Functioneren van kinderen met brandwonden geanalyseerd

​Moniek Akkerman: Functioning beyond pediatric burns. Physical activity, fatigue, and exercise capacity up to 5 years post burn Brandwonden bij …

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Uitgebreide karakterisering van Escherichia coli geïsoleerd uit urinemonsters van gehospitaliseerde patiënten in Rio de Janeiro

​Ana Da Cruz Campos: Comprehensive characterization of Escherichia coli isolated from urine samples of hospitalized patients in Rio de Janeiro, …

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Spatially-guided non-local mean approach for denoising of PET images.

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Spatially-guided non-local mean approach for denoising of PET images.

Med Phys. 2020 Jan 18;:

Authors: Arabi H, Zaidi H

Abstract
PURPOSE: Non-local mean (NLM) filtering proved to be an effective tool for noise reduction in natural and medical imaging. The technique relies on existing redundant information in the input image to discriminate the genuine signal from noise. However, due to the prohibitively long computation time, the search for finding similar information is confined by a predefined search window, which may hamper the performance of this filter. In this work, a spatially-guided non-local mean (SG-NLM) approach is proposed to overcome this issue. The proposed method was evaluated on whole-body PET images presenting with high noise levels, which adversely affect lesion detectability and quantitative accuracy.
METHODS: In the SG-NLM method, as opposed to the conventional NLM method, where a predefined search window is defined to confine exhaustive search for finding similar patterns, the information about similar patterns is extracted from the clustered version (created based on signal intensity levels) of the input image as well as information about prominent edges. The performance of the SG-NLM was evaluated against post-reconstruction NLM, Gaussian, bilateral and BayesShrink Wavelet denoising approaches. A digital phantom containing three small spheres mimicking lesions in the lung, experimental study using the Jaszczak phantom and whole-body PET/CT clinical studies were utilized to assess the performance of abovementioned denoising approaches.
RESULTS: The SG-NLM method led to a signal-to-noise (SNR) increase from 21.3 (unfiltered PET image) to 30.1 in computer simulations of small lesions while the NLM mean filer resulted in an SNR of 29.4 (p<0.05). The experimental Jaszczak phantom study demonstrated that the contrast-to-noise ratio (CNR) increased from 11.3 when using the Gaussian filter to 18.6 and 19.5 when using NLM and SG-NLM filters (p<0.05), respectively. The superior performance of the SG-NLM approach was confirmed by the clinical studies where the bias in malignant lesions decreased to -2.3±1.1% compared to -11.7±2.4 and -2.9±1.1 achieved by the Gaussian and NLM methods (p<0.05), respectively.
CONCLUSIONS: The proposed SG-NLM achieves promising compromise between noise reduction and signal preservation compared to the conventional NLM method. The superior performance of the SG-NLM method was accomplished without adding extra burden to the computational complexity of the conventional NLM filter, which makes it attractive for denoising PET images.

PMID: 31955433 [PubMed – as supplied by publisher]

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Verstoord eiwittransport bij ziektebeelden: op weg naar inzicht in de files bij microvillus inclusieziekte en de ziekte van Wilson

Arend Overeem: Polarized protein trafficking and disease: towards understanding the traffic jams in microvillus inclusion- and Wilson disease. ​Voor …

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Hoe mensen hun dynamische balans bewaren tijdens het lopen

Tom Buurke: Adaptive control of dynamic balance in human walking​ Mensen denken er doorgaans niet veel over na hoe ze eigenlijk rechtop blijven …

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Religiosity and Mental Health: A Contribution to Understanding the Heterogeneity of Research Findings.

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Religiosity and Mental Health: A Contribution to Understanding the Heterogeneity of Research Findings.

Int J Environ Res Public Health. 2020 Jan 13;17(2):

Authors: Malinakova K, Tavel P, Meier Z, van Dijk JP, Reijneveld SA

Abstract
Most studies report positive associations between religiosity and spirituality and aspects of mental health, while a small proportion report mixed or fully negative associations. The aim of this study was to assess the associations of religiosity measured more specifically, with mental health in a secular environment, using a nationally representative sample of Czech adults (n = 1795). We measured religious affiliation, conversion experience, non-religious attitudes and the stability of these attitudes, mental health problems, and anxiety levels. Compared to stable non-religious respondents, unstable non-religious and converted respondents who perceived God as distant were more likely to experience anxiety in close relationships, and had higher risks of worse mental health. Our findings support the idea that the heterogeneity of findings in associations between religiosity/spirituality and mental health could be due to measurement problems and variation in the degree of secularity. A shift towards religiosity could be expected to be seen in a substantial part of non-religious respondents in problematic times.

