Newcomers to Social Categories: Longitudinal Predictors and Consequences of Ingroup Identification.

Related Articles

Newcomers to Social Categories: Longitudinal Predictors and Consequences of Ingroup Identification.

Pers Soc Psychol Bull. 2016 Jun;42(6):811-25

Authors: van Veelen R, Eisenbeiss KK, Otten S

Abstract
In the present article, we propose a dynamic model of the longitudinal predictors and consequences of ingroup identification among newcomers to a social category. We hypothesize a shift in the relative importance of intragroup affiliation as compared with intergroup differentiation for ingroup identification. Two longitudinal studies confirm the theoretical model assessing cross-sectional and longitudinal relationships between ingroup identification and interpersonal attraction, self-prototypicality, and ingroup favoritism at three measurement points during the first 4 months of group membership in two different social categories. Results demonstrate that in the initial phases of group membership, ingroup identification is mainly determined by intragroup affiliation (interpersonal attraction) and that ingroup favoritism starts playing a relevant role later on, when category membership has been established.

PMID: 27460273 [PubMed – in process]

Posted in Pers Soc Psychol Bull | Tagged | Leave a comment

Implant-supported removable partial dentures in the mandible: A 3-16 year retrospective study.

Related Articles

Implant-supported removable partial dentures in the mandible: A 3-16 year retrospective study.

J Prosthodont Res. 2016 Jul 22;

Authors: Jensen C, Meijer HJ, Raghoebar GM, Kerdijk W, Cune MS

Abstract
PURPOSE: The purpose of this retrospective study was to assess performance, together with biological and technical complications, of implant-supported removable partial dentures (ISRPD) in mandibular Kennedy class I situations with implants placed in the anterior or posterior position.
METHODS: 23 subjects with two endosseous implants to support a bilateral-free-ending mandibular removable denture were examined. Eight subjects had implants in the premolar (anterior) region and 15 subjects implants in the molar (posterior) region. Biological and technical complications were recorded from the patients’ medical record. Patients filled out a validated questionnaire regarding their appreciation of oral health related quality of life (OHIP-NL49) and a VAS score on overall satisfaction.
RESULTS: Over a mean follow-up period of 8 years (median 8 years, range 3-16 years) the cumulative implant survival rate was 91.7% (SE 0.05). Mean peri-implant bone loss was 0.9mm (SD 1.0mm). Scores for bleeding on probing, plaque and mucosal health were generally low, but significantly worse for posteriorly placed implants. Significantly more biological complications occurred in the posterior group (X(2)(1)=3.9; p=0.048). In 65% of the cases no technical complications were registered. Mean overall OHIP score was 16.1 (SD 18.4) and patients were highly satisfied (VAS: 8.4; SD 2.1).
CONCLUSIONS: Within the limitations of this retrospective study, in case of a Kennedy class I situation in the mandible, an ISRPD is a viable treatment option with a high implant survival rate and satisfied patients after a maximum of 16 years. Technical and biological complications should be anticipated. Anteriorly placed implants performed slightly better.

PMID: 27461087 [PubMed – as supplied by publisher]

Posted in J Prosthodont Res | Tagged | Leave a comment

Simultaneous pentafluorobenzyl derivatization and GC-ECNICI-MS measurement of nitrite and malondialdehyde in human urine: Close positive correlation between these disparate oxidative stress biomarkers.

