Comments on: Cernes, R. & Zimlichman, R. Role of Paced Breathing for Treatment of Hypertension. Curr Hypertens Rep (2017) 19: 45.

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Comments on: Cernes, R. & Zimlichman, R. Role of Paced Breathing for Treatment of Hypertension. Curr Hypertens Rep (2017) 19: 45.

Curr Hypertens Rep. 2017 Aug;19(8):65

Authors: Landman GWD, van Hateren KJJ, Kleefstra N

PMID: 28735433 [PubMed – in process]

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Electrically controlled cloud of bulk nanobubbles in water solutions.

Electrically controlled cloud of bulk nanobubbles in water solutions.

PLoS One. 2017;12(7):e0181727

Authors: Postnikov AV, Uvarov IV, Lokhanin MV, Svetovoy VB

Abstract
Using different experimental techniques we visualize a cloud of gas in water that is produced electrochemically by the alternating polarity process. Liquid enriched with gas does not contain bubbles strongly scattering visible light but its refractive index changes significantly near the electrodes. The change of the refractive index is a collective effect of bulk nanobubbles with a diameter smaller than 200 nm. Any alternative explanation fails to explain the magnitude of the effect. Spatial structure of the cloud is investigated with the optical lever method. Its dynamics is visualised observing optical distortion of the electrode images or using differential interference contrast method. The cloud covers concentric electrodes, in a steady state it is roughly hemispherical with a size two times larger than the size of the electrode structure. When the electrical pulses are switched off the cloud disappears in less than one second. The total concentration of gases can reach very high value estimated as 3.5 × 1020 cm-3 that corresponds to an effective supersaturation of 500 and 150 for hydrogen and oxygen, respectively.

PMID: 28727812 [PubMed – in process]

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Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers

Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers

Cong, Y., Kriegenburg, F., de Haan, C. A. M. & Reggiori, F. 18-Jul-2017 In : Scientific Reports. 7, 1, 5740

Research output: Scientific – peer-reviewArticle

Original language English
Article number 5740
Journal Scientific Reports
Volume 7
Issue number 1
State Published – 18-Jul-2017
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Andere screening bij longkanker kan beter voorspellen of doelgerichte behandeling aanslaat

​Anthonie van der Wekken: Resistance mechanisms in lung cancer patients with EGFR or ALK aberrations treated with kinase inhibitors Met een nieuwe …

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An unexpected role for bile acid synthesis in adaptation to low temperature.

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An unexpected role for bile acid synthesis in adaptation to low temperature.

Nat Med. 2017 Jul 11;23(7):800-802

Authors: Kuipers F, Groen AK

PMID: 28697185 [PubMed – in process]

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Op weg naar gepersonaliseerde behandeling bij slokdarmkanker

​Jan-Binne Hulshoff: Improving patient selection towards personalized treatment decisions in esophageal cancer Voorbehandeling met chemoradiotherapie …

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Epigenetische aanpak remt activiteit van hepatitus B virus

Julio Rendon Londono: Genetic characterizations and epigenetic interference
to better understand and fight occult Hepatitis B virus infection. Het is …

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Verstoorde genexpressiepatronen bij ziekte herstellen

David Cano-Rodriguez: ​Epigenetic editing. Towards sustained gene expression reprogramming in diseases​ Veel ziekten zijn geassocieerd met …

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Construct validity and test-retest reliability of the revised Upper Extremity Work Demands (UEWD-R) Scale.

Construct validity and test-retest reliability of the revised Upper Extremity Work Demands (UEWD-R) Scale.

Occup Environ Med. 2017 Jul 08;:

Authors: Cavalini MA, Berduszek RJ, van der Sluis CK

Abstract
BACKGROUND: The revised Upper Extremity Work Demand (UEWD-R) Scale is a six-item self-report questionnaire to measure the workload of the upper limbs. UEWD-R consists of a force/posture scale and a repetition scale. Psychometric properties are unknown so far.
PURPOSE: Assess the construct validity and the test-retest reliability of UEWD-R.
METHOD: Participants from different levels of physical work demands (based on the Dictionary of Occupational Titles (DOT) categories) were included. Construct validity was determined by testing 11 predefined hypotheses regarding UEWD-R related to other constructs, including a workplace observation using the Rapid Upper Limb Assessment (RULA). Correlations between these measures were calculated using Spearman correlation coefficients. Test-retest reliability was determined using the intraclass correlation coefficient (ICC) for agreement. The smallest detectable change (SDC) was calculated.
RESULTS: Fifty-four participants participated (63% men, mean age 39.4 years). The four DOT categories were equally represented. Nine out of 11 predefined correlations were confirmed (82%), indicating good construct validity. Strong expected correlations of UEWD-R-total versus RULA-C (r=0.69) and UEWD-R-repetition versus RULA-muscle (r=0.12) were not confirmed. The test-retest reliability was good (ICC agreement=0.79). The SDC was 4.85.
CONCLUSION: Construct validity and the test-retest reliability of UEWD-R were good. UEWD-R can be used to evaluate the workload of the upper extremities. However, further research is advised to assess the validity of the UEWD-R not only by testing associations with RULA,but also with other observational measures.

