Sluggish cognitive tempo and its neurocognitive, social and emotive correlates: a systematic review of the current literature

Anna Katharina Mueller, Lara Tucha, Janneke Koerts, Yvonne Groen, Klaus W Lange, Oliver Tucha
Journal of Molecular Psychiatry 2014, 2:5 (5 August 2014)

Tagged , | Leave a comment

The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma

Ingrid A van Roosmalen, Carlos R Reis, Rita Setroikromo, Saravanan Yuvaraj, Justin V Joseph, Pieter G Tepper, Frank A Kruyt, Wim J Quax
SpringerPlus 2014, 3:495 (1 September 2014)

Tagged , | Leave a comment

Relationship between cognition, clinical and cognitive insight in psychotic disorders: a review and meta-analysis.

Related Articles

Relationship between cognition, clinical and cognitive insight in psychotic disorders: a review and meta-analysis.

Schizophr Res. 2014 Jan;152(1):191-200

Authors: Nair A, Palmer EC, Aleman A, David AS

Abstract

The neurocognitive theory of insight posits that poor insight in psychotic illnesses is related to cognitive deficits in cognitive self-appraisal mechanisms. In this paper we perform a comprehensive meta-analysis examining relationships between clinical insight and neurocognition in psychotic disorders. We have also completed a meta-analysis of studies examining ‘cognitive insight’, as measured by the Beck Cognitive Insight Scale (BCIS), and its relationship with neurocognitive function in patients with psychosis. The clinical insight analysis included data from 72 studies and a total population of 5429 patients. We found that insight in psychosis was significantly associated with total cognition (r=0.16, p<0.001), IQ (r=0.16, p<0.001), memory (r=0.13, p<0.001) and executive function (r=0.14, p<0.001). All of these correlations were stronger when examined in patients with schizophrenia only. In the BCIS analysis we included 7 studies and 466 patients in total. We found that no significant associations were found between the self-reflectiveness sub-component and neurocognition. By contrast there were significant correlations between the self-certainty subcomponent and memory (r=-0.23, p<0.001), IQ (r=-0.19, p<0.001) and total cognition (r=-0.14, p=0.01). We did not find evidence of significant publication bias in any analyses. Overall, our results indicate that there is a small but significant relationship between clinical insight, some aspects of cognitive insight and neurocognition. These findings reflect the complexity of the insight construct and indicate that while the neurocognitive model is important it is likely to be one of many which contribute to the understanding of this phenomenon.

PMID: 24355529 [PubMed - indexed for MEDLINE]

Posted in Schizophr Res | Tagged , | Leave a comment

Effects of discontinuation of long-term used antipsychotics on prolactin and bone turnover markers in patients with intellectual disability.

Related Articles

Effects of discontinuation of long-term used antipsychotics on prolactin and bone turnover markers in patients with intellectual disability.

J Clin Psychopharmacol. 2014 Feb;34(1):157-9

Authors: de Kuijper GM, Mulder H, Evenhuis H, Visser F, Hoekstra PJ

PMID: 24135841 [PubMed - indexed for MEDLINE]

Posted in J Clin Psychopharmacol | Tagged , | Leave a comment

Application of sweat patch screening for 16 drugs and metabolites using a fast and highly selective LC-MS/MS method.

Related Articles

Application of sweat patch screening for 16 drugs and metabolites using a fast and highly selective LC-MS/MS method.

Ther Drug Monit. 2014…

Posted in Ther Drug Monit | Tagged | Leave a comment

The pharmacists’ potential to provide targets for interventions to optimize pharmacotherapy in patients with asthma.

Related Articles

The pharmacists’ potential to provide targets for interventions to optimize pharmacotherapy in patients with asthma.

Int J Clin Pharm. 2013…

Posted in Int J Clin Pharm | Tagged | Leave a comment

Computationally designed libraries for rapid enzyme stabilization.

Related Articles

Computationally designed libraries for rapid enzyme stabilization.

Protein Eng Des Sel. 2014 Feb;27(2):49-58

Authors: Wijma HJ, Floor RJ, Jekel…

Posted in Protein Eng Des Sel | Tagged | Leave a comment

Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics

Claire H Li, Robert E Stratford, Nieves Velez de Mendizabal, Thomas IFH Cremers, Bruce G Pollock, Benoit H Mulsant, Gary Remington, Robert R Bies
Journal of Translational Medicine 2014, 12:203 (20 August 2014)

Tagged , | Leave a comment

Discovery and characterization of a 5-hydroxymethylfurfural oxidase from Methylovorus sp. strain MP688.

