Innovaties in de tandheelkunde: nodig of overbodig?

​Ulf Schepke: Restorative dentistry done digitally Innovaties in de tandheelkunde zijn soms daadwerkelijk verbeteringen, maar soms ook overbodig. Dat …

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Water-based alkyl ketene dimer ink for user-friendly patterning in paper microfluidics

Water-based alkyl ketene dimer ink for user-friendly patterning in paper microfluidics

Hamidon, N. N., Hong, Y., Salentijn, G. I. & Verpoorte, E. 13-Feb-2018 In : Analytica Chimica Acta. 1000, p. 180-190 11 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 180-190
Number of pages 11
Journal Analytica Chimica Acta
Volume 1000
State Published – 13-Feb-2018
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Water-based alkyl ketene dimer ink for user-friendly patterning in paper microfluidics

Water-based alkyl ketene dimer ink for user-friendly patterning in paper microfluidics

Hamidon, N. N., Hong, Y., Salentijn, G. I. & Verpoorte, E. 13-Feb-2018 In : Analytica Chimica Acta. 1000, p. 180-190 11 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 180-190
Number of pages 11
Journal Analytica Chimica Acta
Volume 1000
State Published – 13-Feb-2018
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Onderzoek naar praktische problemen ‘stepped wedge design’ studie

​Zhuozhao Zhan: Evaluation and analysis of stepped wedge designs Zhuozhao Zhan verrichte onderzoek naar de praktische problemen van studies die zijn …

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Veroudering van bloedstamcellen door verandering in genactiviteit

​Seka Simone Lazara: On the molecular mechanisms of hematopoietic stem cell aging Veroudering van bloedstamcellen wordt voor een groot deel …

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Cholesterol Absorption and Synthesis in Vegetarians and Omnivores.

Cholesterol Absorption and Synthesis in Vegetarians and Omnivores.

Mol Nutr Food Res. 2018 Feb 10;:

Authors: Lütjohann D, Meyer S, von Bergmann K, Stellaard F

Abstract
SCOPE: Vegetarian diets are considered health promoting, however, a plasma cholesterol lowering effect is not always observed. We investigated the link between vegetarian diet-induced alterations in cholesterol metabolism.
METHODS AND RESULTS: We studied male and female omnivores, lacto-ovo vegetarians, lacto vegetarians and vegans. Cholesterol intake, absorption and fecal sterol excretion were measured as well as plasma concentrations of cholesterol and non-cholesterol sterols. These served as markers for cholesterol absorption, synthesis and catabolism. The biliary cholesterol secretion rate was estimated. Flux data were related to bodyweight. Individual vegetarian diet groups were statistically compared to the omnivore group. Lacto vegetarians absorbed 44% less dietary cholesterol, synthesized 22% more cholesterol and showed no differences in plasma total and LDL cholesterol. Vegan subjects absorbed 90% less dietary cholesterol, synthesized 35% more cholesterol and had a similar plasma total cholesterol, but a 13% lower plasma LDL cholesterol. No diet-related differences in biliary cholesterol secretion and absorption were observed. Total cholesterol absorption was lower only in vegans. Total cholesterol input was similar under all vegetarian diets.
CONCLUSIONS: Unaltered biliary cholesterol secretion and higher cholesterol synthesis blunt the lowered dietary cholesterol intake in vegetarians. LDL cholesterol was significantly lower only in vegans. This article is protected by copyright. All rights reserved.

PMID: 29427539 [PubMed – as supplied by publisher]

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Navigating the Complexities of Undergraduate Medical Curriculum Change: Change Leaders’ Perspectives.

Navigating the Complexities of Undergraduate Medical Curriculum Change: Change Leaders’ Perspectives.

Acad Med. 2018 Feb 06;:

Authors: Velthuis F, Varpio L, Helmich E, Dekker H, Jaarsma ADC

Abstract
PURPOSE: Changing an undergraduate medical curriculum is a recurring, high-stakes undertaking at medical schools. This study aimed to explore how people leading major curriculum changes conceived of the process of enacting change and the strategies they relied on to succeed in their efforts.
METHOD: The first author individually interviewed nine leaders who were leading or had led the most recent undergraduate curriculum change in one of the eight medical schools in the Netherlands. Interviews were between December 2015 and April 2016, using a semi-structured interview format. Data analysis occurred concurrently with data collection, with themes being constructed inductively from the data.
RESULTS: Leaders conceived of curriculum change as a dynamic, complex process. They described three major challenges they had to deal with while navigating this process: the large number of stakeholders championing a multitude of perspectives, dealing with resistance, and steering the change process. Additionally, strategies for addressing these challenges were described. The authors identified an underlying principle informing the work of these leaders: being and remaining aware of emerging situations, and carefully constructing strategies for ensuring the intended outcomes were reached and contributed to the progress of the change process.
DISCUSSION: This empirical, descriptive study enriches the understanding of how institutional leaders navigate the complexities of major medical curriculum changes. The insights serve as a foundation for training and coaching future change leaders. To broaden the understanding of curriculum change processes, future studies could investigate the processes through alternative stakeholder perspectives.Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.

