Immuunmodulerende eigenschappen van eiwithydrolysaat

​Gea M.B.G. Kiewiet: Gene expression studies from basic research to the clinic Jonge kinderen kunnen door het consumeren van koemelk bevattende …

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Leven met chronische hoofdpijn

Yvette Ciere: Living with chronic headache. A personal goal and self-regulation perspective​ Als iemand met chronische hoofdpijn tijdens een …

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Netwerkbenadering biedt nieuwe aanknopingspunten voor onderzoek naar depressie

​Claudia Debora van Borkulo : Symptom network models in depression research: From methodological exploration to clinical application Waarom gaat bij …

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Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation.

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Non-digestible carbohydrates in infant formula as substitution for human milk oligosaccharide functions: Effects on microbiota and gut maturation.

Crit Rev Food Sci Nutr. 2018 Jan 15;:1-12

Authors: Akkerman R, Faas MM, de Vos P

Abstract
Human milk (HM) is the golden standard for nutrition of newborn infants. Human milk oligosaccharides (HMOs) are abundantly present in HM and exert multiple beneficial functions, such as support of colonization of the gut microbiota, reduction of pathogenic infections and support of immune development. HMO-composition is during lactation continuously adapted by the mother to accommodate the needs of the neonate. Unfortunately, for many valid reasons not all neonates can be fed with HM and are either totally or partly fed with cow-milk derived infant formulas, which do not contain HMOs. These cow-milk formulas are supplemented with non-digestible carbohydrates (NDCs) that have functional effects similar to that of some HMOs, since production of synthetic HMOs is challenging and still very expensive. However, NDCs cannot substitute all HMO functions. More efficacious NDCs may be developed and customized for specific groups of neonates such as pre-matures and allergy prone infants. Here current knowledge of HMO functions in the neonate in view of possible replacement of HMOs by NDCs in infant formulas is reviewed. Furthermore, methods to expedite identification of suitable NDCs and structure/function relationships are reviewed as in vivo studies in babies are impossible.

PMID: 29333864 [PubMed – as supplied by publisher]

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A non-heme iron photocatalyst for light driven aerobic oxidation of methanol.

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A non-heme iron photocatalyst for light driven aerobic oxidation of methanol.

Angew Chem Int Ed Engl. 2018 Jan 15;:

Authors: Browne WR, Chen J, Draksharapu A, Gruden M, Stepanovic S

Abstract
The non-heme (L)FeIII and (L)FeIII-O-FeIII(L) complexes (L = 1,1-di(pyridin-2-yl)-N,N-bis(pyridin-2-ylmethyl)ethan-1-amine) undergoes reduction under irradiation to the FeII state with concomitant oxidation of methanol to methanal, without the need for a secondary photosensitizer. Spectroscopic and Density Functional Theory (DFT) studies support a mechanism in which irradiation results in charge transfer excitation of a FeIII--O-FeIII complex to generate [(L)FeIV=O]2+ (observed transiently during irradiation in acetonitrile), and an equivalent of LFeII. Under aerobic conditions, irradiation accelerates reoxidation from the FeII to FeIII state with O2 closing the cycle of methanol oxidation to methanal.

PMID: 29334586 [PubMed – as supplied by publisher]

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Home alone: a systematic review and meta-analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents.

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Home alone: a systematic review and meta-analysis on the effects of individual housing on body weight, food intake and visceral fat mass in rodents.

Obes Rev. 2018 Jan 15;:

Authors: Schipper L, Harvey L, van der Beek EM, van Dijk G

Abstract
Rats and mice are widely used to study environmental effects on psychological and metabolic health. Study designs differ widely and are often characterized by varying (social) housing conditions. In itself, housing has a profound influence on physiology and behaviour of rodents, affecting energy balance and sustainable metabolic health. However, evidence for potential long-term consequences of individual versus social housing on body weight and metabolic phenotype is inconsistent. We conducted a systematic literature review and meta-analyses assessing effects of individual versus social housing of rats and mice, living under well-accepted laboratory conditions, on measures of metabolic health, including body weight, food intake and visceral adipose tissue mass. Seventy-one studies were included in this review; 59 were included in the meta-analysis. Whilst housing did not affect body weight, both food intake and visceral adipose tissue mass were significantly higher in individually compared with socially housed animals. A combination of emotional stress and lack of social thermoregulation likely contributed to these effects. Increased awareness of consequences and improved specifications of housing conditions are necessary to accurately evaluate efficacy of drugs, diets or other interventions on metabolic and other health outcomes because housing conditions are rarely considered as possible moderators of reported outcomes.

