- Quantification of Tau Load Using [F-18]AV1451 PET
- Optimizing VAP scars after childhood cancer treatment: A pilot study
- Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism
- Comparison of formula and number-right scoring in undergraduate medical training: A Rasch model analysis
- Enrolment of children in psychosocial care: problems upon entry, care received, and outcomes achieved
- Diagnostic Evasion of Highly-Resistant Microorganisms: A Critical Factor in Nosocomial Outbreaks
- Dense and accurate whole-chromosome haplotyping of individual genomes
- Knockdown of TP53 in ASXL1 negative background rescues apoptotic phenotype of human hematopoietic stem and progenitor cells but without overt malignant transformation
- Network Approach to Understanding Emotion Dynamics in Relation to Childhood Trauma and Genetic Liability to Psychopathology: Replication of a Prospective Experience Sampling Analysis
- Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
Most Used Journals
Author Archives: Smits EJ, Tolonen AJ, Cluitmans L, van Gils M, Conway BA, Zietsma RC, Leenders KL, Maurits NM
Standardized handwriting to assess bradykinesia, micrographia and tremor in Parkinson’s disease.
PLoS One. 2014;9(5):e97614
Authors: Smits EJ, Tolonen AJ, Cluitmans L, van Gils M, Conway BA, Zietsma RC, Leenders KL, Maurits NM
OBJECTIVE: To assess whether standardized handwriting can provide quantitative measures to distinguish patients diagnosed with Parkinson’s disease from age- and gender-matched healthy control participants.
DESIGN: Exploratory study. Pen tip trajectories were recorded during circle, spiral and line drawing and repeated character ‘elelelel’ and sentence writing, performed by Parkinson patients and healthy control participants. Parkinson patients were tested after overnight withdrawal of anti-Parkinsonian medication.
SETTING: University Medical Center Groningen, tertiary care, the Netherlands.
PARTICIPANTS: Patients with Parkinson’s disease (n = 10; mean age 69.0 years; 6 male) and healthy controls (n = 10; mean age 68.1 years; 6 male).
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Movement time and velocity to detect bradykinesia and the size of writing to detect micrographia. A rest recording to investigate the presence of a rest-tremor, by frequency analysis.
RESULTS: Mean disease duration in the Parkinson group was 4.4 years and the patients were in modified Hoehn-Yahr stages 1-2.5. In general, Parkinson patients were slower than healthy control participants. Median time per repetition, median velocity and median acceleration of the sentence task and median velocity of the elel task differed significantly between Parkinson patients and healthy control participants (all p<0.0014). Parkinson patients also wrote smaller than healthy control participants and the width of the ‘e’ in the elel task was significantly smaller in Parkinson patients compared to healthy control participants (p<0.0014). A rest-tremor was detected in the three patients who were clinically assessed as having rest-tremor.
CONCLUSIONS: This study shows that standardized handwriting can provide objective measures for bradykinesia, tremor and micrographia to distinguish Parkinson patients from healthy control participants.
PMID: 24854199 [PubMed – in process]