Category Archives: Angew Chem Int Ed Engl

A “dial-a-receptor” dynamic combinatorial library.

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A “dial-a-receptor” dynamic combinatorial library.
Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12368-72
Authors: Hamieh S, Saggiomo V, Nowak P, Mattia E, Ludlow RF, Otto S
Abstract
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Conformationally Constrained Cyclic Peptides: Powerful Scaffolds for Asymmetric Catalysis.

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Conformationally Constrained Cyclic Peptides: Powerful Scaffolds for Asymmetric Catalysis.

Angew Chem Int Ed Engl. 2014 Jun 4;

Authors: Zheng L, Marcozzi A, Gerasimov JY, Herrmann A

Abstract
Cyclic peptides containing a disulfide bridge were identified as a simple and versatile coordination sphere for asymmetric catalysis. Upon complexation with Cu(2+) ions they catalyze Diels-Alder and Friedel-Crafts reactions with high enantioselectivities of up to 99 % ee and 86 % ee, respectively. Moreover, the peptides ligands were systematically optimized with the assistance of “Alanine Scanning”. This biomolecular design could greatly expand the choice of peptide scaffolds for artificial metallopeptide catalysts.

PMID: 24898630 [PubMed – as supplied by publisher]

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Photocaging of Carboxylic Acids: A Modular Approach.

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Photocaging of Carboxylic Acids: A Modular Approach.

Angew Chem Int Ed Engl. 2014 May 6;

Authors: Szymański W, Velema WA, Feringa BL

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Enzyme-Catalyzed Oxidation of 5-Hydroxymethylfurfural to Furan-2,5-dicarboxylic Acid.

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Enzyme-Catalyzed Oxidation of 5-Hydroxymethylfurfural to Furan-2,5-dicarboxylic Acid.

Angew Chem Int Ed Engl. 2014 May 6;

Authors: Dijkman WP,…

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Autoamplification of Molecular Chirality through the Induction of Supramolecular Chirality.

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Autoamplification of Molecular Chirality through the Induction of Supramolecular Chirality.

Angew Chem Int Ed Engl. 2014 Feb 23;

Authors: van Dijken DJ,…

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The Formazanate Ligand as an Electron Reservoir: Bis(Formazanate) Zinc Complexes Isolated in Three Redox States.

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The Formazanate Ligand as an Electron Reservoir: Bis(Formazanate) Zinc Complexes Isolated in Three Redox States.

Angew Chem Int Ed Engl. 2014 Feb 24;

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Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry.

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Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry.

Angew Chem Int Ed Engl. 2014 Feb 14;

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Programmed Death-1: Therapeutic Success after More than 100 Years of Cancer Immunotherapy.

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Programmed Death-1: Therapeutic Success after More than 100 Years of Cancer Immunotherapy.

Angew Chem Int Ed Engl. 2014 Jan 28;

Authors: Dömling A, Holak…

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Hindered Aryllithium Reagents as Partners in Palladium-Catalyzed Cross-Coupling: Synthesis of Tri- and Tetra-ortho-Substituted Biaryls under Ambient Conditions.

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Hindered Aryllithium Reagents as Partners in Palladium-Catalyzed Cross-Coupling: Synthesis of Tri- and Tetra-ortho-Substituted Biaryls under Ambient Conditions.

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13329-33

Authors: Giannerini M, Hornillos V, Vila C, Fañanás-Mastral M, Feringa BL

Abstract
Elegant like a butterfly, stings like a lithium reagent: Mono- and di-ortho-substituted aryllithium reagents were coupled through palladium catalysis with hindered aryl bromides to form highly congested tri- and tetra-ortho-substituted biaryls. The reaction allows the use of easily accessible ortho-functionalized aryllithium compounds. The high reactivity of organolithium reagents facilitates a fast process under ambient conditions.

PMID: 24307017 [PubMed – in process]

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Azobenzene photoswitches for Staudinger-Bertozzi ligation.

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Azobenzene photoswitches for Staudinger-Bertozzi ligation.

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2068-72

Authors: Szymański W, Wu B, Poloni C, Janssen…

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Light-triggered sequence-specific cargo release from DNA block copolymer-lipid vesicles.

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Light-triggered sequence-specific cargo release from DNA block copolymer-lipid vesicles.

Angew Chem Int Ed Engl. 2013 Jan 14;52(3):1008-12

Authors: …

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Modular assembly of a Pd catalyst within a DNA scaffold for the amplified colorimetric and fluorimetric detection of nucleic acids.

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Modular assembly of a Pd catalyst within a DNA scaffold for the amplified colorimetric and fluorimetric detection of nucleic acids.

Angew Chem Int Ed Engl. 2012 Nov…

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Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis.

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Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis.

Angew Chem Int Ed Engl. 2012 Nov 19;51(47):11774-7

Authors:…

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Palladium-Catalyzed Selective Anti-Markovnikov Oxidation of Allylic Esters.

Palladium-Catalyzed Selective Anti-Markovnikov Oxidation of Allylic Esters.

Angew Chem Int Ed Engl. 2013 Apr 16;

Authors: Dong JJ, Fañanás-Mastral M, Alsters PL, Browne WR, Feringa…

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Hydrogel formation upon photoinduced covalent capture of macrocycle stacks from dynamic combinatorial libraries.

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Hydrogel formation upon photoinduced covalent capture of macrocycle stacks from dynamic combinatorial libraries.

Angew Chem Int Ed Engl. 2011 Aug 29;50(36):8384-6

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Peptide-mediated blood-brain barrier transport of polymersomes.

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Peptide-mediated blood-brain barrier transport of polymersomes.

Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8339-42

Authors: Georgieva JV, Brinkhuis RP,…

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Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation.

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Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation.

Angew Chem Int Ed Engl. 2012 Nov 14;

Authors: Wood K, Gallat FX, Otten R,…

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Enantioselective artificial metalloenzymes by creation of a novel active site at the protein dimer interface.

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Enantioselective artificial metalloenzymes by creation of a novel active site at the protein dimer interface.

Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7472-5

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Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to β-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase.

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Bridging between organocatalysis and biocatalysis: asymmetric addition of acetaldehyde to β-nitrostyrenes catalyzed by a promiscuous proline-based tautomerase.

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Asymmetric copper-catalyzed addition of Grignard reagents to aryl alkyl ketones.

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Asymmetric copper-catalyzed addition of Grignard reagents to aryl alkyl ketones.

Angew Chem Int Ed Engl. 2012 Mar 26;51(13):3164-7

Authors: Madduri AV,…

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