PMID: 29334694 [PubMed – as supplied by publisher]

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Genexpressie

​Juha M Karjalainen: Gene expression studies from basic research to the clinic Humane genetica is een spannend en multidisciplinair vakgebied. De …

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Dynamics of dignity and safety: a discussion.

Dynamics of dignity and safety: a discussion.

BMJ Qual Saf. 2018 Jan 13;:

Authors: Goodwin D, Mesman J, Verkerk M, Grant S

PMID: 29331954 [PubMed – as supplied by publisher]

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Myocardial oedema and congestive heart failure: one piece of the puzzle? Reply.

Myocardial oedema and congestive heart failure: one piece of the puzzle? Reply.

Eur J Heart Fail. 2018 Jan 10;:

Authors: Gorter TM, de Boer RA

PMID: 29319924 [PubMed – as supplied by publisher]

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Zuurstofafgevende bolletjes voorkomen zuurstofproblemen in weefsels

​Arina Tjitske Buizer: Towards in vivo application of oxygen-releasing microspheres for enhancing bone regeneration Zuurstofafgevende bolletjes …

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Kosten en complicaties bij levertransplantatie

​Christian Sake van der Hilst: Cost and outcome in liver transplantation Een levertransplantatie is een complexe en kostbare ingreep, waarbij veel …

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Minder ontstekingsreactie door niertransplantatie met heparine

​Ditmer Tjitze Talsma: Renal heparan sulfate proteoglycans Behandeling met afgeleiden van het antibloedstollingsmedicijn heparine kan helpen om …

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Nieuwe vaccinatie strategie voor bescherming van ouderen tegen infecties

​Marieke van der Heiden: VZV booster vaccination in middle-aged adults De wereldbevolking is snel aan het vergrijzen. Volgens de verwachtingen zal …

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Pharmacokinetics of a sustained release formulation of PDGFβ-receptor directed carrier proteins to target the fibrotic liver

Original language English
Pages (from-to) 258-265
Journal Journal of Controlled Release
Volume 269
Early online date 20-Nov-2017
State E-pub ahead of print – 20-Nov-2017
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Public stigma of prolonged grief disorder: An experimental study.

Public stigma of prolonged grief disorder: An experimental study.

Psychiatry Res. 2018 Jan 02;261:173-177

Authors: Eisma MC

Abstract
Prolonged grief disorder (PGD), characterized by severe, persistent and disabling grief, is being considered for inclusion in the International Classification of Diseases’ 11 (ICD-11) and a related disorder, Persistent Complex Bereavement Disorder (PCBD), is included for further investigation in the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5). Establishing diagnoses for pathological grief may lead to stigmatization. Additionally, it has been argued that people experiencing severe grief responses after loss of non-family members (i.e., disenfranchised grief) may experience more stigmatizing reactions. Yet, no research to date has investigated this. To fill this gap in knowledge, 379 adults from the general population were randomly allocated to read one of 4 different vignettes of a person with and without a grief disorder diagnosis who had lost a friend or a spouse. After reading the vignettes, we assessed: 1) characteristics ascribed to the person, 2) emotional reactions to the person, and 3) desire for social distance. Notably, people with a diagnosis were attributed relatively more negative characteristics, and elicited more anger, anxiety and pro-social emotions and a stronger desire for social distance. Stigmatization and its negative consequences appear a valid concern to the establishment of pathological grief disorders in diagnostic manuals.

PMID: 29309956 [PubMed – as supplied by publisher]

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Wormen en slimme algoritmes helpen diagnostiek van menselijke genetische aandoeningen te verbeteren

​Joeri van der Velde: Translational software infrastructure for medical genetics Ze lijken niet echt op mensen, maar wormen, ratten en zebravisjes …

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Do Surrogate Endpoints Better Correlate with Overall Survival in Studies That Did Not Allow for Crossover or Reported Balanced Postprogression Treatments? An Application in Advanced Non-Small Cell Lung Cancer.

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Do Surrogate Endpoints Better Correlate with Overall Survival in Studies That Did Not Allow for Crossover or Reported Balanced Postprogression Treatments? An Application in Advanced Non-Small Cell Lung Cancer.