PMID: 31941039 [PubMed – in process]

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A good beginning: study protocol for a group-randomized trial to investigate the effects of sit-to-stand desks on academic performance and sedentary time in primary education.

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A good beginning: study protocol for a group-randomized trial to investigate the effects of sit-to-stand desks on academic performance and sedentary time in primary education.

BMC Public Health. 2020 Jan 15;20(1):70

Authors: van Delden ALEQ, Band GPH, Slaets JPJ

Abstract
BACKGROUND: Sedentary behavior is associated with health risks and academic under-achievement in children. Still, children spend a large part of their waking hours sitting at a desk at school. Recent short-term studies demonstrated the potential of sit-to-stand desks to reduce sitting time in primary education. The program of “A Good Beginning” was conceived to assess the long-term effects of sit-to-stand desks on sitting time in primary education, and to examine how sit-to-stand desks versus regular desks relate to academic performance, and measures of executive functioning, health and wellbeing. The present paper describes the design of this group-randomized trial, which started in 2017 and will be completed in 2019.
METHODS: Children of two grade-three groups (age 8-9) following regular primary education in Leiden, The Netherlands, were recruited. A coin toss determined which group is the experimental group; the other group is the control group. All children in the experimental group received sit-to-stand desks. They are invited and motivated to reduce sedentary time at school, however, it is their own choice to sit or stand. Children in the control group use regular desks. Otherwise, both groups receive regular treatment. Outcomes are assessed at baseline (T0) and at five follow-up sessions (T1-T5) alternately in winter and summer seasons over three academic years. Primary outcome measures are academic performance, and the proportion of sitting time at school, measured with a 3D accelerometer. Secondary outcome measures are a number of measures related to executive functioning (e.g., N-back task for working memory), health (e.g., height and weight for BMI), and wellbeing (e.g., KIDSCREEN-52 for Quality of Life).
DISCUSSION: A Good Beginning is a two-and-a-half-year research program, which aims to provide a better understanding of the long-term effects of sit-to-stand desks on sedentary time at school and the relation between sitting time reduction and academic performance, executive functioning, health and wellbeing. The findings may serve as useful information for policy making and practical decision making for school and classroom environments.
TRIAL REGISTRATION: The program of “A Good Beginning” is registered at the Netherlands Trial Register (NTR, https://www.trialregister.nl), number NL6166, registration date 24 November 2016.

PMID: 31941471 [PubMed – in process]

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Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients.

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Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients.

Psychol Med. 2020 Jan 16;:1-11

Authors: van Leeuwen JMC, Vinkers CH, Vink M, Kahn RS, Joëls M, Hermans EJ

Abstract
BACKGROUND: An adaptive neural stress response is essential to adequately cope with a changing environment. It was previously argued that sympathetic/noradrenergic activity during acute stress increases salience network (SN) connectivity and reduces executive control network (ECN) connectivity in healthy controls, with opposing effects in the late aftermath of stress. Altered temporal dynamics of these networks in response to stress are thought to play a role in the development of psychopathology in vulnerable individuals.
METHODS: We exposed male healthy controls (n = 40, mean age = 33.9) and unaffected siblings of schizophrenia patients (n = 39, mean age = 33.2) to the stress or control condition of the trier social stress test and subsequently investigated resting state functional connectivity of the SN and ECN directly after and 1.5 h after stress.
RESULTS: Acute stress resulted in increased functional connectivity within the SN in healthy controls, but not in siblings (group × stress interaction pfwe < 0.05). In the late aftermath of stress, stress reduced functional connectivity within the SN in both groups. Moreover, we found increased functional connectivity between the ECN and the cerebellum in the aftermath of stress in both healthy controls and siblings of schizophrenia patients.
CONCLUSIONS: The results show profound differences between siblings of schizophrenia patients and controls during acute stress. Siblings lacked the upregulation of neural resources necessary to quickly and adequately cope with a stressor. This points to a reduced dynamic range in the sympathetic response, and may constitute a vulnerability factor for the development of psychopathology in this at-risk group.

PMID: 31941558 [PubMed – as supplied by publisher]

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Volumetric Effect of Pregnancy on a Unilateral Facial Fat Graft.

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Volumetric Effect of Pregnancy on a Unilateral Facial Fat Graft.