Related Articles

Simultaneous pentafluorobenzyl derivatization and GC-ECNICI-MS measurement of nitrite and malondialdehyde in human urine: Close positive correlation between these disparate oxidative stress biomarkers.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 16;

Authors: Hanff E, Eisenga MF, Beckmann B, Bakker SJ, Tsikas D

Abstract
Urinary nitrite and malondialdehyde (MDA) are biomarkers of nitrosative and oxidative stress, respectively. At physiological pH values of urine and plasma, nitrite and MDA exist almost entirely in their dissociated forms, i.e., as ONO(-) (ONOH, pKa=3.4) and (-)CH(CHO)2 (CH2(CHO)2, pKa=4.5). Previously, we reported that nitrite and MDA react with pentafluorobenzyl (PFB) bromide (PFB-Br) in aqueous acetone. Here, we report on the simultaneous derivatization of nitrite and MDA and their stable-isotope labeled analogs O(15)NO(-) (4μM) and CH2(CDO)2 (1μM or 10μM) with PFB-Br (10μL) to PFBNO2, PFB(15)NO2, C(PFB)2(CHO)2), C(PFB)2(CDO)2 by heating acetonic urine (urine-acetone, 100:400μL) for 60min at 50°C. After acetone evaporation under a stream of nitrogen, derivatives were extracted with ethyl acetate (1mL). A 1-μL aliquot of the ethyl acetate phase dried over anhydrous Na2SO4 was injected in the splitless mode for simultaneous GC-MS analysis in the electron capture negative-ion chemical ionization mode. Quantification was performed by selected-ion monitoring (SIM) the anions [M-PFB](-)m/z 46 for ONO(-), m/z 47 for O(15)NO(-), m/z 251 for (-)C(PFB)(CHO)2, and m/z 253 for (-)C(PFB)(CDO)2. The retention times were 3.18min for PFB-ONO2/PFB-O(15)NO2, and 7.13min for (-)C(PFB)(CHO)2/(-)C(PFB)(CDO)2. Use of CH2(CDO)2 at 1μM but not at 10μM was associated with an unknown interference with the C(PFB)2(CDO)2 peak. Endogenous MDA can be quantified using O(15)NO(-) (4μM) and CH2(CDO)2 (10μM) as the internal standards. The method is also useful for the measurement of nitrate and creatinine in addition to nitrite and MDA. Nitrite and MDA were measured by this method in urine of elderly healthy subjects (10 females, 9 males; age, 60-70 years; BMI, 25-30kg/m(2)). Creatinine-corrected excretion rates did not differ between males and females for MDA (62.6 [24-137] vs 80.2 [52-118]nmol/mmol, P=0.448) and for nitrite (102 [71-174] vs. 278 [110-721]nmol/mmol P=0.053). We report for the first time a close correlation (r=0.819, P<0.0001) between MDA and nitrite in human urine. This correlation is assumed to be due to involvement of myeloperoxidase which catalyzes the formation of hypochlorite ((-)OCl) from chloride and hydrogen peroxide. In turn, hypochlorite reacts both with nitrite and with polyunsaturated fatty acids such as arachidonic acid, with the later reaction generating MDA. The proposed mechanisms are supported by the literature but remain to be fully explored.

PMID: 27461359 [PubMed – as supplied by publisher]

Posted in J Chromatogr B Analyt Technol Biomed Life Sci | Tagged | Leave a comment

Galectin-3, Cardiac Function, and Fibrosis.

Related Articles

Galectin-3, Cardiac Function, and Fibrosis.

Am J Pathol. 2016 Aug;186(8):2232-4

Authors: Meijers WC, López-Andrés N, de Boer RA

Abstract
This Correspondence relates to the article by Frunza et al (Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis. Am J Pathol 2016, 186:1114-1127).

PMID: 27461364 [PubMed – in process]

Posted in Am J Pathol | Tagged | Leave a comment

An Echodensity in the Sinus of Valsalva.

Related Articles

An Echodensity in the Sinus of Valsalva.

J Cardiothorac Vasc Anesth. 2016 Mar 9;

Authors: Amir R, Yeh L, Matyal R, Mahmood F

PMID: 27461797 [PubMed – as supplied by publisher]

Posted in J Cardiothorac Vasc Anesth | Tagged | Leave a comment

The Centrality of Fear Extinction in Linking Risk Factors to PTSD: A Narrative Review.

Related Articles

The Centrality of Fear Extinction in Linking Risk Factors to PTSD: A Narrative Review.

