Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.

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Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.

Atherosclerosis. 2014 Jan;232(1):242-8

Authors: …

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DNA replication at the single-molecule level.

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DNA replication at the single-molecule level.

Chem Soc Rev. 2014 Feb 21;43(4):1201-20

Authors: Stratmann SA, van Oijen AM

Abstract

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Accommodating the Bayley-III for motor and/or visual impairment: a comparative pilot study.

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Accommodating the Bayley-III for motor and/or visual impairment: a comparative pilot study.

Pediatr Phys Ther. 2014;26(1):57-67

Authors: Visser…

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Surgical minimally invasive pulmonary vein isolation for lone atrial fibrillation: midterm results of a multicenter study.

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Surgical minimally invasive pulmonary vein isolation for lone atrial fibrillation: midterm results of a multicenter study.

Innovations (Phila). 2013…

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Light-controlled formation of vesicles and supramolecular organogels by a cholesterol-bearing amphiphilic molecular switch.

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Light-controlled formation of vesicles and supramolecular organogels by a cholesterol-bearing amphiphilic molecular switch.

Chemistry. 2014 Feb…

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What cues do ungulates use to assess predation risk in dense temperate forests?

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What cues do ungulates use to assess predation risk in dense temperate forests?

PLoS One. 2014;9(1):e84607

Authors: Kuijper DP, Verwijmeren M,…

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Efficacy of high dose methotrexate in pediatric auto-immune uveitis

Wineke Armbrust, Wietse Wieringa, Leonie Los
Pediatric Rheumatology 2014, 12:P234 (17 September 2014)

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Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts.

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Glycogen synthase kinase-3 (GSK-3) regulates TGF-β₁-induced differentiation of pulmonary fibroblasts.

Br J Pharmacol. 2013 Jun;169(3):590-603

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Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale.

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Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale.

J…

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Plasma microparticle tissue factor activity in patients with antiphospholipid antibodies with and without clinical complications.

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Plasma microparticle tissue factor activity in patients with antiphospholipid antibodies with and without clinical complications.

Thromb Res. 2014…

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[Dental implants: a solution for lost dental elements].

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[Dental implants: a solution for lost dental elements].

Ned Tijdschr Geneeskd. 2013;157(52):A6552

Authors: Raghoebar GM, Meijer HJ, Cune MS,…

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[Sport performance with a prosthesis].

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[Sport performance with a prosthesis].

Ned Tijdschr Geneeskd. 2013;157(52):A6956

Authors: van Keeken H, Bongers RM, Dekker R, van der Woude LH

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X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes.

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X-ray structure, thermodynamics, elastic properties and MD simulations of cardiolipin/dimyristoylphosphatidylcholine mixed membranes.

Chem Phys Lipids….

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The Gastrin-Releasing Peptide Receptor as Target for Molecular Imaging of Prostate Cancer

No description abstract

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[Does CT scan for blunt abdominal trauma in children amount to a lot of radiation for little yield?].

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[Does CT scan for blunt abdominal trauma in children amount to a lot of radiation for little yield?].

Ned Tijdschr Geneeskd. 2013;158(52):A6519

Authors: Nellensteijn DR, El Moumni M, Greuter M, Kneyber M, Hulscher JB

Abstract

Blunt abdominal trauma in children occurs fairly frequently. Although computed tomography scanning is considered by many to be the gold standard, in children who are hemodynamically stable, CT images do not usually result in new perspectives that lead to changes in treatment management. However, the burden of radiation for the child is considerable. CT scanning for blunt abdominal trauma should therefore be avoided in children who are hemodynamically stable. Novel algorithms, using parameters from the patient’s history, physical examination, and possibly ultrasound and laboratory tests, seem to be sufficient for ruling out intra-abdominal injury in more than 95% of cases.

PMID: 24382053 [PubMed - indexed for MEDLINE]

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Sluggish cognitive tempo and its neurocognitive, social and emotive correlates: a systematic review of the current literature

Anna K Mueller, Lara Tucha, Janneke Koerts, Yvonne Groen, Klaus W Lange, Oliver Tucha
Journal of Molecular Psychiatry 2014, 2:5 (5 August 2014)

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PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.

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PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.

Neuroimage. 2014 Feb 15;87:395-402

Authors: de Paula Faria D, de Vries EF, Sijbesma JW, Dierckx RA, Buchpiguel CA, Copray S

