Category Archives: Prostaglandins Leukot Essent Fatty Acids

Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort.

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Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort.

Prostaglandins Leukot Essent Fatty Acids. 2015 Jun 14;

Authors: Jochems SH, Gielen M, Rump P, Hornstra G, Zeegers MP

Abstract
BACKGROUND: Increasing evidence suggests that long-chain polyunsaturated fatty acid (LCPUFA) availability in utero could program later health.
OBJECTIVE: The objective of the study was to explore whether prenatal LCPUFA availability could be involved in programming cardiometabolic disease risk at childhood.
METHODS: Data of 242 mother-child pairs from the Maastricht Essential Fatty Acid Birth (MEFAB) cohort were used. Multi-variable linear regression analysis was applied to identify associations between maternal LCPUFA concentrations around weeks 11, 22 and 32 of pregnancy and at time of delivery and cardiometabolic risk factors of their children (glucose metabolism, blood lipids, and blood pressure) at age 7.
RESULTS: Maternal eicosapentaenoic acid (20:5n-3) at week 11 of pregnancy was negatively associated with children׳s glucose (B=-0.34mmol/L; 95% CI: -0.56, -0.12). Positive associations were found between maternal linoleic acid (18:2n-6) at time of delivery and children׳s proinsulin (B=0.25pmol/L; 95% CI: 0.08, 0.41); maternal 3-docosapentaenoic acid (22:5n-3) at week 11 and children׳s total cholesterol (B=1.23mmol/L; 95% CI: 0.45, 2.01) and low-density-lipoprotein cholesterol (B=1.12mmol/L; 95% CI: 0.42, 1.82); and maternal osbond acid (22:5n-6) at week 22 and tetracosadienoic acid (24:2n-6) at week 32 and children׳s diastolic blood pressure (B=16.86mmHg; 95% CI: 7.63, 26.08 and B=17.75mmHg; 95% CI: 6.37, 29.94, respectively).
CONCLUSION: Our findings suggest that maternal omega-6 (n-6) fatty acids may be of particular importance in relation to children׳s glucose metabolism and blood pressure, whereas omega-3 (n-3) fatty acids seem particularly related to blood lipids at childhood. In general, the strength of the associations appeared stronger with fatty acid concentrations in early pregnancy compared to late pregnancy.

PMID: 26115761 [PubMed – as supplied by publisher]

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Yes, we can define an infant’s need from the composition of human milk as long as the breastmilk derives from mothers with healthy lifestyles.

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Yes, we can define an infant’s need from the composition of human milk as long as the breastmilk derives from mothers with healthy lifestyles.

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Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort.

Prostaglandins Leukot Essent Fatty Acids. 2014 Apr 25;

Authors: de Vries PS, Gielen M, Rizopoulos D, Rump P, Godschalk R, Hornstra G, Zeegers MP

Abstract
Prenatal polyunsaturated fatty acid (PUFA) concentrations may be involved in the prenatal programming of adiposity. In this study we therefore explored the association between maternal PUFA concentrations, measured up to four times during pregnancy, and offspring adiposity at age 7 in 234 mother-child pairs of the Maastricht Essential Fatty Acid Birth cohort. Only dihomo-gamma-linolenic acid (DGLA, an n-6 fatty acid) concentration was associated with adiposity: per standard deviation increase in relative DGLA concentration, BMI increased by 0.44kg/m(2) (CI95: 0.16, 0.72), sum of skinfolds increased by 3.41mm (CI95: 1.88, 4.95), waist circumference increased by 1.09cm (CI95: 0.40, 1.78), and plasma leptin concentration increased by 0.66µg/l (CI95: 0.20, 1.11). In conclusion, maternal DGLA throughout gestation was associated with increased BMI and some additional measures of adiposity at age 7. This suggests that maternal DGLA might play a role in or reflect the prenatal programming of adiposity.

PMID: 24813643 [PubMed – as supplied by publisher]

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Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue.

Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue.

Prostaglandins Leukot Essent Fatty Acids. 2012…

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Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates.

Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates.

Prostaglandins Leukot Essent Fatty Acids. 2012 Jan-Feb;86(1-2):13-20

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Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition.

Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition.

Prostaglandins Leukot Essent Fatty Acids. 2011…

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Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA).

Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA).

Prostaglandins Leukot Essent Fatty Acids. 2011 Nov;85(5):245-52

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The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status.

The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status.

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Postdelivery changes in maternal and infant erythrocyte fatty acids in 3 populations differing in fresh water fish intakes.

Postdelivery changes in maternal and infant erythrocyte fatty acids in 3 populations differing in fresh water fish intakes.

Prostaglandins Leukot Essent Fatty Acids. 2011 Sep 12;

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