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Currently the article with the highest attention score #altmetric #umcg Estimating the reproducibility of psychological science http://flip.it/AiBVNJ
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Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry.
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Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry.
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Ischaemia in heart failure with preserved ejection fraction; is it important?
Eur J Heart Fail. 2016 Apr 20;
Authors: van Veldhuisen DJ, de Boer RA
PMID: 27095562 [PubMed – as supplied by publ… Continue reading
Surgical management and autologous intestinal reconstruction in short bowel syndrome.
Best Pract Res Clin Gastroenterol. 2016 Apr;30(2):263-80
Authors: Hommel MJ, van Baren R, Haveman JW
Abstract
Shor… Continue reading
Neuroscience: Listening in on yourself.
Nature. 2016 Apr 6;532(7597):32-33
Authors: Draaisma D
PMID: 27078554 [PubMed – as supplied by publisher]
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Predicting Performance in Higher Education Using Proximal Predictors.
PLoS One. 2016;11(4):e0153663
Authors: Niessen AS, Meijer RR, Tendeiro JN
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Conflicting Role of Water in the Activation of H2O2 and the Formation and Reactivity of Non-Heme Fe(III)-OOH and Fe(III)-O-Fe(III) Complexes at Room Temperature.
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Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial.
Am J Clin Nutr. 2016 Apr 6;
Authors: Joris PJ, Plat J, Bakker SJ, Mensink RP
Abstract
BACKGROUND: Epidemiologic studies have suggested a protective effect of magnesium intake on cardiovascular disease risk. However, intervention trials of magnesium supplementation on blood pressure and conventional cardiometabolic risk markers are inconsistent. Effects on vascular function markers related to cardiovascular disease risk have rarely been studied.
OBJECTIVE: The objective was to evaluate the effects of long-term magnesium supplementation on arterial stiffness.
DESIGN: We performed a 24-wk, randomized, double-blind, placebo-controlled intervention study. Fifty-two overweight and slightly obese individuals (30 men and 22 postmenopausal women, mean ± SD age: 62 ± 6 y) were randomly allocated to receive either 3 times daily magnesium (3 × 117 mg or 350 mg/d) or placebo capsules. Twenty-four-hour urine collections and 24-h ambulatory blood pressure assessments were performed at the start and end of the study. Carotid-to-femoral pulse wave velocity (PWVc-f) was assessed at baseline, after 12 wk, and at week 24.
RESULTS: Serum magnesium concentrations did not differ after 12 wk but tended to increase after 24-wk magnesium supplementation compared with placebo by 0.02 mmol/L (95% CI: 0.00, 0.04 mmol/L;P= 0.09). Twenty-four-hour urinary magnesium excretion increased by 2.01 mmol (95% CI: 1.22, 2.93 mmol;P< 0.001) at week 24. PWVc-fwas not changed after 12 wk (0.0 m/s; 95% CI: -0.6, 0.5 m/s;P= 0.90) but was improved in the magnesium compared with the placebo group by 1.0 m/s (95% CI: 0.4, 1.6 m/s;P= 0.001) after 24 wk. Office and 24-h ambulatory blood pressure levels were not changed. No adverse events were observed.
CONCLUSION: Our data indicate that a daily magnesium supplement of 350 mg for 24 wk in overweight and obese adults reduces arterial stiffness, as estimated by a decrease in PWVc-f, suggesting a potential mechanism by which an increased dietary magnesium intake beneficially affects cardiovascular health. This trial was registered atclinicaltrials.govasNCT02235805.
PMID: 27053384 [PubMed – as supplied by publisher]
The General Movement Assessment Helps Us to Identify Preterm Infants at Risk for Cognitive Dysfunction.
Front Psychol. 2016;7:406
Authors: Einspieler C, Bos AF, Libertus…
Sympathetic denervation in patients with ischemic cardiomyopathy and risk on ventricular tachy-arrhythmias. A pilot study.
Q J Nucl Med Mol Imaging. 2016 Apr 5;
Authors: Noordzij W, Elvan A, Demirel F, Jager P, Tio R, Slart R
Abstract
BACKGROUND: Patients with ischemic cardiomyopathy (ICM) are at risk for ventricular arrhythmias and are protected by an implantable cardioverter defibrillator (ICD). Visualization of cardiac sympathetic innervation may play an additional role to left ventricular ejection fraction (LVEF) in identifying those patients who will benefit from ICD therapy. The purpose of this study was to detect the role of sympathetic denervation in the genesis of ventricular arrhythmias in ICM patients.
METHOD: 20 patients with ICM and LVEF < 30% were included in this pilot study. Included patients were equally stratified into two groups: no history of arrhythmias (group A) and recurrent arrhythmias (group B). All patients underwent cardiac sympathetic denervation (using carbon-11 labelled meta-hydroxy-ephedrine ([11C]-mHED)), myocardial ischemia and viability detection. Patients were followed up to one year after the imaging studies.
RESULTS: Mean age was 63 ± 7.5 years. Mean global retention of [11C]-mHED was 0.055 ± 0,012 min-1, and was not different between the two patient groups: 0.056 ± 0.011 min-1 vs 0.054 ± 0.013 min-1 for group A vs group B, respectively. During follow-up, seven patients developed ventricular arrhythmias, and four patients died. No difference in [11C]-mHED retention was found between patients with and without ventricular arrhythmia during follow up. However, size of denervated area was larger in patients who died during follow up: 10 ± 1 segments vs 6 ± 2 segments, p = 0.002.
CONCLUSION: Cardiac sympathetic innervation is impaired in patients with ischemic cardiomyopathy. All-cause mortality occurred in those patients with large areas of [11C]- mHED defect.
PMID: 27045577 [PubMed – as supplied by publisher]
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Anthranilic Acid: A New Biomarker and Treatment Target for Schizophrenia.
Ann Psychiatry Ment Health. 2016;4(2)
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Clonal Analysis of Cells with Cellular Barcoding: When Numbers and Sizes Matter.
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Is there a relation between type of primary melanoma treatment and the development of intralymphatic metastasis? A review of the literature.
Cancer Treat Rev. 2016 Mar 2;45:120-128
Authors: Sloot S, Speijers MJ, Bast… Continue reading
Family donors are critical and legitimate in developing countries.
Asian J Transfus Sci. 2016 Jan-Jun;10(1):5-11
Authors: Allain JP, Sibinga CT
Abstract
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Turning Points in the Conception and Regulation of Physician-Assisted Dying in the Netherlands.
Am J Med. 2016 Mar 15;
Authors: Koopman JJ, Boer TA
PMID: 26992560 [PubMed – as supplied by publisher]
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The Puzzle of Structural Brain Connectivity Following Traumatic Incidents.
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