Category Archives: Eur Child Adolesc Psychiatry

Differentiating between ADHD and ASD in childhood: some directions for practitioners.

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Differentiating between ADHD and ASD in childhood: some directions for practitioners.
Eur Child Adolesc Psychiatry. 2018 May 12;:
Authors: Rommelse N, Visser J, Hartman C
PMID: 29754280 [PubM… Continue reading

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The influence of comorbid oppositional defiant disorder on white matter microstructure in attention-deficit/hyperactivity disorder.

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The influence of comorbid oppositional defiant disorder on white matter microstructure in attention-deficit/hyperactivity disorder.

Eur Child Adolesc…

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Mental health care use in adolescents with and without mental disorders.

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Mental health care use in adolescents with and without mental disorders.

Eur Child Adolesc Psychiatry. 2015 Aug 15;

Authors: Jörg F, Visser E, Ormel J, Reijneveld SA, Hartman CA, Oldehinkel AJ

Abstract
The aim of the study was to estimate the proportion of adolescents with and without a psychiatric diagnosis receiving specialist mental health care and investigate their problem levels as well as utilization of other types of mental health care to detect possible over- and undertreatment. Care utilization data were linked to psychiatric diagnostic data of 2230 adolescents participating in the TRAILS cohort study, who were assessed biannually starting at age 11. Psychiatric diagnoses were established at the fourth wave by the Composite International Diagnostic Interview. Self-, parent- and teacher-reported emotional and behavioral problems and self-reported mental health care use were assessed at all four waves. Of all diagnosed adolescents, 35.3 % received specialist mental health care. This rate increased to 54.5 % when three or more disorders were diagnosed. Almost a third (28.5 %) of specialist care users had no psychiatric diagnosis; teachers gave them relatively high ratings on attention and impulsivity subscales. Diagnosed adolescents without specialist mental health care also reported low rates of other care use. We found no indication of overtreatment. Half of the adolescents with three or more disorders do not receive specialist mental health care nor any other type of care, which might indicate unmet needs.

PMID: 26275772 [PubMed – as supplied by publisher]

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Expectations of barriers to psychosocial care: views of parents and adolescents in the community.

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Expectations of barriers to psychosocial care: views of parents and adolescents in the community.

Eur Child Adolesc Psychiatry. 2015 May 13;

Authors: Nanninga M, Reijneveld SA, Knorth EJ, Jansen DE

Abstract
Parents with a child suffering from psychosocial problems frequently experience barriers to psychosocial care, which may hinder access. Expectations of barriers may have the same effect, but evidence is lacking. The aim of this study is to examine parents’ and adolescents’ expectations of barriers regarding psychosocial care for the child, along with associated child and family characteristics. We obtained data on an age-stratified random sample of school children/pupils aged 4-18 via questionnaires (N = 666; response rate 70.3 %). Expectations of barriers to psychosocial care were measured with the “Barriers to Treatment Participation Scale-Expectancies” questionnaire (BTPS-exp). Results showed that 64 % of the parents of children below age 12, 59 % of the parents of adolescents (age 12-18), and 84 % of the adolescents expected one or more barriers. Parents and adolescents expected barriers most frequently with respect to irrelevance of treatment. Mainly parents with low educational level and their adolescents expected barriers regarding treatment, and quite a few characteristics of parents of adolescents were associated with expecting multiple barriers regarding treatment demands and issues, for example, single parents, parents of lower educational level and of adolescent boys, and parents of adolescents with psychosocial problems. We conclude that adolescents especially, but also their parents and parents of younger children, expect major barriers to psychosocial care, which may greatly hinder appropriate care seeking. This evidence may support professionals and policymakers in their attempts to improve access to psychosocial care.

PMID: 25969373 [PubMed – as supplied by publisher]

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Tourette syndrome research in Europe has entered a new era of collaboration.

