Nieuwe analysesoftware vergemakkelijkt DNA-analyse

​Aaron Taudt ontwikkelde drie softwarepakketten die kunnen helpen om vragen te beantwoorden over de ziekte van Alzheimer, veranderingen in het DNA …

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Effect van zuurstoftekort en diabetes op bloedvaten in hersenen en netvlies beter begrepen

​Endotheelcellen spelen een belangrijke rol bij het functioneren van bloedvaten. Dat toont Youhai Li aan in zijn proefschrift, waarin hij het …

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Disruptive membrane interactions of alpha-synuclein aggregates.

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Disruptive membrane interactions of alpha-synuclein aggregates.

Biochim Biophys Acta Proteins Proteom. 2018 Oct 10;:

Authors: Iyer A, Claessens MMAE

Abstract
Alpha synuclein (αS) is a ~14 kDa intrinsically disordered protein. Decades of research have increased our knowledge on αS yet its physiological function remains largely elusive. The conversion of monomeric αS into oligomers and amyloid fibrils is believed to play a central role of the pathology of Parkinson’s disease (PD). It is becoming increasingly clear that the interactions of αS with cellular membranes are important for both αS’s functional and pathogenic actions. Therefore, understanding interactions of αS with membranes seems critical to uncover functional or pathological mechanisms. This review summarizes our current knowledge of how physicochemical properties of phospholipid membranes affect the binding and aggregation of αS species and gives an overview of how post-translational modifications and point mutations in αS affect phospholipid membrane binding and protein aggregation. We discuss the disruptive effects resulting from the interaction of αS aggregate species with membranes and highlight current approaches and hypotheses that seek to understand the pathogenic and/or protective role of αS in PD.

PMID: 30315896 [PubMed – as supplied by publisher]

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Validity and feasibility of a temperature sensor for measuring use and non-use of orthopaedic footwear.

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Validity and feasibility of a temperature sensor for measuring use and non-use of orthopaedic footwear.

J Rehabil Med. 2018 Oct 09;:

Authors: Lutjeboer T, van Netten JJ, Postema K, Hijmans JM

Abstract
OBJECTIVE: Adherence is a prerequisite for the effectiveness of orthopaedic footwear. The aim of this study is to assess the validity of a new temperature sensor for objective assessment of footwear use and non-use.
DESIGN: Observational study.
METHODS: The validity of a temperature sensor (Orthotimer, Balingen, Germany) to discriminate between time periods of use and non-use of footwear over a period of 48 h was assessed using 3 algorithms, in 10 healthy participants (mean age 32.8 years (standard deviation (SD) 14.1 years)). Footwear use measured with the sensor was compared with a reference standard, footwear use measured with a time-lapse sports camera secured to the shoe.
MAIN OUTCOME MEASURE: Hours of footwear use.
RESULTS: Mean footwear use measured with the camera was 8.10 (SD 2.46) h per day. Mean footwear uses measured with the sensor and calculated with the 3 algorithms were 8.16 (SD 2.37), 8.86 (SD 2.48) and 4.91 (SD 3.17) h per day for the Groningen algorithm, algorithm-25, and algorithm-29, respectively. The correlation between footwear use assessed with the camera and with the sensor was: rGroningen = 0.995, ralg25 = 0.919 and ralg29 = 0.680).
CONCLUSION: The temperature sensor is a valid instrument to measure footwear use and non-use when using the Groningen algorithm.

PMID: 30299524 [PubMed – as supplied by publisher]

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Influence of mirror therapy and motor imagery on intermanual transfer effects in upper-limb prosthesis training of healthy participants: A randomized pre-posttest study.

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Influence of mirror therapy and motor imagery on intermanual transfer effects in upper-limb prosthesis training of healthy participants: A randomized pre-posttest study.