Plast Reconstr Surg Glob Open. 2019 Sep;7(9):e2358

Authors: Tuin AJ, Schepers RH, Spijkervet FKL, Vissink A, Jansma J

Abstract
Weight gain can affect the volume of a facial fat graft, resulting in unfavorable asymmetries. Weight gain during pregnancy is more complex and does not just entail an increase in adipose tissue. This case report objectifies whether pregnancy results in volume changes of a facial fat graft. A 24-year-old woman received a fat graft (7 ml) in the mandibular area to mask a volume deficiency. This deficiency occurred after a fibula reconstruction of a mandibular defect resulting from the removal of an ameloblastoma. The patient became pregnant 3 weeks after the fat graft procedure. Standardized 3-dimensional photographs (3dMD) were available preoperatively and at 7 weeks (first trimester), 6 months (second trimester), 9 months (third trimester), and 14 months (4 months after delivery) postoperatively. Three-dimensional analysis revealed that no substantial volume changes of the fat graft occurred during pregnancy other than the overall proportional gain in facial volume. Pregnancy apparently does not affect the volume of a small unilateral fat graft applied in the facial region.

PMID: 31942369 [PubMed]

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Fysieke activiteit en fysieke fitheid bij kinderen met een chronische aandoening

Joyce Bos: Physical activity and physical fitness in children with chronic conditions ​Bos richtte zich in haar proefschrift op fysieke activiteit en …

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The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients

Tiantian Zhai: The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients​ Elk …

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Human ADME for YH12852 using wavelength scanning cavity ring-down spectroscopy (WS-CRDS) after a low radioactivity dose.

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Human ADME for YH12852 using wavelength scanning cavity ring-down spectroscopy (WS-CRDS) after a low radioactivity dose.

Bioanalysis. 2020 Jan;12(2):87-98

Authors: Kim A, Dueker SR, Dong F, Roffel AF, Lee SW, Lee H

Abstract
Aim: Human 14C radiotracer studies provide information-rich data sets that enable informed decision making in clinical drug development. These studies are supported by liquid scintillation counting after conventional-sized 14C doses (50-200 μCi) or complex accelerator mass spectrometry (AMS) after microtracer-sized doses (∼0.1-1 μCi). Mid-infrared laser-based ‘cavity ring-down spectroscopy’ (CRDS) is an emerging platform for the sensitive quantitation of 14C tracers. Results & methodology: We compared the total 14C concentrations in plasma and urine samples from a microtracer study using both CRDS and AMS technology. The data were evaluated using statistical and pharmacokinetic modeling. Conclusion: The CRDS method closely reproduced the AMS method for total 14C concentrations. With optimization of the automated sample interface and further testing, it promises to be an accessible, robust system for pivotal microtracer investigations.

PMID: 31928227 [PubMed – in process]

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The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery.

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The association of preoperative anxiety and depression with neurocognitive disorder following oncological surgery.

J Surg Oncol. 2020 Jan 12;:

Authors: Du J, Plas M, Absalom AR, van Leeuwen BL, de Bock GH

Abstract
BACKGROUND: The proposed underlying mechanisms of anxiety and depression, and of postoperative neurocognitive disorder (NCD), each include immune system involvement. Therefore, the aims of this study were to investigate the incidence of postoperative NCD 3 months after surgery among oncological patients undergoing surgery and to evaluate the role of preoperative anxiety and depression.
METHOD: A consecutive series of patients (age ≥ 18 years) undergoing surgery for the removal of solid tumors were included (n = 218). Cognitive performance was assessed preoperatively and at 3 months postoperatively. Preoperative anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale.
RESULTS: NCD affected 12.3% of elderly patients (age ≥ 70 years, n = 57) at 3 months after surgery, with executive function mostly affected. By contrast, 8.4% of younger patients (age < 70 years, n = 107) were affected, with information processing speed mostly affected. Low educational attainment was a risk factor (OR, 6.0; 95% CI, 1.9-19.0) of overall NCD, whereas preoperative anxiety was associated with decline in the domain of executive function.
CONCLUSION: Postoperative NCD is a complication of oncological surgery for all adults instead of the elderly only. Preoperative anxiety was associated with an increased risk of executive function decline, and low educational attainment was a key factor for overall NCD.

PMID: 31930514 [PubMed – as supplied by publisher]

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Social stress and glucocorticoids alter PERIOD2 rhythmicity in the liver, but not in the suprachiasmatic nucleus.

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Social stress and glucocorticoids alter PERIOD2 rhythmicity in the liver, but not in the suprachiasmatic nucleus.

