Most Used Journals
Author Archives: Rong J, Oost R, Desmarchelier A, Minnaard AJ, Harutyunyan SR
Catalytic Asymmetric Alkylation of Acylsilanes.
Angew Chem Int Ed Engl. 2014 Nov 17;
Authors: Rong J, Oost R, Desmarchelier A, Minnaard AJ, Harutyunyan SR
The highly enantioselective addition of Grignard reagents to acylsilanes is catalyzed by copper diphosphine complexes. This transformation affords tertiary aryl- and vinyl-substituted α-hydroxysilanes in up to 97 % yield and 98:2 enantiomeric ratio. The competing Meerwein-Ponndorf-Verley reduction is suppressed by the use of a mixture of Lewis acid additives. The chiral catalyst can be recovered as a copper complex and used repeatedly without any loss of catalytic activity.
PMID: 25403641 [PubMed – as supplied by publisher]