Category Archives: J Control Release

Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging.

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Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging.

J Control Release. 2018 Aug 02;:

Authors: Kröger APP, Paulusse JMJ

Abstract
As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures. Exclusive intramolecular collapse of individual polymer chains results in individual nanoparticles. With sizes an order of magnitude smaller than conventional polymer nanoparticles, SCNPs are in the size regime of many proteins and viruses (1-20 nm). Multifaceted syntheses and design strategies give access to a wide set of highly modular SCNP materials. This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry.

PMID: 30077737 [PubMed – as supplied by publisher]

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Bio-inspired pulmonary surfactant-modified nanogels: a promising siRNA delivery system.

Bio-inspired pulmonary surfactant-modified nanogels: a promising siRNA delivery system.

J Control Release. 2015 Mar 16;

Authors: De Backer L, Braeckmans K, Stuart MC, Demeester J, De Smedt SC, Raemdonck K

Abstract
Inhalation therapy with small interfering RNA (siRNA) is a promising approach in the treatment of pulmonary disorders. However, clinical translation is severely limited by the lack of suitable delivery platforms. In this study, we aim to address this limitation by designing a novel bioinspired hybrid nanoparticle with a core-shell nanoarchitecture, consisting of a siRNA-loaded dextran nanogel (siNG) core and a pulmonary surfactant (Curosurf®) outer shell. The decoration of siNGs with a surfactant shell enhances the colloidal stability and prevents siRNA release in the presence of competing polyanions, which are abundantly present in biofluids. Additionally, the impact of the surfactant shell on the biological efficacy of the siNGs is determined in lung cancer cells. The presence of the surfactants substantially reduces the cellular uptake of siNGs. Remarkably, the lowered intracellular dose does not impede the gene silencing effect, suggesting a crucial role of the pulmonary surfactant in the intracellular processing of the nanoparticles. In order to surmount the observed reduction in cellular dose, folate is incorporated as a targeting ligand in the pulmonary surfactant shell to incite receptor-mediated endocytosis. The latter substantially enhances both cellular uptake and gene silencing potential, achieving efficient knockdown at siRNA concentrations in the low nanomolar range.

PMID: 25791835 [PubMed – as supplied by publisher]

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Solid Lipid Nanoparticles as Nucleic Acid Delivery System: Properties and Molecular Mechanisms.

Solid Lipid Nanoparticles as Nucleic Acid Delivery System: Properties and Molecular Mechanisms.
J Control Release. 2015 Jan 8;
Authors: de Jesus MB, Zuhorn IS
Abstract
Solid lipid nanoparticles (SLNs)… Continue reading

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Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.

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Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.
J Control Release. 2014 Jan 28;174:51-62
Authors: Patil HP, Murugappan S, ter Veer W, Meijerhof T, de Haan … Continue reading

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The role of pathogen-associated molecular patterns in inflammatory responses against alginate based microcapsules.

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The role of pathogen-associated molecular patterns in inflammatory responses against alginate based microcapsules.

J Control Release. 2013 Dec…

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ColoPulse tablets perform comparably in healthy volunteers and Crohn’s patients and show no influence of food and time of food intake on bioavailability.

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ColoPulse tablets perform comparably in healthy volunteers and Crohn’s patients and show no influence of food and time of food intake on bioavailability.

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Use of optical imaging to progress novel therapeutics to the clinic.

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Use of optical imaging to progress novel therapeutics to the clinic.
J Control Release. 2013 Dec 10;172(2):523-34
Authors: Byrne WL, DeLille A, Kuo C, de Jong JS, van Dam GM, Francis KP, Tangney M
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Drug delivery systems based on nucleic acid nanostructures.

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Drug delivery systems based on nucleic acid nanostructures.
J Control Release. 2013 Dec 10;172(2):467-83
Authors: de Vries JW, Zhang F, Herrmann A
Abstract
The field of DNA nanotechno… Continue reading

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On-demand antimicrobial release from a temperature-sensitive polymer – comparison with ad libitum release from central venous catheters.

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On-demand antimicrobial release from a temperature-sensitive polymer – comparison with ad libitum release from central venous catheters.

J Control…

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Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo.

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Interferon gamma peptidomimetic targeted to hepatic stellate cells ameliorates acute and chronic liver fibrosis in vivo.

J Control Release. 2014 Jan 31;

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Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

J Control Release. 2014 Jan 2;

Authors: Kowalski PS, Zwiers PJ, Morselt HW, Kuldo JM, Leus NG, Ruiters MH, Molema G, Kamps JA

Abstract
The pivotal role of endothelial cells in the pathology of inflammatory diseases raised interest in the development of short interfering RNA (siRNA) delivery devices for selective pharmacological intervention in the inflamed endothelium. The current study demonstrates endothelial specific delivery of siRNAs and downregulation of inflammatory genes in activated endothelium in vivo, applying a novel type of targeted liposomes based on the cationic amphiphile SAINT-C18 (1-methyl-4-(cis-9-dioleyl)methyl-pyridinium-chloride). To create specificity for inflamed endothelial cells, these so-called SAINT-O-Somes were harnessed with antibodies against vascular cell adhesion protein 1 (VCAM-1). In TNFα challenged mice, intravenously administered anti-VCAM-1 SAINT-O-Somes exerted long circulation times and homed to VCAM-1 expressing endothelial cells in inflamed organs. The formulations were devoid of liver and kidney toxicity. Using anti-VCAM-1 SAINT-O-Somes we successfully delivered siRNA to knock down VE-cadherin mRNA in inflamed renal microvasculature, as demonstrated by using laser microdissection of different microvascular beds prior to analysis of gene expression. Using the same strategy, we demonstrated local attenuation of endothelial inflammatory response towards lipopolysaccharide in kidneys of mice treated with anti-VCAM-1 SAINT-O-Somes containing NFκB p65 specific siRNA. This study is a first demonstration of a novel, endothelial specific carrier that is suitable for selective in vivo delivery of siRNAs into inflamed microvascular segments and interference with disease associated endothelial activation.

PMID: 24389338 [PubMed – as supplied by publisher]

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Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.

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Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.

J Control Release. 2013 Feb…

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How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances.

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How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances.

J Control Release. 2013 Feb 28;166(1):46-56

Authors: …

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PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.

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PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl₄-induced fibrogenesis in mice.

J Control Release….

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Drug targeting to the diseased liver.

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Drug targeting to the diseased liver.

J Control Release. 2012 Jul 20;161(2):188-97

Authors: Poelstra K, Prakash J, Beljaars L

Abstract

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Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection.

Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection.
J Control Release. 2011 Nov 30;156(1):76-84
Authors: ur Rehman Z, Hoekstra D, Zuhorn … Continue reading

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PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis.

PEGylation improves pharmacokinetic profile, liver uptake and efficacy of Interferon gamma in liver fibrosis.

J Control Release. 2011 Sep 25;154(3):233-40

Authors: Bansal R, Post…

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