Author Archives: Lisman T

Assessing in vivo platelet activation in patients with liver diseases.

Assessing in vivo platelet activation in patients with liver diseases.
J Thromb Thrombolysis. 2016 Jul 30;
Authors: Lisman T
PMID: 27476174 [PubMed – as supplied by publisher] Continue reading

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Decreased Plasma Fibrinolytic Potential As a Risk for Venous and Arterial Thrombosis.

Decreased Plasma Fibrinolytic Potential As a Risk for Venous and Arterial Thrombosis.

Semin Thromb Hemost. 2016 Jul 29;

Authors: Lisman T

Abstract
It has been well established that inherited or acquired hypercoagulability is a risk factor for venous thrombosis. In addition, hypercoagulability may contribute to the risk of arterial events. Much less is known regarding the role of the fibrinolytic system in the risk of thrombotic disease, which partly relates to the lack of validated assays. A plasma-based global fibrinolysis assay, which is sensitive to plasma levels of plasminogen, regulators of fibrinolysis, and proteins involved in coagulation, has been used in large epidemiological studies to assess the role of fibrinolysis in thrombosis. It has been demonstrated that a hypofibrinolytic state increases the risk of a first venous thrombosis, but not of a recurrence. This increased risk of venous thrombosis associated with plasma hypofibrinolysis appears primarily driven by elevated plasma levels of thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor type 1. The combination of hypercoagulability and hypofibrinolysis synergistically enhances the risk of a first venous event. Plasma hypofibrinolysis may constitute a risk factor for the postthrombotic syndrome. Decreased fibrinolytic potential is also associated with an increased risk of arterial thrombosis, but only in individuals younger than 55 years. The association between hypofibrinolysis and myocardial infarction appears primarily driven by elevated levels of α2-antiplasmin. Although recent studies have clearly demonstrated a role of the fibrinolytic system in thrombotic disease, the clinical utility of plasma-based clot lysis assays is probably limited.

PMID: 27472427 [PubMed – as supplied by publisher]

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Platelets and fibrin in progression of liver disease: friends or foes?

Platelets and fibrin in progression of liver disease: friends or foes?
J Thromb Haemost. 2014 Nov 13;
Authors: Lisman T
Abstract
Patients with chronic liver diseases may acquire substantial alteration… Continue reading

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Low molecular weight heparin in management and prevention of portal vein thrombosis.

Low molecular weight heparin in management and prevention of portal vein thrombosis.
Thromb Res. 2014 Aug 16;
Authors: Lisman T
PMID: 25179517 [PubMed – as supplied by publisher]

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