Beweging witte bloedcellen in beeld gebracht met microfluïdische chips

​​​Beweging witte bloedcellen in beeld gebracht met microfluïdische chips Leo Boneschansker ontwikkelde samen met zijn collega’s de eerste …

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Apathie hangt samen met veranderde hersenactiviteit

​ Apathie hangt samen met een ander volume en ander activiteitsniveau van bepaalde hersengebieden. Dat laat Claire Kos zien in haar proefschrift over …

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Herstel na licht traumatisch hersenletsel hangt af van structuur en functie hersennetwerken

Hans van der Horn: Herstel na licht traumatisch hersenletsel hangt af van structuur en functie hersennetwerken In Nederland bezoeken ieder jaar zo’n …

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Stap dichter bij vaccins tegen resistente bacteriën

​​Danny Koedijk: Stap dichter bij vaccins tegen resistente bacteriën​ Vaccins kunnen mens en dier beschermen tegen infecties. Het blijkt echter erg …

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p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies

Soto, M., Raaijmakers, J. A., Bakker, B., Spierings, D., Lansdorp, P., Foijer, F. & Medema, R. H. 20-Jun-2017 In : Cell reports. 19, 12, p. 2423-2431 8 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 2423-2431
Number of pages 8
Journal Cell reports
Volume 19
Issue number 12
State Published – 20-Jun-2017
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The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.

The short- to mid-term symptom prevalence of dumping syndrome after primary gastric-bypass surgery and its impact on health-related quality of life.

Surg Obes Relat Dis. 2017 Apr 28;:

Authors: Emous M, Wolffenbuttel BHR, Totté E, van Beek AP

Abstract
BACKGROUND: Early and late dumping are complications of gastric bypass surgery. Early dumping occurs within an hour after eating, when the emptying of food into the small intestine triggers rapid fluid shifts into the intestinal lumen and the release of gastrointestinal hormones, resulting in gastrointestinal and vasomotor symptoms. Late dumping occurs between 1 and 3 hours after carbohydrate ingestion and is caused by an exaggerated insulin release, resulting in hypoglycemia. Almost no data are currently available on the prevalence of early and late dumping or their impact on health-related quality of life (QoL).
OBJECTIVES: To study the prevalence of early and late dumping in a large population of patients having undergone a primary Roux-en-Y gastric bypass (RYGB) and its effect on QoL.
SETTING: Cross-sectional study at a single bariatric department in the Medical Center Leeuwarden, The Netherlands between 2008 and 2011.
METHODS: In 2013, this descriptive cohort study approached by email or post all patients who underwent a primary RYGB in the setting between 2008 and 2011 in one hospital. These patients were asked to fill in standardized questionnaires measuring their QoL (RAND-36), anxiety and depression (HADS), fatigue (MFI-20) and any disease specific indicators of early and late dumping syndrome.
RESULTS: The questionnaire was completed and returned by 351 of 613 patients (57.1%) and 121 nonobese volunteers. Participants were mostly female (80%), aged 42 (40-54 years), with an excess weight loss of 76.8% [IQR 61-95] after RYGB surgery 2.3 [ IQR 1.6-3.4] years earlier. Self-reported complaints of moderate to severe intensity suggestive of early and late dumping were present in 18.8% and 11.7% of patients, respectively. Patients with early and late dumping demonstrated significantly lower scores on the RAND-36 and HADS compared with patients without dumping. No differences were seen in the MFI-20 scores between patients with or without early and late dumping.
CONCLUSION: In this descriptive cohort, self-reported complaints suggestive of early and late dumping of moderate-to-severe intensity were, respectively, 18.8% and 11.7% in a cohort after primary gastric bypass surgery. These complaints were associated with markedly reduced health-related QoL.

PMID: 28624531 [PubMed – as supplied by publisher]

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Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.

Superior return to sports rate after patellar tendon autograft over patellar tendon allograft in revision anterior cruciate ligament reconstruction.