PLoS One. 2018;13(10):e0204839

Authors: Romkema S, Bongers RM, van der Sluis CK

Abstract
The effect that a motor skill trained on one side can lead to improvement in the untrained side is called intermanual transfer. Intermanual transfer can help enhance upper limb prosthetic training. To determine the influence of mirror therapy and motor imagery on intermanual transfer in upper limb prosthesis training, a pseudo-randomized clinical trial, single blinded, with a pre-posttest design was used. Forty-seven able-bodied, right-handed participants were pseudo-randomly assigned to two training groups and one control group. One training group undertook an intermanual transfer training program, using an upper-limb prosthetic simulator with added mirror therapy and motor imagery. The second training group completed only the intermanual transfer training program. The control group completed a sham training: a dummy training without using the prosthesis simulator. The program lasted five consecutive days. To determine the improvement in skill, a test was administered before, immediately after, and six days after the training program. Training used the “unaffected” arm; tests were performed with the “affected” arm, resembling the amputated limb. Movement time, the time from the beginning of the movement until completion of the task; hand opening, the duration of the maximum prosthetic hand opening; and grip-force control, the deviation from the required force during a tracking task. No intermanual transfer effects were found: neither the intermanual transfer training program, nor the additional mirror therapy and motor imagery affected prosthesis skills. A limitation of the study was that the training program was applied to able-bodied subjects instead of patients with an amputation. Contrary to previous studies, no intermanual transfer effects were found. Additional mirror therapy and motor imagery did not ameliorate intermanual transfer effects.

PMID: 30300378 [PubMed – in process]

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Voedselallergie bepaalt door genen en omgevingsfactoren

​Dorien Westerlaken – van Ginkel: The multifactorial nature of food allergy Er zijn meerdere genen die de kans op voedselallergie vergroten, maar de …

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Nanodiamanten veelzijdig en veelbelovend voor onderzoek naar kanker en veroudering

​Simon Hemelaar: a fluorescent nanodiamond foundation for quantum sensing in cells Fluorescente nanodiamanten, hele kleine diamanten die onder …

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Onderzoek naar aanpassing levercellen aan hepatitis C virus

​Wilson Rios Ocampo: cellullar stress response during hepatitis C virus infection: a balancing act between viral persistence and host cell survival …

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Geslacht en tijdstip van conceptie als risicofactor van complicaties bij zwangerschap

​Petra Verburg: pregnancy outcome in South Australia: Population and cohort studies Het geslacht van het kind en het seizoen waarin het kind is …

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What is the added value of the waist-to-hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply.

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What is the added value of the waist-to-hip ratio on top of the BIOSTAT risk prediction model in patients with heart failure? Reply.

Eur J Heart Fail. 2018 Oct 08;:

Authors: Streng KW, Lang CC, Voors AA

PMID: 30295977 [PubMed – as supplied by publisher]

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Observation of Spin-Valley-Coupling-Induced Large Spin-Lifetime Anisotropy in Bilayer Graphene.

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Observation of Spin-Valley-Coupling-Induced Large Spin-Lifetime Anisotropy in Bilayer Graphene.

Phys Rev Lett. 2018 Sep 21;121(12):127702

Authors: Leutenantsmeyer JC, Ingla-Aynés J, Fabian J, van Wees BJ

Abstract
We report the first observation of a large spin-lifetime anisotropy in bilayer graphene (BLG) fully encapsulated between hexagonal boron nitride. We characterize the out-of-plane (τ_{⊥}) and in-plane (τ_{∥}) spin lifetimes by oblique Hanle spin precession. At 75 K and the charge neutrality point (CNP), we observe a strong anisotropy of τ_{⊥}/τ_{∥}=8±2. This value is comparable to graphene-transition-metal-dichalcogenide heterostructures, whereas our high-quality BLG provides with τ_{⊥} up to 9 ns, a spin lifetime more than 2 orders of magnitude larger. The anisotropy decreases to 3.5±1 at a carrier density of n=6×10^{11}  cm^{-2}. Temperature-dependent measurements show above 75 K a decrease of τ_{⊥}/τ_{∥} with increasing temperature, reaching the isotropic case close to room temperature. We explain our findings with electric-field-induced spin-valley coupling arising from the small intrinsic spin-orbit fields in BLG of 12  μeV at the CNP.

