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Author Archives: Hornillos V, Vila C, Otten E, Feringa BL
Catalytic Asymmetric Synthesis of Phosphine Boronates.
Angew Chem Int Ed Engl. 2015 May 7;
Authors: Hornillos V, Vila C, Otten E, Feringa BL
The first catalytic enantioselective synthesis of ambiphilic phosphine boronate esters is presented. The asymmetric boration of α,β-unsaturated phosphine oxides catalyzed by a copper bisphosphine complex affords optically active organoboronate esters that bear a vicinal phosphine oxide group in good yields and high enantiomeric excess. The synthetic utility of the products is demonstrated through stereospecific transformations into multifunctional optically active compounds.
PMID: 25950871 [PubMed – as supplied by publisher]