Genotype-fenotype relaties en hun klinische implicaties bij inflammatoire darmaandoeningen en type 2 diabetes

​Shifteh Abedian: Genotype-phenotype relationships and their clinical implications in inflammatory bowel disease and type 2 diabetes Complexe ziekten …

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Energie- en remodelleringsprocessen van de abnormaal belaste rechter hartkamer

​Anne-marie Koop: Right ventricular adaptation, In conditions of increased pressure load Abnormale belasting van de rechter hartkamer (RK) komt voor …

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Ontdekking van prognostische markers bij larynxkanker behandeld met radiotherapie

​Leonie Bruine de Bruin: Discovery of prognostic markers in laryngeal cancer treated with radiotherapy Hoofd-halskanker is met 890.000 nieuwe …

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GP4: an integrated Gram-Positive Protein Prediction Pipeline for subcellular localization mimicking bacterial sorting.

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GP4: an integrated Gram-Positive Protein Prediction Pipeline for subcellular localization mimicking bacterial sorting.

Brief Bioinform. 2020 Nov 24;:

Authors: Grasso S, van Rij T, van Dijl JM

Abstract
Subcellular localization is a critical aspect of protein function and the potential application of proteins either as drugs or drug targets, or in industrial and domestic applications. However, the experimental determination of protein localization is time consuming and expensive. Therefore, various localization predictors have been developed for particular groups of species. Intriguingly, despite their major representation amongst biotechnological cell factories and pathogens, a meta-predictor based on sorting signals and specific for Gram-positive bacteria was still lacking. Here we present GP4, a protein subcellular localization meta-predictor mainly for Firmicutes, but also Actinobacteria, based on the combination of multiple tools, each specific for different sorting signals and compartments. Novelty elements include improved cell-wall protein prediction, including differentiation of the type of interaction, prediction of non-canonical secretion pathway target proteins, separate prediction of lipoproteins and better user experience in terms of parsability and interpretability of the results. GP4 aims at mimicking protein sorting as it would happen in a bacterial cell. As GP4 is not homology based, it has a broad applicability and does not depend on annotated databases with homologous proteins. Non-canonical usage may include little studied or novel species, synthetic and engineered organisms, and even re-use of the prediction data to develop custom prediction algorithms. Our benchmark analysis highlights the improved performance of GP4 compared to other widely used subcellular protein localization predictors. A webserver running GP4 is available at http://gp4.hpc.rug.nl/.

PMID: 33227814 [PubMed – as supplied by publisher]

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Beschermingsmechanisme van NOD bij niertransplantaties

Prama Pallavi : N-acyl Dopamines – renoprotective therapeutics, acting on TRPV1 signaling. Biological properties and molecular mechanisms​ Om de kans …

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Belangrijke factoren die bijdragen aan stressreacties geïdentificeerd

​Yuanyuan Xin: Motivation, reward and stress: individual difference and neural basis Stress is overal aanwezig in ons dagelijks leven. De meeste …

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Risicofactoren voor atriumfibrilleren en verschillen tussen mannen en vrouwen in kaart gebracht

​Mariëlle Kloosterman: Characterization of different patient populations with atrial fibrillation Atriumfibrilleren (AF) is de meest voorkomende …

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Bewustwording van belang bij creëren van effectieve therapeutische alliantie binnen de revalidatie

​Davy Paap: The therapeutic alliance in rehabilitation​ Patiënten die revalideren hebben baat bij een goede samenwerking met de …

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Hemostase bij levertransplantatie bij kinderen

​Maureen Werner-Paap: Hemostasis in pediatric liver transplantation In de afgelopen jaren zijn de uitkomsten van kinderen na levertransplantatie …

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Bestraling kan bij borstkankerpatiënten leiden tot verhoogd risico op hartschade

​Veerle van den Bogaard: Radiation-induced cardiac toxicity in breast cancer patients Borstkanker is in Nederland de meest voorkomende kankersoort …

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Activatie van stellaatcellen als aangrijpingspunt voor de behandeling van leverfibrose

​Mengfan Zhang: Targeting hepatic stellate cells to prevent or reverse liver fibrosis Zhang introduceert in zijn proefschrift de cruciale rol van de …

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Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse.

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Reward prospect improves inhibitory control in female university students with a history of childhood sexual and physical abuse.

J Behav Ther Exp Psychiatry. 2020 Nov 07;71:101629

Authors: Kiyar M, Lommen MJJ, Krebs RM, Daniels JK, Mueller SC

Abstract
BACKGROUND AND OBJECTIVES: Childhood abuse and neglect increase the risk for psychiatric disorders (e.g., depression and anxiety) during adulthood and have been associated with deficits in cognitive control. The specific mechanisms underlying these cognitive control deficits are still unknown.
METHODS: This study examined the expectation for reward to improve inhibitory control in young women (ages 18-35 years) with a history of childhood sexual and/or physical abuse (AG, N = 28), childhood emotional and/or physical neglect (NG, N = 30), or unaffected comparison women (HC, N = 40). They completed a previously validated rewarded (color-word) Stroop task and filled out questionnaires on depression, anxiety, and resilience.
RESULTS: Surprisingly, a significant group by reward interaction revealed larger performance benefits under reward prospect (relative to no-reward) for the AG group relative to both the NG and HC groups.
LIMITATIONS: A small sample size limiting generalizability.
CONCLUSIONS: These results demonstrate sensitivity of abused subjects to reward in modulating cognitive control and might aid in discussing whether using reward schedules during therapeutic interventions could be effective.

PMID: 33217704 [PubMed – as supplied by publisher]

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Bioinspired PDMS-graphene cantilever flow sensors using 3D printing and replica moulding.