Neurosci Biobehav Rev. 2016 Jul 23;

Authors: Zuj DV, Palmer MA, Lommen MJ, Felmingham KL

Abstract
Recent prospective studies in emergency services have identified impaired fear extinction learning and memory to be a significant predictor of Posttraumatic Stress Disorder (PTSD), complementing a wealth of cross-sectional evidence of extinction deficits associated with the disorder. Additional fields of research show specific risk factors and biomarkers of the disorder, including candidate genotypes, stress and sex hormones, cognitive factors, and sleep disturbances. Studies in mostly nonclinical populations also reveal that the aforementioned factors are involved in fear extinction learning and memory. Here, we provide a comprehensive narrative review of the literature linking PTSD to these risk factors, and linking these risk factors to impaired fear extinction. On balance, the evidence suggests that fear extinction may play a role in the relationship between risk factors and PTSD. Should this notion hold true, this review carries important implications for the improvement of exposure-based treatments, as well as strategies for the implementation of treatment.

PMID: 27461912 [PubMed – as supplied by publisher]

Posted in Neurosci Biobehav Rev | Tagged | Leave a comment

The Facial Appearance of CEOs: Faces Signal Selection but Not Performance.

Related Articles

The Facial Appearance of CEOs: Faces Signal Selection but Not Performance.

PLoS One. 2016;11(7):e0159950

Authors: Stoker JI, Garretsen H, Spreeuwers LJ

Abstract
Research overwhelmingly shows that facial appearance predicts leader selection. However, the evidence on the relevance of faces for actual leader ability and consequently performance is inconclusive. By using a state-of-the-art, objective measure for face recognition, we test the predictive value of CEOs’ faces for firm performance in a large sample of faces. We first compare the faces of Fortune500 CEOs with those of US citizens and professors. We find clear confirmation that CEOs do look different when compared to citizens or professors, replicating the finding that faces matter for selection. More importantly, we also find that faces of CEOs of top performing firms do not differ from other CEOs. Based on our advanced face recognition method, our results suggest that facial appearance matters for leader selection but that it does not do so for leader performance.

PMID: 27462986 [PubMed – as supplied by publisher]

Posted in PLoS One | Tagged | Leave a comment

STARDing Again: Revised Guidelines for Reporting Information in Studies of Diagnostic Test Accuracy.

Related Articles

STARDing Again: Revised Guidelines for Reporting Information in Studies of Diagnostic Test Accuracy.

J Pers Assess. 2016 Jul 27;:1-4

Authors: Streiner DL, Sass DA, Meijer RR, Furr RM

PMID: 27464308 [PubMed – as supplied by publisher]

Posted in J Pers Assess | Tagged | Leave a comment

The generation and exploitation of protein mutability landscapes for enzyme engineering.

The generation and exploitation of protein mutability landscapes for enzyme engineering.

Chembiochem. 2016 Jul 21;

Authors: Van Der Meer JY, Biewenga L, Poelarends GJ

Abstract
The increasing number of enzyme applications in chemical synthesis calls for new engineering methods to develop the biocatalysts of the future. An interesting concept in enzyme engineering is the generation of large-scale mutational data to chart protein mutability landscapes. These landscapes allow the important discrimination between beneficial mutations and those that are neutral or detrimental, providing detailed insight into sequence-function relationships. As such, mutability landscapes are a powerful tool to identify functional hotspots at any place in the amino acid sequence of an enzyme. These hotspots can be used as targets for combinatorial mutagenesis to yield superior enzymes with improved catalytic properties, stability or even new enzymatic activities. The generation of mutability landscapes for multiple properties of one enzyme provides the exciting opportunity to select mutations that are beneficial for either one or several of these properties. This review presents an overview of the recent advances in the construction of mutability landscapes and discusses their importance for enzyme engineering.

