Author Archives: Giannerini M, Hornillos V, Vila C, Fañanás-Mastral M, Feringa BL

Hindered Aryllithium Reagents as Partners in Palladium-Catalyzed Cross-Coupling: Synthesis of Tri- and Tetra-ortho-Substituted Biaryls under Ambient Conditions.

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Hindered Aryllithium Reagents as Partners in Palladium-Catalyzed Cross-Coupling: Synthesis of Tri- and Tetra-ortho-Substituted Biaryls under Ambient Conditions.

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13329-33

Authors: Giannerini M, Hornillos V, Vila C, Fañanás-Mastral M, Feringa BL

Abstract
Elegant like a butterfly, stings like a lithium reagent: Mono- and di-ortho-substituted aryllithium reagents were coupled through palladium catalysis with hindered aryl bromides to form highly congested tri- and tetra-ortho-substituted biaryls. The reaction allows the use of easily accessible ortho-functionalized aryllithium compounds. The high reactivity of organolithium reagents facilitates a fast process under ambient conditions.

PMID: 24307017 [PubMed – in process]

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