Horm Behav. 2020 Jan 10;:104683

Authors: Ota SM, Hut R, Riede SJ, Crosby P, Suchecki D, Meerlo P

Abstract
Circadian (~24 h) rhythms in behavior and physiological functions are under control of an endogenous circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN directly drives some of these rhythms or serves as a coordinator of peripheral oscillators residing in other tissues and organs. Disruption of the circadian organization may contribute to disease, including stress-related disorders. Previous research indicates that the master clock in the SCN is resistant to stress, although it is unclear whether stress affects rhythmicity in other tissues, possibly mediated by glucocorticoids released in stressful situations. In the present study, we examined the effect of uncontrollable social defeat stress and glucocorticoid hormones on the central and peripheral clocks, respectively in the SCN and liver. Transgenic PERIOD2::LUCIFERASE knock-in mice were used to assess the rhythm of the clock protein PERIOD2 (PER2) in SCN slices and liver tissue collected after 10 consecutive days of social defeat stress. The rhythmicity of PER2 expression in the SCN was not affected by stress exposure, whereas in the liver the expression showed a delayed phase in defeated compared to non-defeated control mice. In a second experiment, brain slices and liver samples were collected from transgenic mice and exposed to different doses of corticosterone. Corticosterone did not affect PER2 rhythm of the SCN samples, but caused a phase shift in PER2 expression in liver samples. This study confirms earlier findings that the SCN is resistant to stress and shows that clocks in the liver are affected by social stress, which might be due to the direct influence of glucocorticoids released from the adrenal gland.

PMID: 31930968 [PubMed – as supplied by publisher]

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Neutrophil-endothelial interactions in respiratory syncytial virus bronchiolitis: An understudied aspect with a potential for prediction of severity of disease.

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Neutrophil-endothelial interactions in respiratory syncytial virus bronchiolitis: An understudied aspect with a potential for prediction of severity of disease.

J Clin Virol. 2019 Dec 31;123:104258

Authors: Juliana A, Zonneveld R, Plötz FB, van Meurs M, Wilschut J

Abstract
Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) causes significant morbidity and mortality among young infants worldwide. It is currently widely accepted that neutrophil influx into the airways is a hallmark of the pathophysiology. However, the exact mechanism of neutrophil migration from the vasculature into the alveolar space in RSV LRTI has received little attention. Data shows that endothelial cells become activated upon RSV infection, driving a ‘pro-adhesive state’ for circulating neutrophils with upregulation of endothelial intercellular adhesion molecule-1 (ICAM-1). During RSV LRTI different subsets of immature and mature neutrophils are present in the bloodstream, that upregulate integrins lymphocyte-function associated antigen (LFA)-1 and macrophage (Mac)-1, serving as ICAM-1 ligands. An alveolar gradient of interleukin-8 may serve as a potent chemoattractant for circulating neutrophils. Neutrophils from lung aspirates of RSV-infected infants show further signs of inflammatory and migratory activation, while soluble endothelial cell adhesion molecules (sCAMs), such as sICAM-1, have become measurable in the systemic circulation. Whether these mechanisms are solely responsible for neutrophil migration into the alveolar space remains under debate. However, data indicate that the currently postulated neutrophil influx into the lungs should rather be regarded as a neutrophil efflux from the vasculature, involving substantial neutrophil-endothelial interactions. Molecular patterns of these interactions may be clinically useful to predict outcomes of RSV LRTI and deserve further study.

PMID: 31931445 [PubMed – as supplied by publisher]

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Nieuwe therapeutische targets tegen neurodegeneratie

Angelica Sabogal Guaqueta: Unraveling molecular signaling in neurodegenerative diseases. Focus on a protective mechanism mediated by linalool …

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De gevolgen van aneuploïdie en chromosoominstabiliteit: overleven, celdood en kanker

Klaske Schukken: The consequences of aneuploidy and chromosome instability. Survival, cell death and cancer​ Als een cel deelt, moet zij alle …

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Bijwerkingen na manueel therapeutische handelingen aan de halswervelkolom

​Rik Kranenburg: Adverse events following cervical manual physical therapy techniques Kranenburg richtte zich in zijn proefschrift op het verkrijgen …

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Effecten van hand- en polsletsel bij jonge patiënten zonder botontkalking

​Charlotte Lameijer: Perspectives on outcome following hand and wrist injury in non-osteoporotic patients Als jonge patiënten die nog geen last …

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Endovasculaire benaderingen van complexe aorta-aneurysma’s

​Arne De Niet: Arne de Niet : Endovascular approaches to complex aortic aneurysms De behandeling van de verwijde buikslagader, het abdominaal …

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