Knee Surg Sports Traumatol Arthrosc. 2017 Jun 17;:

Authors: Keizer MNJ, Hoogeslag RAG, van Raay JJAM, Otten E, Brouwer RW

Abstract
PURPOSE: After revision anterior cruciate ligament reconstruction (ACLR), the rate of return to the pre-injury type of sport (RTS type) is low and graft choice might be an important factor. The aim of this study was to determine whether there is a difference in outcome after revision ACLR using a patellar tendon allograft compared to an ipsilateral patellar tendon autograft. It was hypothesized that the rate of RTS type using an ipsilateral patellar tendon autograft will be superior to using patellar tendon allograft.
METHODS: The design is a retrospective cohort study. Inclusion criteria were patients who underwent revision ACLR with a minimum follow-up of 1 year after revision using a patellar allograft or ipsilateral autograft. Primary study parameter was rate of RTS type. Secondary study parameters were RTS level, subscores of the KOOS, the IKDCsubjective, the Tegner score and reasons for no RTS.
RESULTS: Eighty-two patients participated in this study (36 allografts and 46 autografts). In patients with a minimum follow-up of 1 year, rate of RTS type was 51.4% for the patellar tendon allograft and 62.8% for the patellar tendon autograft group (n.s.). In patients with a minimum follow-up rate of 2 years, rate of RTS type was 43.3 versus 75.0%, respectively (p = 0.027). No differences in secondary study parameters were found. In patients with a minimum follow-up of 1 year, rate of RTS type was significantly higher (p = 0.025) for patients without anxiety compared to patients who were anxious to perform certain movements.
CONCLUSION: After a minimum follow-up of 2 years, rate of RTS type is in favour of using an ipsilateral patellar tendon autograft when compared to using a patellar tendon allograft in patients undergoing revision ACLR; after a minimum follow-up of 1 year, no significant difference was found. In revision ACLR, the results of this study might influence graft choice in favour of autologous graft when the use of an allograft or autograft patellar tendon is considered.
LEVEL OF EVIDENCE: III.

PMID: 28624854 [PubMed – as supplied by publisher]

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EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.

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EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies.

Eur J Nucl Med Mol Imaging. 2017 Jun 16;:

Authors: Aide N, Lasnon C, Veit-Haibach P, Sera T, Sattler B, Boellaard R

Abstract
Quantitative positron emission tomography/computed tomography (PET/CT) can be used as diagnostic or prognostic tools (i.e. single measurement) or for therapy monitoring (i.e. longitudinal studies) in multicentre studies. Use of quantitative parameters, such as standardized uptake values (SUVs), metabolic active tumor volumes (MATVs) or total lesion glycolysis (TLG), in a multicenter setting requires that these parameters be comparable among patients and sites, regardless of the PET/CT system used. This review describes the motivations and the methodologies for quantitative PET/CT performance harmonization with emphasis on the EANM Research Ltd. (EARL) Fluorodeoxyglucose (FDG) PET/CT accreditation program, one of the international harmonization programs aiming at using FDG PET as a quantitative imaging biomarker. In addition, future accreditation initiatives will be discussed. The validation of the EARL accreditation program to harmonize SUVs and MATVs is described in a wide range of tumor types, with focus on therapy assessment using either the European Organization for Research and Treatment of Cancer (EORTC) criteria or PET Evaluation Response Criteria in Solid Tumors (PERCIST), as well as liver-based scales such as the Deauville score. Finally, also presented in this paper are the results from a survey across 51 EARL-accredited centers reporting how the program was implemented and its impact on daily routine and in clinical trials, harmonization of new metrics such as MATV and heterogeneity features.

PMID: 28623376 [PubMed – as supplied by publisher]

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Assessment of variant pathogenicity in a highly admixed population.

Assessment of variant pathogenicity in a highly admixed population.

Hum Mutat. 2017 Jul;38(7):749

Authors: Guryev V

PMID: 28609575 [PubMed – in process]

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Hemostatic Complications in Hepatobiliary Surgery.

Hemostatic Complications in Hepatobiliary Surgery.

Semin Thromb Hemost. 2017 Jun 13;:

Authors: Bos S, Bernal W, Porte R, Lisman T

PMID: 28609799 [PubMed – as supplied by publisher]

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Discovery of novel heart rate-associated loci using the Exome Chip

Discovery of novel heart rate-associated loci using the Exome Chip

van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y-P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Mueller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikainen, L-P., Hall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S-J., Kahonen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orru, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A., Vaartjes, I., Hoes, A. W., van der Meer, P., Voelker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., Duijn, C. M., Zeggini, E., Jukema, W. J., Asselbergs, F. W., Samani, N. J., Lehtimaki, T., Gudnason, V., Wilson, J. G., Lubitz, S. A., Kaeaeb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Doerr, M., O’Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. & Munroe, P. B. 15-Jun-2017 In : Human Molecular Genetics. 26, 12, p. 2346-2363 18 p.