PMID: 27441919 [PubMed – as supplied by publisher]

Posted in Chembiochem | Tagged , | Leave a comment

Gastroenterological endpoints in drug trials for cystic fibrosis.

Gastroenterological endpoints in drug trials for cystic fibrosis.

Pediatr Pulmonol. 2016 Jul 21;

Authors: Bodewes FA, Verkade HJ, Wilschanski M

Abstract
The phenotype of cystic fibrosis includes a wide variety of clinical and biochemical gastrointestinal presentations. These gastrointestinal characteristics of the disease have come under renewed interest as potential outcome measures and clinical endpoints for therapeutic trials in cystic fibrosis. Established gastrointestinal clinical endpoints, like e.g. fecal elastase-1, are already used in trials. Other potential gastrointestinal outcome measures gather more scientific interest for evaluation in future trials. Gastrointestinal outcome measures look particularly relevant and promising for trials in CF patients with normal lung function or therapeutic studies in young children and infants. We review, the currently reported gastrointestinal effects of CFTR modulation therapies and discuss the potential of gastrointestinal outcome measures for therapeutic trials in cystic fibrosis. Pediatr Pulmonol.. © 2016 Wiley Periodicals, Inc.

PMID: 27442207 [PubMed – as supplied by publisher]

Posted in Pediatr Pulmonol | Tagged , | Leave a comment

Post-error adjustments and ADHD symptoms in adults: The effect of laterality and state regulation.

Related Articles

Post-error adjustments and ADHD symptoms in adults: The effect of laterality and state regulation.

Brain Cogn. 2016 Jul 15;108:11-19

Authors: Mohamed SM, Börger NA, Geuze RH, van der Meere JJ

Abstract
Evidence is accumulating that individuals with Attention-Deficit/Hyperactivity Disorder (ADHD) do not adjust their responses after committing errors. Post-error response adjustments are taken to reflect, among others, error monitoring that is essential for learning, flexible behavioural adaptation, and achieving future goals. Many behavioural studies have suggested that atypical lateral brain functions and difficulties in allocating effort to protect performance against stressors (i.e., state regulation) are key factors in ADHD. Whether these factors contribute to the absence of post-error response adjustments in ADHD is unknown. The aim of the present study is to investigate the contribution of the left and right hemispheres and the deficiency in effort allocation to deviant post-error processing in adults with high ADHD symptoms. From a pool of 87 university students, two groups were formed: a group with higher (n=30) and a group with lower (n=26) scores on the ADHD index subscale of the Conners’ Adult ADHD Rating Scales. The groups performed a lateralized lexical decision task with a fast and slower stimulus presentation rate. Post-error slowing and post-error response accuracy to stimuli presented in the left and right visual field were measured in each stimulus presentation rate. Results indicated that subjects with the lower ADHD scores slowed down and improved their response accuracy after errors, especially when stimuli were presented in the right visual field at the slower rate. In contrast, subjects with the higher ADHD scores showed no post-error adjustments. Results suggest that during lexical decision performance, impaired error processing in adults with ADHD is associated with affected ability of the left hemisphere to compensate for errors, especially when extra effort allocation is needed to meet task demands.

PMID: 27429094 [PubMed – as supplied by publisher]