PMID: 30296147 [PubMed – in process]

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COPD-patiënten hebben tijdens longaanval vaak te veel lucht in hun longen

​Wouter van Geffen: Hyperinflation and COPD exacerbations Artsen vermoedden het al, en onderzoek van MCL-longarts Wouter van Geffen bevestigt nu dat …

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Kortere behandeling voor weke delen tumor net zo effectief

​Marc Stevenson: Localized extremity soft tissue sarcoma: towards a patient-tailored approach Behandeling van een tumor in weke delen van ledematen, …

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Griepvaccin via de luchtwegen effectiever dan vaccin in spier

​Yoshita Bhide: Towards improved and broadly protective influenza vaccines: Focus on delivery systems, routes of administration and animal models. …

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Nieuwe MRSA-varianten passen zich slim aan nieuwe condities aan

​Solomon Mekonnen: on the missing links between the epidemiology and pathophysiology of Staphylococcus aureus Hoe passen nieuwe, veel agressievere …

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Examining Symptom Clusters of Childbirth-Related Posttraumatic Stress Disorder.

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Examining Symptom Clusters of Childbirth-Related Posttraumatic Stress Disorder.

Prim Care Companion CNS Disord. 2018 Sep 27;20(5):

Authors: Thiel F, Ein-Dor T, Dishy G, King A, Dekel S

Abstract
Objective: Recent studies document posttraumatic stress disorder (PTSD) symptoms in women following at-term deliveries with health baby outcomes. However, the notion that childbirth can trigger PTSD remains controversial, and the symptom clusters are mostly unknown. The objective of this study was to examine the clustering of childbirth-induced postpartum PTSD (PP-PTSD) symptoms in comparison to DSM-5 clusters.
Methods: We examined the symptom presentation of childbirth-related postpartum PTSD (PP-PTSD) in a sample of 685 women. The majority of these women delivered at term. Peritraumatic stress reactions to childbirth and PP-PTSD symptoms were assessed approximately 3 months after delivery. A hierarchical cluster analysis was used to detect grouping of the PP-PTSD symptoms.
Results: Childbirth-related peritraumatic stress was strongly and positively associated with PP-PTSD symptom severity. Cluster modeling revealed 4 distinguished symptom groups: reliving (some reexperiencing symptoms), namely nightmares and flashbacks; avoidance coupled with unwanted memories (other reexperiencing symptoms); negative cognitions and mood; and hyperarousal reactivity.
Conclusions: Our findings show that the representation of symptoms of PTSD that develops following a stressogenic childbirth experience appears, for the most part, to resemble DSM-5 symptom clusters. More research integrating descriptive symptom assessment with biological measures is warranted to better characterize the symptom presentation of this neglected posttraumatic stress syndrome.

PMID: 30277674 [PubMed – in process]

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Schema Modes and Personality Disorder Symptoms in Alcohol-Dependent and Cocaine-Dependent Patients.

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Schema Modes and Personality Disorder Symptoms in Alcohol-Dependent and Cocaine-Dependent Patients.

Eur Addict Res. 2018 Oct 02;24(5):226-233

Authors: Boog M, van Hest KM, Drescher T, Verschuur MJ, Franken IHA

Abstract
Substance use disorders (SUD) and personality disorders co-occur frequently. This relationship might be understood by studying schema modes (a key concept in Schema therapy), which explain the dysfunctions characterizing personality disorder patients. In the present study, we compared the schema modes and personality disorder symptoms between alcohol-dependent patients, cocaine-dependent patients and healthy controls. We found indications that specific schema modes are specific for SUD patients. However, no differences between specific subtypes of SUD patients (alcohol- vs. cocaine-dependent patients) could be found regarding schema modes. Further, it is suggested that borderline personality disorder symptoms are highly relevant for SUD patients. A first step is made in understanding the relationship between schema modes and SUD, which may contribute to the understanding of the problematic behaviour seen in patients with personality disorders and SUD (and may possibly contribute to the improvement of the treatment of this group of patients).

PMID: 30278456 [PubMed – as supplied by publisher]

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Effectieve beweeginterventie voor moeilijk bereikbare mensen met een lichamelijke beperking

​Mensen met een lichamelijke beperking hebben een lagere gezondheid gerelateerde kwaliteit van leven. Met behulp van de vernieuwde interventie …

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Een lage dosis bestraling veroorzaakt meer schade dan verwacht

​Een lage dosis bestraling kan het weefsel rondom een tumor onevenredig veel beschadigen. Dat concludeert Peter Nagle in zijn proefschrift. Dat is …

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Variabiliteit in gewrichten niet altijd negatief bij bewegingsstoornissen

​Als kinderen hun gewrichten op meer verschillende manieren gebruiken tijdens het reiken naar voorwerpen, is dat niet per se negatief. Dat …

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