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Bioinspired PDMS-graphene cantilever flow sensors using 3D printing and replica moulding.

Nanotechnology. 2020 Nov 20;:

Authors: Kamat AM, Zheng X, Jayawardhana B, Kottapalli AGP

Abstract
Flow sensors found in animals often feature soft and slender structures (e.g. fish neuromasts, insect hairs, mammalian stereociliary bundles, etc.) that bend in response to the slightest flow disturbances in their surroundings and heighten the animal’s vigilance with respect to prey and/or predators. However, fabrication of bioinspired flow sensors that mimic the material properties (e.g. low elastic modulus) and geometries (e.g. high-aspect ratio structures) of their biological counterparts remains a challenge. In this work, we develop a facile and low-cost method of fabricating high-aspect ratio (HAR) cantilever flow sensors inspired by the mechanotransductory flow sensing principles found in nature. The proposed workflow entails high-resolution 3D printing to fabricate the master mould, replica moulding to create HAR polydimethylsiloxane (PDMS) cantilevers (thickness = 0.5 – 1 mm, width = 3 mm, aspect ratio = 20) with microfluidic channel (150 µm wide × 90 µm deep) imprints, and finally graphene nanoplatelet ink drop-casting into the microfluidic channels to create a piezoresistive strain gauge near the cantilever’s fixed end. The piezoresistive flow sensors were tested in controlled airflow (0 – 9 m/s) inside a wind tunnel where they displayed high sensitivities of up to 5.8 kΩ/ms-1, low hysteresis (11% of full-scale deflection), and good repeatability. The sensor output showed a second order dependence on airflow velocity and agreed well with analytical and finite element model predictions. Further, the sensor was also excited inside a water tank using an oscillating dipole where it was able to sense oscillatory flow velocities as low as 16 – 30 µm/s at an excitation frequency of 15 Hz. The methods presented in this work can enable facile and rapid prototyping of flexible HAR structures that can find applications as functional biomimetic flow sensors and/or physical models which can be used to explain biological phenomena.

PMID: 33217747 [PubMed – as supplied by publisher]

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Pre-Transplant Plasma Potassium as a Potential Risk Factor for the Need of Early Hyperkalaemia Treatment after Kidney Transplantation: A Cohort Study.

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Pre-Transplant Plasma Potassium as a Potential Risk Factor for the Need of Early Hyperkalaemia Treatment after Kidney Transplantation: A Cohort Study.

Nephron. 2020 Nov 19;:1-8

Authors: de Vries BCS, Berger SP, Bakker SJL, de Borst MH, de Jong MFC

Abstract
INTRODUCTION: Plasma potassium (K+) abnormalities are common among patients with chronic kidney disease and are associated with higher rates of death, major adverse cardiac events, and hospitalization in this population. Currently, no guidelines exist on how to handle pre-transplant plasma K+ in renal transplant recipients (RTR).
OBJECTIVE: The aim of this study is to examine the relation between pre-transplant plasma K+ and interventions to resolve hyperkalaemia within 48 h after kidney transplantation.
METHODS: In a single-centre cohort study, we addressed the association between the last available plasma K+ level before transplantation and the post-transplant need for dialysis or use of K+-lowering medication to resolve hyperkalaemia within 48 h after renal transplantation using multivariate logistic regression analysis.
RESULTS: 151 RTR were included, of whom 51 (33.8%) patients received one or more K+ interventions within 48 h after transplantation. Multivariate regression analysis revealed that a higher pre-transplant plasma K+ was associated with an increased risk of post-transplant intervention (odds ratio 2.2 [95% CI: 1.1-4.4]), independent of donor type (deceased or living) and use of K+-lowering medication within 24 h prior to transplantation).
CONCLUSIONS: This study indicates that a higher pre-transplant plasma K+ is associated with a higher risk of interventions necessary to resolve hyperkalaemia within 48 h after renal transplantation. Further research is recommended to determine a cutoff level for pre-transplant plasma K+ that can be used in practice.

PMID: 33212442 [PubMed – as supplied by publisher]

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Inhalator voor hoge dosering isoniazide kan resistentie bij tubercolose doorbreken

​​Imco Sibum: Resistance is Futile, The targeted delivery of antibiotics to the lungs Imco Sibum beschrijft in zijn proefschrift de verschillende …

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Revalidatiebeleid na totale heupartroplastiek

​Annet Wijnen: Rehabilitation policies following total hip arthroplasty Een totale heupartroplastiek (THA) is één van de meest succesvolle …

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Verband tussen blootstelling aan schadelijke stoffen tijdens het werk gedurende de zwangerschap en het risico op het krijgen van een kind met een aangeboren afwijking

Nynke Spinder: Maternal occupational exposure and congenital anomalies Wereldwijd wordt één op de 33 kinderen geboren met een aangeboren aandoening. …

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Tyrosinemie type 1: resterende uitdagingen na introductie van het medicijn NTBC

​​Wiggert Van Ginkel: Tyrosinemia type 1, remaining challenges after introduction of NTBC​ Tyrosinemie type 1 is een erfelijke stofwisselingsziekte …

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Tyrosinemie type 1: resterende uitdagingen na introductie van het medicijn NTBC

​​ ​Wiggert Van Ginkel: Tyrosinemia type 1, remaining challenges after introduction of NTBC​ Tyrosinemie type 1 is een erfelijke stofwisselingsziekte …

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Behandelingen van longziekten met steroïden onderzocht en mechanismen geanalyseerd

​Jan Zijlstra: Mechanisms of glucocorticoid insensitivity in asthma Obstructieve longziekten zoals astma en COPD worden vaak behandeld met …

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