Related Articles

Discovery and characterization of a 5-hydroxymethylfurfural oxidase from Methylovorus sp. strain MP688.

Appl Environ Microbiol. 2014 Feb;80(3):1082-90

Authors: Dijkman WP, Fraaije MW

Abstract

In the search for useful and renewable chemical building blocks, 5-hydroxymethylfurfural (HMF) has emerged as a very promising candidate, as it can be prepared from sugars. HMF can be oxidized to 2,5-furandicarboxylic acid (FDCA), which is used as a substitute for petroleum-based terephthalate in polymer production. On the basis of a recently identified bacterial degradation pathway for HMF, candidate genes responsible for selective HMF oxidation have been identified. Heterologous expression of a protein from Methylovorus sp. strain MP688 in Escherichia coli and subsequent enzyme characterization showed that the respective gene indeed encodes an efficient HMF oxidase (HMFO). HMFO is a flavin adenine dinucleotide-containing oxidase and belongs to the glucose-methanol-choline-type flavoprotein oxidase family. Intriguingly, the activity of HMFO is not restricted to HMF, as it is active with a wide range of aromatic primary alcohols and aldehydes. The enzyme was shown to be relatively thermostable and active over a broad pH range. This makes HMFO a promising oxidative biocatalyst that can be used for the production of FDCA from HMF, a reaction involving both alcohol and aldehyde oxidations.

PMID: 24271187 [PubMed - indexed for MEDLINE]

Posted in Appl Environ Microbiol | Tagged , | Leave a comment

Asymmetry in primary auditory cortex activity in tinnitus patients and controls.

Related Articles

Asymmetry in primary auditory cortex activity in tinnitus patients and controls.

Neuroscience. 2014 Jan 3;256:117-25

Authors: Geven LI, de…

Posted in Neuroscience | Tagged | Leave a comment

Concurrent gemcitabine and 3D radiotherapy in patients with stage III unresectable non-small cell lung cancer

Gerald SMA Kerner, Leon FA van Dullemen, Erwin M Wiegman, Joachim Widder, Edwin Blokzijl, Ellen M Driever, John WG van Putten, Jeroen JW Liesker, Tineke EJ Renkema, Remge M Pieterman, Marc JF Mertens, Thijo JN Hiltermann, Harry JM Groen
Radiation Oncology 2014, 9:190 (29 August 2014)

Tagged , | Leave a comment

Lactic Acid Bacteria: embarking on 30 more years of research

Jan Kok, Eric Johansen, Michiel Kleerebezem, Bas Teusink
Microbial Cell Factories 2014, 13:I1 (29 August 2014)

Tagged , | Leave a comment

Acceptance or challenge?

No description abstract

Posted in Thesis | Tagged | Leave a comment

Development and preclinical evaluation of radioligands for the PET studies of cerebral adenosine A1 and A2A receptors

No description abstract

Posted in Thesis | Tagged | Leave a comment

Innovations in studying in vivo cell behavior and pharmacology in complex tissues–microvascular endothelial cells in the spotlight.

Related Articles

Innovations in studying in vivo cell behavior and pharmacology in complex tissues–microvascular endothelial cells in the spotlight.

Cell Tissue Res. 2013…

Posted in Cell Tissue Res | Tagged | Leave a comment

Infants with severe respiratory syncytial virus needed less ventilator time with nasal continuous airways pressure then invasive mechanical ventilation.

Related Articles

Infants with severe respiratory syncytial virus needed less ventilator time with nasal continuous airways pressure then invasive mechanical ventilation.

Posted in Acta Paediatr | Tagged | Leave a comment

Intra-operator and inter-operator reliability of manual and semiautomated measurement of fetal nuchal translucency: a cross sectional study.

Related Articles

Intra-operator and inter-operator reliability of manual and semiautomated measurement of fetal nuchal translucency: a cross sectional study.

Prenat Diagn….

Posted in Prenat Diagn | Tagged | Leave a comment

Proteomic studies related to genetic determinants of variability in protein concentrations.

Related Articles

Proteomic studies related to genetic determinants of variability in protein concentrations.

J Proteome Res. 2014 Jan 3;13(1):5-14

Authors: …

Posted in J Proteome Res | Tagged | Leave a comment

The effect of visual representation style in problem-solving: a perspective from cognitive processes.

Related Articles

The effect of visual representation style in problem-solving: a perspective from cognitive processes.

PLoS One. 2013;8(11):e80550

Authors: …

Posted in PLoS One | Tagged | Leave a comment

Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker.

Related Articles

Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker.

Int J Cardiol. 2014 Jan…

Posted in Int J Cardiol | Tagged | Leave a comment