Posted in Brain Cogn | Tagged , | Leave a comment

Privacy is gewoon prettig: privacybeleving van patiënten binnen Sector C

Inleiding en onderzoeksvragen
Binnen het Universitair Medisch Centrum Groningen vindt een verbouwing en herindeling van verschillende poliklinieken plaats, zodat er ruimte komt voor nieuwe operatiekamers en spoedeisende hulp. De nieuw poliklinieken vormen clusters waarvan Moeder & Kind en Urologie & Gynaecologie er twee zijn. Deze clusters omvatten de huidige poliklinieken van het Beatrixkinderziekenhuis, Obstetrie & Gynaecologie en Urologie. Deze afdelingen willen de toekomstige poliklinieken zoveel mogelijk richten naar de wensen en behoeften van hun patiënten.
Een vraag waarop men graag het antwoord krijgt, is hoe patiënten denken over privacyaspecten zoals gehorigheid bij de balie en of andere mensen hun gesprek meekrijgen. Daarnaast spelen er vragen met betrekking tot inrichting, informatievoorziening en healing environment.
Door Sundstrom, Burt en Kamp (1980) wordt onderscheid gemaakt in twee soorten privacy, psychologische en architectonische privacy. Psychologische privacy omvat het gevoel van controle over de informatie uitwisseling vanuit jezelf naar anderen en controle over de input van anderen. Architectonische privacy wordt gedefinieerd als de visuele en auditieve isolatie die wordt gecreëerd door een omgeving.
Dit onderscheid van privacy is terug te vinden in de hoofdvraag van dit onderzoek:
‘Hoe kunnen de psychologische en architectonische privacy van de wachtkamer geoptimaliseerd worden naar de ervaringen van patiënten binnen het Beatrixkinderziekenhuis, Urologie en Obstetrie & Gynaecologie?’
Om deze vraag te beantwoorden zijn drie deelvragen geformuleerd:
1. Hoe ervaren patiënten de verspreiding van persoonlijke informatie?
2. Hoe ervaren patiënten het ontvangen van andermans informatie?
3. Hoe ervaren de patiënten de indeling van de wachtkamer met betrekking tot privacy?

Methode
Er zijn 10 interviews gehouden met patiënten van de huidige drie poliklinieken.
Daarnaast is er een workshop gehouden met 8 patiënten van verschillende ziekenhuizen. De workshop bestond uit drie rondes. In de eerste ronde hebben de deelnemers elkaar geïnterviewd. In ronde twee hebben de deelnemers in duo’s mindmaps gemaakt over de vier onderzoeksonderwerpen. In de laatste ronde hebben de deelnemers een prototype gemaakt van hun ideale wachtkamer.
De data uit de interviews en workshop zijn gecodeerd en gegroepeerd. De resultaten zijn gegroepeerd op psychologische en architectonische privacy.

Resultaten
Met betrekking tot psychologische privacy gaven respondenten aan liever niet de gesprekken van andere patiënten te horen. Respondenten gaven aan dit ‘uit’ te zetten en er hierdoor niet naar te luisteren. Andere respondenten gaven juist aan soms informatie te horen die zij liever niet hadden gehoord.
Verder gaven respondenten aan dat zij een stille wachtkamer niet prettig vinden, doordat iedereen hierdoor jouw gesprek meekrijgt. Respondenten geven aan het niet erg te vinden als zij bij naam opgeroepen worden. Met betrekking tot architectonische privacy gaven respondenten aan een open wachtruimte prettig te vinden. Hierbij is aangegeven dat het fijn is als er mogelijkheid tot afzondering is. Verder gaven respondenten aan niet te dichtbij, of tegenover andere patiënten te willen zitten. Over geluid gaven respondenten aan dat prettig is wanneer er rumoer is in de wachtruimte. Tot slot wordt er over de balie door meerdere respondenten genoemd dat het prettig is als deze in het zicht van de wachtkamer is.

Conclusie
Met betrekking tot psychologische privacy willen patiënten zo min mogelijk van elkaars gesprekken meekrijgen. Andersom geldt ook dat patiënten het fijn vinden wanneer anderen zo min mogelijk van hun gesprekken of informatie meekrijgen.
Met betrekking tot architectonische privacy willen patiënten één overzichtelijke wachtkamer met verschillende soorten zitplekken, van open tot afgezonderde zitplekken. Hierbij is het ook belangrijk dat wanneer je een spreekkamer uitloopt je afzondering kan opzoeken en niet direct de wachtkamer inloopt.

Posted in Thesis | Tagged | Leave a comment

Blood pressure lowering effects of sulodexide depend on albuminuria severity: Post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies.