Research output: Scientific – peer-reviewArticle

Original language English
Pages (from-to) 2346-2363
Number of pages 18
Journal Human Molecular Genetics
Volume 26
Issue number 12
State Published – 15-Jun-2017
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Grootste, internationale onderzoek naar glycogeenstapelingsziekte type III

​Chris Peter Sentner: Clinical, biochemical and genetic aspects of glycogen storage disease type III Het is het grootste onderzoek naar …

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Meer aandacht voor beweging en gezond eten houdt ouderen met lage gezondheidsvaardigheden langer gezond

​Bas Geboers: Understanding the role of health literacy in self-management and health behaviors among older adults Ouderen met lage …

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Blijvend nierfunctieverlies door CMV-infectie na transplantatie

​Wouter Lollinga: The impact of cytomegalovirus in renal transplant recipients. From patient to cell Wouter Lollinga ontdekte dat infectie met het …

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The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.

The effects of a non-cognitive versus cognitive admission procedure within cohorts in one medical school.

Adv Health Sci Educ Theory Pract. 2017 Jun 10;:

Authors: de Visser M, Fluit C, Cohen-Schotanus J, Laan R

Abstract
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor’s curriculum simultaneously. 574 students (2013 and 2014 cohorts), admitted through non-cognitive selection (based on portfolio, CASPer and MMI, n = 135) or cognitive selection (curriculum sample selection, n = 439) were included in the study. We compared dropout rates, course credits and grades, using logistic and linear regression. The dropout rate was the highest in the non-cognitive selection group (p < 0.001). Students admitted through non-cognitive selection more often obtained the highest grade for the nursing attachment (p = 0.02) and had a higher mean grade for the practical clinical course in year 3 (p = .04). No differences in course grades were found. The results indicate that students perform best on the elements of the curriculum that are represented most strongly in the selection procedure they had participated in. We recommend the use of curriculum sample procedures, resembling the early medical school curriculum,-whether it has a more cognitive or a more non-cognitive focus-, to select the students who are likely to be successful in the subsequent curriculum.

PMID: 28601913 [PubMed – as supplied by publisher]

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Trainen met een spiegel vergroot kracht in het niet-getrainde ledemaat

​Tjerk Zult: Inter-limb mechanisms and clinical relevance of cross-education in humans Bij krachttraining met alleen de rechterarm, neemt ook de …

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Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.

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Association Between Attention-Deficit/Hyperactivity Disorder and Asthma Among Adults: A Case-Control Study.

Chest. 2017 Jun;151(6):1406-1407

Authors: van der Schans J, Aikman B, de Vries TW, Hoekstra PJ, Hak E

PMID: 28599940 [PubMed – in process]

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Toll-like receptor mediated activation is possibly involved in immunoregulating properties of cow’s milk hydrolysates

Toll-like receptor mediated activation is possibly involved in immunoregulating properties of cow’s milk hydrolysates

Kiewiet, M. B. G., Dekkers, R., Gros, M., van Neerven, R. J. J., Groeneveld, A., de Vos, P. & Faas, M. M. 8-Jun-2017 In : PLoS ONE. 12, 6, e0178191

Research output: Scientific – peer-reviewArticle

Original language English
Article number e0178191
Journal PLoS ONE
Volume 12
Issue number 6
State Published – 8-Jun-2017
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How competent are adolescent bullying perpetrators and victims in vastering normative developmental tasks in early adulthood?

How competent are adolescent bullying perpetrators and victims in vastering normative developmental tasks in early adulthood?

Kretschmer, T., Veenstra, R., Branje, S., Reijneveld, S. A., Meeus, W. H. J., Deković, M., Koot, H. M., Vollebergh, W. A. M. & Oldehinkel, A. J. 8-Jun-2017 In : Journal of Abnormal Child Psychology. 16 p.

Research output: Scientific – peer-reviewArticle

Original language English
Number of pages 16
Journal Journal of Abnormal Child Psychology
State E-pub ahead of print – 8-Jun-2017
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The intention of Dutch general practitioners to offer vaccination against pneumococcal disease, herpes zoster and pertussis to people aged 60 years and older

The intention of Dutch general practitioners to offer vaccination against pneumococcal disease, herpes zoster and pertussis to people aged 60 years and older

Lehmann, B. A., Eilers, R., Mollema, L., Ferreira, J. & de Melker, H. E. 7-Jun-2017 In : BMC Geriatrics. 17, 10 p., 122

Research output: Scientific – peer-reviewArticle

Original language English
Article number 122
Number of pages 10
Journal BMC Geriatrics
Volume 17
State Published – 7-Jun-2017
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