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Confinement properties of 2D porous molecular networks on metal surfaces.

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Confinement properties of 2D porous molecular networks on metal surfaces.

J Phys Condens Matter. 2016 Mar 16;28(15):153003

Authors: Müller K,…

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Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones.

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Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones.

Expert Opin Drug Metab Toxicol. 2016 Mar 16;

Authors: …

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Validation of a Dutch version of the TFI in a tertiairy referral tinnitus clinic.

Validation of a Dutch version of the TFI in a tertiairy referral tinnitus clinic.

Arnold, R., Tuinstra, J. & van Dijk, P. 16-Mar-2016

Research output: Other research outputPoster

Original language English
State Published – 16-Mar-2016

Conference

Conference International Tinnitus Research Initiative Conference.
Country United Kingdom
City Nottingham
Period 16/03/201618/03/2016

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Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions.

Tissue adhesives for meniscus tear repair: an overview of current advances and prospects for future clinical solutions.

J Mater Sci Mater Med. 2016 May;27(5):85

Authors: Bochyńska AI, Hannink G, Grijpma DW, Buma P

Abstract
Menisci are crucial structures in the knee joint as they play important functions in load transfer, maintaining joint stability and in homeostasis of articular cartilage. Unfortunately, ones of the most frequently occurring knee injuries are meniscal tears. Particularly tears in the avascular zone of the meniscus usually do not heal spontaneously and lead to pain, swelling and locking of the knee joint. Eventually, after a (partial) meniscectomy, they will lead to osteoarthritis. Current treatment modalities to repair tears and by that restore the integrity of the native meniscus still carry their drawbacks and a new robust solution is desired. A strong tissue adhesive could provide such a solution and could potentially improve on sutures, which are the current gold standard. Moreover, a glue could serve as a carrier for biological compounds known to enhance tissue healing. Only few tissue adhesives, e.g., Dermabond(®) and fibrin glue, are already successfully used in clinical practice for other applications, but are not considered suitable for gluing meniscus tissue due to their sub-optimal mechanical properties or toxicity. There is a growing interest and research field focusing on the development of novel polymer-based tissue adhesives, but up to now, there is no material specially designed for the repair of meniscal tears. In this review, we discuss the current clinical gold standard treatment of meniscal tears and present an overview of new developments in this field. Moreover, we discuss the properties of different tissue adhesives for their potential use in meniscal tear repair. Finally, we formulate recommendations regarding the design criteria of material properties and adhesive strength for clinically applicable glues for meniscal tears.

PMID: 26970767 [PubMed – as supplied by publisher]

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Calreticulin, a therapeutic target?

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Calreticulin, a therapeutic target?
Expert Opin Ther Targets. 2016 Mar 9;
Authors: Eggleton P, Bremer E, Dudek E, Michalak M
Abstract
Introduction Calreticulin is an endoplasmic reticu… Continue reading

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Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).

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Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm).

Acta Crystallogr D Struct Biol. 2016…

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Hypothermic machine perfusion in kidney transplantation.

Hypothermic machine perfusion in kidney transplantation.

Curr Opin Organ Transplant. 2016 Mar 3;

Authors: De Deken J, Kocabayoglu P, Moers C

Abstract

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The Impact of Extremes in Outdoor Temperature and Sunshine Exposure on Birth Weight.

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The Impact of Extremes in Outdoor Temperature and Sunshine Exposure on Birth Weight.
J Environ Health. 2016 Jan-Feb;78(6):92-100
Authors: Poeran J, Birnie E, Steegers EA
Abstract
Follo… Continue reading

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The sooner the better? An investigation into the role of age of onset and its relation with transfer and exposure in bilingual Frisian-Dutch children.

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The sooner the better? An investigation into the role of age of onset and its relation with transfer and exposure in bilingual Frisian-Dutch children.
J Child Lang. 2016 Feb 26;:1-27
Authors: Blom E, … Continue reading

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Group-Level Symptom Networks in Depression-Reply.

Group-Level Symptom Networks in Depression-Reply.

JAMA Psychiatry. 2016 Feb 24;

Authors: van Borkulo CD, Borsboom D, Schoevers RA

PMID: 26915056 [PubMed – as…

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Potentiating the Activity of Nisin against Escherichia coli.

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Potentiating the Activity of Nisin against Escherichia coli.

Front Cell Dev Biol. 2016;4:7

Authors: Zhou L, van Heel AJ, Montalban-Lopez M,…

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Neonatal Gallstones Serendipitously Discovered by Point-of-Care Ultrasound in the Pediatric Emergency Department.

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Neonatal Gallstones Serendipitously Discovered by Point-of-Care Ultrasound in the Pediatric Emergency Department.
Pediatr Emerg Care. 2016 Feb 15;
Authors: Damman J, Doniger SJ, Atigapramoj N
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The fibrosis-cell death axis in heart failure.

