Category Archives: Curr Opin Chem Biol

Advances of epigenetic editing.

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Advances of epigenetic editing.
Curr Opin Chem Biol. 2020 Jun 29;57:75-81
Authors: Gjaltema RAF, Rots MG
Abstract
Epigenetic editing refers to the locus-specific targeting of epigene… Continue reading

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Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation.

Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation.

Curr Opin Chem Biol. 2016 Jun 29;33:160-168

Authors: Leus NG, Zwinderman MR, Dekker FJ

Abstract
Activation of inflammatory gene expression is regulated, among other factors, by post-translational modifications of histone proteins. The most investigated type of histone modifications is lysine acetylations. Histone deacetylases (HDACs) remove acetylations from lysines, thereby influencing (inflammatory) gene expression. Intriguingly, apart from histones, HDACs also target non-histone proteins. The nuclear factor κB (NF-κB) pathway is an important regulator in the expression of numerous inflammatory genes, and acetylation plays a crucial role in regulating its responses. Several studies have shed more light on the role of HDAC 1-3 in inflammation with a particular pro-inflammatory role for HDAC 3. Nevertheless, the HDAC-NF-κB interactions in inflammatory signalling have not been fully understood. An important challenge in targeting the regulatory role of HDACs in the NF-κB pathway is the development of highly potent small molecules that selectively target HDAC iso-enzymes. This review focuses on the role of HDAC 3 in (NF-κB-mediated) inflammation and NF-κB lysine acetylation. In addition, we address the application of frequently used small molecule HDAC inhibitors as an approach to attenuate inflammatory responses, and their potential as novel therapeutics. Finally, recent progress and future directions in medicinal chemistry efforts aimed at HDAC 3-selective inhibitors are discussed.

PMID: 27371876 [PubMed – as supplied by publisher]

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Mechanisms of mechanosensing-mechanosensitive channels, function and re-engineering.

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Mechanisms of mechanosensing-mechanosensitive channels, function and re-engineering.

Curr Opin Chem Biol. 2015 Nov 20;29:120-127

Authors: Kocer…

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Recent developments in enzyme promiscuity for carbon-carbon bond-forming reactions.

Recent developments in enzyme promiscuity for carbon-carbon bond-forming reactions.
Curr Opin Chem Biol. 2015 Jan 15;25C:115-123
Authors: Miao Y, Rahimi M, Geertsema EM, Poelarends GJ
Abstract
Numerou… Continue reading

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DNA-based hybrid catalysis.

DNA-based hybrid catalysis.

Curr Opin Chem Biol. 2015 Jan 8;25C:80-87

Authors: Rioz-Martínez A, Roelfes G

Abstract
In the past decade, DNA-based hybrid catalysis has merged as a promising novel approach to homogeneous (asymmetric) catalysis. A DNA hybrid catalysts comprises a transition metal complex that is covalently or supramolecularly bound to DNA. The chiral microenvironment and the second coordination sphere interactions provided by the DNA are key to achieve high enantioselectivities and, often, additional rate accelerations in catalysis. Nowadays, current efforts are focused on improved designs, understanding the origin of the enantioselectivity and DNA-induced rate accelerations, expanding the catalytic scope of the concept and further increasing the practicality of the method for applications in synthesis. Herein, the recent developments will be reviewed and the perspectives for the emerging field of DNA-based hybrid catalysis will be discussed.

PMID: 25579454 [PubMed – as supplied by publisher]

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Artificial metalloenzymes for enantioselective catalysis.

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Artificial metalloenzymes for enantioselective catalysis.
Curr Opin Chem Biol. 2014 Apr;19:135-43
Authors: Bos J, Roelfes G
Abstract
Artificial metalloenzymes have emerged over the la… Continue reading

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Priming ammonia lyases and aminomutases for industrial and therapeutic applications.

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Priming ammonia lyases and aminomutases for industrial and therapeutic applications.

Curr Opin Chem Biol. 2013 Apr;17(2):250-60

Authors: Heberling MM, Wu…

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