PMID: 28689174 [PubMed – as supplied by publisher]

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Op weg naar verbeterde PET bij neuropsychiatrische aandoeningen

​Vladimir Shalgunov: Development of 18F-labeled agonist radioligands for PET imaging of the high-affinity state of cerebral dopamine D2/3 receptors …

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​Op weg naar verbeterde PET bij neuropsychiatrische aandoeningen

Vladimir Shalgunov: Development of 18F-labeld agonist radioligands for PET imaging of the high-affinity dopamine D2/3 receptor.​ Bij …

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Interim Fluorodeoxyglucose Positron Emission Tomography-Adapted Therapy Is Not an Efficient Approach to Improving Outcome in Early-Stage Hodgkin Lymphoma.

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Interim Fluorodeoxyglucose Positron Emission Tomography-Adapted Therapy Is Not an Efficient Approach to Improving Outcome in Early-Stage Hodgkin Lymphoma.

J Clin Oncol. 2017 Jul 06;:JCO2017733816

Authors: Adams HJA, Kwee TC

PMID: 28682684 [PubMed – as supplied by publisher]

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A personalised or procrustean approach to treating hypertension?

A personalised or procrustean approach to treating hypertension?

Lancet. 2017 Jul 01;390(10089):26-27

Authors: Gabb GM, Mol PGM, Arnolda LF

PMID: 28677555 [PubMed – in process]

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Partially hydrolyzed whey proteins prevent clinical symptoms in a cow’s milk allergy mouse model and enhance regulatory T and B cell frequencies.

Partially hydrolyzed whey proteins prevent clinical symptoms in a cow’s milk allergy mouse model and enhance regulatory T and B cell frequencies.

Mol Nutr Food Res. 2017 Jul 05;:

Authors: Kiewiet MBG, van Esch BCAM, Garssen J, Faas MM, de Vos P

Abstract
SCOPE: Partially hydrolyzed cow’s milk proteins are used to prevent cow’s milk allergy in children. Here we studied the immunomodulatory mechanisms of partial cow’s milk hydrolysates in vivo.
METHODS AND RESULTS: Mice were sensitized with whey or partially hydrolyzed whey using cholera toxin. Whey-specific IgE levels were measured to determine sensitization and immune cell populations from spleen, mesenteric lymph nodes and Peyer’s patches after oral whey administration were measured by flowcytometry. Whey-specific IgE and IgG1 levels in partial whey hydrolysate sensitized animals were enhanced, but challenge did not induce clinical symptoms. This immunomodulatory effect of partial whey hydrolysate was associated with increased regulatory B and T cells in the spleen, together with a prevention of IgM-IgA class switching in the mesenteric lymph nodes and an increased Th1 and activated Th17 in the Peyer’s patches.
CONCLUSION: Partial hydrolysate sensitization did not induce whey induced clinical symptoms, even though sensitization was established. Increased regulatory cell populations in the systemic immune system and a prevention of increased total Th1 and activated Th17 in the intestinal immune organs could contribute to the suppression of allergic symptoms. This knowledge is important for a better understanding of the beneficial effects of hydrolysates. This article is protected by copyright. All rights reserved.

PMID: 28679035 [PubMed – as supplied by publisher]

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Chromosome segregation drives division site selection in Streptococcus pneumoniae.

Chromosome segregation drives division site selection in Streptococcus pneumoniae.

Proc Natl Acad Sci U S A. 2017 Jul 03;:

Authors: van Raaphorst R, Kjos M, Veening JW

Abstract
Accurate spatial and temporal positioning of the tubulin-like protein FtsZ is key for proper bacterial cell division. Streptococcus pneumoniae (pneumococcus) is an oval-shaped, symmetrically dividing opportunistic human pathogen lacking the canonical systems for division site control (nucleoid occlusion and the Min-system). Recently, the early division protein MapZ was identified and implicated in pneumococcal division site selection. We show that MapZ is important for proper division plane selection; thus, the question remains as to what drives pneumococcal division site selection. By mapping the cell cycle in detail, we show that directly after replication both chromosomal origin regions localize to the future cell division sites, before FtsZ. Interestingly, Z-ring formation occurs coincidently with initiation of DNA replication. Perturbing the longitudinal chromosomal organization by mutating the condensin SMC, by CRISPR/Cas9-mediated chromosome cutting, or by poisoning DNA decatenation resulted in mistiming of MapZ and FtsZ positioning and subsequent cell elongation. Together, we demonstrate an intimate relationship between DNA replication, chromosome segregation, and division site selection in the pneumococcus, providing a simple way to ensure equally sized daughter cells.

PMID: 28674002 [PubMed – as supplied by publisher]

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Nieuwe inzichten in ziekteverloop RRP

​Michel San Giorgi: Recurrent Respiratory Papillomatosis, clinical course and psychosocial aspects Het is een zeldzame ziekte met zo’n tweehonderd …

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Patiënt centraal tijdens ontwikkeling van nieuwe onderbeenspalk

​Dymphy van der Wilk: Patient centered development and clinical evaluation of an ankle foot orthosis Bewegingswetenschapper en Orthopedisch …

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Krachttraining bij ouderen doet looppatroon niet verjongen

​Chantal Beijersbergen: Effects of lower extremity power training on gait biomechanics in old adults Gezonde ouderen (>65 jaar) lopen langzamer dan …

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Subtypes van psychotische patiënten voorspellen symptomen bij broers en zussen

​Atiqul Islam: Statistical approaches to explore clinical heterogeneity in psychosis Subtypes van psychotische symptomen blijken het functioneren en …

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Ongevoeligheid voor medicatie bij type 2 diabetes in kaart

​Sergei Petrykiv: Variability in drug response: towards more personalized diabetes care Patiënten met diabetes, bij wie bloeddrukverlagende …

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