Abstract

Multiple Sclerosis (MS) is a neurodegenerative disease characterized by demyelinated lesions. PET imaging using specific myelin radioligands might solve the lack of a specific imaging tool for diagnosing and monitoring demyelination and remyelination in MS patients. In recent years, a few tracers have been developed for in vivo PET imaging of myelin, but they have not been fully evaluated yet. In this study, we compared [(11)C]CIC and [(11)C]MeDAS as PET tracers for monitoring demyelination and remyelination in cuprizone-fed mice. The ex vivo biodistribution of [(11)C]CIC showed decreased tracer uptake in mice fed with 0.2% cuprizone diet for 5 weeks, as compared to control mice. However, tracer uptake did not increase again after normal diet was restored for 5 weeks (remyelination). Surprisingly, in vivo PET imaging with [(11)C]CIC in cuprizone-fed mice revealed a significant reduction in whole brain tracer uptake after 5 weeks of remyelination. No correlation between ex vivo biodistribution and in vivo imaging data was found for [(11)C]CIC (r(2)=0.15, p=0.11). However, a strong correlation was found for [(11)C]MeDAS (r(2)=0.88, p<0.0001). [(11)C]MeDAS ex vivo biodistribution revealed significant decreased brain uptake in the demyelination group, as compared to controls and increased the tracer uptake after 5 weeks of remyelination. [(11)C]MeDAS images showed a low background signal and clear uptake in the brain white matter and spinal cord. Taken together, the results of this comparative study between [(11)C]CIC and [(11)C]MeDAS clearly show that [(11)C]MeDAS is the preferred PET tracer to monitor myelin changes in the brain and spinal cord in vivo.

PMID: 24188813 [PubMed - indexed for MEDLINE]

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Calculating optimal surveillance for detection of von Hippel-Lindau-related manifestations.

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Calculating optimal surveillance for detection of von Hippel-Lindau-related manifestations.

Endocr Relat Cancer. 2014 Feb;21(1):63-71

Authors: Kruizinga RC, Sluiter WJ, de Vries EG, Zonnenberg BA, Lips CJ, van der Horst-Schrivers AN, Walenkamp AM, Links TP

Abstract

von Hippel-Lindau (VHL) mutation carriers develop benign and malignant tumors, requiring regular surveillance. The aim of this study was to calculate the optimal organ-specific age to initiate surveillance and optimal intervals to detect initial and subsequent VHL-related manifestations. In this study, we compare these results with the current VHL surveillance guidelines. We collected data from 82 VHL mutation carriers in the Dutch VHL surveillance program. The cumulative proportion of carriers diagnosed with a first VHL-related manifestation was estimated by the Kaplan-Meier method. The Poisson distribution model was used to calculate average time to detection of the first VHL-related manifestation and subsequent manifestations. We used this to calculate the optimal organ-specific age to initiate surveillance and the surveillance interval that results in a detection probability of 5%. The calculated organ-specific ages to initiate surveillance were 0 years (birth) for adrenal glands, 7 years for the retina, 14 years for the cerebellum, 15 years for the spinal cord, 16 years for pancreas, and 18 years for the kidneys. The calculated surveillance intervals were 4 years for the adrenal glands, biennially for the retina and pancreas, and annually for the cerebellum, spinal cord, and kidneys. Compared with current VHL guidelines, the calculated starting age of surveillance was 6 years later for the retina and 5 years earlier for adrenal glands. The surveillance intervals were two times longer for the retina and four times longer for the adrenal glands. To attain a 5% detection probability rate per organ, our mathematical model indicates that several modifications of current VHL surveillance guidelines should be considered.

PMID: 24132471 [PubMed - indexed for MEDLINE]

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Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.

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Evaluation of monophosphoryl lipid A as adjuvant for pulmonary delivered influenza vaccine.

J Control Release. 2014 Jan 28;174:51-62

Authors: Patil HP, Murugappan S, ter Veer W, Meijerhof T, de Haan A, Frijlink HW, Wilschut J, Hinrichs WL, Huckriede A

Abstract

Prophylaxis against influenza could be improved by the development of a stable, easy to deliver, potent mucosal vaccine. In this study, we spray-freeze-dried (SFD) whole inactivated virus influenza vaccine (WIV) alone or supplemented with monophosphoryl lipid A (MPLA) using inulin as a lyoprotectant. Physical characterization revealed that the SFD powder consisted of highly porous particles with a size distribution suitable for pulmonary administration. The receptor-binding properties of WIV and the immunostimulatory properties of MPLA were preserved after spray-freeze-drying as indicated by unchanged hemagglutination titers and a retained ability of the vaccine to activate NFkB after incubation with a reporter cell line, respectively. Pulmonary vaccination of mice with MPLA-adjuvanted liquid or powder WIV resulted in induction of higher mucosal and systemic antibody concentrations than vaccination with non-adjuvanted formulations. When exposed to influenza virus, mice immunized with MPLA-adjuvanted pulmonary vaccine showed similar protection in terms of reduction in lung virus titers and prevention of weight loss as mice immunized intramuscularly with subunit vaccine. Characterization of the antibody response revealed a balanced IgG2a-to-IgG1 profile along with induction of both memory IgA- and IgG-producing B cells in mice immunized with MPLA-adjuvanted vaccine. These studies suggest that the mucosal and systemic immune responses to pulmonary delivered influenza vaccines can be significantly enhanced by using MPLA as adjuvant. MPLA-adjuvanted SFD vaccine was particularly effective implying that delivery of adjuvanted vaccine powder to the lungs can be an attractive way of immunization against influenza.

PMID: 24269505 [PubMed - indexed for MEDLINE]

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The effectiveness of the Allen Carr smoking cessation training in companies tested in a quasi-experimental design

Arie Dijkstra, Rixt Zuidema, Diederick Vos, Marike van Kalken
BMC Public Health 2014, 14:952 (13 September 2014)

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