Blood pressure lowering effects of sulodexide depend on albuminuria severity: Post hoc analysis of the sulodexide microalbuminuria and macroalbuminuria studies.

Br J Clin Pharmacol. 2016 Jul 14;

Authors: Olde Engberink RH, Heerspink HJ, de Zeeuw D, Vogt L

Abstract
AIMS: It has been suggested that sulodexide is able to lower blood pressure (BP). This may be attributed to sulodexide’s ability to restore the endothelial surface layer (ESL). As ESL perturbation is known to be related to the degree of kidney damage, we investigated whether albuminuria, reflecting ESL status, modified the BP lowering potential of sulodexide.
METHODS: A post hoc analysis of the double-blind randomized placebo-controlled sulodexide microalbuminuria (Sun-MICRO) and macroalbuminuria studies (Sun-MACRO) including 1,056 microalbuminuric and 843 macroalbuminuric subjects with type 2 diabetes receiving maximal tolerated renin-angiotensin inhibitor therapy. We compared the effect of placebo and sulodexide on systolic BP (SBP) among albuminuria groups.
RESULTS: Analysis of covariance including data from both trials showed that baseline urine albumin-to-creatinine ratio (UACR) was the only modifier of the SBP response (interaction with treatment p = 0.001). In subjects with an UACR >1,000 mg/g, sulodexide lowered SBP by 4.6 mmHg (95% CI: 3.6-5.6, p < 0.001) compared to placebo, whereas a 2.3 mmHg (95% CI: 0.9-3.7, p = 0.001) reduction was seen in subjects with an UACR 300-1000 mg/g. Sulodexide did not lower SBP in subjects with an UACR <300 mg/g (-0.2 mmHg, 95% CI -0.8-0.5, p = 0.60). SBP lowering effects were not accompanied by changes in body weight.
CONCLUSION: The BP reducing potency of sulodexide is modified by the degree of albuminuria in subjects with type 2 diabetes. As ESL status deteriorates with increasing albuminuria and nephropathy severity, this suggests that ESL restoration may represent a new target for BP treatment in subjects with diabetic nephropathy.

PMID: 27412828 [PubMed – as supplied by publisher]

Posted in Br J Clin Pharmacol | Tagged , | Leave a comment

Changes in dynamic balance control over time in children with and without Developmental Coordination Disorder.

Changes in dynamic balance control over time in children with and without Developmental Coordination Disorder.

Hum Mov Sci. 2016 Jul 9;49:148-159

Authors: Jelsma LD, Smits-Engelsman BC, Krijnen WP, Geuze RH

Abstract
The aim of this study was to examine differences in underlying adaptations of dynamic balance in children with and without Developmental Coordination Disorder (DCD) during a Wii Fit game and to measure changes over time and after intervention. Twenty-eight children with DCD and 21 typically developing (TD) children participated in the study. Analyses of force plate variables showed that the TD group initially used a longer path length for the ski slope descent and tended toward more variation in Center of Pressure (CoP) displacement in lateral direction than the children with DCD. In contrast, the TD group showed a trend of fewer reversals per cm in both AP and lateral direction. After the nonintervention period, the TD group improved performance by decreasing the path length, while the DCD group improved by increasing the path length and by decreasing the number of reversals. After intervention, no changes were found in sway characteristics. Individual analyses within the DCD group showed that the path length per run fell more often within the 95% confidence Interval of the faultless runs. In conclusion both TD and DCD children modify the underlying kinetics of dynamic balance control, but in different ways and both lead to better performance.