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The fibrosis-cell death axis in heart failure.

Heart Fail Rev. 2016 Feb 16;

Authors: Piek A, de Boer RA, Silljé HH

Abstract
Cardiac stress can induce morphological, structural and functional changes of the heart, referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of pathological causes such as hypertension or valve insufficiency may result in progressive remodeling and finally lead to heart failure (HF). Whereas pathological and physiological (exercise, pregnancy) overload both stimulate cardiomyocyte growth (hypertrophy), only pathological remodeling is characterized by increased deposition of extracellular matrix proteins, termed fibrosis, and loss of cardiomyocytes by necrosis, apoptosis and/or phagocytosis. HF is strongly associated with age, and cardiomyocyte loss and fibrosis are typical signs of the aging heart. Fibrosis results in stiffening of the heart, conductivity problems and reduced oxygen diffusion, and is associated with diminished ventricular function and arrhythmias. As a consequence, the workload of cardiomyocytes in the fibrotic heart is further augmented, whereas the physiological environment is becoming less favorable. This causes additional cardiomyocyte death and replacement of lost cardiomyocytes by fibrotic material, generating a vicious cycle of further decline of cardiac function. Breaking this fibrosis-cell death axis could halt further pathological and age-related cardiac regression and potentially reverse remodeling. In this review, we will describe the interaction between cardiac fibrosis, cardiomyocyte hypertrophy and cell death, and discuss potential strategies for tackling progressive cardiac remodeling and HF.

PMID: 26883434 [PubMed – as supplied by publisher]

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Poly(trimethylene carbonate) as a carrier for rifampicin and vancomycin to target therapy-recalcitrant staphylococcal biofilms.

Poly(trimethylene carbonate) as a carrier for rifampicin and vancomycin to target therapy-recalcitrant staphylococcal biofilms.

J Orthop Res. 2016 Feb 15;

Authors: Kluin OS, Busscher HJ, Neut D, van der Mei HC

Abstract
Standard antibiotic therapy in osteomyelitis patients is of limited value when methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis (MRSE), or small-colony variants (SCV) are present. Far better results are obtained by local drug delivery of antibiotic combinations including rifampicin, using a suitable carrier. We therefore investigated release kinetics of antibiotics from biodegradable poly(trimethylene carbonate) (PTMC) and in vitro biofilm inhibition of MRSA, MRSE, and S. aureus SCV strains in the course of 24, 72 and 168 h treatment by PTMC, either unloaded, gentamicin-loaded, loaded with rifampicin and fosfomycin or rifampicin and vancomycin. PTMC appeared to be a suitable carrier for rifampicin alone or in combination with other antibiotics. Biofilm colony forming units and metabolic activity measurement (MTT assay) demonstrated significant (p < 0.05) inhibition for all strains when PTMC loaded with rifampicin and vancomycin was employed, especially after 168 h treatment. Confocal laser scanning microscopy images showed similar qualitative results. PTMC loaded with only gentamicin did not show any inhibition. This exemplifies that PTMC loaded with rifampicin and vancomycin holds promise for the treatment of recalcitrant osteomyelitis. This article is protected by copyright. All rights reserved.

PMID: 26876651 [PubMed – as supplied by publisher]

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The peroxisome proliferator-activated receptors under epigenetic control in placental metabolism and fetal development.

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The peroxisome proliferator-activated receptors under epigenetic control in placental metabolism and fetal development.
Am J Physiol Endocrinol Metab. 2016 Feb 9;:ajpendo.00372.2015
Authors: Lendvai A… Continue reading

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Effects of Oxygen Limitation on the Biosynthesis of Photo Pigments in the Red Microalgae Galdieria sulphuraria Strain 074G.

Effects of Oxygen Limitation on the Biosynthesis of Photo Pigments in the Red Microalgae Galdieria sulphuraria Strain 074G.

PLoS One. 2016;11(2):e0148358

Authors: Sarian…

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Bile ductal injury and ductular reaction are frequent phenomena with different significance in autoimmune hepatitis.

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Bile ductal injury and ductular reaction are frequent phenomena with different significance in autoimmune hepatitis.

Liver Int. 2016 Feb 5;

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Optimising Extinction of Conditioned Disgust.

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Optimising Extinction of Conditioned Disgust.

PLoS One. 2016;11(2):e0148626

Authors: Bosman RC, Borg C, de Jong PJ

Abstract

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Biomarkers or Clinical Observations to Identify (outcome of) Emergency Department Patients with Infection?

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Biomarkers or Clinical Observations to Identify (outcome of) Emergency Department Patients with Infection?

Shock. 2016 Feb 3;

Authors: Quinten…

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The influence of training characteristics on the effect of aerobic exercise training in patients with chronic heart failure: A meta-regression analysis.

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The influence of training characteristics on the effect of aerobic exercise training in patients with chronic heart failure: A meta-regression analysis.

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