Category Archives: J Control Release

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Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging.

J Control Release. 2018 Aug 02;:

Authors: Kröger APP, Paulusse JMJ

Abstract
As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the formation of bio-inspired nanosized architectures. Exclusive intramolecular collapse of individual polymer chains results in individual nanoparticles. With sizes an order of magnitude smaller than conventional polymer nanoparticles, SCNPs are in the size regime of many proteins and viruses (1-20 nm). Multifaceted syntheses and design strategies give access to a wide set of highly modular SCNP materials. This review describes how SCNPs have been rendered water-soluble and highlights ongoing research efforts towards biocompatible SCNPs with tunable properties for controlled drug delivery, targeted imaging and protein mimicry.

PMID: 30077737 [PubMed – as supplied by publisher]

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Related Articles
Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.
J Control Release. 2014 Jan 28;174:51-62
Authors: Patil HP, Murugappan S, ter Veer W, Meijerhof T, de Haan … Continue reading →

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Drug delivery systems based on nucleic acid nanostructures.
J Control Release. 2013 Dec 10;172(2):467-83
Authors: de Vries JW, Zhang F, Herrmann A
Abstract
The field of DNA nanotechno… Continue reading →

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

J Control Release. 2014 Jan 2;

Authors: Kowalski PS, Zwiers PJ, Morselt HW, Kuldo JM, Leus NG, Ruiters MH, Molema G, Kamps JA

Abstract
The pivotal role of endothelial cells in the pathology of inflammatory diseases raised interest in the development of short interfering RNA (siRNA) delivery devices for selective pharmacological intervention in the inflamed endothelium. The current study demonstrates endothelial specific delivery of siRNAs and downregulation of inflammatory genes in activated endothelium in vivo, applying a novel type of targeted liposomes based on the cationic amphiphile SAINT-C18 (1-methyl-4-(cis-9-dioleyl)methyl-pyridinium-chloride). To create specificity for inflamed endothelial cells, these so-called SAINT-O-Somes were harnessed with antibodies against vascular cell adhesion protein 1 (VCAM-1). In TNFα challenged mice, intravenously administered anti-VCAM-1 SAINT-O-Somes exerted long circulation times and homed to VCAM-1 expressing endothelial cells in inflamed organs. The formulations were devoid of liver and kidney toxicity. Using anti-VCAM-1 SAINT-O-Somes we successfully delivered siRNA to knock down VE-cadherin mRNA in inflamed renal microvasculature, as demonstrated by using laser microdissection of different microvascular beds prior to analysis of gene expression. Using the same strategy, we demonstrated local attenuation of endothelial inflammatory response towards lipopolysaccharide in kidneys of mice treated with anti-VCAM-1 SAINT-O-Somes containing NFκB p65 specific siRNA. This study is a first demonstration of a novel, endothelial specific carrier that is suitable for selective in vivo delivery of siRNAs into inflamed microvascular segments and interference with disease associated endothelial activation.

PMID: 24389338 [PubMed – as supplied by publisher]

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Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection.
J Control Release. 2011 Nov 30;156(1):76-84
Authors: ur Rehman Z, Hoekstra D, Zuhorn … Continue reading →