Value Health. 2018 Jan;21(1):9-17

Authors: Hashim M, Pfeiffer BM, Bartsch R, Postma M, Heeg B

Abstract
BACKGROUND: In previous studies, correlation between overall survival (OS) and surrogate endpoints like objective response rate (ORR) or progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) was poor. This can be biased by crossover and postprogression treatments.
OBJECTIVES: To evaluate the relationship between these two surrogate endpoints and OS in advanced NSCLC studies that did not allow for crossover or reported balanced post-progression treatments.
METHODS: A systematic review in patients with advanced NSCLC receiving second- and further-line therapy was performed. The relationship between the absolute difference in ORR or median PFS (mPFS) and the absolute difference in median OS (mOS) was assessed using the correlation coefficient (R) and weighted regression models. The analysis was repeated in predefined data cuts based on crossover and balance of postprogression treatments. When the upper limit of R’s 95% confidence interval (CI) was more than 0.7, the surrogate threshold effect (STE) was estimated.
RESULTS: In total, 146 randomized clinical trials (43,061 patients) were included. The mean ORR, mPFS, and mOS were 12.2% ± 11.2%, 3.2 ± 1.3 months, and 9.6 ± 4.1 months, respectively. The correlation coefficients of ORR and mPFS were 0.181 (95% CI 0.016-0.337) and 0.254 (95% CI 0.074-0.418), respectively, with mOS. Nevertheless, in trials that did not allow crossover and reported balanced postprogression treatments, the correlation coefficients of ORR and mPFS were 0.528 (95% CI 0.081-0.798) and 0.778 (95% CI 0.475-0.916), respectively, with mOS. On the basis of STE estimation, in trials showing significant treatment effect size of 41.0% or more ORR or 4.15 or more mPFS months, OS benefit can be expected with sufficient certainty.
CONCLUSIONS: Crossover and postprogression treatments may bias the relationship between surrogate endpoints and OS. Presented STE calculation can be used to interpret treatment effect on either ORR or PFS when used as primary endpoints.

PMID: 29304946 [PubMed – in process]

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Heart rate variability and its relation to chronic kidney disease: Results from the PREVEND Study.

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Heart rate variability and its relation to chronic kidney disease: Results from the PREVEND Study.

Psychosom Med. 2018 Jan 02;:

Authors: Thio CHL, van Roon AM, Lefrandt JD, Gansevoort RT, Snieder H

Abstract
OBJECTIVE: In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes.
METHODS: In the population-based PREVEND Study, renal outcomes (CKD, eGFR, urinary albumin) were measured at baseline and three consecutive examinations. HRV measures (among which SDNN, standard deviation of normal-to-normal RR-intervals) were calculated from time-series of beat-to-beat pulse-wave recordings at baseline. The lowest (risk) quartile was compared to the upper three quartiles combined, in multivariable survival and linear mixed-effects analyses.
RESULTS: In 4,605 participants (49% males, age range 33-80, 0.6% blacks), we observed 341 new cases of CKD during a median follow-up duration of 7.4 years. Low SDNN was associated with higher incidence of CKD (crude HR: 1.66, 95%CI [1.30;2.12], p<0.001), but this association was no longer significant after adjustment for age, sex, and cardiovascular risk factors (adjusted HR: 1.13, 95%CI [0.86;1.48], p=0.40, similar for other HRV measures). No associations between SDNN and eGFR trajectories were found in the total sample. However, in a subgroup of participants with baseline CKD (N=939), we found a significant association of low SDNN (but not other HRV measures) with lower baseline eGFR, even after multivariable adjustment (adjusted βlevel difference=-3.73 ml/min/1.73m, 95%CI [-6.70;-0.75], p=0.014), but not with steeper eGFR decline.
CONCLUSIONS: These results suggest that reduced HRV may be a complication of CKD rather than a causal factor.

PMID: 29298214 [PubMed – as supplied by publisher]

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Occurrence, biochemistry and biological effects of host-selective plant mycotoxins.

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Occurrence, biochemistry and biological effects of host-selective plant mycotoxins.

Food Chem Toxicol. 2017 Dec 27;:

Authors: Petrov V, Qureshi MK, Hille J, Gechev T

PMID: 29288760 [PubMed – as supplied by publisher]

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45,180 ways to have “persistent complex bereavement disorder” yet only 48 ways to have “prolonged grief disorder”.

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45,180 ways to have “persistent complex bereavement disorder” yet only 48 ways to have “prolonged grief disorder”.

Psychiatry Res. 2017 Dec 20;261:88-89

Authors: Lenferink LIM, Eisma MC

Abstract
Persistent complex bereavement disorder (PCBD) is a condition for further study in the Diagnostic and Statistical Manual of Mental Disorders-5. Prolonged grief disorder (PGD) will likely be included in the International Classification of Diseases’-11. While it has been argued that PCBD and PGD cover the same diagnostic entity, their symptom count differs. A higher symptom count may increase the complexity of diagnostic algorithm and thereby the symptom profile heterogeneity of a disorder. Using binomial equations, a nearly thousand-fold difference in possible symptom profiles to meet PGD versus PCBD criteria was demonstrated, showing both disorders may differ more than just semantically.

PMID: 29289026 [PubMed – as supplied by publisher]

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