PMID: 27404396 [PubMed – as supplied by publisher]

Posted in Hum Mov Sci | Tagged | Leave a comment

Physician Clinical Gestalt Formation in Acute Coronary Syndrome: A Qualitative Study

Introduction: Patients presenting with acute chest pain form a large portion of the
cases seen in the emergency department. Quick recognition of chest pain due to Acute
Coronary Syndrome (ACS) is of vital importance. Diagnostics in patients presenting
without obvious signs of cardiac ischemia is challenging, and is mainly based on the
information from the clinical history and the current presentation. This information
can be assessed objectively by using risk scores like the HEART score. However,
physicians can also form an unstructured, more subjective estimation on the
likelihood of ACS, called the physicians ‘clinical gestalt’. These strategies have
similar validity, however, the exact information used in forming the clinical gestalt is
unclear. The current study aims to identify the factors contributing to the formation of
the physician’s clinical gestalt in cases of suspected ACS without obvious signs of
cardiac ischemia.
Methods: Ten cardiology residents working in the emergency department of the
University Medical Center Groningen (UMCG) were interviewed about their
diagnostics process. Face-to-face interviews were conducted, then transcribed and
coded using qualitative analysis software.
Results: The residents based their assessment of the patient on experience, guidelines,
and training. The most important factors contributing to the formation of the
physician’s clinical gestalt were the pain presentation, the patient’s clinical history,
risk factors for cardiovascular disease, and unquantifiable factors related to the
patients appearance. Some residents used risk scores to objectively assess the
information from the clinical history, though none of the risk scores used were
designed for diagnostic purposes.
Discussion: Not all pain characteristics used by the residents in this study are
sufficiently validated to be used as diagnostic for ACS. However, pain radiating to
one or both arms that is provoked by exercise is validated as typical for ischemic
cardiac chest pain, so these characteristics should be used when suspecting ACS.
Residents in this study also value certain subjective factors related to a patient’s
presentation, like ‘appearing sick’. These factors are difficult to quantify. A risk score
combining objective, validated factors of ACS and the physician’s subjective,
unstructured clinical gestalt is suggested. Further quantitative research is needed to
verify this.

Posted in Thesis | Tagged | Leave a comment

Effects of parenting quality on adolescents’ personality resemblance to their parents. The TRAILS study.

Effects of parenting quality on adolescents’ personality resemblance to their parents. The TRAILS study.

J Adolesc. 2016 Jul 8;51:163-175

Authors: Langenhof MR, Komdeur J, Oldehinkel AJ

Abstract
This study considers the development of resemblance between 741 adolescents and their biological parents, across six NEO-PI-R personality traits known to be important in psychological problems: anger-hostility, impulsiveness, vulnerability, assertiveness, excitement-seeking, and self-discipline. We modelled the association between perceived parental warmth and rejection at age eleven and personality resemblance to parents at about age sixteen. Parenting experienced during early adolescence was related to the degree and direction in which adolescents resembled their parents five years later in life. Rejection, especially from fathers, significantly predicted a smaller resemblance to both the parents. Girls were more strongly affected by parental quality than boys, and there was some indication that adolescents responded in opposite ways to parenting from mothers and fathers. This study is a first step in uncovering the complex interplay between parenting, gender, and the current generation’s ability to develop personality traits independent from the previous generation.

PMID: 27400032 [PubMed – as supplied by publisher]

Posted in J Adolesc | Tagged | Leave a comment

Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives.

Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives.

Expert Rev Neurother. 2016 Jul 11;

Authors: De Tommaso M, Kunz M, Valeriani M

Abstract
INTRODUCTION Neurodegenerative diseases are increasing in parallel to the lengthening of survival. The management of Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD-related disorders, and motor neuron diseases (MND), is mainly targeted to motor and cognitive impairment, with special care for vital functions such as breathing and feeding. AREAS COVERED The present review focuses on chronic pain in main neurodegenerative diseases, addressing current evidence on pain therapeutic management, pain frequency and clinical features, and possible pathophysiological mechanisms. The search on PubMed had no time limits and was performed by searching for the following key issues: pain, dementia, Alzheimer disease, Parkinson’s disease, extrapyramidal disorders, motoneuronal disease, Amyotrophic lateral sclerosis, FXTAS, frequency, pathophysiology, treatments, therapy, efficacy, opioids, side effects. No controlled therapeutic trials and guidelines are currently available. The effects of current therapies such as LDopa or riluzole on pain symptoms are not clear. Emerging evidences on the possible anti-nociceptive effects of cannabis or botulinum toxin might be available soon. EXPERT COMMENTARY Pain needs to be better evaluated and fully considered in the global management of neurodegenerative disease because a more focused treatment may have a positive impact on the global burden of these devastating disorders.

