- Low-dose triple drug combination targeting the PI3K/AKT/mTOR pathway and the MAPK pathway is an effective approach in ovarian clear cell carcinoma
- Equivalent Long-term Transplantation Outcomes for Kidneys Donated After Brain Death and Cardiac Death: Conclusions From a Nationwide Evaluation
- Sampling issues of cerebrospinal fluid and plasma monoamines: Investigation of the circadian rhythm and rostrocaudal concentration gradient
- Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study
- Quantification of surfactant protein D (SPD) in human serum by liquid chromatography-mass spectrometry (LC-MS)
- Long-term prevention of capsular opacification after lens-refilling surgery in a rabbit model
- White matter architecture in major depression with anxious distress symptoms
- Handrail Holding during Treadmill Walking Reduces Locomotor Learning in Able-Bodied Persons
- Early detection of heart function abnormality by native T1: a comparison of two T1 quantification methods
- The Wayfinding Questionnaire: A clinically useful self-report instrument to identify navigation complaints in stroke patients
Most Used Journals
Comparison of psychotherapies for adult depression to pill placebo control groups: a meta-analysis.
Psychol Med. 2014 Mar;44(4):685-95
Authors: Cuijpers P, Turner EH, Mohr DC, Hofmann SG, Andersson G, Berking M, Coyne J
BACKGROUND: The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advantages over placebo and that psychotherapy is therefore a better alternative. To test this, we conducted a meta-analysis of studies comparing psychotherapy with pill placebo.
METHOD: Ten 10 studies comparing psychotherapies with pill placebo were identified. In total, 1240 patients were included in these studies. For each study, Hedges’ g was calculated. Characteristics of the studies were extracted for subgroup and meta-regression analyses.
RESULTS: The effect of psychotherapy compared to pill placebo at post-test was g = 0.25 [95% confidence interval (CI) 0.14-0.36, I² = 0%, 95% CI 0-58]. This effect size corresponds to a number needed to treat (NNT) of 7.14 (95% CI 5.00-12.82). The psychotherapy conditions scored 2.66 points lower on the Hamilton Depression Rating Scale (HAMD) than the placebo conditions, and 3.20 points lower on the Beck Depression Inventory (BDI). Some indications for publication bias were found (two missing studies). We found no significant differences between subgroups of the studies and in meta-regression analyses we found no significant association between baseline severity and effect size.
CONCLUSIONS: Although there are differences between the role of placebo in psychotherapy and pharmacotherapy research, psychotherapy has an effect size that is comparable to that of antidepressant medications. Whether these effects should be deemed clinically relevant remains open to debate.
PMID: 23552610 [PubMed – indexed for MEDLINE]