PMID: 29419547 [PubMed – as supplied by publisher]

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Malaria in Venezuela requires response.

Malaria in Venezuela requires response.

Science. 2018 Feb 02;359(6375):528

Authors: Grillet ME, Villegas L, Oletta JF, Tami A, Conn JE

PMID: 29420282 [PubMed – in process]

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Correction: Variability and cost implications of three generations of the Roche LightCycler® 480

Correction: Variability and cost implications of three generations of the Roche LightCycler® 480

Dullaert-de Boer, M., Akkerman, O. W., Vermeer, M., Hess, D. L. J., Kerstjens, H. A. M., Anthony, R. M., van der Werf, T. S., van Soolingen, D. & van der Zanden, A. G. M. 9-Feb-2018 In : PLoS ONE. 13, 2, 3 p., e0192946

Research output: ScientificArticle

Original language English
Article number e0192946
Number of pages 3
Journal PLoS ONE
Volume 13
Issue number 2
State Published – 9-Feb-2018
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Cellular immune regulation in the pathogenesis of ANCA-associated Vasculitides

Original language English
Number of pages 9
Journal Autoimmunity reviews
State E-pub ahead of print – 9-Feb-2018
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Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Appelhof, B., Bakker, C., Van Duinen-van Den IJssel, J. C. L., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U. & Koopmans, R. T. C. M. 9-Feb-2018 In : AGING & MENTAL HEALTH. p. 1-6 6 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 1-6
Number of pages 6
Journal AGING & MENTAL HEALTH
State E-pub ahead of print – 9-Feb-2018
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Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Appelhof, B., Bakker, C., Van Duinen-van Den IJssel, J. C. L., Zwijsen, S. A., Smalbrugge, M., Verhey, F. R. J., de Vugt, M. E., Zuidema, S. U. & Koopmans, R. T. C. M. 9-Feb-2018 In : AGING & MENTAL HEALTH. p. 1-6 6 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 1-6
Number of pages 6
Journal AGING & MENTAL HEALTH
State E-pub ahead of print – 9-Feb-2018
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Geef verpleegkundigen voldoende steun bij overgang van opleiding naar praktijk

​Yvonne ten Hoeve: From student nurse to nurse professional Het tekort aan verpleegkundigen is een steeds groter probleem. Door vergrijzing hebben …

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patiënten met schokken

Rodi Steenbergen-Zutt: Myoclonus, a diagnostic challenge Een onvrijwillige spierschok als je bijna in slaap valt – dat is een voorbeeld van …

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Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

Ortiz Zacarías, N. V., Dijkmans, A. C., Burggraaf, J., Mouton, J. W., Wilms, E. B., van Nieuwkoop, C., Touw, D. J., Kamerling, I. M. C. & Stevens, J. 7-Feb-2018 In : Pharmacology Research & Perspectives. 6, 1, p. 1-8 e00378

Research output: Scientific – peer-reviewArticle

Original language English
Article number e00378
Pages (from-to) 1-8
Journal Pharmacology Research & Perspectives
Volume 6
Issue number 1
State Published – 7-Feb-2018
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Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

Fosfomycin as a potential therapy for the treatment of systemic infections: a population pharmacokinetic model to simulate multiple dosing regimens

Ortiz Zacarías, N. V., Dijkmans, A. C., Burggraaf, J., Mouton, J. W., Wilms, E. B., van Nieuwkoop, C., Touw, D. J., Kamerling, I. M. C. & Stevens, J. 7-Feb-2018 In : Pharmacology Research & Perspectives. 6, 1, p. 1-8 e00378

Research output: Scientific – peer-reviewArticle

Original language English
Article number e00378
Pages (from-to) 1-8
Journal Pharmacology Research & Perspectives
Volume 6
Issue number 1
State Published – 7-Feb-2018
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metabolische

​Lidiya Georgieva Dimova: Metabolic memories Blootstelling aan oxidatieve stress tijdens de zwangerschap is misschien niet zo slecht voor …

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Verbeterd muismodel voor onderzoek naar leukemie

​Marco Carretta: Modeling of MLL-AF9-rearranged pediatric leukemia Dankzij een verbeterde techniek in muizen zijn we beter in staat om het belang van …

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Fatigue and depressive symptoms improve but remain negatively related to work functioning over 18 months after return to work in cancer patients

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Fatigue and depressive symptoms improve but remain negatively related to work functioning over 18 months after return to work in cancer patients

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