Verbetering van de acute en perioperatieve hemodynamische monitoring

​Thomas Kaufmann: Improving the acute and perioperative hemodynamic assessment Kaufmann had als doel van zijn proefschrift bewijs over de …

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Radiofarmaca voor moleculaire beeldvormingsstudies op het gebied van immunotherapie bij kanker

​Elly van der Veen: Radiopharmaceuticals for translational imaging studies in the field of cancer immunotherapy Van der Veen richtte zich in haar …

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Analyse van het gebruik van preventieve antibiotica bij operaties en empirische antibiotica bij longontstekingen

​Abdul Purba: Pharmacoeconomics of prophylactic, empirical, and diagnostic-based antibiotic treatments. Focus on surgical site infection and …

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Moleculaire tools voor lichtgestuurde therapie

​Friederike Reeßing: Molecular tools for light-navigated therapy Door nieuwe innovaties in de moderne geneeskunde is de gezondheid en kwaliteit van …

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Doelen en voorkeuren van ouderen begrijpen om zorg op maat te kunnen leveren

​Wanda Rietkerk: Tailoring care for older adults. Understanding older adults’ goals and preferences Rietkerk richtte zich in haar proefschrift op het …

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Voorkomen en impact van bewegingsstoornissen bij patiënten met stofwisselingsziekten

​Anouk Kuiper: Movement disorders in inborn errors of metabolism – characterisation of motor and non-motor symptoms Stofwisselingsziekten zijn …

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Nieuwe moleculaire doelwitten in stellaatcellen in de lever voor de behandeling van leverfibrose

Natalia Oyarce Diaz-Smith Cortínez: Novel molecular targets in hepatic stellate cells for the treatment of liver fibrosis​ Leverfibrose is het gevolg …

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Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

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Hemostatic Changes of Acute Kidney Injury in Patients With Cirrhosis: What Do They Mean?

Hepatology. 2020 Jul 04;:

Authors: Lisman T

Abstract
Historically, patients with liver disease were considered to have a bleeding tendency that was a consequence of changes in their hemostatic system. An important consequence of this concept is the ever-ongoing policy of prophylactic blood product transfusion prior to invasive procedures aimed to reduce bleeding risk. However, it is increasingly acknowledged that although bleeding in patients with liver diseases can be the consequence of a (temporal) hypocoagulable state, it is frequently unrelated to hemostatic failure and rather caused by portal hypertension (e.g., variceal bleeding) or inadvertent laceration of a blood vessel (e.g., during liver biopsy or paracentesis).

PMID: 32623738 [PubMed – as supplied by publisher]

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‘Heartbeat-to-heartbeat’-karakterisering van hartweefsel

Maaike van den Boomen: Heartbeat-to-heartbeat cardiac tissue characterization ​Er bestaan verschillende MRI-technieken om veranderingen in het …

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Risicofactoren voor het krijgen van een subarachnoïdale bloeding en tweede bloeding onderzocht

​Karlijn van Donkelaar: Epidemiological insights in management of aneurysmal subarachnoid hemorrhage Bij een beroerte gaat er iets mis in de …

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Plasticiteit van gezichtsveldrepresentaties

​Joana De Oliveira Carvalho : Plasticity of visual field representations Om het aanpassingsvermogen van de visuele cortex te begrijpen is het …

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Advances of epigenetic editing.

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Advances of epigenetic editing.

Curr Opin Chem Biol. 2020 Jun 29;57:75-81

Authors: Gjaltema RAF, Rots MG

Abstract
Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the local epigenetic landscape of an endogenous genomic site, often with the aim of transcriptional reprogramming. Implementing clustered regularly interspaced short palindromic repeat-dCas9 greatly accelerated the advancement of epigenetic editing, yielding preclinical therapeutic successes using a variety of epigenetic enzymes. ,CRISPR/dCas9 Here, were review the current applications of these epigenetic editing tools in mammalians and shed light on biochemical improvements that facilitate versatile applications.