PMID: 27400329 [PubMed – as supplied by publisher]

Posted in Expert Rev Neurother | Tagged | Leave a comment

Lubricating the swordfish head.

Lubricating the swordfish head.

J Exp Biol. 2016 Jul 1;219(Pt 13):1953-1956

Authors: Videler JJ, Haydar D, Snoek R, Hoving HT, Szabo BG

Abstract
The swordfish is reputedly the fastest swimmer on Earth. The concave head and iconic sword are unique characteristics, but how they contribute to its speed is still unknown. Recent computed tomography scans revealed a poorly mineralised area near the base of the rostrum. Here we report, using magnetic resonance imaging and electron microscopy scanning, the discovery of a complex organ consisting of an oil-producing gland connected to capillaries that communicate with oil-excreting pores in the skin of the head. The capillary vessels transport oil to abundant tiny circular pores that are surrounded by denticles. The oil is distributed from the pores over the front part of the head. The oil inside the gland is identical to that found on the skin and is a mixture of methyl esters. We hypothesize that the oil layer, in combination with the denticles, creates a super-hydrophobic layer that reduces streamwise friction drag and increases swimming efficiency.

PMID: 27385753 [PubMed – as supplied by publisher]

Posted in J Exp Biol | Tagged | Leave a comment

The Sound of Silence: A Proxy for Platinum Toxicity.

The Sound of Silence: A Proxy for Platinum Toxicity.

J Clin Oncol. 2016 Jul 5;

Authors: Oldenburg J, Gietema JA

PMID: 27382103 [PubMed – as supplied by publisher]

Posted in J Clin Oncol | Tagged | Leave a comment

Expression of the ERK and AKT –pathway in placentas from severe intra-uterine growth restricted pregnancies

Introduction: Intra-uterine growth restriction (IUGR) is a complicated condition of the fetus and is associated with perinatal morbidity and mortality. There is a link between low birth weight and adverse long term health outcomes. Improper placental function is the most important cause for IUGR. Phosphorylated proteins like AKT and ERK play an important role in several pathways associated with cell growth and proliferation. On the other hand, the method of immunohistochemistry (IHC) is a widely used technique and very time-efficient in combination with a Tissue Microarray (TMA). However, the construction of a TMA is not yet validated for placenta paraffin material.
Aims: We want to find out whether the TMA is a valid method for performing immunohistochemistry in placenta tissue and if there a correlation between the expression of the pERK and pAKT pathway in placentas from IUGR children.
Materials and methods: For this retrospective case control study we used placenta paraffin material which were taken from 2005 until 2015 at the University Medical Centre Groningen (UMCG). 22 IUGR cases were selected and these were matched to 15 controls based on their gestational age and birth weight. A TMA was constructed with 222 cores (placenta parenchyma) and 16 control cores. Immunohistochemistry were performed with antibodies for pERK and pAKT.
Results: The TMA was constructed successfully without any core loss. Staining with pERK and pAKT was not successful because it was hard to specify the correct location of staining in placenta paraffin material.
Conclusion: Validation of a TMA with the use of pERK and pAKT was difficult because the relative unknown staining-patterns of these proteins in placenta and the possible degeneration of the phosphorylated proteins. We can conclude that validation of a TMA should be possible, but is more achievable with a protein that gives better staining results in placenta paraffin.
Key words: Tissue Microarray; intra-uterine growth restriction; validation; placenta; immunohistochemistry

Posted in Thesis | Tagged | Leave a comment