchopulmonary dysplasia and their effects on general movements in preterm infants.
Pediatr Res. 2012 Jan;71(1):100-6
Authors: Hitzert MM, Benders MJ, Roescher AM, van Bel F, de… Continue reading

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Cerebral oxygenation during the first days of life in preterm and term neonates: differences between different brain regions.

Cerebral oxygenation during the first days of life in preterm and term neonates: differences between different brain regions.

Pediatr Res. 2011 Oct;70(4):389-94

Authors: Wijbenga…

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The relationship between electrocerebral activity and cerebral fractional tissue oxygen extraction in preterm infants.

The relationship between electrocerebral activity and cerebral fractional tissue oxygen extraction in preterm infants.

Pediatr Res. 2011 Oct;70(4):384-8

Authors: ter Horst HJ,…

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Functional impairments at school age of children with necrotizing enterocolitis or spontaneous intestinal perforation.

Functional impairments at school age of children with necrotizing enterocolitis or spontaneous intestinal perforation.
Pediatr Res. 2011 Aug 18;
Authors: Roze E, Ta BD, van der Ree MH, Tanis JC, Van Braeckel KN, Hulscher JB, B… Continue reading

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Metabolomics of volatile organic compounds in cystic fibrosis patients and controls.

Metabolomics of volatile organic compounds in cystic fibrosis patients and controls.
Pediatr Res. 2010 Jul;68(1):75-80
Authors: Robroeks CM, van Berkel JJ, Dallinga JW, Jöbsis Q, Zimmermann LJ, Hendriks HJ, Wouters MF, van de… Continue reading

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