Tourette syndrome research in Europe has entered a new era of collaboration.
Eur Child Adolesc Psychiatry. 2015 Feb 4;
Authors: Hoekstra PJ, Dietrich A
PMID: 25650008 [PubMed – as supplied by publisher]

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Multifinality of peer victimization: maladjustment patterns and transitions from early to mid-adolescence.

Multifinality of peer victimization: maladjustment patterns and transitions from early to mid-adolescence.
Eur Child Adolesc Psychiatry. 2014 Dec 25;
Authors: Kretschmer T, Barker ED, Dijkstra JK, Oldehinkel AJ, Veen… Continue reading

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Combined stimulant and antipsychotic treatment in adolescents with attention-deficit/hyperactivity disorder: a cross-sectional observational structural MRI study.

Combined stimulant and antipsychotic treatment in adolescents with attention-deficit/hyperactivity disorder: a cross-sectional observational structural MRI study.

Eur Child Adolesc Psychiatry. 2014 Nov 14;

Authors: Schweren LJ, Hartman CA, Zwiers MP, Heslenfeld DJ, van der Meer D, Franke B, Oosterlaan J, Buitelaar JK, Hoekstra PJ

Abstract
Meta-analyses suggest normalizing effects of methylphenidate on structural fronto-striatal abnormalities in patients with attention-deficit/hyperactivity disorder (ADHD). A subgroup of patients receives atypical antipsychotics concurrent with methylphenidate. Long-term safety and efficacy of combined treatment are unknown. The current study provides an initial investigation of structural brain correlates of combined methylphenidate and antipsychotic treatment in patients with ADHD. Structural magnetic resonance imaging was obtained in 31 patients who had received combined methylphenidate and antipsychotic treatment, 31 matched patients who had received methylphenidate but not antipsychotics, and 31 healthy controls (M age 16.7 years). We analyzed between-group effects in total cortical and subcortical volume, and in seven frontal cortical and eight subcortical-limbic volumes of interest, each involved in dopaminergic neurotransmission. Patients in the combined treatment group, but not those in the methylphenidate only group, showed a reduction in total cortical volume compared to healthy controls (Cohen’s d = 0.69, p < 0.004), which was apparent in most frontal volumes of interest. Further, the combined treatment group, but not the methylphenidate group, showed volume reduction in bilateral ventral diencephalon (Left Cohen’s d = 0.48, p < 0.04; Right Cohen’s d = 0.46, p < 0.05) and the left thalamus (Cohen’s d = 0.47, p < 0.04). These findings may indicate antipsychotic treatment counteracting the normalizing effects of methylphenidate on brain structure. However, it cannot be ruled out that pre-existing clinical differences between both patient groups may have resulted in anatomical differences at the time of scanning. The absence of an untreated ADHD group hinders unequivocal interpretation and implications of our findings.

PMID: 25395383 [PubMed – as supplied by publisher]

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Peer dislike and victimisation in pathways from ADHD symptoms to depression.

Peer dislike and victimisation in pathways from ADHD symptoms to depression.

Eur Child Adolesc Psychiatry. 2014 Oct 28;

Authors: Roy A, Hartman CA, Veenstra R, Oldehinkel AJ

Abstract
The following hypotheses were tested in a longitudinal, population-based study: (1) Attention deficit hyperactivity disorder (ADHD) symptoms are associated with peer dislike and victimisation; (2) Peer dislike and victimisation increase the risk for subsequent depression; and (3) The effect of ADHD symptoms on depression is partly mediated through peer dislike and victimisation. Gender differences in mediating pathways through peer dislike and victimisation to depression were additionally explored. The Child Behaviour Checklist (CBCL), Youth Self Report (YSR) and Teacher’s Checklist of Pathology (TCP) assessed ADHD symptoms in 728 adolescents. Peer nominations were used to assess peer dislike and victimisation. The Composite International Diagnostic Interview (CIDI) was used to assess depression. Effects of peer dislike, victimisation, and ADHD symptoms on depression were modelled using Cox regression. ADHD symptoms were associated with peer dislike (rs = 0.17, p < 0.001) and victimisation (rs = 0.11, p = 0.001). Dislike, victimisation, and ADHD symptoms increased risk for depression. Risk for depression associated with victimisation and ADHD symptoms reduced with time. Dislike and victimisation mediated 7 % of the effect of ADHD symptoms on depression. Pathways through dislike and victimisation were present in girls but not in boys. Peer dislike and victimisation explain, to a limited extent, the prospective association between ADHD and depression, particularly in girls.