PMID: 32619853 [PubMed – as supplied by publisher]

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(University Medical Center Groni*[ad] OR University Medical Centre Groni*[ad] OR university Medical Centre of Groni*[ad] OR university Medical Center of Groni*[ad] OR University Medical Center, Groni*[ad] OR University Medical Centre, Groni*[ad] OR university of groni*[ad] OR groningen universit*[ad] OR UMC groni*[ad] OR medical center groni*[ad] OR medical centre groni*[ad] OR university hospital groni*[ad] OR university groni*[ad] OR Universitair Medisch Centrum Groni*[ad] OR Rijksuniversiteit Groni*[ad] OR academic hospital groni*[ad] OR academisch ziekenhuis groni*[ad] OR azg[ad] OR UMCG[ad] OR 9713 GZ[ad] OR 9713GZ[ad] OR 9713 AV[ad] OR 9713AV[ad] OR hanzeplein[ad] OR deusinglaan[ad] OR (beatrix*[ad] AND groni*[ad]) OR (rug[ad] AND groni*[ad])); +124 new citations

124 new pubmed citations were retrieved for your search.
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(University Medical Center Groni*[ad] OR University Medical Centre Groni*[ad] OR university Medical Centre of Groni*[ad] OR university Medical Center of Groni*[ad] OR University Medical Center, Groni*[ad] OR University Medical Centre, Groni*[ad] OR university of groni*[ad] OR groningen universit*[ad] OR UMC groni*[ad] OR medical center groni*[ad] OR medical centre groni*[ad] OR university hospital groni*[ad] OR university groni*[ad] OR Universitair Medisch Centrum Groni*[ad] OR Rijksuniversiteit Groni*[ad] OR academic hospital groni*[ad] OR academisch ziekenhuis groni*[ad] OR azg[ad] OR UMCG[ad] OR 9713 GZ[ad] OR 9713GZ[ad] OR 9713 AV[ad] OR 9713AV[ad] OR hanzeplein[ad] OR deusinglaan[ad] OR (beatrix*[ad] AND groni*[ad]) OR (rug[ad] AND groni*[ad]))

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Nieuwe inzichten in de desinfectie van het wortelkanaalsysteem met behulp van verschillende onderzoeksmodellen

Thais Pereira: New insights into the disinfection of the root canal system using different research models ​Een endodontische infectie is een door …

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Van de wond naar het lab: wondkoloniserende bacteriën en hun interacties

​Andrea García Pérez: From the wound to the bench: A study of wound-colonising bacteria and their interactions: A study of wound-colonising bacteria …

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Effect van griepvaccins voor ouderen op ziekenhuisopnames

​Rob van Aalst: An economic assessment of high-dose influenza vaccine. Estimating the vaccine-preventable burden of disease in the United States …

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Nanomedicine in Thrombosis and Hemostasis: The Future of Nanotechnology in Thrombosis and Hemostasis Research and Clinical Applications.

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Nanomedicine in Thrombosis and Hemostasis: The Future of Nanotechnology in Thrombosis and Hemostasis Research and Clinical Applications.

Semin Thromb Hemost. 2020 Jul;46(5):521-523

Authors: Hagemeyer CE, Lisman T, Kwaan HC

PMID: 32604418 [PubMed – as supplied by publisher]

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Effect van sigarettenrook op darmepitheel

​Yingying Cui: Epithelial and subepithelial players in chronic intestinal disease Een belangrijke barrière in je darmen is het zogenoemde …

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De rollen van MYO5B in epitheelcellen en de darm

​Changsen Leng: The roles of MYO5B in epithelial cells and the intestine. A focus on microvillus inclusion disease MYO5B speelt een belangrijke rol …

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De gunstige effecten van oligosacchariden in moedermelk en hun structuur-functie relaties

​Lianghui Cheng: Mom’s sweet gift. The beneficial effects of human milk oligosaccharides and its structure-function relationships Cheng richtte zich …

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