LATEST OPEN ACCESS UMCG
- Assessing intestinal permeability in Crohn's disease patients using orally administered 52Cr-EDTA
- Adaptation, validity and reliability of the modified painDETECT questionnaire for patients with subacromial pain syndrome
- Leg muscle strength is reduced and is associated with physical quality of life in Antineutrophil cytoplasmic antibody-associated vasculitis
- Borderline tumours of the ovary: Common practice in the Netherlands
- A Weighted Genetic Risk Score Predicts Surgical Recurrence Independent of High-Risk Clinical Features in Dupuytren's Disease
- Identifying critical process steps to protein stability during spray drying using a vibrating mesh or a two-fluid nozzle
- Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
- Active smoking and macrocytosis in the general population: Two population-based cohort studies
- Effect of self-monitoring through experience sampling on emotion differentiation in depression
- Development and construct validation of a parent-proxy quality of life instrument in children with bronchopulmonary dysplasia aged 4-8 years old
Pages
Reading Tip!
>To get to the fulltext easy, use the library proxy bookmarklet or activate our Pubmed url for the Get it! button!
Tags
Archives
Journals
Pages
Meta
Stats
Most Used Journals
Category Archives: Cell Rep
De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.
De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.
Cell Rep. 2018 Sep 25;24(13):3441-3454.e12
Authors: Wang S, Mandell JD, Kumar Y,… Continue reading
Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Related Articles |
Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.
Cell Rep. 2015 Jun 17;
Authors: Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ
Abstract
The polymorphism ATG16L1 T300A, associated with increased risk of Crohn’s disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown. Here, we use perturbational profiling of human peripheral blood cells to reveal that CLEC12A is regulated in an ATG16L1-T300A-dependent manner. Antibacterial autophagy is impaired in CLEC12A-deficient cells, and this effect is exacerbated in the presence of the ATG16L1(∗)300A risk allele. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo. CLEC12A is recruited to sites of bacterial entry, bacteria-autophagosome complexes, and sites of sterile membrane damage. Integrated genomics identified a functional interaction between CLEC12A and an E3-ubiquitin ligase complex that functions in antibacterial autophagy. These data identify CLEC12A as early adaptor molecule for antibacterial autophagy and highlight perturbational profiling as a method to elucidate defense pathways in complex genetic disease.
PMID: 26095365 [PubMed – as supplied by publisher]
Posted in Cell Rep
Leave a comment