PMID: 25348085 [PubMed – as supplied by publisher]

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Behavioural and emotional problems in moderately preterm children with low socioeconomic status: a population-based study.

Behavioural and emotional problems in moderately preterm children with low socioeconomic status: a population-based study.

Eur Child Adolesc Psychiatry. 2014 Oct 8;

Authors: Potijk MR, de Winter AF, Bos AF, Kerstjens JM, Reijneveld SA

Abstract
Moderately preterm (MP) birth is associated with higher rates of behavioural and emotional problems. To determine the extent to which low socioeconomic status (SES) contributes to these higher rates, we assessed independent and joint effects of MP birth and low SES, overall and by gender. Dutch preventive child health care centres provided a population-based sample of 915 MP children (32-36 weeks gestation) and 543 term-born children, born in 2002/2003. In multivariable logistic regression analyses, we determined the risk of behavioural and emotional problems per standard deviation (SD) decrease in gestational age and SES, using standardized measures for both. We also assessed three SES categories, being low (1SD or more below mean of standardized SES), intermediate (mean ± 1SD), and high (greater than mean + 1SD). The Child Behavior Checklist for 1.5-5 years was used to assess behavioural (externalizing), emotional (internalizing), and total problems at age 4 years. MP children with low SES had significantly higher total problem scores than those with high SES (11.3 vs. 5.1 %, respectively). Each SD decrease in SES was associated with a 42 % higher odds of elevated total problem scores (OR 1.42, 95 % CI 1.14-1.77). No joint effects were found, meaning that lower gestational age independently added to the risk of behaviour problems (OR 1.24, 95 % CI 1.00-1.56). Effects of MP birth and low SES were more pronounced in girls. In conclusion, MP birth and low SES multiply the risk of behavioural and emotional problems. The combination of risk factors identifies children who could benefit greatly from early intervention.

PMID: 25293643 [PubMed – as supplied by publisher]

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Enrolment of children and adolescents in psychosocial care: more likely with low family social support and poor parenting skills.

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Enrolment of children and adolescents in psychosocial care: more likely with low family social support and poor parenting skills.

Eur Child Adolesc Psychiatry. 2014 Aug 13;

Authors: Nanninga M, Jansen DE, Knorth EJ, Reijneveld SA

Abstract
Knowledge about determinants of child and adolescent enrolment in psychosocial care concerns only single types of care and usually only socio-demographic factors. The social environment is also a likely key determinant but evidence is lacking. The aim of this study was to examine the associations between family social support, parenting skills and child and adolescent enrolment in psychosocial care. We obtained data on 1,331 children (response rate 56.6 %), 4-18 years old, enrolled in preventive child health care, and child and adolescent social care and mental health care because of psychosocial problems, and on 463 children (response rate 70.3 %) not enrolled in psychosocial care. Results showed that enrolment in psychosocial care was associated with low family social support (odds ratio; 95 %-confidence interval: 3.2; 2.4-4.4), and with poor parenting skills, i.e. poor supervision (1.5; 1.1-2.1) and inconsistent disciplining (1.5; 1.1-2.1). Children’s psychosocial problems partially mediated the associations with family social support and completely with parenting skills. Children’s problems did not moderate the associations. Positive parenting was not associated with care enrolment. We conclude that low family social support and poor parenting are important factors associated with enrolment, in particular because they are associated with more frequent occurrence of children’s psychosocial problems. This implies that professionals and policymakers need to be aware that factors in children’s social environment are related with enrolment in psychosocial care, in addition to children’s psychosocial problems.

PMID: 25116036 [PubMed – as supplied by publisher]

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Attention-deficit/hyperactivity disorder: seeking the right balance between over- and undertreatment.

Attention-deficit/hyperactivity disorder: seeking the right balance between over- and undertreatment.
Eur Child Adolesc Psychiatry. 2014 Aug 7;
Authors: Hoekstra PJ, Dietrich A
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Paternal influences on treatment outcome of behavioral parent training in children with attention-deficit/hyperactivity disorder.

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Paternal influences on treatment outcome of behavioral parent training in children with attention-deficit/hyperactivity disorder.

Eur Child Adolesc…

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Stressful events and psychological difficulties: testing alternative candidates for sensitivity.

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Stressful events and psychological difficulties: testing alternative candidates for sensitivity.

Eur Child Adolesc Psychiatry. 2014 Feb;23(2):103-13

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It is time for a harmonized ethical review procedure across Europe.

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It is time for a harmonized ethical review procedure across Europe.
Eur Child Adolesc Psychiatry. 2013 Oct;22(10):587-8
Authors: Hoekstra PJ, Buitelaar JK
PMID: 24013351 [PubMed – indexed for… Continue reading

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The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods.

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The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods.
Eur Child Adolesc Psychiatry. 2014 Apr 26;
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A longitudinal perspective on childhood adversities and onset risk of various psychiatric disorders.

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A longitudinal perspective on childhood adversities and onset risk of various psychiatric disorders.

Eur Child Adolesc Psychiatry. 2014 Apr 11;

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Outcomes of childhood conduct problem trajectories in early adulthood: findings from the ALSPAC study.

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Outcomes of childhood conduct problem trajectories in early adulthood: findings from the ALSPAC study.

Eur Child Adolesc Psychiatry. 2013 Nov 7;

Authors: Kretschmer T, Hickman M, Doerner R, Emond A, Lewis G, Macleod J, Maughan B, Munafò MR, Heron J

Abstract
Although conduct problems in childhood are stably associated with problem outcomes, not every child who presents with conduct problems is at risk. This study extends previous studies by testing whether childhood conduct problem trajectories are predictive of a wide range of other health and behavior problems in early adulthood using a general population sample. Based on 7,218 individuals from the Avon longitudinal study of parents and children, a three-step approach was used to model childhood conduct problem development and identify differences in early adult health and behavior problems. Childhood conduct problems were assessed on six occasions between age 4 and 13 and health and behavior outcomes were measured at age 18. Individuals who displayed early-onset persistent conduct problems throughout childhood were at greater risk for almost all forms of later problems. Individuals on the adolescent-onset conduct problem path consumed more tobacco and illegal drugs and engaged more often in risky sexual behavior than individuals without childhood conduct problems. Levels of health and behavior problems for individuals on the childhood-limited path were in between those for stable low and stable high trajectories. Childhood conduct problems are pervasive and substantially affect adjustment in early adulthood both in at-risk samples as shown in previous studies, but also in a general population sample. Knowing a child’s developmental course can help to evaluate the risk for later maladjustment and be indicative of the need for early intervention.

PMID: 24197169 [PubMed – as supplied by publisher]

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Economic impact of childhood/adolescent ADHD in a European setting: the Netherlands as a reference case.

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Economic impact of childhood/adolescent ADHD in a European setting: the Netherlands as a reference case.

Eur Child Adolesc Psychiatry. 2013 Oct 29;

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Anhedonia and depressed mood in adolescence: course, stability, and reciprocal relation in the TRAILS study.

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Anhedonia and depressed mood in adolescence: course, stability, and reciprocal relation in the TRAILS study.

Eur Child Adolesc Psychiatry. 2013 Oct 24;

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Emotional development in children with tics: a longitudinal population-based study.

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Emotional development in children with tics: a longitudinal population-based study.

Eur Child Adolesc Psychiatry. 2013 Mar;22(3):185-92

Authors: Hoekstra…

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